专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07888285B2 2,4,6-phenyl substituted cyclic ketoenols 有权
标题翻译： 2,4,6-苯基取代的环酮酮
公开(公告)号：US07888285B2
公开(公告)日：2011-02-15
申请号：US10549074
申请日：2004-03-02
申请人： Reiner Fischer , Klaus Kunz , Stefan Lehr , Michael Ruther , Udo Schneider , Markus Dollinger , Mark Wilhelm Drewes , Dieter Feucht , Jörg Konze , Ulrike Wachendorff-Neumann , Guido Bojack , Thomas Auler , Martin Jeffrey Hills , Thomas Bretschneider , Olga Malsam , Christoph Erdelen , Angelika Lubos-Erdelen, legal representative , Alfred Angermann , Heinz Kehne , Christopher Hugh Rosinger
发明人： Reiner Fischer , Klaus Kunz , Stefan Lehr , Michael Ruther , Udo Schneider , Markus Dollinger , Mark Wilhelm Drewes , Dieter Feucht , Jörg Konze , Ulrike Wachendorff-Neumann , Guido Bojack , Thomas Auler , Martin Jeffrey Hills , Thomas Bretschneider , Olga Malsam , Christoph Erdelen , Alfred Angermann , Heinz Kehne , Christopher Hugh Rosinger
IPC分类号： A01N43/713 , A01N43/08 , C07D207/46 , C07D307/33
CPC分类号： A01N43/38 , A01N43/36 , C07C43/225 , C07C59/64 , C07C69/734 , C07C235/34 , C07C235/36 , C07C2601/14 , C07D207/38 , C07D209/52 , C07D209/54 , C07D231/14 , C07D231/32 , C07D237/04 , C07D307/60 , C07D307/94 , C07D309/08 , C07D309/14 , C07D471/04 , C07D487/04 , C07D491/10 , C07D491/14 , C07D493/10 , C07D495/10 , C07D513/04
摘要： The present invention relates to novel 2,4,6-phenyl-substituted cyclic ketoenols of the formula (I) in which W, X, Y and CKE have the meanings given in the disclosure, to a plurality of processes for their preparation and to their use as pesticides and/or herbicides. The invention further relates to selectively herbicidal compositions containing 2,4,6-phenyl-substituted cyclic ketoenols and a compound which improves crop plant tolerance.
摘要翻译：本发明涉及其中W，X，Y和CKE具有本公开中给出的含义的式（I）的新的2,4,6-苯基取代的环戊烯醇与多种制备方法和它们用作农药和/或除草剂。本发明还涉及含有2,4,6-苯基取代的环酮酮的选择性除草组合物和改善作物耐受性的化合物。

2. 发明授权

US07504518B2 Process for producing blocked isocyanate compound 失效
标题翻译：封端异氰酸酯化合物的制备方法
公开(公告)号：US07504518B2
公开(公告)日：2009-03-17
申请号：US11666696
申请日：2005-10-27
申请人： Hideo Miyata , Masatoshi Murakami , Katsutoshi Ohno
发明人： Hideo Miyata , Masatoshi Murakami , Katsutoshi Ohno
IPC分类号： C07D231/00 , C07D231/10
CPC分类号： C07D231/32 , C07D231/12
摘要： Disclosed is a process for producing a blocked isocyanate compound represented by general formula (III): wherein R1, R2, Q1, and Q2 are as defined in the specification, characterized by comprising reacting a pyrazole compound (I) with an ethylenically unsaturated group-containing isocyanate compound (II) at a temperature in the range of 0° C. to 90° C. The production process can efficiently produce a high-purity blocked isocyanate compound without substantially producing by-products. In the production process, unlike the prior art technique, since there is no need to use any inert solvent such as toluene or xylene, safety to the human body and environment is excellent and the production processes and equipment can be simplified. The blocked isocyanate compound produced by the production process contains no residual inert solvent and is suitable for use in extensive fields such as various coating agents, adhesives, and molding materials.
摘要翻译：公开了一种制备由通式（III）表示的封端异氰酸酯化合物的方法：其中R1，R2，Q1和Q2如说明书中所定义，其特征在于包括使吡唑化合物（I）与烯属不饱和基团 - 含有异氰酸酯化合物（II）的温度在0℃〜90℃的范围内。制造方法可以有效地制造高纯度的封端异氰酸酯化合物而基本不产生副产物。在生产过程中，与现有技术不同，由于不需要使用甲苯或二甲苯等惰性溶剂，因此对人体和环境的安全性优异，可以简化生产方法和设备。通过生产方法生产的封端异氰酸酯化合物不含残留的惰性溶剂，适用于各种涂料，粘合剂和成型材料等广泛领域。

