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1. 发明授权

US5100921A Angucyclinones from Streptomycetes, a process for the preparation thereof, and the use thereof 失效
标题翻译：来自溶酶体的神经球蛋白，其制备方法及其用途
公开(公告)号：US5100921A
公开(公告)日：1992-03-31
申请号：US342936
申请日：1989-04-25
申请人： Susanne Grabley , Joachim Wink , Carlo Giani , Gerhard Seibert , Wolfgang Raether , Susanne Dobreff , Axel Zeeck
发明人： Susanne Grabley , Joachim Wink , Carlo Giani , Gerhard Seibert , Wolfgang Raether , Susanne Dobreff , Axel Zeeck
IPC分类号： A61K31/05 , A61K31/12 , A61P31/04 , C07C49/747 , C07C50/36 , C07C69/00 , C12N1/20 , C12P15/00 , C12R1/465
CPC分类号： C07C69/00 , C07C49/747 , C07C50/36 , C12P15/00 , C07C2103/00 , C07C2103/42
摘要： New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.
摘要翻译：借助于链霉菌属的菌株可以制备具有治疗作用的新的角叉菜碱。

2. 发明授权

US4945108A Angucyclinones from streptomycetes, a process for the preparation thereof, and the use thereof 失效
标题翻译：来自链霉菌的安cy啶，其制备方法及其用途
公开(公告)号：US4945108A
公开(公告)日：1990-07-31
申请号：US342061
申请日：1989-04-24
申请人： Susanne Grabley , Joachim Wink , Carlo Giani , Gerhard Seibert , Wolfgang Raether , Susanne Dobreff , Axel Zeeck
发明人： Susanne Grabley , Joachim Wink , Carlo Giani , Gerhard Seibert , Wolfgang Raether , Susanne Dobreff , Axel Zeeck
IPC分类号： A61K31/12 , A61P31/04 , C07C45/00 , C07C49/747 , C07C67/00 , C07D303/17 , C07D303/32 , C12N1/20 , C12P15/00 , C12P17/02 , C12R1/465
CPC分类号： C12P17/02 , C07D303/32 , C12P15/00
摘要： New angucyclinones with a therapeutic action can be prepared with the aid of a strain of the genus Streptomyces.
摘要翻译：借助于链霉菌属的菌株可以制备具有治疗作用的新的角叉菜碱。

3. 发明授权

US5158888A Streptomyces parvullus DSM 3816 失效
标题翻译： STREPTOMYCES PARVULLUS DSM 3816
公开(公告)号：US5158888A
公开(公告)日：1992-10-27
申请号：US836533
申请日：1992-02-19
申请人： Peter Hammann , Susanne Grabley , Hartmut Voelskow , Burkhard Sachse , Wolfgang Raether , Carlo Giani , Gerhard Seibert
发明人： Peter Hammann , Susanne Grabley , Hartmut Voelskow , Burkhard Sachse , Wolfgang Raether , Carlo Giani , Gerhard Seibert
IPC分类号： C12P17/08 , A01N47/44 , A01N63/02 , A61K20060101 , A61K31/365 , A61P31/00 , A61P31/10 , C07D313/00 , C07D493/04 , C07D493/08 , C12N20060101 , C12P20060101 , C12P1/02 , C12P1/06 , C12P17/16 , C12P17/18 , C12R1/465
CPC分类号： C07D493/08 , A01N47/44 , C07D313/00 , C12P17/181 , C12R1/465 , Y10S435/886
摘要： Streptomyces parvullus, DSM 3816, produces on aerobic fermentation new antibiotics which are distinguished by antimicrobial activity even after derivatization.

