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1. 发明授权

US5264206A Nail lacquer with antimycotic activity, and a process for the preparation thereof 失效
标题翻译：具有抗真菌活性的指甲油及其制备方法
公开(公告)号：US5264206A
公开(公告)日：1993-11-23
申请号：US206363
申请日：1988-06-14
申请人： Manfred Bohn , Walter Dittmar , Karl Kraemer , Heinz G. Peil , Eberhard Futterer
发明人： Manfred Bohn , Walter Dittmar , Karl Kraemer , Heinz G. Peil , Eberhard Futterer
IPC分类号： A61K31/41 , A61K8/00 , A61K8/41 , A61K8/46 , A61K8/49 , A61K9/70 , A61K31/135 , A61K31/27 , A61K31/415 , A61P17/00 , A61P31/04 , A61P31/10 , A61Q3/02 , A61K7/043 , A61K31/325
CPC分类号： A61K8/49 , A61K8/41 , A61K8/46 , A61K8/4946 , A61Q3/02
摘要： A nail lacquer containing at least one film-former which is insoluble in water and at least one substance which has antimycotic activity and is from the group comprising tioconazole, econazole, oxiconazole, miconazole, tolnaftate and naftifine hydrochloride.
摘要翻译：含有至少一种不溶于水的成膜剂和至少一种具有抗真菌活性的物质的指甲油，其特征在于包含噻康唑，益康唑，奥昔康唑，咪康唑，盐酸萘非那定和萘替芬盐酸盐组。

2. 发明授权

US4870088A 1-[1-aryl-1-hydroxy-2-azolyl-ethyl]-1-aryl-cyclopropane derivatives, and their fungicidal use thereof 失效
标题翻译： 1- [1-芳基-1-羟基-2-唑基 - 乙基] -1-芳基 - 环丙烷衍生物及其杀真菌用途
公开(公告)号：US4870088A
公开(公告)日：1989-09-26
申请号：US25621
申请日：1987-03-13
申请人： Ernst Blume , Wolfgang Schaper , Heinz Ehrhardt , Wolfgang Raether , Walter Dittmar , Heinz Hanel , Burkhard Sachse
发明人： Ernst Blume , Wolfgang Schaper , Heinz Ehrhardt , Wolfgang Raether , Walter Dittmar , Heinz Hanel , Burkhard Sachse
IPC分类号： C07D247/00 , A01N43/50 , A01N43/653 , C07C41/00 , C07C43/18 , C07C67/00 , C07C201/00 , C07C213/00 , C07C215/42 , C07C217/48 , C07C217/74 , C07C253/00 , C07C255/54 , C07C313/00 , C07C317/12 , C07C317/14 , C07C317/18 , C07C317/20 , C07C323/22 , C07D233/56 , C07D233/60 , C07D233/61 , C07D249/08 , C07D307/38 , C07D333/00 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D521/00
CPC分类号： C07D231/12 , A01N43/653 , C07D233/56 , C07D249/08
摘要： Compounds I ##STR1## where A equals t-butyl or a large number of (substituted) aromatics; Y equals azolyl; or Y equals --X--R.sup.1 where X=oxygen or sulfur and R.sup.1 equals (cyclo)alkyl or (heterocyclic) aryl; or Y equals ##STR2## where R.sup.2 equals (cyclo)alkyl, acetyl or aryl; or Y equals --NR.sup.3 R.sup.4 where R.sup.3 /R.sup.4 is alkyl; or Y equals several nitrogen-containing heterocyclic rings; Z equals OH, alkylcarbonyloxy, hal, alkoxy or benzyloxy; and the salts thereof are effective antimycotics or fungicides.They are obtained by reaction of II ##STR3## with (CH.sub.3).sub.2 ##STR4## and further reaction of the compound IV ##STR5## obtained from this with a nucleophile YM (M=hydrogen or a metal equivalent).The compounds I (where Z=OH) resulting from this can be acylated or alkylated, or converted into I where Z=hal.
摘要翻译：其中A等于叔丁基或大量（取代的）芳族化合物; Y等于唑基; 或Y表示-X-R1，其中X =氧或硫，R1表示（环）烷基或（杂环）芳基; 或Y等于，其中R2等于（环）烷基，乙酰基或芳基; 或Y为-NR 3 R 4，其中R 3 / R 4为烷基; 或Y等于若干含氮杂环; Z为OH，烷基羰基氧基，卤素，烷氧基或苄氧基; 其盐是有效的抗真菌剂或杀真菌剂。它们通过II（II）与（CH 3）2图像III的反应和从其获得的化合物IV＆lt; IMAGE＆gt;与亲核试剂YM（M =氢或金属当量）的反应获得。由此产生的化合物I（其中Z = OH）可以被酰化或烷基化，或转化为I，其中Z = hal。

