专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4284627A Antimalarial compositions 失效
标题翻译：抗疟组成
公开(公告)号：US4284627A
公开(公告)日：1981-08-18
申请号：US166295
申请日：1980-07-07
申请人： Wolfgang Raether , Walter Durckheimer , Hans Seidenath
发明人： Wolfgang Raether , Walter Durckheimer , Hans Seidenath
IPC分类号： C07D219/06 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/49 , A61K31/505 , A61K31/53 , A61K31/635 , A61P33/02 , A61K31/625 , A61K31/435
CPC分类号： A61K31/635 , A61K31/44 , A61K31/47 , A61K31/49 , A61K31/505 , A61K31/53 , Y10S514/895
摘要： Antimalarial compositions are disclosed containing as the active ingredient a mixture of a tetrahydroacridone of the general formula I ##STR1## in which R.sup.1 represents methyl, phenyl, p-chlorophenyl, m-chlorophenyl, p-fluorophenyl, p-trifluoromethylphenyl, o-trifluoromethylphenyl or o-chloro-p-trifluoromethylphenyl,R.sup.2 represents hydrogen or methyl, andR.sup.3 represents fluorine or chlorine,or a salt of such a compound with a physiologically compatible acid or base, with(a) 6-methoxy-.alpha.-(5-vinyl-2-quinuclidinyl)-4-quinoline-methanol (Quinine),(b) 7-chloro-4-(diethylamino-1-methyl-butylamino)-quinoline (Chloroquine),(c) .alpha.-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol (Mefloquine),(d) 8-(4-amino-1-methylbutylamino)-6-methoxy-quinoline (Primaquine),(e) 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine (Pyrimethamine),(f) 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine (Cycloguanil),(g) 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine (Trimethoprim),(h) N'-(5,6-dimethoxy-4-pyrimidyl)-sulfanilamide (Sulfadoxine), or(i) 4,4'-diaminodiphenylsulfone (Dapsone),or with a salt of a compound sub (a) to (i), with a physiologically compatible acid or base, the mixtures being in a proportion by weight of between 25:1 and 1:300 (tetrahydroacridone to compound sub (a) to (i)) in admixture with a pharmaceutically acceptable carrier and/or adjuvant.This is a division of application Ser. No. 954,900, filed October 26, 1978.
摘要翻译：公开了抗疟组合物，其包含作为活性成分的通式I的四氢吖啶酮的混合物，其中R 1表示甲基，苯基，对氯苯基，间氯苯基，对氟苯基，对三氟甲基苯基，邻三氟甲基苯基或对 - 邻 - 氯 - 对三氟甲基苯基，R 2代表氢或甲基，R 3代表氟或氯，或这种化合物与生理相容的酸或碱的盐与（a）6-甲氧基-α-（5-乙烯基 -2-喹喔啉基）-4-喹啉 - 甲醇（奎宁），（b）7-氯-4-（二乙基氨基-1-甲基 - 丁基氨基） - 喹啉（氯喹），（c）α-（2-哌啶基） 2,8-双（三氟甲基）-4-喹啉甲醇（Mefloquine），（d）8-（4-氨基-1-甲基丁基氨基）-6-甲氧基 - 喹啉（Primaquine），（e）2,4-二氨基-5 对 - 氯苯基-6-乙基嘧啶（Pyrimethamine），（f）4,6-二氨基-1-（对氯苯基）-1,2-二氢-2,2-二甲基-s-三嗪（Cycloduanil），（g ）2,4-二氨基-5-（3,4,5-三甲氧基苄基） - 嘧啶（Trimethopri m），（h）N' - （5,6-二甲氧基-4-嘧啶基） - 磺胺（磺胺多辛），或（i）4,4'-二氨基二苯砜（氨苯砜），或与化合物）至（i）与生理上相容的酸或碱，所述混合物的重量比为25:1至1:300（四氢吖啶酮与化合物（a）至（i））的混合物与药学上可接受的载体和/或佐剂。

2. 发明授权

US4260615A Antimalarial compositions 失效
公开(公告)号：US4260615A
公开(公告)日：1981-04-07
申请号：US954900
申请日：1978-10-26
申请人： Wolfgang Raether , Walter Durckheimer , Hans Seidenath
发明人： Wolfgang Raether , Walter Durckheimer , Hans Seidenath
IPC分类号： C07D219/06 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/49 , A61K31/505 , A61K31/53 , A61K31/635 , A61P33/02 , A61K31/435
CPC分类号： A61K31/635 , A61K31/44 , A61K31/47 , A61K31/49 , A61K31/505 , A61K31/53 , Y10S514/895
摘要： Antimalarial compositions are disclosed containing as the active ingredient a mixture of a tetrahydroacridone of the general formula I ##STR1## in which R.sup.1 represents methyl, phenyl, p-chlorophenyl, m-chlorophenyl, p-fluorophenyl, p-trifluoromethylphenyl, o-trifluoromethylphenyl or o-chloro-p-trifluoromethylphenyl,R.sup.2 represents hydrogen or methyl, andR.sup.3 represents fluorine or chlorine,or a salt of such a compound with a physiologically compatible acid or base, with(a) 6-methoxy-.alpha.-(5-vinyl-2-quinuclidinyl)-4-quinoline-methanol (Quinine),(b) 7-chloro-4-(diethylamino-1-methyl-butylamino)-quinoline (Chloroquine),(c) .alpha.-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol (Mefloquine),(d) 8-(4-amino-1-methylbutylamino)-6-methoxy-quinoline (Primaquine),(e) 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine (Pyrimethamine),(f) 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-s-triazine (Cycloguanil),(g) 2,4-diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine (Trimethoprim),(h) N'-(5,6-dimethoxy-4-pyrimidyl)-sulfanilamide (Sulfadoxine), or(i) 4,4'-diaminodiphenylsulfone (Dapsone),or with a salt of a compound sub (a) to (i), with a physiologically compatible acid or base, the mixtures being in a proportion by weight of between 25:1 and 1:300 (tetrahydroacridone to compound sub (a) to (i)) in admixture with a pharmaceutically acceptable carrier and/or adjuvant.

