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1. 发明授权

US5763688A Method for producing an alcohol 失效
标题翻译：醇的制造方法
公开(公告)号：US5763688A
公开(公告)日：1998-06-09
申请号：US568589
申请日：1995-12-07
申请人： Takao Ikariya , Takeshi Ohkuma , Hirohito Ooka , Shohei Hashiguchi , Nobuo Seido , Ryoji Noyori
发明人： Takao Ikariya , Takeshi Ohkuma , Hirohito Ooka , Shohei Hashiguchi , Nobuo Seido , Ryoji Noyori
IPC分类号： C07B41/02 , C07B53/00 , C07C29/145 , C07C41/26 , C07C67/31 , C07D213/30 , C07F17/02 , C07C29/36
CPC分类号： C07D213/30 , C07B41/02 , C07B53/00 , C07C29/145 , C07C403/08 , C07C41/26 , C07C67/31 , C07F17/02 , C07B2200/07 , C07B2200/09 , C07C2101/14 , C07C2101/16 , C07C2102/10 , C07C2103/18 , C07C2103/26
摘要： The present invention provides a method for producing a alcohol including an optically active alcohol by hydrogenating a carbonyl compound in the presence of a homogeneous catalyst, a base and a nitrogen-containing organic compound. Thus, the reaction employs an inexpensive catalyst and proceeds in high yield and high efficiency.
摘要翻译：本发明提供通过在均相催化剂，碱和含氮有机化合物的存在下氢化羰基化合物来制备包含光学活性醇的醇的方法。因此，反应采用廉价的催化剂，并以高产率和高效率进行。

2. 发明授权

US06887820B1 Method for producing optically active compounds 失效
标题翻译：光学活性化合物的制造方法
公开(公告)号：US06887820B1
公开(公告)日：2005-05-03
申请号：US09661560
申请日：2000-09-14
申请人： Takao Ikariya , Shohei Hashiguchi , Jun Takehara , Nobuyuki Uematsu , Kazuhiko Matsumura , Ryoji Noyori , Akio Fujii
发明人： Takao Ikariya , Shohei Hashiguchi , Jun Takehara , Nobuyuki Uematsu , Kazuhiko Matsumura , Ryoji Noyori , Akio Fujii
IPC分类号： B01J31/02 , B01J31/18 , C07C29/143 , C07C67/31 , C07C209/52 , C07C211/27 , C07C211/30 , C07C211/40 , C07C213/02 , C07C217/84 , B01J31/00 , C07C37/00 , C07F15/00
CPC分类号： B01J31/0271 , B01J31/0237 , B01J31/0267 , B01J31/1805 , B01J2531/82 , B01J2531/821 , B01J2531/84 , C07C29/143 , C07C67/31 , C07C209/52 , C07C213/02 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07C2603/66 , C07C211/27 , C07C211/30 , C07C211/40 , C07C217/84 , C07C33/18 , C07C33/20 , C07C35/32 , C07C31/1355 , C07C35/08 , C07C35/36 , C07C35/14 , C07C35/37
摘要： A method for producing optically active compounds is disclosed. The method is highly practical for producing optically active compounds useful for various utilities such as intermediates for synthesizing pharmaceutical agents, liquid crystal materials and agents for optical resolution.
摘要翻译：公开了一种制备光学活性化合物的方法。该方法对于制备可用于各种用途的光学活性化合物，例如用于合成药剂的中间体，液晶材料和光学拆分剂。