3. 发明授权

US4829075A Antimycotic 1,1-disubstituted cyclopropane derivatives 失效
标题翻译：抗真菌剂1,1-二取代环丙烷衍生物
公开(公告)号：US4829075A
公开(公告)日：1989-05-09
申请号：US25581
申请日：1987-03-13
申请人： Heinz Ehrhardt , Ernst Blume , Wolfgang Raether , Walter Dittmar
发明人： Heinz Ehrhardt , Ernst Blume , Wolfgang Raether , Walter Dittmar
IPC分类号： C07C41/00 , A01N43/50 , A01N43/653 , A61K31/12 , A61K31/13 , A61K31/41 , A61K31/495 , C07C49/175 , C07C49/84 , C07C67/00 , C07C201/00 , C07C205/59 , C07C213/00 , C07D213/70 , C07D233/56 , C07D233/60 , C07D239/38 , C07D249/08 , C07D295/10 , C07D295/116 , C07D307/38 , C07D333/28 , C07D401/14 , C07D403/06 , C07D405/06 , C07D409/06 , C07D521/00
CPC分类号： C07D213/70 , C07C205/59 , C07C317/00 , C07C321/00 , C07C323/00 , C07C49/175 , C07C49/84 , C07D231/12 , C07D233/56 , C07D239/38 , C07D249/08 , C07D295/116 , C07D307/38 , C07D333/28
摘要： Compounds I ##STR1## where A equals t-butyl, phenyl, biphenylyl, phenoxyphenyl, benzylphenyl, benzyloxyphenyl, phenylthiophenyl, phenylsulfinylphenyl, phenylsulfonylphenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, indanyl, fluorenyl, thienyl, furyl, pyridyl, isoxazolyl, pyrazolyl, benzofuryl or benzothienyl,Z equals CO, CH.sub.2 or radicals of ketone derivatives;Y equals azole or equals --X--R.sup.8 (R.sup.8 =(cyclo)alkyl or an aromatic) or equals a number of amine derivatives or equal acyl,are antimycotics. The preparation and use as medicaments are described.
摘要翻译：化合物Ⅰ其中A等于叔丁基，苯基，联苯基，苯氧基苯基，苄基苯基，苄氧基苯基，苯硫基苯基，苯基亚磺酰基苯基，苯基磺酰基苯基，萘基，1,2,3,4-四氢萘基，茚满基，芴基，噻吩基，呋喃基，吡啶基，异恶唑基，吡唑基，苯并呋喃基或苯并噻吩基，Z表示CO，CH2或酮衍生物的自由基; Y等于唑或等于-X-R8（R8 =（环）烷基或芳族）或等于多个胺衍生物或等同酰基，为抗真菌剂。描述了作为药物的制备和用途。

