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1. 发明申请

US20120052457A1 THERMAL PROCESSING APPARATUS 审中-公开
标题翻译：热处理设备
公开(公告)号：US20120052457A1
公开(公告)日：2012-03-01
申请号：US13196330
申请日：2011-08-02
申请人： Takanori Saito , Makoto Nakajima
发明人： Takanori Saito , Makoto Nakajima
IPC分类号： F27B11/00
CPC分类号： H01L21/67109 , C23C16/46 , C30B25/08 , C30B25/10 , C30B29/06 , C30B33/02 , C30B35/002
摘要： There is provided a thermal processing apparatus in which the outer shell of a vacuum insulation layer-forming structure has an increased buckling strength. The thermal processing apparatus 1 includes a cylindrical reaction tube 3, a boat 5 for holding wafers W, a heater 2 provided around the reaction tube 3, and a vacuum insulation layer-forming structure 10 provided around the heater 2. The vacuum insulation layer-forming structure 10 includes an inner shell 11 and an outer shell 12 which forms a vacuum insulation layer 10a between the outer shell 12 and the inner shell 11. The outer shell 12 is comprised of a thin plate having an undulating cross-sectional shape formed by plastic forming.
摘要翻译：提供了一种热处理装置，其中真空绝热层形成结构的外壳具有增加的屈曲强度。热处理装置1包括圆柱形反应管3，用于保持晶片W的舟形件5，设置在反应管3周围的加热器2和设置在加热器2周围的真空绝热层形成结构10.真空绝热层 - 成形结构10包括内壳11和外壳12，外壳12和外壳12在外壳12和内壳11之间形成真空绝热层10a。外壳12由具有波浪形横截面形状的薄板构成，塑料成型。

2. 发明授权

US07432475B2 Vertical heat treatment device and method controlling the same 有权
标题翻译：立式热处理装置及其控制方法
公开(公告)号：US07432475B2
公开(公告)日：2008-10-07
申请号：US10584258
申请日：2004-12-22
申请人： Makoto Nakajima , Takanori Saito , Tsuyoshi Takizawa , Manabu Honma
发明人： Makoto Nakajima , Takanori Saito , Tsuyoshi Takizawa , Manabu Honma
IPC分类号： F27B5/14
CPC分类号： F27B17/0025 , F27B5/04 , F27B5/18
摘要： A vertical heat processing apparatus includes a process chamber (5) defining a process field (A1) configured to accommodate a plurality of target substrates (W) supported at intervals in a vertical direction. The apparatus further includes a heating furnace (8) surrounding the process chamber (5) and including an electric heater (15), and an electric blower (16) configured to send a cooling gas into the heating furnace (8). A control section (22) executes, in order to converge the process field (A1) to a target temperature, performing power feeding to the heater (15) to heat up the process field (A1) to a predetermined temperature immediately below the target temperature, and at a time point when the process field (A1) reaches the predetermined temperature, decreasing the power feeding to the heater (15), and supplying the cooling gas from the blower (16) to forcibly cool the process field (A1).
摘要翻译：垂直加热设备包括一个处理室（5），该处理室（5）限定一个处理场（A 1），该处理区域被配置为容纳在垂直方向间隔地支撑的多个目标衬底（W）。该装置还包括围绕处理室（5）并包括电加热器（15）的加热炉（8）和构造成将冷却气体送入加热炉（8）的电动鼓风机（16）。控制部（22）为了将处理场（A 1）收敛到目标温度，执行向加热器（15）供电以将处理场（A 1）加热至紧接在目标温度，并且当处理场（A 1）达到预定温度的时间点，减少对加热器（15）的供电，并且从鼓风机（16）供应冷却气体以强制冷却过程场（ A 1）。