4. 发明授权

US4914216A Amycin and its derivatives, a process for their preparation, and their use 失效
标题翻译：霉素及其衍生物，其制备方法及其用途
公开(公告)号：US4914216A
公开(公告)日：1990-04-03
申请号：US136393
申请日：1987-12-22
申请人： Peter Hammann , Susanne Grabley , Hartmut Voelskow , Burkhard Sachse , Wolfgang Raether , Carlo Giani , Gerhard Seibert
发明人： Peter Hammann , Susanne Grabley , Hartmut Voelskow , Burkhard Sachse , Wolfgang Raether , Carlo Giani , Gerhard Seibert
IPC分类号： C12P17/08 , A01N47/44 , A01N63/02 , A61K20060101 , A61K31/365 , A61P31/00 , A61P31/10 , C07D313/00 , C07D493/04 , C07D493/08 , C12N20060101 , C12P20060101 , C12P1/02 , C12P1/06 , C12P17/16 , C12P17/18 , C12R1/465
CPC分类号： C07D493/08 , A01N47/44 , C07D313/00 , C12P17/181 , C12R1/465 , Y10S435/886
摘要： Streptomyces parvullus, DSM 3816, produces on aerobic fermentation new antibiotics which are distinguished by antimicrobial activity even after derivatization.
摘要翻译： Parpullus parvullus，DSM 3816，在有氧发酵生产新的抗生素，即使在衍生化后也被抗菌活性区分开来。

5. 发明授权

US4873347A Process for the preparation of the demalonyl compound of macrolide lactones 失效
标题翻译：用于制备大环内酯内酯的去甲基化合物的方法
公开(公告)号：US4873347A
公开(公告)日：1989-10-10
申请号：US136768
申请日：1987-12-22
申请人： Peter Hammann , Susanne Grabley , Wolfgang Raether , Bernd Ciommer , Heinz Kluge , Burkhard Sachse
发明人： Peter Hammann , Susanne Grabley , Wolfgang Raether , Bernd Ciommer , Heinz Kluge , Burkhard Sachse
IPC分类号： C07D493/04 , A61K31/365 , A61P31/04 , A61P31/10 , C07D20060101 , C07D313/00 , C07D493/08 , C07H13/04 , C07H19/01
CPC分类号： C07H13/04 , C07H19/01
摘要： It is possible to prepare the demalonyl compound of macrolide lactones by hydrolysis in the presence of a base without a retro-aldol cleavage occurring.
摘要翻译：可以在碱的存在下通过水解制备大环内酯内酯的去甲酰化合物，而不会发生醛醇醛脱离。

6. 发明授权

US5100890A Arylmethylazoles and their salts, agents which contain these compounds, and their use 失效
标题翻译：亚油嘧啶及其盐，含有这些化合物的试剂及其使用
公开(公告)号：US5100890A
公开(公告)日：1992-03-31
申请号：US411256
申请日：1989-09-25
申请人： Herbert Siegel , Klaus-Dieter Kampe , Hans-Georg Alpermann , Hermann J. Gerhards , Patricia Usinger , Ulrich Schacht , Margret Leven , Wolfgang Raether , Walter Dittmar , Burkhard Sachse
发明人： Herbert Siegel , Klaus-Dieter Kampe , Hans-Georg Alpermann , Hermann J. Gerhards , Patricia Usinger , Ulrich Schacht , Margret Leven , Wolfgang Raether , Walter Dittmar , Burkhard Sachse
IPC分类号： A61K31/41 , A61K31/415 , C07D233/60 , C07D233/64 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;Z is CH or N;R.sup.1 and Q are H or alkyl;R.sup.2 is H, alk(en)yl or alkynyl;R.sup.3 and R.sup.4 are H, alkyl or other hydrocarbons; orR.sup.3 and R.sup.4 together are a--(CH.sub.2).sub.2-11 chain or a bridged--(CH.sub.2).sub.4-5 chain,and their acid addition salts, stereoisomers and optically active enantiomers possess outstanding antimycotic and antidepressant activity.They are obtained, inter alia, from arylmethylazoles II ##STR2## which are reacted with a strong base and then with a carbonyl compound III O.dbd.CR.sup.3 R.sup.4 ; thereafter, the product is reacted with the protic acid or with an alkyl halide IV R.sup.2 Hal.If desired, the products are converted to the acid addition salts, or the stereoisomers or optically active enantiomes are resolved.

