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    • 1. 发明申请
    • Mass Spectrometric Method for Matrix-Free Laser Desorption/Ionization of Self-Assembled Monolayers
    • 自组装单层无矩阵激光解吸/电离质谱法
    • US20110101217A1
    • 2011-05-05
    • US12988925
    • 2009-04-24
    • Sang Yun HanTae Geol LeeDae Won Moon
    • Sang Yun HanTae Geol LeeDae Won Moon
    • H01J49/00
    • G01N33/6851G01N2610/00H01J49/0418
    • Disclosed is a method for carrying out matrix-free mass spectrometry, which includes subjecting an analyte sample containing a self-assembled monolayer on the surface of a substrate to laser desorption/ionization. The method for carrying out matrix-free mass spectrometry involves simple pretreatment of an analyte sample with a cationic solution without using any solid matrix to cause effective laser desorption/ionization of the analyte sample, and minimizes a biochemical and physiological change in the sample that may occur during the pretreatment of the sample. In addition, the method is applicable to quantitative analysis because it provides high reproducibility of the results by virtue of the uniform treatment with the cationic solution over the whole areas of the sample. Further, the method enables two-dimensional mapping analysis.
    • 公开了一种进行无基质质谱的方法,其包括使含有自组装单层的分析物样品在基板的表面上进行激光解吸/电离。 用于进行无基质质谱的方法包括用阳离子溶液简单地预处理分析物样品,而不使用任何固体基质来引起分析物样品的有效激光解吸/电离,并且最小化样品中的生物化学和生理变化, 在样品的预处理期间发生。 此外,该方法适用于定量分析,因为通过在样品的整个区域上的阳离子溶液的均匀处理,提供了高结果的再现性。 此外,该方法能够进行二维映射分析。