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1. 发明授权

US4853403A 3-phenylthiomethylstyrene derivative, process for preparing the same, and antiallergic agent and tyrosinekinase inhibiting agent containing the same 失效
标题翻译： 3-苯基硫代甲基苯乙烯衍生物，其制备方法，以及含有它们的抗过敏剂和酪氨酸激酶抑制剂
公开(公告)号：US4853403A
公开(公告)日：1989-08-01
申请号：US890034
申请日：1986-07-28
申请人： Tadayoshi Shiraishi , Naohiro Imai , Takeshi Domoto , Keiji Kameyama , Ikuo Katsumi , Takayoshi Hidaka , Kazunori Hosoe , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Naohiro Imai , Takeshi Domoto , Keiji Kameyama , Ikuo Katsumi , Takayoshi Hidaka , Kazunori Hosoe , Kiyoshi Watanabe
IPC分类号： C12N9/99 , A61K31/10 , A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/235 , A61K31/275 , A61K31/34 , A61K31/341 , A61K31/40 , A61K31/4015 , A61K31/415 , A61P3/00 , A61P11/00 , A61P35/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C313/00 , C07C317/44 , C07C323/16 , C07C323/29 , C07C323/56 , C07C323/65 , C07D207/26 , C07D207/267 , C07D207/38 , C07D231/32 , C07D231/36 , C07D231/56 , C07D307/33 , C07D307/58
CPC分类号： C07D207/267 , C07C323/00 , C07D231/32 , C07D307/33
摘要： A 3-phenylthiomethylstyrene derivative having the general formula (1): ##STR1## or salt thereof with a base, when X is hydroxyl group, R.sup.1 is hydrogen atom or R.sup.2 is hydrogen atom, a process for preparing the 3-phenylthiomethylstyrene derivative (1), and an antiallergic agent and a tyrosinekinase inhibiting agent containing the 3-phenylthiomethylstyrene derivative (1) as an effective component. The compound (1) of the present invention is a useful intermediate for preparing various organic compounds, and has excellent antiallergic and tyrosinekinase inhibiting activities.
摘要翻译：具有通式（1）的3-苯基硫代甲基苯乙烯衍生物：其中X为羟基，R 1为氢原子或R 2为氢原子时，其碱为碱的3-苯基硫代甲基苯乙烯衍生物（1）和含有3-苯基硫代甲基苯乙烯衍生物（1）作为有效成分的抗过敏剂和酪氨酸激酶抑制剂。本发明的化合物（1）是制备各种有机化合物的有用的中间体，具有优异的抗过敏和酪氨酸激酶抑制活性。

2. 发明授权

US5202341A Hydroxystyrene compounds having tyrosine kinase inhibiting activity 失效
标题翻译：具有酪氨酸激酶抑制活性的羟基苯乙烯化合物
公开(公告)号：US5202341A
公开(公告)日：1993-04-13
申请号：US735581
申请日：1991-07-25
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： A61K31/26 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
CPC分类号： C07D277/20 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.
摘要翻译：由式（I）表示的羟基苯乙烯衍生物：其中当R1和R2：苯基，苄基或苯乙基或R1：R5O-（R5：H，C1-C5烷基或苄基基团）和R 2：苄基或PhSCH 2，R 3和R 4一起表示-CONH-CS-S-，或（X1：H，卤素，甲基，乙基，R7O-（ R7：甲基或乙基），硝基，氨基磺酰基或氨基，m1：1或2），吡啶基，呋喃基或噻吩基，n1：0〜3的整数）。当R1和R2：苯基，苄基或苯乙基或R1：R5O-（R5：如上定义）和R2：苄基，R3：氰基和R4：氨基甲酰基，或R3和R4合在一起表示-CO-Y-CH 2 CH 2 - （Y：O或-NH-）或，并且当R 1和R 2为C 1至C 3烷基时，R 3和R 4一起表示（n1，R6 ：如上所定义），或其盐。羟基苯乙烯衍生物或其盐是可用作抗变应性剂的活性成分，5-脂氧合酶抑制剂，抗菌剂，酪氨酸激酶抑制剂，紫外线吸收剂或逆转录酶抑制剂的化合物，以及也可用作制备各种有机化合物的中间体。