3. 发明申请

US20070060531A1 Pyrazole derivative, drug composition containing the same and production intermediate therefor 失效
标题翻译：吡唑衍生物，含有它们的药物组合物及其制备中间体
公开(公告)号：US20070060531A1
公开(公告)日：2007-03-15
申请号：US10561217
申请日：2004-06-15
申请人： Norihiko Kikuchi , Hideki Fujikura , Shigeki Tazawa , Tokuhisa Yamato , Masayuki Isaji
发明人： Norihiko Kikuchi , Hideki Fujikura , Shigeki Tazawa , Tokuhisa Yamato , Masayuki Isaji
IPC分类号： A61K31/7052 , C07H15/00
CPC分类号： C07D231/32 , A61K31/7056 , A61K31/706 , C07D231/52 , Y10S514/866
摘要： The present invention provides pyrazole derivatives represented by the general formula: wherein R1 represents H, an optionally substituted C1-6 alkyl, etc.; one of Q and T represents a group selected from the following: , and the other represents -Z-Ar wherein Z represents —O—, —S—, etc.; Ar represents an optionally substituted C6-10 aryl, etc.; R represents an optionally substituted C3-8 cycloalkyl, an optionally substituted C6-10 aryl, etc., pharmaceutically acceptable salts thereof, and prodrugs thereof, which exhibit an excellent inhibitory activity in human sodium/glucose cotransporter (SGLT) and are useful as agents for the prevention, inhibition of progression or treatment of a disease associated with the excess uptake of at least a kind of carbohydrates selected from glucose, fructose and mannose (diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, etc.), and pharmaceutical compositions containing the same, medicinal uses thereof and intermediates for production therefor.
摘要翻译：本发明提供由以下通式表示的吡唑衍生物：其中R 1表示H，任选取代的C 1-6烷基等; Q和T中的一个表示选自以下的基团：另一个表示-Z-Ar，其中Z表示-O-，-S-等; Ar表示任选取代的C 6-10芳基等; R表示任选取代的C 3-8环烷基，任选取代的C 6-10芳基等，其药学上可接受的盐及其前药，其表现出优异的在人钠/葡萄糖协同转运蛋白（SGLT）中的抑制活性，并且可用作预防，抑制与选自葡萄糖，果糖和甘露糖中的至少一种碳水化合物的过量摄取相关的疾病的进展或治疗的药剂（糖尿病，餐后高血糖，葡萄糖耐量降低，糖尿病并发症等），含有该组合物的药物组合物，其医药用途和用于其生产的中间体。

4. 发明授权

US6022870A Fungicidal cyclic amides 失效
标题翻译：杀真菌环酰胺
公开(公告)号：US6022870A
公开(公告)日：2000-02-08
申请号：US311672
申请日：1999-05-13
申请人： Richard James Brown , King-Mo Sun , Deborah Ann Frasier
发明人： Richard James Brown , King-Mo Sun , Deborah Ann Frasier
IPC分类号： A01N43/653 , A01N43/80 , C07D231/30 , C07D231/32 , C07D233/78 , C07D249/08 , C07D249/12 , C07D261/12 , C07D275/02 , C07D275/03 , C07D403/12 , C07D417/12 , C07D401/10 , A61K31/41 , C07D413/10
CPC分类号： C07D275/03 , A01N43/653 , A01N43/80 , C07D231/30 , C07D231/32 , C07D233/78 , C07D249/12 , C07D261/12 , C07D403/12 , C07D417/12
摘要： Cyclic amides of Formula I which are useful as fungicides: ##STR1## wherein A is N; G is N and the floating double bond is attached to A; W is O or S; X is OR.sup.1, S(O).sub.m R.sup.1 or halogen; R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z are defined in the disclosure, are disclosed. Also, disclosed are fungicidal compositions containing these compounds and the use of these cyclic amide compounds for controlling plant diseases caused by fungal plant pathogens.
摘要翻译：可用作杀真菌剂的式I的环状酰胺：其中A是N; G是N，浮动双键连接到A; W为O或S; X是OR 1，S（O）m R 1或卤素; 在本公开中限定了R1，R2，R3，R4，Y和Z。此外，还公开了含有这些化合物的杀真菌组合物，以及这些环状酰胺化合物用于防治真菌植物病原体引起的植物病害的用途。