4. 发明授权

US4797409A 1-hydroxy-2-pyridones, a process for their preparation, and medicaments which contain them, and intermediates formed in the preparation of the 1-hydroxy-2-pyridones 失效
标题翻译： 1-羟基-2-吡啶酮，其制备方法和含有它们的药物，以及在制备1-羟基-2-吡啶酮时形成的中间体
公开(公告)号：US4797409A
公开(公告)日：1989-01-10
申请号：US038903
申请日：1987-04-16
申请人： Gerhard Lohaus , Walter Dittmar , Heinz Hanel , Wolfgang Raether , Dieter Reuschling , Bengt-Thomas Grobel
发明人： Gerhard Lohaus , Walter Dittmar , Heinz Hanel , Wolfgang Raether , Dieter Reuschling , Bengt-Thomas Grobel
IPC分类号： A61K31/44 , C07D213/89 , C07D309/38
CPC分类号： C07D213/89 , C07D309/38
摘要： New 1-hydroxy-2-pyridones of the general formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3, which are identical or different, denote hydrogen or lower alkyl having 1-4 carbon atoms, R.sup.1 and R.sup.3 preferably being hydrogen, and R.sup.2 preferably being methyl,X denotes S or, preferably, O,Y denotes hydrogen or up to 2 halogen atoms, namely chlorine and/or bromine,Z denotes a single bond or the bivalent radicals O, S, --CR.sub.2 -- (R=H or C.sub.1 -C.sub.4 -alkyl) or other 2-valent radicals with 2-10 carbon and, optionally, oxygen and/or sulfur atoms linked to form a chain, it being obligatory when the radicals contain 2 or more oxygen and/or sulfur atoms for the latter to be separated by at least 2 carbon atoms, and it being possible for 2 adjacent carbon atoms also to be linked together by a double bond, and the free valencies of the carbon atoms being saturated by H and/or C.sub.1 -C.sub.4 -alkyl groups,Ar denotes an aromatic ring system which has up to two rings and can be substituted by up to three radicals from the group comprising fluorine, chlorine, bromine, methoxy, C.sub.1 -C.sub.4 -alkyl, trifluoromethyl and trifluoromethoxy, are prepared by a variety of process variants. The compounds and their physiologically tolerated salts with inorganic or organic bases mainly have antimycotic, anti-bacterial and antiviral activity. The compounds of the formula V ##STR2## in which R.sup.1, R.sup.2, R.sup.3, X, Y, Z and Ar have the same meaning as in formula I, which occur in the preparation of the compounds of the formula I, are also new.
摘要翻译：通式I的新的1-羟基-2-吡啶酮其中R1，R2和R3相同或不同，表示氢或具有1-4个碳原子的低级烷基，R1和R3优选为氢，并且R2优选为甲基，X表示S或优选O，Y表示氢或最多2个卤素原子，即氯和/或溴，Z表示单键或二价基团O，S，-CR 2 - （R = H或C 1 -C 4 - 烷基）或其它具有2-10个碳的任选的2-价基团和任选的连接形成链的氧和/或硫原子，当基团含有2个或更多个氧和/或后者的硫原子被至少2个碳原子分开，并且可以通过双键将两个相邻的碳原子连接在一起，并且碳原子的自由价被H和/或C1饱和 -C4-烷基，Ar表示芳族环系，其具有多达两个环，并且可以被至少三个基团取代。通过各种工艺变体制备氟，氯，溴，甲氧基，C 1 -C 4 - 烷基，三氟甲基和三氟甲氧基。化合物及其与无机或有机碱的生理耐受盐主要具有抗真菌，抗细菌和抗病毒活性。其中R 1，R 2，R 3，X，Y，Z和Ar具有与式I化合物相同的含义的式Ⅴ的化合物也是新的。

5. 发明授权

US4717724A 1-(1,3-dioxolan-2-ylmethyl)azoles, their salts and their use 失效
标题翻译： 1-（1,3-二氧戊环-2-基甲基）唑，它们的盐及其用途
公开(公告)号：US4717724A
公开(公告)日：1988-01-05
申请号：US587585
申请日：1984-03-08
申请人： Wolfgang Schaper , Ernst Blume , Wolfgang Raether , Walter Dittmar
发明人： Wolfgang Schaper , Ernst Blume , Wolfgang Raether , Walter Dittmar
IPC分类号： A61K31/47 , A61K31/472 , A61P31/04 , A61P33/02 , C07D217/04 , C07D217/06 , C07D217/10 , C07D217/14 , C07D217/16 , C07D217/18 , C07D221/02 , C07D221/20 , C07D401/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D471/10 , C07D491/10 , C07D491/107 , C07D495/10 , C07D521/00 , C07D401/14
CPC分类号： C07D221/20 , C07D217/04 , C07D217/06 , C07D217/10 , C07D217/14 , C07D217/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D471/10 , C07D491/10 , C07D495/10
摘要： New 1-(1,3-dioxolan-2-ylmethyl)azoles, their stereoisomers and their salts are described, as are processes for their preparation. The new compounds are chemotherapeutic agents. They are active against skin fungi, mold fungi and yeasts and against bacteria.
摘要翻译：描述了新的1-（1,3-二氧戊环-2-基甲基）唑，它们的立体异构体及其盐，以及它们的制备方法。新化合物是化学治疗剂。它们对皮肤真菌，霉菌，酵母和细菌都有活性。