3. 发明授权

US06184381B2 Process for preparing optically active compounds 有权
标题翻译：光学活性化合物的制备方法
公开(公告)号：US06184381B2
公开(公告)日：2001-02-06
申请号：US09077787
申请日：1998-09-29
申请人： Takao Ikariya , Shohei Hashiguchi , Jun Takehara , Nobuyuki Uematsu , Kazuhiko Matsumura , Ryoji Noyori , Akio Fujii
发明人： Takao Ikariya , Shohei Hashiguchi , Jun Takehara , Nobuyuki Uematsu , Kazuhiko Matsumura , Ryoji Noyori , Akio Fujii
IPC分类号： C07D45302
CPC分类号： B01J31/2295 , B01J31/0237 , B01J31/0239 , B01J31/0252 , B01J31/0267 , B01J31/0271 , B01J31/1805 , B01J2231/643 , B01J2531/821 , C07B2200/07 , C07C29/143 , C07C67/31 , C07C209/52 , C07C213/02 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C211/27 , C07C211/30 , C07C211/40 , C07C217/84 , C07C35/32
摘要： This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various applications, for example, as synthetic intermediates of pharmaceuticals, liquid crystal materials, and reagents for optical resolution, wherein a hydrogen transfer type asymmetric reduction is carried out in the presence of both a transition metal complex and an optically active nitrogen compound or a transition metal complex having an optically active nitrogen compounds as an asymmetric ligand, and a hydrogen-donating organic or inorganic compound.
摘要翻译：该文献描述了用于制备光学活性化合物（例如可用于各种应用的光学活性醇或胺）的新颖且实际上优异的方法，例如用作药物，液晶材料和用于光学拆分的试剂的合成中间体，其中氢转移型不对称还原在过渡金属配合物和光学活性氮化合物或具有光学活性氮化合物作为不对称配体的过渡金属配合物和供氢有机或无机化合物的存在下进行。

4. 发明授权

US06787650B1 Urea compounds, process for producing the same and use thereof 失效
标题翻译：尿素化合物，其制造方法及其用途
公开(公告)号：US06787650B1
公开(公告)日：2004-09-07
申请号：US10089961
申请日：2002-04-05
申请人： Osamu Kurasawa , Shinichi Imamura , Shohei Hashiguchi , Osamu Nishimura , Naoyuki Kanzaki , Masanori Baba
发明人： Osamu Kurasawa , Shinichi Imamura , Shohei Hashiguchi , Osamu Nishimura , Naoyuki Kanzaki , Masanori Baba
IPC分类号： C07D41700
CPC分类号： C07D211/14
摘要： A compound of the formula: [wherein R1 is a hydrocarbon group which may be substituted; R2 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; R3 is halogen atoms, a carbamoyl group which may be substituted, a sulfamoyl group which may be substituted, an acyl group derived from sulfonic acid, a C1-4 alkyl group which may be substituted, a C1-4 alkoxy group which may be substituted, an amino group which may be substituted, a nitro group or a cyano group; R4 is hydrogen atoms or a hydroxy group; n is 0 or 1; and p is 0 or 1 to 4]; or a salt thereof, has potent CCR5 antagonistic activity and can be advantageously used as a medicament for inhibition of HIV infection to human peripheral blood mononuclear cells, especially for the treatment or prevention of AIDS.
摘要翻译：下式的化合物：其中R 1为可被取代的烃基; R 2为可被取代的环状烃基或可被取代的杂环基; R 3为卤素原子，可以被取代的氨基甲酰基，可以被取代的氨磺酰基，可以被取代的酰基，可以被取代的C1-4烷基，可被取代的C1-4烷氧基，氨基其可以被取代，硝基或氰基; R 4是氢原子或羟基; n是0或1; 和p为0或1至4];或其盐具有有效的CCR5拮抗活性，并且可有利地用作抑制人外周血单核细胞的HIV感染的药物，特别是用于治疗或预防AIDS。

5. 发明授权

US06906055B2 Phosphonocephem compound 有权
标题翻译：膦酰基化合物
公开(公告)号：US06906055B2
公开(公告)日：2005-06-14
申请号：US10343285
申请日：2001-08-10
申请人： Tomoyasu Ishikawa , Shohei Hashiguchi , Yuji Iizawa
发明人： Tomoyasu Ishikawa , Shohei Hashiguchi , Yuji Iizawa
IPC分类号： A61K31/675 , A61P31/04 , C07D501/14 , C07F9/6561 , C07D501/59 , A61K31/546
CPC分类号： A61K31/675 , C07F9/65613
摘要： A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CH3COOH, CH3CH2COOH or CH3CN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior quality such as high solid stability, possible long-term stable preservation and the like.
摘要翻译：由式[I]表示的头孢烯化合物（特别是其结晶），其中X是CH 3 COOH，CH 3 CH 2 COOH或 CH 3 CN，n为0〜5，可用作抗菌剂（特别是抗MRSA剂），并且具有优异的质量，例如高固体稳定性，可能的长期稳定保存等。