5. 发明授权

US5668179A Potent inducers of terminal differentiation and method of use thereof 失效
标题翻译：终末分化的潜在诱导剂及其使用方法
公开(公告)号：US5668179A
公开(公告)日：1997-09-16
申请号：US485619
申请日：1995-06-07
申请人： Ronald Breslow , Paul A. Marks , Richard A. Rifkind
发明人： Ronald Breslow , Paul A. Marks , Richard A. Rifkind
IPC分类号： C07C233/05 , C07C233/36 , C07C235/74 , C07C243/28 , C07C259/06 , C07D231/32 , C07D239/62 , C07D243/08 , A61K31/16
CPC分类号： C07D239/62 , C07C233/05 , C07C233/36 , C07C235/74 , C07C243/28 , C07C259/06 , C07D231/32 , C07D243/08
摘要： The invention also concerns a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells which comprises contacting the cells under suitable condition with an amount of the compound effect to selectively induce terminal differentiation.Moreover, the invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells which comprises administering to the patient an amount of the compound effective to selectively induce terminal differentiation of such neoplastic cells, thereby inhibiting their proliferation and suppressing oncogenicity.Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound in an amount effective less than an amount which would cause toxicity in the patient.
摘要翻译：其中R，R 1和R 4各自为氢原子或甲基，乙基或丙基，R和R 1相同，R和R 4相同或不同; 本发明还涉及一种选择性诱导肿瘤细胞的终末分化并从而抑制这些细胞增殖的方法，其包括在合适条件下将细胞与一定量的化合物作用选择性地接触诱导终末分化。此外，本发明提供了一种治疗肿瘤特征在于肿瘤细胞增殖的患者的方法，其包括给予患者一定量的有效选择性诱导这些肿瘤细胞的终末分化，从而抑制其增殖并抑制致癌性的化合物。最后，本发明提供一种药物组合物，其包含药学上可接受的载体和化合物，其量有效量小于在患者中引起毒性的量。

6. 发明授权

US5358924A 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use 失效
标题翻译： 3-羟基-4-芳基-5-氧代 - 吡咯啉衍生物，组合物和用途
公开(公告)号：US5358924A
公开(公告)日：1994-10-25
申请号：US999058
申请日：1992-12-31
申请人： Bernd-Wieland Kruger , Reiner Fischer , Heinz-Jurgen Bertram , Thomas Bretschneider , Stefan Bohm , Andreas Krebs , Thomas Schenke , Hans-Joachim Santel , Klaus Lurssen , Robert R. Schmidt , Christoph Erdelen , Ulrike Wachendorff-Neumann , Wilhelm Stendel
发明人： Bernd-Wieland Kruger , Reiner Fischer , Heinz-Jurgen Bertram , Thomas Bretschneider , Stefan Bohm , Andreas Krebs , Thomas Schenke , Hans-Joachim Santel , Klaus Lurssen , Robert R. Schmidt , Christoph Erdelen , Ulrike Wachendorff-Neumann , Wilhelm Stendel
IPC分类号： A01N43/56 , A01N43/90 , A01N47/06 , A01N47/18 , A01N57/16 , C07D231/32 , C07D487/04 , C07D487/08 , A01N57/24 , C07D237/26 , C07F9/40
CPC分类号： C07D487/04 , A01N43/56 , A01N43/90 , A01N47/06 , A01N47/18 , A01N57/16 , C07D231/32 , C07D487/08
摘要： There are provided new 3-hydroxy-4-aryl-5-oxo-pyrazoline derivatives of the formula (I) ##STR1## in which A and B are identical or different and independently of one another in each case represent hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, alkythioalkyl, cycloalkyl or optionally substituted aryl orA and B together represent the bivalent radical of a saturated or unsaturated, optionally substituted, mono-, bi-, tri- or polycyclic system,X represents alkyl, halogen or alkoxy,Y represents hydrogen, alkyl, halogen, alkoxy or halogenoalkyl,Z represents alkyl, halogen or alkoxy,n represents a number 0, 1, 2 or 3,G represents hydrogen (a) or the groups ##STR2## in which E represents a metal ion equivalent or an ammonium ion,L and M represents oxygen and/or sulphur,and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 have the meaning given in the text of the application.The new 3-hydroxy-4-aryl-5-oxo-pyrazoline derivatives of the formula (I) have a particularly pronounced activity against animal pests, in particular against insects and arachnids, and against weeds.
摘要翻译：提供了式（I）的新的3-羟基-4-芳基-5-氧代 - 吡唑啉衍生物，其中A和B相同或不同，并且在每种情况下彼此独立地表示氢，烷基，烯基，炔基，烷氧基烷基，链烷基，环烷基或任选取代的芳基或A和B一起表示饱和或不饱和的任选取代的单，双，三或多环体系的二价基团，X表示烷基，卤素或烷氧基，Y表示氢，烷基，卤素，烷氧基或卤代烷基，Z表示烷基，卤素或烷氧基，n表示数0,1,2或3，G表示氢（a）或基团COR1，（b）（c）SO2R3，（d）图像（e）其中E表示金属离子当量或铵离子，L和M表示氧和/或硫，，R1，R2，R3，R4，R5，R6和R7具有本申请文本中给出的含义。式（I）的新的3-羟基-4-芳基-5-氧代 - 吡唑啉衍生物对动物害虫特别是显着的活性，特别是针对昆虫和蜘蛛，以及对杂草。