6. 发明授权

US4957730A Antimycotic nail varnish 失效
标题翻译：抗真菌指甲油
公开(公告)号：US4957730A
公开(公告)日：1990-09-18
申请号：US942699
申请日：1986-12-17
申请人： Manfred Bohn , Walter Dittmar , Heinz G. Peil , Eberhard Futterer , Karl Kraemer
发明人： Manfred Bohn , Walter Dittmar , Heinz G. Peil , Eberhard Futterer , Karl Kraemer
IPC分类号： A61K8/00 , A61K8/49 , A61K31/44 , A61Q3/02 , C07D213/89
CPC分类号： A61K31/44 , A61K8/4926 , A61Q3/02
摘要： A nail varnish comprising a water-insoluble film-forming substance and an antimycotic compound which is a 1-hydroxy-2-pyridone I of the general formula ##STR1## in which R.sup.1 is a hydrocarbon group which contains from 6 to 9 carbon atoms, but is free from olefinic and acetylenic bonds, one of the groups R.sup.2 and R.sup.4 is hydrogen and the other is hydrogen, methyl or ethyl and R.sup.3 is alkyl having up to two carbon atoms, said antimycotic ingredient being present in free form or in the form of a salt.
摘要翻译：一种指甲油，其包含水不溶性成膜物质和抗真菌化合物，其为通式（I）的1-羟基-2-吡啶酮I，其中R 1为含有6至9个碳原子的烃基碳原子，但不含烯属和炔属键，R2和R4之一是氢，另一个是氢，甲基或乙基，R3是具有至多2个碳原子的烷基，所述抗真菌成分以游离形式或以盐的形式。

7. 发明授权

US4859670A 2-Azolylmethyl-2-aryl-1,3-dioxolanes and the salts thereof, agents containing same, and the use thereof 失效
标题翻译： 2-唑基甲基-2-芳基-1,3-二氧戊环及其盐，含有它们的试剂及其用途
公开(公告)号：US4859670A
公开(公告)日：1989-08-22
申请号：US028193
申请日：1987-03-19
申请人： Klaus-Dieter Kampe , Wolfgang Raether , Walter Dittmar , Heinz Hanel
发明人： Klaus-Dieter Kampe , Wolfgang Raether , Walter Dittmar , Heinz Hanel
IPC分类号： A61K31/44 , A01N43/60 , A01N43/653 , A61K31/443 , A61K31/47 , A61P31/04 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/36 , C07D317/00 , C07D405/12 , C07D521/00
CPC分类号： C07D239/26 , A01N43/60 , A01N43/653 , C07D231/12 , C07D233/56 , C07D239/28 , C07D239/34 , C07D239/36 , C07D249/08
摘要： Compounds of the formula I ##STR1## in which A equals CH or N, Ar equals phenyl, naphthyl or thienyl, R.sup.1 equals alkyl or halogen, and Y is a number of nitrogen-containing heterocyclic rings, have an excellent antimycotic action.The compounds IIIa ##STR2## are valuable intermediates for the preparation thereof.
摘要翻译：其中A等于CH或N，Ar等于苯基，萘基或噻吩基，R1等于烷基或卤素，Y是多个含氮杂环的式I 的化合物具有优异的抗真菌作用。化合物IIIa IIIa是制备它们的有价值的中间体。