3. 发明申请

US20070148606A1 Vertical heat treatment device and method controlling the same 有权
标题翻译：立式热处理装置及其控制方法
公开(公告)号：US20070148606A1
公开(公告)日：2007-06-28
申请号：US10584258
申请日：2004-12-22
申请人： Makoto Nakajima , Takanori Saito , Tsuyoshi Takizawa , Manabu Honma
发明人： Makoto Nakajima , Takanori Saito , Tsuyoshi Takizawa , Manabu Honma
IPC分类号： F27D15/02
CPC分类号： F27B17/0025 , F27B5/04 , F27B5/18
摘要： A vertical heat processing apparatus includes a process chamber (5) defining a process field (A1) configured to accommodate a plurality of target substrates (W) supported at intervals in a vertical direction. The apparatus further includes a heating furnace (8) surrounding the process chamber (5) and including an electric heater (15), and an electric blower (16) configured to send a cooling gas into the heating furnace (8). A control section (22) executes, in order to converge the process field (A1) to a target temperature, performing power feeding to the heater (15) to heat up the process field (A1) to a predetermined temperature immediately below the target temperature, and at a time point when the process field (A1) reaches the predetermined temperature, decreasing the power feeding to the heater (15), and supplying the cooling gas from the blower (16) to forcibly cool the process field (A1).
摘要翻译：垂直加热设备包括一个处理室（5），该处理室（5）限定一个处理场（A 1），该处理区域被配置为容纳在垂直方向间隔地支撑的多个目标衬底（W）。该装置还包括围绕处理室（5）并包括电加热器（15）的加热炉（8）和构造成将冷却气体送入加热炉（8）的电动鼓风机（16）。控制部（22）为了将处理场（A 1）收敛到目标温度，执行向加热器（15）供电以将处理场（A 1）加热至紧接在目标温度，并且当处理场（A 1）达到预定温度的时间点，减少对加热器（15）的供电，并且从鼓风机（16）供应冷却气体以强制冷却过程场（ A 1）。

4. 发明授权

US09324591B2 Heat treatment apparatus and heat treatment method 有权
标题翻译：热处理设备及热处理方法
公开(公告)号：US09324591B2
公开(公告)日：2016-04-26
申请号：US13438234
申请日：2012-04-03
申请人： Koji Yoshii , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji Yoshii , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
IPC分类号： F27D21/00 , H01L21/67
CPC分类号： H01L21/67109 , H01L21/67248
摘要： A heat treatment apparatus including: a processing container for processing wafers held in a boat; heaters for heating the processing container; and a control section for controlling the heaters. Heater temperature sensors are provided between the heaters and the processing container, in-container temperature sensors are provided in the processing container, and movable temperature sensors are provided in the boat. The temperature sensors are connected to a temperature estimation section. The temperature estimation section selects two of the three types of temperature sensors, e.g. the movable temperature sensors and the in-container temperature sensors, and determines the temperature of a wafer according to the following formula: T=T1×(1−α)+T2×α, α>1, where T1 and T2 represent detection temperatures of the selected temperature sensors, and α represents a mixing ratio.
摘要翻译：一种热处理设备，包括：处理容器，用于处理保存在船上的晶片; 用于加热处理容器的加热器; 以及用于控制加热器的控制部。加热器温度传感器设置在加热器和处理容器之间，容器内温度传感器设置在处理容器中，并且可移动的温度传感器设置在船上。温度传感器连接到温度估计部。温度估计部分选择三种类型的温度传感器中的两种，例如，可移动温度传感器和容器内温度传感器，并根据以下公式确定晶片的温度：T = T1×（1-α）+ T2×α，α> 1，其中T1和T2表示检测温度的选定温度传感器，α表示混合比。

5. 发明授权

US09273128B2 Pharmaceutical composition for treatment and/or prophylaxis of cancer 有权
标题翻译：用于治疗和/或预防癌症的药物组合物
公开(公告)号：US09273128B2
公开(公告)日：2016-03-01
申请号：US14236793
申请日：2012-08-03
申请人： Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
发明人： Fumiyoshi Okano , Shinichi Kobayashi , Yoshitaka Minamida , Takanori Saito
IPC分类号： C07K16/30 , A61K39/395 , C07K16/18 , A61K45/06 , C07K16/28
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： This invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof as a therapeutic and/or preventive agent for cancer. More specifically, the present invention provides an antibody, or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown by SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer comprising the same as an active ingredient.
摘要翻译：本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其作为癌症治疗和/或预防剂的用途。更具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列或具有80％以上序列同一性的氨基酸序列组成的部分CAPRIN-1多肽具有免疫学反应性的抗体或其片段和用于治疗和/或预防癌症的药物组合物，其包含其作为活性成分。