7. 发明授权

US4507488A N-Pyrazolylalkylenediamine intermediates 失效
标题翻译： N-吡唑基亚烷基二胺中间体
公开(公告)号：US4507488A
公开(公告)日：1985-03-26
申请号：US483788
申请日：1983-04-11
申请人： Fritz Wiedemann , Ewald Rieger
发明人： Fritz Wiedemann , Ewald Rieger
IPC分类号： A61K31/38 , A61K31/045 , A61K31/135 , A61K31/138 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/435 , A61K31/47 , A61K31/472 , A61K31/473 , A61K31/495 , A61K31/498 , A61K31/50 , A61K31/505 , A61K31/52 , A61K31/522 , A61P9/00 , A61P9/04 , C07C217/32 , C07C217/72 , C07C217/78 , C07C219/06 , C07C219/08 , C07C219/14 , C07D209/48 , C07D213/74 , C07D215/46 , C07D217/22 , C07D219/12 , C07D231/06 , C07D231/20 , C07D231/32 , C07D231/38 , C07D231/46 , C07D231/52 , C07D231/56 , C07D237/20 , C07D239/42 , C07D239/54 , C07D239/545 , C07D239/557 , C07D239/56 , C07D239/84 , C07D239/95 , C07D241/44 , C07D249/18 , C07D333/36 , C07D473/16 , C07D473/32 , C07D473/34 , C07D487/00 , C07D487/04
CPC分类号： C07D473/16 , C07D209/48 , C07D213/74 , C07D215/46 , C07D217/22 , C07D219/12 , C07D231/06 , C07D231/20 , C07D231/32 , C07D231/38 , C07D231/52 , C07D231/56 , C07D237/20 , C07D239/42 , C07D239/545 , C07D239/557 , C07D239/56 , C07D239/84 , C07D239/95 , C07D333/36 , C07D473/34 , C07D487/04
摘要： New N-heteroarylalkylenediamine ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen, an alkyl radical containing up to 6 carbon atoms, or a benzyl radical,X is an alkylene radical containing 2 to 6 carbon atoms,A is a mono- or bicyclic heteroaromatic radical, which can be partly hydrogenated, with the proviso that it contains 2 or 3 adjacent ring heteroatoms, whereby the bound ring heteroatoms can be an oxygen atom and a nitrogen atom or 2 or 3 nitrogen atoms, andR.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 each independently is hydrogen, or an alkyl radical containing up to 6 carbon atoms, which can be substituted by hydroxyl, carbamyl, nitrile or carboxyl, an alkenyl radical containing 2 to 6 carbon atoms, a phenyl or carbamyl radical or one of the divalent substituents oxygen or sulphur,or a salt thereof. The compounds are intermediates in the synthesis of cardioactive compounds.
摘要翻译：新的N-杂芳基亚烷基二胺其中R 1和R 2各自独立地是氢，含有至多6个碳原子的烷基或苄基，X是含有2至6个碳原子的亚烷基，A是单环或双环杂芳族基团，其可部分氢化，条件是其含有2或3个相邻的环杂原子，其中结合的环杂原子可以是氧原子和氮原子或2或3个氮原子，并且R 3，R 4，R 5， R6和R7各自独立地是氢或含有至多6个碳原子的烷基，其可以被羟基，氨基甲酰基，腈或羧基取代，含有2-6个碳原子的烯基，苯基或氨基甲酰基或其中之一二价取代基为氧或硫，或其盐。这些化合物是合成心脏活性化合物的中间体。