7. 发明授权

US4808606A Alkenylazoles, a process for their preparation and their use 失效
标题翻译：烯基唑，它们的制备和使用过程
公开(公告)号：US4808606A
公开(公告)日：1989-02-28
申请号：US909697
申请日：1986-09-22
申请人： Herbert Siegel , Wolfgang Raether , Walter Dittmar
发明人： Herbert Siegel , Wolfgang Raether , Walter Dittmar
IPC分类号： A01N43/50 , A01N43/653 , A01N45/02 , A61K31/41 , A61K31/415 , A61P31/04 , C07D233/56 , C07D233/58 , C07D233/60 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , A01N45/02 , C07D233/56 , C07D249/08
摘要： Alkenylazoles of formula I a/b ##STR1## in which X/Y is H, alkyl, phenyl, Hal, alkoxy or alkylthio; Z is CH or N; R is alkyl or a bridged (CH.sub.2).sub.m chain; and A is alkylene or a bridged alkylene chain; and the salts of these alkenylazoles are antimycotic agents or fungicides. They are obtained by elimination of water from the compounds II ##STR2##
摘要翻译：其中X / Y是H，烷基，苯基，卤素，烷氧基或烷硫基的式Ⅰa的烯基唑; Z是CH或N; R是烷基或桥连（CH2）m链; A是亚烷基或桥连的亚烷基链; 并且这些烯基唑的盐是抗真菌剂或杀真菌剂。它们是通过从化合物II中除去水而获得的

8. 发明授权

US4284627A Antimalarial compositions 失效
标题翻译：抗疟组成
公开(公告)号：US4284627A
公开(公告)日：1981-08-18
申请号：US166295
申请日：1980-07-07
申请人： Wolfgang Raether , Walter Durckheimer , Hans Seidenath
发明人： Wolfgang Raether , Walter Durckheimer , Hans Seidenath
IPC分类号： C07D219/06 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/49 , A61K31/505 , A61K31/53 , A61K31/635 , A61P33/02 , A61K31/625 , A61K31/435
CPC分类号： A61K31/635 , A61K31/44 , A61K31/47 , A61K31/49 , A61K31/505 , A61K31/53 , Y10S514/895
摘要： Antimalarial compositions are disclosed containing as the active ingredient a mixture of a tetrahydroacridone of the general formula I ##STR1## in which R.sup.1 represents methyl, phenyl, p-chlorophenyl, m-chlorophenyl, p-fluorophenyl, p-trifluoromethylphenyl, o-trifluoromethylphenyl or o-chloro-p-trifluoromethylphenyl,R.sup.2 represents hydrogen or methyl, andR.sup.3 represents fluorine or chlorine,or a salt of such a compound with a physiologically compatible acid or base, with(a) 6-methoxy-.alpha.-(5-vinyl-2-quinuclidinyl)-4-quinoline-methanol (Quinine),(b) 7-chloro-4-(diethylamino-1-methyl-butylamino)-quinoline (Chloroquine),(c) .alpha.-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol (Mefloquine),(d) 8-(4-amino-1-methylbutylamino)-6-methoxy-quinoline (Primaquine),(e) 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine (Pyrimethamine),(f) 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine (Cycloguanil),(g) 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine (Trimethoprim),(h) N'-(5,6-dimethoxy-4-pyrimidyl)-sulfanilamide (Sulfadoxine), or(i) 4,4'-diaminodiphenylsulfone (Dapsone),or with a salt of a compound sub (a) to (i), with a physiologically compatible acid or base, the mixtures being in a proportion by weight of between 25:1 and 1:300 (tetrahydroacridone to compound sub (a) to (i)) in admixture with a pharmaceutically acceptable carrier and/or adjuvant.This is a division of application Ser. No. 954,900, filed October 26, 1978.
摘要翻译：公开了抗疟组合物，其包含作为活性成分的通式I的四氢吖啶酮的混合物，其中R 1表示甲基，苯基，对氯苯基，间氯苯基，对氟苯基，对三氟甲基苯基，邻三氟甲基苯基或对 - 邻 - 氯 - 对三氟甲基苯基，R 2代表氢或甲基，R 3代表氟或氯，或这种化合物与生理相容的酸或碱的盐与（a）6-甲氧基-α-（5-乙烯基 -2-喹喔啉基）-4-喹啉 - 甲醇（奎宁），（b）7-氯-4-（二乙基氨基-1-甲基 - 丁基氨基） - 喹啉（氯喹），（c）α-（2-哌啶基） 2,8-双（三氟甲基）-4-喹啉甲醇（Mefloquine），（d）8-（4-氨基-1-甲基丁基氨基）-6-甲氧基 - 喹啉（Primaquine），（e）2,4-二氨基-5 对 - 氯苯基-6-乙基嘧啶（Pyrimethamine），（f）4,6-二氨基-1-（对氯苯基）-1,2-二氢-2,2-二甲基-s-三嗪（Cycloduanil），（g ）2,4-二氨基-5-（3,4,5-三甲氧基苄基） - 嘧啶（Trimethopri m），（h）N' - （5,6-二甲氧基-4-嘧啶基） - 磺胺（磺胺多辛），或（i）4,4'-二氨基二苯砜（氨苯砜），或与化合物）至（i）与生理上相容的酸或碱，所述混合物的重量比为25:1至1:300（四氢吖啶酮与化合物（a）至（i））的混合物与药学上可接受的载体和/或佐剂。

