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1. 发明申请

US20110152119A1 Quantification Method of Biochemical Substances Using Ion Scattering Spectroscopy and Specific-Binding Efficiency Quantification Method of Biochemical Substances Using Ion Scattering Spectroscopy 审中-公开
标题翻译：使用离子散射光谱法和生物化学物质的特异性结合效率定量方法的生物化学物质的定量方法
公开(公告)号：US20110152119A1
公开(公告)日：2011-06-23
申请号：US13059445
申请日：2009-08-21
申请人： Tae Geol Lee , Dae Won Moon , Hye geun Min
发明人： Tae Geol Lee , Dae Won Moon , Hye geun Min
IPC分类号： C40B30/04
CPC分类号： G01N33/54353
摘要： A method for direct quantification of the areal density (number per surface area of a substrate) of an analyte including a biochemical substance bound on the surface of a substrate and for direct quantification of the binding efficiency of biochemical substances is disclosed. Specifically, the areal density of an analyte including a biochemical substance bound on the surface of a substrate, and the binding efficiency between a first biochemical substance fixed on the substrate surface and a second biochemical substance is measured by ion scattering spectroscopy (ISS).
摘要翻译：公开了用于直接定量包含结合在基材表面上的生物化学物质的分析物的面密度（基底的每个表面积的数量）和用于直接定量生化物质的结合效率的方法。具体地，通过离子散射光谱法（ISS）测量包含结合在基材表面上的生物化学物质的分析物的面密度和固定在基材表面上的第一生物化学物质与第二生化物质之间的结合效率。

2. 发明申请

US20110163228A1 QUANTIFICATION METHOD OF FUNCTIONAL GROUPS OF ORGANIC LAYER 有权
标题翻译：有机层功能组数量化方法
公开(公告)号：US20110163228A1
公开(公告)日：2011-07-07
申请号：US13063616
申请日：2009-09-24
申请人： Tae Geol Lee , Dae Won Moon , Hyegeun Min
发明人： Tae Geol Lee , Dae Won Moon , Hyegeun Min
IPC分类号： H01J49/40 , G01N23/225
CPC分类号： G01N23/2255
摘要： A quantification method of functional groups in an organic thin layer includes: a) measuring an absolute quantity per unit area of an analysis reference material having functional groups included in a reference organic thin layer by means of MEIS spectroscopy; b) carrying out spectrometry for the same reference organic thin layer as in a) and thereby obtaining peak intensities of the functional groups in the reference organic thin layer; c) carrying out the same spectrometry as in b) for an organic thin layer to be analyzed having the same functional groups and thereby measuring peak intensities of the functional groups with unknown quantity; and d) comparing the peak intensities of the functional groups measured in b) with respect to the absolute quantity of the analysis reference material in a) and thereby determining the absolute quantity per unit area of the functional groups with unknown quantity measured in c).
摘要翻译：有机薄层中的官能团的定量方法包括：a）通过MEIS光谱测量具有包括在参考有机薄层中的官能团的分析参考材料的每单位面积的绝对量; b）进行与a）相同的参考有机薄层的光谱测定，从而获得参考有机薄层中的官能团的峰值强度; c）进行与b）相同的光谱测定，对于具有相同官能团的待分析有机薄层，从而测量具有未知量的官能团的峰强度; 和d）比较a）中测定的官能团的峰强度相对于分析参考物质的绝对量，从而确定在c）中测量的具有未知量的官能团的每单位面积的绝对量。

3. 发明授权

US08283117B2 Disease diagnosis method, marker screening method and marker using TOF-SIMS 有权
标题翻译：疾病诊断方法，标记筛选方法和使用TOF-SIMS的标记
公开(公告)号：US08283117B2
公开(公告)日：2012-10-09
申请号：US12994263
申请日：2008-06-25
申请人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
发明人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
IPC分类号： A61K38/21
CPC分类号： G01N33/6851 , G01N33/57446 , Y10T436/173845 , Y10T436/200833
摘要： The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of- flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
摘要翻译：本发明涉及疾病诊断方法，标记筛选方法和使用飞行时间二次离子质谱法（TOF-SIMS）的标记物，更具体地，涉及大肠癌诊断方法，大肠癌症标志物筛选方法和使用飞行时间二次离子质谱（TOF-SIMS）的大肠癌标记物。具体地，本发明提供了使用以飞行时间二次离子质谱法（TOF-SIMS）作为标记测定的生物样品的二次离子质量（m / z）峰的图案，标记物，标记筛选方法是判断疾病的存在或不存在的参考，以及由特定二次离子质量峰构成的标记。