8. 发明授权

US3808227A Pyrazolo(thiono)phosphoric(phosphonic)acid esters 失效
标题翻译： PYRAZOLO（THIONO）磷酸（PHOSPHONIC）酸酯
公开(公告)号：US3808227A
公开(公告)日：1974-04-30
申请号：US20431271
申请日：1971-12-02
申请人： BAYER AG
发明人： BEHRENZ W , HOFFMANN H , HAMMANN I
IPC分类号： A01N57/08 , C07D231/32 , C07F9/6509 , C07F9/08 , C07F9/40
CPC分类号： C07F9/650929 , A01N57/08 , C07D231/32
摘要： PYRAZOLO(THIONO)PHOSPHORIC(PHOSPHONIC) ACID ESTERS OF THE GENERAL FORMULA

1-R3,3-(R-O-P(=Y)(-R1)-O-),4-(NC-),5-(R2-O-)PYRAZOLE

IN WHICH RI IS AN ALKYL RADICAL WITH 1 TO 6 CARBON ATOMS, R1 IS AN ALKYL OR ALKOXY RADICAL WITH 1 TO 6 CARBON ATOMS, R2 AND R3 ARE LOWER RADICALS, AND Y IS OXYGEN OR SULFUR, WHICH POSSESS INSECTICIDAL, ACARICIDAL, RODENTICIDAL AND FUNGICIDAL PROPERTIES.

9. 发明授权

US3703528A 1,2-diphenyl-3,5-dioxo-4-substituted pyrazolidines 失效
标题翻译： 1,2-二苯基-3,5-二氧代-4-取代的吡咯烷酮
公开(公告)号：US3703528A
公开(公告)日：1972-11-21
申请号：US3703528D
申请日：1970-06-12
申请人： ANGELI INST SPA
发明人： CASADIO SILVANO , PALA GIANFRANCO
IPC分类号： C07D231/32 , C07D49/08
CPC分类号： C07D231/32
摘要： 1,2-DIPHENYL-3,5-DIOXOPYRAZOLIDINES HAVING A 3-METHYL2-BUTENYL OR 4-METHYL-3-PENTENYL GROUP AT THE 4-POSITION. THESE COMPOUNDS HAVE ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF THE ORDER OF PHENYLBUTAZONE, BUT MARKEDLY LESS ULCEROGENIC ACTIVITY.

10. 发明授权

US3615506A Silver halide emulsions containing 3-cyclicamino-5-pyrazolone color couplers 失效
标题翻译：含有3-环丙氨基-5-吡唑啉酮颜料偶联剂的银盐乳液
公开(公告)号：US3615506A
公开(公告)日：1971-10-26
申请号：US3615506D
申请日：1970-02-09
申请人： EASTMAN KODAK CO
发明人： ABBOTT JOHN R , COFFEY WILLIAM F
IPC分类号： C07D231/32 , G03C7/384 , G03C7/00 , G03C1/40
CPC分类号： G03C7/384 , C07D231/32
摘要： Novel 3-(cyclicamino)-5-pyrazolones and other 3-(substituted amino)-5-pyrazolone couplers valuable for use in color photography are advantageously prepared in good yields from the corresponding 3-alkoxy-5-pyrazolones by a novel single step synthesis in which a mixture of (1) the appropriate 3-alkoxy-5pyrazolone, or a primary amine and (3) an acid catalyst having a pKa smaller than about 10.2 is heated.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式