9. 发明授权

US4235899A Substituted O-(2-hydroxypropyl)-aldoximes 失效
标题翻译：取代的O-（2-羟丙基） - 肟
公开(公告)号：US4235899A
公开(公告)日：1980-11-25
申请号：US849936
申请日：1977-11-09
申请人： Ulrich Gebert , Wolfgang Raether
发明人： Ulrich Gebert , Wolfgang Raether
IPC分类号： A61K31/341 , A61K31/345 , A61K31/395 , A61K31/415 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/495 , A61P33/02 , C07D233/95 , C07D307/73 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12
CPC分类号： C07D307/73 , C07D233/95
摘要： Compounds of general formula ##STR1## wherein X represents a methine group and Y is an oxygen atom, or X represents a nitrogen atom and Y the group NR.sup.3 in which R.sup.3 represents a radical selected from the group consisting of a hydrogen atom, a methyl, ethyl and hydroxyethyl group; and R.sup.1 and R.sup.2 each represent a radical of the group hydrogen atom, an alkyl and hydroxyalkyl group each containing up to 6 carbon atoms, or an aryl group containing up to 10 carbon atoms; and R.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, form a 5- to 7-membered saturated ring which contains not more than one further, heterocyclic atom selected from the group consisting of oxygen, sulphur and nitrogen and being unsubstituted or substituted by one of the groups an alkyl and hydroxyalkyl group each containing up to 6 carbon atoms and an aryl group containing up to 10 carbon atoms and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing them.
摘要翻译：通式（I）的化合物，其中X表示次甲基，Y是氧原子，或X表示氮原子，Y表示NR3基团，其中R3表示选自氢原子，甲基，乙基和羟乙基; 并且R 1和R 2各自表示基团氢原子的基团，各自含有至多6个碳原子的烷基和羟烷基，或含有至多10个碳原子的芳基; 并且R 1和R 2与它们所连接的氮原子一起形成5-至7-元饱和环，其含有不多于一个另外的选自氧，硫和氮的杂环原子，并且是未被取代的或者由一个基团取代各自含有至多6个碳原子的烷基和羟基烷基和含有至多10个碳原子的芳基及其生理上可接受的酸加成盐和含有它们的药物组合物。

10. 发明授权

US4105763A 1-Methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles 失效
标题翻译： 1-甲基-2-（苯基 - 氧甲基）-5-硝基 - 咪唑
公开(公告)号：US4105763A
公开(公告)日：1978-08-08
申请号：US734765
申请日：1976-10-22
申请人： Erhardt Winkelmann , Wolfgang Raether
发明人： Erhardt Winkelmann , Wolfgang Raether
IPC分类号： C07D233/94 , A61K31/415 , A61K31/535 , C07D233/95 , C07D413/12
CPC分类号： C07D233/94
摘要： New 1-methyl-2-(phenyl-oxymethyl)-5-nitro-imidazoles are disclosed as well as a process for their manufacture. The new compounds are suitable for the treatment of protozoal diseases and show a marked activity against helminths, ectoparasites and ticks.
摘要翻译：公开了新的1-甲基-2-（苯基 - 氧甲基）-5-硝基 - 咪唑及其制备方法。新化合物适用于治疗原生动物疾病，并显示针对蠕虫，外寄生虫和蜱的明显活性。

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