4. 发明授权

US08871438B2 Disease diagnosis method, marker screening method and marker using TOF-SIMS 有权
标题翻译：疾病诊断方法，标记筛选方法和使用TOF-SIMS的标记
公开(公告)号：US08871438B2
公开(公告)日：2014-10-28
申请号：US13570507
申请日：2012-08-09
申请人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
发明人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/6851 , G01N33/57446 , Y10T436/173845 , Y10T436/200833
摘要： The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
摘要翻译：本发明涉及疾病诊断方法，标记筛选方法和使用飞行时间二次离子质谱法（TOF-SIMS）的标记物，更具体地，涉及大肠癌诊断方法，大肠癌症标志物筛选方法和使用飞行时间二次离子质谱（TOF-SIMS）的大肠癌标记物。具体地，本发明提供使用飞行时间二次离子质谱法（TOF-SIMS）作为标记测定的生物样品的二次离子质量（m / z）峰图案，标记物筛选方法是判断疾病的存在或不存在的参考，以及由特定二次离子质量峰构成的标记。

5. 发明申请

US20130065266A1 Disease Diagnosis Method, Marker Screening Method and Marker Using TOF-SIMS 有权
标题翻译：疾病诊断方法，使用TOF-SIMS的标记筛选方法和标记
公开(公告)号：US20130065266A1
公开(公告)日：2013-03-14
申请号：US13570507
申请日：2012-08-09
申请人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
发明人： Tae Geol Lee , Dae Won Moon , Byong Chul Yoo , In Hoo Kim
IPC分类号： G01N27/62 , H01J49/40
CPC分类号： G01N33/6851 , G01N33/57446 , Y10T436/173845 , Y10T436/200833
摘要： The present invention relates to a disease diagnosis method, a marker screening method, and a marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS), and more particularly, to a large intestine cancer diagnosis method, a large intestine cancer marker screening method, and a large intestine cancer marker using a time-of-flight secondary ion mass spectrometry (TOF-SIMS). Specifically, the present invention provides a method diagnosing a disease using a pattern of secondary ion mass (m/z) peaks of biological samples measured using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) as a marker, a marker screening method being a reference judging an existence or non-existence of a disease, and a marker configured of specific secondary ion mass peaks.
摘要翻译：本发明涉及疾病诊断方法，标记筛选方法和使用飞行时间二次离子质谱法（TOF-SIMS）的标记物，更具体地，涉及大肠癌诊断方法，大肠癌症标志物筛选方法和使用飞行时间二次离子质谱（TOF-SIMS）的大肠癌标记物。具体地，本发明提供使用飞行时间二次离子质谱法（TOF-SIMS）作为标记测定的生物样品的二次离子质量（m / z）峰图案，标记物筛选方法是判断疾病的存在或不存在的参考，以及由特定二次离子质量峰构成的标记。