6. 发明授权

US09180188B2 Pharmaceutical composition for treatment and/or prophylaxis of cancer 有权
标题翻译：用于治疗和/或预防癌症的药物组合物
公开(公告)号：US09180188B2
公开(公告)日：2015-11-10
申请号：US14236795
申请日：2012-08-03
申请人： Shinichi Kobayashi , Fumiyoshi Okano , Yoshitaka Minamida , Takanori Saito
发明人： Shinichi Kobayashi , Fumiyoshi Okano , Yoshitaka Minamida , Takanori Saito
IPC分类号： C07K16/30 , A61K39/395 , A61K45/06 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/732 , A61K2300/00
摘要： It is intended to identify a cancer antigenic protein specifically expressed on the surface of cancer cells and to provide an antibody targeting the antigenic protein and use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody comprising a heavy chain variable region comprising amino acid sequences of SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences of SEQ ID NOs: 9, 10, and 11, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising this antibody or fragment as an active ingredient.
摘要翻译：旨在鉴定在癌细胞表面上特异性表达的癌抗原蛋白，并提供靶向抗原蛋白的抗体和使用抗体作为癌症的治疗和/或预防剂。本发明提供了与CAPRIN-1蛋白具有免疫反应性的抗体或其片段，所述抗体包含包含SEQ ID NO：5,6和7的氨基酸序列的重链可变区和轻链可变区包含SEQ ID NO：9,10和11的氨基酸序列，和包含该抗体或片段作为活性成分的用于治疗和/或预防癌症的药物组合物。

7. 发明申请

US20140178373A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PROPHYLAXIS OF CANCER 有权
公开(公告)号：US20140178373A1
公开(公告)日：2014-06-26
申请号：US14236665
申请日：2012-08-03
申请人： Shinichi Kobayashi , Fumiyoshi Okano , Takanori Saito
发明人： Shinichi Kobayashi , Fumiyoshi Okano , Takanori Saito
IPC分类号： C07K16/30 , A61K45/06 , A61K39/395
CPC分类号： C07K16/30 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6861 , A61K47/6865 , A61K47/6869 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/732
摘要： An object of the present invention is to prepare an antibody that targets CAPRIN-1 specifically expressed on the surface of cancer cells and is superior in antitumor activity to conventional antibodies and to provide use of the antibody as a therapeutic and/or preventive agent for cancer. The present invention provides use of an antibody targeting an identified cancer antigenic protein specifically expressed on the surface of cancer cells as a therapeutic and/or preventive agent for cancer, specifically, a pharmaceutical composition for treatment and/or prevention of cancer, comprising as an active ingredient an antibody or a fragment thereof which has immunological reactivity with a CAPRIN-1 protein, the antibody or the fragment thereof comprising a heavy chain variable region comprising amino acid sequences represented by SEQ ID NOs: 5, 6, and 7 and a light chain variable region comprising amino acid sequences represented by SEQ ID NOs: 9, 10, and 11.

8. 发明申请

US20120258415A1 HEAT TREATMENT APPARATUS AND HEAT TREATMENT METHOD 有权
标题翻译：热处理设备和热处理方法
公开(公告)号：US20120258415A1
公开(公告)日：2012-10-11
申请号：US13438234
申请日：2012-04-03
申请人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
发明人： Koji YOSHII , Tatsuya Yamaguchi , Wenling Wang , Takanori Saito
IPC分类号： F27D21/00 , F27D3/00
CPC分类号： H01L21/67109 , H01L21/67248
摘要： A heat treatment apparatus including: a processing container for processing wafers held in a boat; heaters for heating the processing container; and a control section for controlling the heaters. Heater temperature sensors are provided between the heaters and the processing container, in-container temperature sensors are provided in the processing container, and movable temperature sensors are provided in the boat. The temperature sensors are connected to a temperature estimation section. The temperature estimation section selects two of the three types of temperature sensors, e.g. the movable temperature sensors and the in-container temperature sensors, and determines the temperature of a wafer according to the following formula: T=T1×(1−α)+T2×α, α>1, where T1 and T2 represent detection temperatures of the selected temperature sensors, and α represents a mixing ratio.
摘要翻译：一种热处理设备，包括：处理容器，用于处理保存在船上的晶片; 用于加热处理容器的加热器; 以及用于控制加热器的控制部。加热器温度传感器设置在加热器和处理容器之间，容器内温度传感器设置在处理容器中，并且可移动的温度传感器设置在船上。温度传感器连接到温度估计部。温度估计部分选择三种类型的温度传感器中的两种，例如，可移动温度传感器和容器内温度传感器，并根据以下公式确定晶片的温度：T = T1×（1-α）+ T2×α，α> 1，其中T1和T2表示检测温度的选定温度传感器，α表示混合比。