6. 发明授权

US5270308A 1,3-benzoxazine derivatives, their production and use 失效
标题翻译： 1,3-苯并恶嗪衍生物，其生产和使用
公开(公告)号：US5270308A
公开(公告)日：1993-12-14
申请号：US764692
申请日：1991-09-25
申请人： Mitsuru Shiraishi , Shohei Hashiguchi , Toshifumi Watanabe
发明人： Mitsuru Shiraishi , Shohei Hashiguchi , Toshifumi Watanabe
IPC分类号： C07D265/16 , C07D413/04 , C07D417/04 , C07F7/08 , A61K31/535 , C07D265/12 , C07D498/04
CPC分类号： C07D413/04 , C07D265/16 , C07D417/04 , C07F7/0812
摘要： A new compound of the formula: ##STR1## wherein ##STR2## is an optionally substituted benzene ring; R.sup.1 is a carbocyclic or heterocyclic group which is linked to the 4-position of the 1,3-benzoxazine ring through a carbon-carbon bond, a hydrocarbon residue, etc.; and R.sup.2 and R.sup.3 are independently a hydrogen atom or an optionally substituted C.sub.1-6 alkyl group, etc., or a salt thereof is useful for treating and preventing heart, circulatory, respiratory and cerebral diseases.

7. 发明授权

US07348324B2 Cyclic amine compounds as CCR5 antagonists 有权
标题翻译：环胺化合物作为CCR5拮抗剂
公开(公告)号：US07348324B2
公开(公告)日：2008-03-25
申请号：US10273111
申请日：2002-10-18
申请人： Shinichi Imamura , Shohei Hashiguchi , Taeko Hattori , Osamu Nishimura , Naoyuki Kanzaki , Masanori Baba , Yoshihiro Sugihara
发明人： Shinichi Imamura , Shohei Hashiguchi , Taeko Hattori , Osamu Nishimura , Naoyuki Kanzaki , Masanori Baba , Yoshihiro Sugihara
IPC分类号： A61P31/18 , A61K31/535 , A61K31/4965 , A61K31/44 , A61K31/47 , C07D413/00 , C07D241/00 , C07D211/00
CPC分类号： C07D401/12 , C07D211/58 , C07D211/62 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/14
摘要： A compound of formula (I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R1 and R2 may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N+—R5.Y− (R5 is a hydrocarbon group; Y− is a counter anion); R3 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R4 is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G1 is a bond, CO or SO2; G2 is CO, SO2, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C1-3 aliphatic hydrocarbon which may be substituted; provided that J is methine when G2 is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G1 is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).
摘要翻译：式（I）化合物（其中R 1为氢原子，可被取代的烃基，可被取代的非芳香族杂环基，R 2 O 2 >可以被取代的烃基，可以被取代的非芳族杂环基，或者R 1和R 2可以彼此结合形成A至形成可以被取代的杂环基; A是N或N + - - - - - - - （R 5） SUP>为烃基; Y为 - 抗衡阴离子）; R 3为可被取代的环状烃基或可被取代的杂环基; n 为0或1; R 4为氢原子，可被取代的烃基，可被取代的杂环基，可被取代的烷氧基，可被取代的芳氧基，或可以被取代的氨基，E是可以是二价脂族烃基被除氧基以外的基团取代; G 1是一个键，CO或SO 2; G 2是CO，SO 2，NHCO，CONH或OCO; J为次甲基或氮原子; 并且Q和R中的每一个是可被取代的键或二价C 1-3烷基脂族烃; 条件是当G 2 O是OCO时J为次甲基，当另一个为键并且Q和R各自不被氧代基取代时，Q和R中的一个不为键，当G 1是一个键时）或其盐具有强的CCR5拮抗活性，并且可以有利地用于治疗或预防人类各种HIV感染性疾病（如艾滋病）。