8. 发明授权

US4824846A 2-Azolylmethyl-2-aryl-1,3-dioxolanes and the salts thereof, agents containing same, and the use thereof 失效
标题翻译： 2-唑基甲基-2-芳基-1,3-二氧戊环及其盐，含有它们的试剂及其用途
公开(公告)号：US4824846A
公开(公告)日：1989-04-25
申请号：US28087
申请日：1987-03-19
申请人： Klaus D. Kampe , Wolfgang Raether , Walter Dittmar , Heinz Hanel
发明人： Klaus D. Kampe , Wolfgang Raether , Walter Dittmar , Heinz Hanel
IPC分类号： C07D247/00 , A01N43/60 , A01N43/653 , A61K31/44 , A61K31/443 , A61K31/47 , A61P25/08 , C07D213/72 , C07D213/85 , C07D215/54 , C07D237/34 , C07D239/14 , C07D239/42 , C07D317/00 , C07D333/00 , C07D405/14 , C07D521/00 , A61K31/505
CPC分类号： C07D239/42 , A01N43/60 , A01N43/653 , C07D213/72 , C07D213/85 , C07D215/54 , C07D231/12 , C07D233/56 , C07D237/34 , C07D239/14 , C07D249/08
摘要： Compounds I ##STR1## where A equals CH or N; Ar equals naphthyl, thienyl or phenyl; R.sup.1 equals alkyl, F or Cl; g equals zero, 1 or 2; and Y equals various heterocyclic bases, and the acid-addition salts thereof, are described.Several preparation processes are described.The compounds IIIa ##STR2## where R.sup.1, g and Y are as specified in the case of the formula I, serve as intermediates for the preparation of these compounds. Processes are also specified for the preparation of IIIa.I represent valuable antimycotics.
摘要翻译：化合物I 其中A等于CH或N; Ar等于萘基，噻吩基或苯基; R1等于烷基，F或Cl; g等于零，1或2; 和Y等于各种杂环碱，并描述其酸加成盐。描述几个准备过程。其中R1，g和Y如式I所示的化合物IIIa用作制备这些化合物的中间体。还规定了制备IIIa的方法。我代表有价值的抗菌药。

9. 发明授权

US4711775A Cosmetic compositions 失效
标题翻译：化妆品组合物
公开(公告)号：US4711775A
公开(公告)日：1987-12-08
申请号：US677891
申请日：1984-12-04
申请人： Walter Dittmar , Eberhard Futterer , Gerhard Lohaus
发明人： Walter Dittmar , Eberhard Futterer , Gerhard Lohaus
IPC分类号： A61K8/00 , A61K20060101 , A61K8/33 , A61K8/37 , A61K8/49 , A61K8/92 , A61K31/12 , A61K31/44 , A61P17/08 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q7/00 , C07D20060101 , C07D207/26 , C07D213/89 , C11D3/28 , C11D3/48 , A61K7/06
CPC分类号： A61Q5/006 , A61K8/4926 , Y10S424/01 , Y10S424/02 , Y10S424/04
摘要： A cosmetic composition comprising a content of an 1-hydroxy-2-pyridone of the general formula ##STR1## in which R.sub.1 stands for hydrogen, alkyl of 1 to 17 carbon atoms, alkenyl of 2 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, bicycloalkyl of 7 to 9 carbon atoms, cycloalkyl-alkyl of 1 to 4 alkyl carbon atoms, the cycloalkyl groups being optionally substituted by alkyl groups of 1 to 4 carbon atoms, aryl, aralkyl of 1 to 4 alkyl carbon atoms, aryl-alkenyl of 2 to 4 alkenyl carbon atoms, aryloxy-alkyl or arylthio-alkyl of 1 to 4 alkyl carbon atoms, benzhydryl, phenylsulfonyl-alkyl of 1 to 4 alkyl carbon atoms, furyl or furyl-alkenyl of 2 to 4 alkenyl carbon atoms, the aryl groups being optionally substituted by alkyl of 1 to 4 carbon atoms, by alkoxy of 1 to 4 carbon atoms, by nitro, cyano or halogen atoms,R.sub.2 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl or alkinyl of 2 to 4 carbon atoms, halogen atoms or benzyl,R.sub.3 stands for hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, andR.sub.4 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, methoxy-methyl, halogen or benzyl, and/or salt thereof, which may be used as an anti-dandruff agent.
摘要翻译：一种化妆品组合物，其包含通式“IMAGE”的1-羟基-2-吡啶酮的含量，其中R1代表氢，1至17个碳原子的烷基，2至17个碳原子的链烯基，5至8个的环烷基碳原子数为7〜9的双环烷基，1〜4个碳原子的环烷基 - 烷基，环烷基任选被1〜4个碳原子的烷基取代，芳基，1〜4个碳原子的芳烷基，芳基 2至4个烯基碳原子的烯基，1至4个烷基碳原子的芳氧基 - 烷基或芳硫基 - 烷基，2至4个烷基碳原子的二苯甲基，苯基磺酰基 - 烷基，2至4个烯基碳原子的呋喃基或呋喃基 - 烯基，芳基任选被1至4个碳原子的烷基，1至4个碳原子的烷氧基，硝基，氰基或卤素原子取代，R2代表氢，1至4个碳原子的烷基，烯基或炔基 2至4个碳原子，卤素原子或苄基，R3代表氢，1至4个碳原子的烷基 R苯基，R4代表氢，1至4个碳原子的烷基，2至4个碳原子的链烯基，甲氧基 - 甲基，卤素或苄基，和/或其盐，可用作抗头皮屑剂。