9. 发明申请

US20110256144A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF CANCERS 有权
标题翻译：用于治疗和预防癌症的药物组合物
公开(公告)号：US20110256144A1
公开(公告)日：2011-10-20
申请号：US13057709
申请日：2009-08-05
申请人： Fumiyoshi Okano , Takayoshi Ido , Takanori Saito , Shinichi Kobayashi
发明人： Fumiyoshi Okano , Takayoshi Ido , Takanori Saito , Shinichi Kobayashi
IPC分类号： A61K39/395 , A61P35/00 , A61P35/02 , C07K16/18
CPC分类号： C07K16/3015 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.
摘要翻译：本发明涉及用于治疗和/或预防癌症的药物组合物，其包含与包含7个或更多个连续氨基酸的CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分酸。

10. 发明申请

US20100224614A1 Heat Treatment Apparatus, Heater, and Method for Manufacturing the Heater 有权
标题翻译：热处理装置，加热器及加热器制造方法
公开(公告)号：US20100224614A1
公开(公告)日：2010-09-09
申请号：US12223162
申请日：2007-02-07
申请人： Makoto Kobayashi , Kenichi Yamaga , Takanori Saito
发明人： Makoto Kobayashi , Kenichi Yamaga , Takanori Saito
IPC分类号： F27D11/00 , H05B3/02
CPC分类号： H01L21/67109 , H01L21/425 , Y10T29/49083
摘要： The present invention provides a heat treatment apparatus having a high degree of freedom of an outlet design and capable of adjusting the rate of a reduction in the temperature of each part of a heater without using an adjustment valve. The heat treatment apparatus having a simple flow path structure can be constructed with simplified sealing and a reduced cost.The heat treatment apparatus 1 includes a process chamber 2, a tubular heater 3, a heat exhaust system 25 and a cooling section 26. The process chamber 2 accommodates objects W to be placed in multiple stages and to be treated. A predetermined heat treatment is performed in the process chamber. The heater 3 surrounds an outer circumference of the process chamber 2 and heats the objects W to be treated. The heat exhaust system 25 is adapted to exhaust an atmosphere present in a space 24 existing between the heater 3 and the process chamber 2. The cooling section 26 is adapted to blow a cooling fluid into the space 24 to cool the atmosphere. The heater 3 includes a tubular heat insulator 17, a heat generating resistor 18 and an outer shell 20. The heat generating resistor 18 is provided on an inner circumference of the heat insulator 17. The outer shell 20 is provided on an outer circumference of the heat insulator 17. The cooling section 26 includes at least one annular flow path 28 and an outlet 29. The annular flow path 28 is arranged between the heat insulator 17 and the outer shell 20. The outlet 29 is provided in the heat insulator 17. The outlet 29 is arranged to ensure that the cooling fluid is blown out of the outlet 29 toward a vertical central axis of the heat insulator 17 or in a direction oblique to the direction toward vertical central axis of the heat insulator 17.
摘要翻译：本发明提供一种热处理装置，其具有出口设计的高自由度，并且能够调节加热器的每个部件的温度降低的速率而不使用调节阀。具有简单的流路结构的热处理装置可以以简单的密封和降低的成本构成。热处理设备1包括处理室2，管状加热器3，散热系统25和冷却部分26.处理室2容纳待放置的多个物体W并进行处理。在处理室中进行预定的热处理。加热器3围绕处理室2的外周并加热被处理物体W. 散热系统25适于排出存在于加热器3和处理室2之间的空间24中的气氛。冷却部分26适于将冷却流体吹入空间24以冷却大气。加热器3包括管状隔热件17，发热电阻18和外壳20.发热电阻18设置在隔热材料17的内周上。外壳20设置在绝热体17的外周。绝热体17.冷却部分26包括至少一个环形流动路径28和出口29.环形流路28设置在绝热体17和外壳20之间。出口29设置在绝热体17中。出口29布置成确保冷却流体从出口29朝向隔热件17的垂直中心轴线或者沿着与隔热件17的垂直中心轴方向倾斜的方向吹出。

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