8. 发明授权

US07067537B2 Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof 失效
标题翻译：带有3-吡啶基的取代噻唑衍生物，其制备方法及其应用
公开(公告)号：US07067537B2
公开(公告)日：2006-06-27
申请号：US10433910
申请日：2001-12-07
申请人： Noritaka Kuroda , Yoshi Nara , Shohei Hashiguchi , Akihiro Tasaka , Masami Kusaka , Masuo Yamaoka , Tomohiro Kaku
发明人： Noritaka Kuroda , Yoshi Nara , Shohei Hashiguchi , Akihiro Tasaka , Masami Kusaka , Masuo Yamaoka , Tomohiro Kaku
IPC分类号： A01N43/40 , A61K31/44
CPC分类号： C07D417/04 , A61K31/4439 , A61K31/4545 , A61K31/4725 , C07D417/14
摘要： The present invention provides a pharmaceutical composition having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism, tumor such as breast cancer and the like, more particularly, a steroid C17,20-lyase inhibitor containing a compound represented by the formula: wherein A1 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, one of A2 and A3 is a hydrogen atom, a halogen atom, a C1-4 aliphatic hydrocarbon group optionally having substituents or an optionally esterified carboxyl group, the other of A2 and A3 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, and at least one of A1, A2 and A3 is a 3-pyridyl group optionally having substituents, or a salt thereof or a prodrug thereof.
摘要翻译：本发明提供了具有类固醇C 17-20半胱氨酸酶抑制活性的药物组合物，其可用作前列腺症的预防或治疗剂，诸如乳腺癌等肿瘤，更具体地，含有由下式表示的化合物的类固醇C 17-20重量酶抑制剂：其中A 1是任选具有取代基的芳族烃基或任选具有取代基的杂环基， A 2和A 3之一是氢原子，卤素原子，任选具有取代基的C 1-4烷基脂族烃基或任选地酯化的羧基，A 2和A 3中的另一个是任选具有取代基的芳族烃基或任选具有取代基的杂环基，并且A < SUP> 1，A 2和A 3是任选具有取代基的3-吡啶基，或其盐或前药其中。

9. 发明申请

US20050176697A1 Phosphonocephem compound 有权
公开(公告)号：US20050176697A1
公开(公告)日：2005-08-11
申请号：US11063715
申请日：2005-02-23
申请人： Tomoyasu Ishikawa , Shohei Hashiguchi , Yuji Iizawa
发明人： Tomoyasu Ishikawa , Shohei Hashiguchi , Yuji Iizawa
IPC分类号： A61K31/675 , A61P31/04 , C07D501/14 , C07F9/6561 , A61K31/545
CPC分类号： A61K31/675 , C07F9/65613
摘要： A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CH3COOH, CH3CH2COOH or CH3CN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior quality such as high solid stability, possible long-term stable preservation and the like.

10. 发明授权

US5351230A Optical information system focal point displacement detecting means having Fresnel zone plates with rectilinear grating 失效
标题翻译：光信息系统焦点位移检测装置，具有带有直线光栅的菲涅耳带片
公开(公告)号：US5351230A
公开(公告)日：1994-09-27
申请号：US964964
申请日：1992-10-22
申请人： Tadashi Takeda , Hiroyuki Wada , Kenji Fukui , Ricardo M. Okamoto , Shohei Hashiguchi
发明人： Tadashi Takeda , Hiroyuki Wada , Kenji Fukui , Ricardo M. Okamoto , Shohei Hashiguchi
IPC分类号： G11B7/09 , G11B7/135 , G11B7/00
CPC分类号： G11B7/1353 , G11B7/0909
摘要： This invention pertains to a displacement detecting device for an optical head for detecting focal point displacement of irradiation light. The displacement detecting device has optical means for converting reflected rays from an irradiated face into an astigmatic bundle of rays and a photodetector for detecting a change in the the focused shape. The displacement detecting device thus detects focal point displacement of irradiation light. The optical means is obtained by integrally forming a plurality of Fresnel zone plates having rectilinear gratings, focusing reflected rays from the irradiated face, and having different focal lengths.
摘要翻译：本发明涉及用于检测照射光的焦点位移的光学头的位移检测装置。位移检测装置具有用于将来自照射面的反射光线转换成散光束的光学装置和用于检测聚焦形状的变化的光电检测器。因此，位移检测装置检测照射光的焦点位移。光学装置是通过一体地形成多个具有直线光栅的菲涅耳带板，聚焦来自照射面的反射光线并具有不同的焦距而获得的。

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