10. 发明授权

US4185106A Pyridones as antidandruff agents 失效
标题翻译：吡啶酮作为去头皮屑剂
公开(公告)号：US4185106A
公开(公告)日：1980-01-22
申请号：US605210
申请日：1975-08-15
申请人： Walter Dittmar , Eberhard Futterer , Gerhard Lohaus
发明人： Walter Dittmar , Eberhard Futterer , Gerhard Lohaus
IPC分类号： A61K8/49 , A61K31/44 , A61Q5/00
CPC分类号： A61Q5/006 , A61K8/4926 , Y10S424/04
摘要： A cosmetic composition comprising a content of an 1-hydroxy-2-pyridone of the general formula ##STR1## in which R.sub.1 stands for hydrogen, alkyl of 1 to 17 carbon atoms, alkenyl of 2 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, bicycloalkyl of 7 to 9 carbon atoms, cycloalkyl-alkyl of 1 to 4 alkyl carbon atoms, the cycloalkyl groups being optionally substituted by alkyl groups of 1 to 4 carbon atoms, aryl, aralkyl of 1 to 4 alkyl carbon atoms, aryl-alkenyl of 2 to 4 alkenyl carbon atoms, aryloxy-alkyl or arylthio-alkyl of 1 to 4 alkyl carbon atoms, benzhydryl, phenylsulfonyl-alkyl of 1 to 4 alkyl carbon atoms, furyl or furyl-alkenyl of 2 to 4 alkenyl carbon atoms, the aryl groups being optionally substituted by alkyl of 1 to 4 carbon atoms, by alkoxy of 1 to 4 carbon atoms, by nitro, cyano or halogen atoms, R.sub.2 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl or alkinyl of 2 to 4 carbon atoms, halogen atoms or benzyl, R.sub.3 stands for hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, and R.sub.4 stands for hydrogen, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, methoxy-methyl, halogen or benzyl, and/or salt thereof, which may be used as an anti-dandruff agent.
摘要翻译：一种化妆品组合物，其包含通式“IMAGE”的1-羟基-2-吡啶酮的含量，其中R1代表氢，1至17个碳原子的烷基，2至17个碳原子的链烯基，5至8个的环烷基碳原子数为7〜9的双环烷基，1〜4个碳原子的环烷基 - 烷基，环烷基任选被1〜4个碳原子的烷基取代，芳基，1〜4个碳原子的芳烷基，芳基 2至4个烯基碳原子的烯基，1至4个烷基碳原子的芳氧基 - 烷基或芳硫基 - 烷基，2至4个烷基碳原子的二苯甲基，苯基磺酰基 - 烷基，2至4个烯基碳原子的呋喃基或呋喃基 - 烯基，芳基任选被1至4个碳原子的烷基，1至4个碳原子的烷氧基，硝基，氰基或卤素原子取代，R2代表氢，1至4个碳原子的烷基，烯基或炔基 2至4个碳原子，卤素原子或苄基，R3代表氢，1至4个碳原子的烷基 R苯基，R4代表氢，1至4个碳原子的烷基，2至4个碳原子的链烯基，甲氧基 - 甲基，卤素或苄基，和/或其盐，可用作抗头皮屑剂。

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