3. 发明授权

US5089516A 1-phenyl-3,5-pyrazolidinedione hydroxystyrene compounds which have tyrosine kinase inhibiting activity 失效
标题翻译：具有酪氨酸激酶抑制活性的1-苯基-3,5-二异氰酸酯化羟基苯乙烯化合物
公开(公告)号：US5089516A
公开(公告)日：1992-02-18
申请号：US584683
申请日：1990-09-19
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： A61K31/425 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12 , A61K31/415 , C07D231/04
CPC分类号： C07D277/20 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

4. 发明授权

US4971996A Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors 失效
标题翻译：可用作酪氨酸激酶抑制剂的羟基苯乙烯化合物
公开(公告)号：US4971996A
公开(公告)日：1990-11-20
申请号：US283992
申请日：1988-11-10
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： B21B31/16 , A61K31/26 , A61K31/27 , A61K31/275 , A61K31/34 , A61K31/425 , B21B31/02 , B21B31/20 , B21B33/00 , B21B37/18 , B21B37/72 , C07C253/30 , C07C255/34 , C07C255/41 , C07C255/44 , C07C255/53 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/32 , C07D307/33 , C07D307/52 , C07D307/58 , C07D417/12 , C09K3/00
CPC分类号： C07D277/20 , B21B31/02 , B21B31/203 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tryosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

5. 发明授权

US5057538A Hydroxystyrene compounds which have useful pharmaceutical utility 失效
标题翻译：具有有用的药用实用性的羟基苯乙烯化合物
公开(公告)号：US5057538A
公开(公告)日：1991-10-15
申请号：US587147
申请日：1990-09-24
申请人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunoro Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
发明人： Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunoro Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
IPC分类号： B21B31/16 , A61K31/26 , A61K31/27 , A61K31/275 , A61K31/34 , A61K31/425 , B21B31/02 , B21B31/20 , B21B33/00 , B21B37/18 , B21B37/72 , C07C253/30 , C07C255/34 , C07C255/41 , C07C255/44 , C07C255/53 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/20 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/32 , C07D307/33 , C07D307/52 , C07D307/58 , C07D417/12 , C09K3/00 , C07C121/75
CPC分类号： C07D277/20 , B21B31/02 , B21B31/203 , C07C255/00 , C07C255/34 , C07D207/38 , C07D209/34 , C07D231/36 , C07D277/36 , C07D277/54 , C07D279/16 , C07D307/58 , C07D417/12
摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## Wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sub.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O--(R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O--(R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 --(Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxybenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