6. 发明授权

US07951572B2 Construction of gold nanoparticle-based peptide chip, and assaying enzyme activity and inhibitor effect using secondary ion mass spectrometric analysis thereof 有权
标题翻译：基于金纳米颗粒的肽芯片的构建，以及使用其二次离子质谱分析测定酶活性和抑制剂作用
公开(公告)号：US07951572B2
公开(公告)日：2011-05-31
申请号：US11711036
申请日：2007-02-27
申请人： Hak-Sung Kim , Young-Pil Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Tae Geol Lee , Dae Won Moon
发明人： Hak-Sung Kim , Young-Pil Kim , Eunkeu Oh , Mi-Young Hong , Dohoon Lee , Tae Geol Lee , Dae Won Moon
IPC分类号： C12N9/50 , C07K5/00
CPC分类号： G01N33/6848 , B82Y15/00 , C12Q1/00 , C12Q1/37 , C12Q1/42 , C12Q1/485 , G01N33/553 , G01N33/588 , G01N2500/04 , G01N2610/00
摘要： Disclosed herein is a gold nanoparticle (AuNP)-based peptide chip prepared by forming a monolayer of AuNPs onto a self-assembled monolayer constructed on a solid support, and then immobilizing a peptide on the AuNPs. The AuNPs can effectively amplify the mass signal of the peptide, thus making it possible to measure the mass change of the peptide in a simple and accurate manner. Also, when secondary ion mass spectrometric analysis (spectrum or imaging) is performed on the AuNP-based peptide chip, the activities of enzymes and related inhibitors can be effectively quantified. The disclosed invention enables various enzyme activities to be analyzed rapidly and accurately, and thus can provide an important method for disease diagnosis and new drug development through the elucidation of signaling and interaction mechanisms.
摘要翻译：本文公开了通过在固体支持物上构建的自组装单层上形成单层AuNP，然后将肽固定在AuNP上而制备的金纳米颗粒（AuNP）基肽芯片。 AuNPs可以有效地扩增肽的质量信号，从而使得可以以简单和准确的方式测量肽的质量变化。此外，当在基于AuNP的肽芯片上进行二次离子质谱分析（光谱或成像）时，可以有效地量化酶和相关抑制剂的活性。所公开的发明使得能够快速且准确地分析各种酶活性，因此可以通过阐明信号和相互作用机制来提供疾病诊断和新药开发的重要方法。

7. 发明授权

US08450684B2 Quantification method of functional groups of organic layer 有权
标题翻译：有机层官能团的定量方法
公开(公告)号：US08450684B2
公开(公告)日：2013-05-28
申请号：US13063616
申请日：2009-09-24
申请人： Tae Geol Lee , Dae Won Moon , Hyegeun Min
发明人： Tae Geol Lee , Dae Won Moon , Hyegeun Min
IPC分类号： G01N23/203
CPC分类号： G01N23/2255
摘要： A quantification method of functional groups in an organic thin layer includes: a) measuring an absolute quantity per unit area of an analysis reference material having functional groups included in a reference organic thin layer by means of MEIS spectroscopy; b) carrying out spectrometry for the same reference organic thin layer as in a) and thereby obtaining peak intensities of the functional groups in the reference organic thin layer; c) carrying out the same spectrometry as in b) for an organic thin layer to be analyzed having the same functional groups and thereby measuring peak intensities of the functional groups with unknown quantity; and d) comparing the peak intensities of the functional groups measured in b) with respect to the absolute quantity of the analysis reference material in a) and thereby determining the absolute quantity per unit area of the functional groups with unknown quantity measured in c).
摘要翻译：有机薄层中的官能团的定量方法包括：a）通过MEIS光谱测量具有包括在参考有机薄层中的官能团的分析参考材料的每单位面积的绝对量; b）进行与a）相同的参考有机薄层的光谱测定，从而获得参考有机薄层中的官能团的峰值强度; c）进行与b）相同的光谱测定，对于具有相同官能团的待分析有机薄层，从而测量具有未知量的官能团的峰强度; 和d）比较a）中测定的官能团的峰强度相对于分析参考物质的绝对量，从而确定在c）中测量的具有未知量的官能团的每单位面积的绝对量。

8. 发明授权

US08772713B1 Flight time based mass microscope system for ultra high-speed multi mode mass analysis 有权
标题翻译：用于超高速多模质量分析的飞行时间质量显微镜系统
公开(公告)号：US08772713B1
公开(公告)日：2014-07-08
申请号：US14117116
申请日：2012-05-03
申请人： Jeong Hee Moon , Dae Won Moon , Tae Geol Lee , Sohee Yoon , Ju Hwang Kim
发明人： Jeong Hee Moon , Dae Won Moon , Tae Geol Lee , Sohee Yoon , Ju Hwang Kim
IPC分类号： H01J49/40 , H01J37/26 , H01J37/28 , B01D59/44 , H01J49/00
CPC分类号： H01J49/0004 , H01J49/142 , H01J49/164 , H01J49/40 , H01J49/406
摘要： The present invention aims to provide a time-of-flight based mass microscope system for an ultra-high speed multi-mode mass analysis, for using a laser beam or an ion beam simultaneously to enable both a low molecular weight analysis such as for drugs/metabolome/lipids/peptides and a high molecular weight analysis such as for genes/proteins, without being limited by the molecular weight of the object being analyzed, and for significantly increasing the measuring speed by using a microscope method instead of a microprobe method.
摘要翻译：本发明旨在提供一种用于超高速多模式质量分析的飞行时间质量显微镜系统，用于同时使用激光束或离子束，以实现低分子量分析，例如用于药物 /代谢组胺/脂质/肽和高分子量分析，例如用于基因/蛋白质，而不受被分析物体的分子量的限制，并且通过使用显微镜法而不是微探针法显着增加测量速度。