6. 发明授权

US4440784A Anti-inflammatory, analgesic, and antipyretic pharmaceutical composition 失效
标题翻译：抗炎，止痛和解热药物组合物
公开(公告)号：US4440784A
公开(公告)日：1984-04-03
申请号：US337130
申请日：1982-01-05
申请人： Ikuo Katsumi , Hideo Kondo , Katsuji Yamashita , Takayoshi Hidaka , Kazunori Hosoe , Yutaka Ariki , Toshiaki Yamashita , Kiyoshi Watanabe
发明人： Ikuo Katsumi , Hideo Kondo , Katsuji Yamashita , Takayoshi Hidaka , Kazunori Hosoe , Yutaka Ariki , Toshiaki Yamashita , Kiyoshi Watanabe
IPC分类号： A61K31/05 , A61K31/22 , A61K31/255 , A61K31/275 , C07C49/248 , C07C49/747 , C07C49/753 , C07C49/835 , C07C59/52 , C07C59/90 , A61K31/19 , A61K31/235
CPC分类号： C07C205/17 , C07C255/00 , C07C49/248 , C07C49/747 , C07C49/753 , C07C49/835 , C07C59/52 , C07C59/90 , Y10S514/916
摘要： A new anti-inflammatory, analgesic, and antipyretic pharmaceutical composition is disclosed which contains a 3,5-di-tert-butyl-4-hydroxystyrene derivative of the formula: ##STR1## wherein R.sup.1 stands for a group represented by COR.sup.3 [R.sup.3 denotes a group of OR.sup.4 (R.sup.4 is a hydrogen atom or an alkyl group with C.sub.1 .about.C.sub.4), an alkyl group with C.sub.1 .about.C.sub.3, a phenyl group, or an amino group], a nitro group, or an alkylsulfonyl group represented by SO.sub.2 R.sup.5 (R.sup.5 is an alkyl group with C.sub.1 .about.C.sub.3); and R.sup.2 stands for a hydrogen atom, an alkyl group with C.sub.1 .about.C.sub.4, a hydroxyalkyl group with C.sub.1 .about.C.sub.4, a cyano group, or an acyl group represented by COR.sup.6 (R.sup.6 is an alkyl group with C.sub.1 .about.C.sub.3),or its pharmaceutically acceptable salt as an active ingredient in association with pharmaceutical excipients. The pharmaceutical composition has excellent anti-inflammatory, analgesic, and antipyretic activities and low toxicity.
摘要翻译：公开了一种新的抗炎，止痛和解热药物组合物，其含有下式的3,5-二叔丁基-4-羟基苯乙烯衍生物：其中R1代表由COR3表示的基团[R3表示一组OR4（R4为氢原子或C1-C6烷基，C1-C6烷基，C1〜C6烷基，苯基或氨基），硝基或SO2R5表示的烷基磺酰基（ R5是具有C1差异C3的烷基）; R2代表氢原子，具有C1差异C4的烷基，具有C1差异C4的羟基烷基，氰基或由COR6表示的酰基（R6是具有C1差异C3的烷基）或其药学上可接受的盐作为与药物赋形剂相关的活性成分。该药物组合物具有优异的抗炎，止痛和解热活性，毒性低。

7. 发明授权

US4431656A 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient 失效
标题翻译： 3,5-二叔丁基苯乙烯衍生物，其盐和含有该活性成分的药物组合物
公开(公告)号：US4431656A
公开(公告)日：1984-02-14
申请号：US337168
申请日：1982-01-05
申请人： Ikuo Katsumi , Hideo Kondo , Katsuji Yamashita , Takayoshi Hidaka , Kazunori Hosoe , Yutaka Ariki , Toshiaki Yamashita , Kiyoshi Watanabe
发明人： Ikuo Katsumi , Hideo Kondo , Katsuji Yamashita , Takayoshi Hidaka , Kazunori Hosoe , Yutaka Ariki , Toshiaki Yamashita , Kiyoshi Watanabe
IPC分类号： C07C49/248 , C07C49/747 , C07C49/753 , C07C49/835 , C07C59/52 , C07C59/90 , C07D233/96 , C07D307/58 , A61K31/415 , C07D307/26
CPC分类号： C07C255/00 , C07C49/248 , C07C49/747 , C07C49/753 , C07C49/835 , C07C59/52 , C07C59/90 , C07D233/96 , C07D307/58 , Y10S514/825 , Y10S514/916
摘要： Novel compounds, 3,5-di-tert-butylstyrene derivatives and their salts, are disclosed, which derivatives are represented by the general formula: ##STR1## wherein R.sup.1 stands for an acyloxy group represented by R.sup.3 COO (R.sup.3 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.6), an alkoxyl group of R.sub.4 O (R.sup.4 is an alkyl group with C.sub.1 -C.sub.4), a hydroxyl group, or a hydrogen atom; R.sup.2 stands for ##STR2## (R.sup.5 is a hydrogen atom or an alkyl group with C.sub.1 -C.sub.3 and X.sup.1 is CH.sub.2 or an oxygen atom), ##STR3## (R.sup.5 and X.sup.1 are each the same as defined above), or ##STR4## (X.sup.2 is an oxygen or sulfur atom). There are also disclosed an anti-inflammatory, analgesic, and antipyretic pharmaceutical composition and an anti-platelet aggregation pharmaceutical composition, both pharmaceutical compositions comprising the foregoing 3,5-di-tert-butylstyrene derivative or its pharmaceutically acceptable salt as an active ingredient in association with pharmaceutical excipients.
摘要翻译：公开了新的化合物，3,5-二叔丁基苯乙烯衍生物及其盐，该衍生物由以下通式表示：其中R1代表由R3COO表示的酰氧基（R3是氢原子或具有C1-C6的烷基），R4O的烷氧基（R4是具有C1-C4的烷基），羟基或氢原子; R2代表（R5是氢原子或具有C1-C3和X1是CH2的烷基或氧原子），＆lt; IMAGE＆gt;（R5和X1各自与上述相同）或（X2是氧或硫原子）。还公开了抗炎，镇痛和解热药物组合物和抗血小板聚集药物组合物，两种药物组合物包含前述3,5-二叔丁基苯乙烯衍生物或其药学上可接受的盐作为活性成分与药物赋形剂的关联。

8. 发明授权

US07754205B2 Composition for transmucosal administration containing conenzyme Q as the active ingredient 有权
标题翻译：用于经粘膜给药的组合物，其含有辅酶Q作为活性成分
公开(公告)号：US07754205B2
公开(公告)日：2010-07-13
申请号：US10476208
申请日：2002-05-08
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K38/43
CPC分类号： A61K31/122 , A23L33/10 , A23V2002/00 , A61K9/0031 , A61K9/0048 , A61K9/02 , A61K31/047 , A61K31/09 , Y10S514/882 , A61K2300/00 , A23V2250/314
摘要： The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having swallowing difficulties and patients with diseases caused by topical disorders. It is found that the coenzyme Q concentration in the blood or topical mucosae can be elevated by using a composition for transmucosal administration containing oxidized coenzyme Q and/or reduced coenzyme Q as the active ingredient, wherein the total content of the oxidized coenzyme Q and the reduced coenzyme Q amounts to 0.0001 to 99% by weight of the whole composition.
摘要翻译：本发明涉及能够维持人体健康的辅酶Q的供给，提供可以将辅酶Q有效地供给口服给药困难的患者，患有吞咽困难的老年患者以及由局部疾病。通过使用含有氧化型辅酶Q和/或还原型辅酶Q作为活性成分的经粘膜给药用组合物，可以提高血液或局部粘膜中的辅酶Q浓度，其中氧化型辅酶Q和还原型辅酶Q占整个组合物的0.0001-99重量％。

9. 发明申请

US20060165672A1 Fatigue reducing agent 有权
公开(公告)号：US20060165672A1
公开(公告)日：2006-07-27
申请号：US10541020
申请日：2004-01-19
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K38/43 , A01N31/14
CPC分类号： A61K31/09 , A61K31/122
摘要： To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.

10. 发明授权

US07015252B2 Compositions for lessening oxidative stress 有权
标题翻译：用于减轻氧化应激的组合物
公开(公告)号：US07015252B2
公开(公告)日：2006-03-21
申请号：US10492164
申请日：2002-10-15
申请人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
发明人： Kenji Fujii , Taizo Kawabe , Kazunori Hosoe , Takayoshi Hidaka
IPC分类号： A61K31/12
CPC分类号： A61K31/085 , A61K31/122
摘要： The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease. It was confirmed that by using a composition containing oxidized coenzyme Q and/or reduced coenzyme Q, the amount of urinary 8-hydroxydeoxyquanosine can be decreased in normal or diabetic animals. Also, in histopathological research of the spleens of diabetic rats, it was confirmed that spleen tissue denaturation caused by oxidative stress can be prevented. It was thus found that oxidative stress in vivo can be lessened. According to the present invention, oxidative stress in vivo can be lessened by using a composition containing coenzyme Q as an active ingredient.
摘要翻译：本发明提供了具有高安全性的抗氧化组合物，其能够在体内减少由活性氧，自由基等引起的氧化应激，从而防止疾病的发生或恶化。确认通过使用含有氧化型辅酶Q和/或还原型辅酶Q的组合物，在正常或糖尿病动物中尿8-羟基脱氧奎诺糖的量可以降低。此外，在糖尿病大鼠脾脏的组织病理学研究中，证实可以预防由氧化应激引起的脾脏组织变性。因此发现体内的氧化应激可以减轻。根据本发明，通过使用含有辅酶Q作为有效成分的组合物，可以减轻体内的氧化应激。

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