9. 发明申请

US20140183354A1 FLIGHT TIME BASED MASS MICROSCOPE SYSTEM FOR ULTRA HIGH-SPEED MULTI MODE MASS ANALYSIS 有权
标题翻译：用于超高速多模式质量分析的基于飞行时间的大量显微系统
公开(公告)号：US20140183354A1
公开(公告)日：2014-07-03
申请号：US14117116
申请日：2012-05-03
申请人： Jeong Hee Moon , Dae Won Moon , Tae Geol Lee , Sohee Yoon , Ju Hwang Kim
发明人： Jeong Hee Moon , Dae Won Moon , Tae Geol Lee , Sohee Yoon , Ju Hwang Kim
IPC分类号： H01J49/00 , H01J49/40
CPC分类号： H01J49/0004 , H01J49/142 , H01J49/164 , H01J49/40 , H01J49/406
摘要： The present invention aims to provide a time-of-flight based mass microscope system for an ultra-high speed multi-mode mass analysis, for using a laser beam or an ion beam simultaneously to enable both a low molecular weight analysis such as for drugs/metabolome/lipids/peptides and a high molecular weight analysis such as for genes/proteins, without being limited by the molecular weight of the object being analyzed, and for significantly increasing the measuring speed by using a microscope method instead of a microprobe method.
摘要翻译：本发明旨在提供一种用于超高速多模式质量分析的飞行时间质量显微镜系统，用于同时使用激光束或离子束，以实现低分子量分析，例如用于药物 /代谢组胺/脂质/肽和高分子量分析，例如用于基因/蛋白质，而不受被分析物体的分子量的限制，并且通过使用显微镜法而不是微探针法显着增加测量速度。

10. 发明申请

US20110101217A1 Mass Spectrometric Method for Matrix-Free Laser Desorption/Ionization of Self-Assembled Monolayers 审中-公开
标题翻译：自组装单层无矩阵激光解吸/电离质谱法
公开(公告)号：US20110101217A1
公开(公告)日：2011-05-05
申请号：US12988925
申请日：2009-04-24
申请人： Sang Yun Han , Tae Geol Lee , Dae Won Moon
发明人： Sang Yun Han , Tae Geol Lee , Dae Won Moon
IPC分类号： H01J49/00
CPC分类号： G01N33/6851 , G01N2610/00 , H01J49/0418
摘要： Disclosed is a method for carrying out matrix-free mass spectrometry, which includes subjecting an analyte sample containing a self-assembled monolayer on the surface of a substrate to laser desorption/ionization. The method for carrying out matrix-free mass spectrometry involves simple pretreatment of an analyte sample with a cationic solution without using any solid matrix to cause effective laser desorption/ionization of the analyte sample, and minimizes a biochemical and physiological change in the sample that may occur during the pretreatment of the sample. In addition, the method is applicable to quantitative analysis because it provides high reproducibility of the results by virtue of the uniform treatment with the cationic solution over the whole areas of the sample. Further, the method enables two-dimensional mapping analysis.
摘要翻译：公开了一种进行无基质质谱的方法，其包括使含有自组装单层的分析物样品在基板的表面上进行激光解吸/电离。用于进行无基质质谱的方法包括用阳离子溶液简单地预处理分析物样品，而不使用任何固体基质来引起分析物样品的有效激光解吸/电离，并且最小化样品中的生物化学和生理变化，在样品的预处理期间发生。此外，该方法适用于定量分析，因为通过在样品的整个区域上的阳离子溶液的均匀处理，提供了高结果的再现性。此外，该方法能够进行二维映射分析。

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