3. 发明授权

US3947449A Tetrahydroacridones having chemotherapeutic action and process for preparing them 失效
标题翻译：具有化疗作用的四氢吖啶酮及其制备方法
公开(公告)号：US3947449A
公开(公告)日：1976-03-30
申请号：US490652
申请日：1974-07-22
申请人： Walter Durckheimer , Wolfgang Raether , Hubert Georg Seliger
发明人： Walter Durckheimer , Wolfgang Raether , Hubert Georg Seliger
IPC分类号： C07D219/02 , A61K31/47 , A61K31/473 , A61P33/02 , C07D219/06 , C07D219/08
CPC分类号： C07D219/06 , C07D219/08
摘要： Tetrahydroacridones and their salts with physiologically tolerated acids and bases and process for preparing them. The compounds have a valuable chemotherapeutic action and may be used as drugs against protozoan diseases.
摘要翻译：四氢吖啶酮及其与生理上耐受的酸和碱的盐及其制备方法。这些化合物具有有价值的化学治疗作用，可用作抗原生动物疾病的药物。

4. 发明授权

US4593027A 3-aryl-7-chloro-3,4-dihydroacridine-1,9(2H,10H)-dione 1-oximes and 1-hydrazone derivatives, their salts, a process for their preparation, agents containing them and their use 失效
标题翻译： 3-芳基-7-氯-3,4-二氢吖啶-1,9（2H，10H） - 二酮1-肟和1-腙衍生物，其盐，其制备方法，含有它们的试剂及其用途
公开(公告)号：US4593027A
公开(公告)日：1986-06-03
申请号：US540647
申请日：1983-10-11
申请人： Erhardt Winklemann , Walter Durckheimer , Wolfgang Raether
发明人： Erhardt Winklemann , Walter Durckheimer , Wolfgang Raether
IPC分类号： C07D219/06 , C07D219/08 , A61K31/495 , A61K31/435 , C07D295/04 , C07D471/00
CPC分类号： C07D219/06 , C07D219/08
摘要： 3-Aryl-7-chloro-3,4-dihydroacridine-1,9(2H,10H)-dione 1-oximes and 1-hydrazone derivatives of the formula I ##STR1## and their physiologically tolerated acid addition and ammonium salts are described, as is a process for their preparation. The new compounds are chemotherapeutic agents and are active against protozoa, especially malaria plasmodia.
摘要翻译： 3-芳基-7-氯-3,4-二氢吖啶-1,9（2H，10H） - 二酮1-肟和式I的1-腙衍生物（I）及其生理上耐受的酸加成和铵描述了盐，以及它们的制备方法。新化合物是化学治疗剂，对抗原生动物，特别是疟疾疟原虫是有活性的。

5. 发明授权

US5306717A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US5306717A
公开(公告)日：1994-04-26
申请号：US924598
申请日：1992-07-24
申请人： Friedhelm Adam , Walter Durckheimer , Gerd Fischer , Burkhard Mencke , Gerhard Seibert , Dieter Isert , Norbert Klesel
发明人： Friedhelm Adam , Walter Durckheimer , Gerd Fischer , Burkhard Mencke , Gerhard Seibert , Dieter Isert , Norbert Klesel
IPC分类号： A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/04 , C07D501/06 , C07D501/22 , C07D501/34 , C07D501/46
CPC分类号： C07D501/34
摘要： Cephalosporin derivatives of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections and contain such cephem derivatives, processes for the preparation of the cephem derivatives and the pharmaceutical preparations and the use of the cephem derivatives for combating bacterial infections.
摘要翻译：具有抗细菌感染和含有此类头孢烯衍生物的通式为“IMAGE”+ TR 的药物制剂的头孢菌素衍生物，头孢烯衍生物和药物制剂的制备方法以及头孢烯衍生物用于对抗细菌感染。

6. 发明授权

US4701452A Use of cephem compounds as immunomodulators 失效
标题翻译：使用头孢烯化合物作为免疫调节剂
公开(公告)号：US4701452A
公开(公告)日：1987-10-20
申请号：US702319
申请日：1985-02-15
申请人： Michael Limbert , Walter Durckheimer , Hans-Ulrich Schorlemmer , Gerhard Dickneite
发明人： Michael Limbert , Walter Durckheimer , Hans-Ulrich Schorlemmer , Gerhard Dickneite
IPC分类号： C07D501/36 , A61K31/545 , A61K31/546 , A61P37/00
CPC分类号： A61K31/545
摘要： The use of cephem compounds of the general formula I ##STR1## to increase the immunological responsiveness of mammals and formulations which contain an effective content of cephem compounds of the general formula I.
摘要翻译：使用通式I的头孢烯化合物增加哺乳动物和制剂的免疫应答性，其含有通式I的头孢烯化合物的有效含量。

7. 发明授权

US4454129A Cephem derivatives 失效
标题翻译： Cephem衍生物
公开(公告)号：US4454129A
公开(公告)日：1984-06-12
申请号：US373790
申请日：1982-04-30
申请人： Burkhard Mencke , Eberhard Ehlers , Jurgen Blumbach , Walter Durckheimer , Karl Seeger
发明人： Burkhard Mencke , Eberhard Ehlers , Jurgen Blumbach , Walter Durckheimer , Karl Seeger
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07C235/74 , C07D277/36 , C07D501/34 , C07D501/36 , C07D501/46 , C07D501/56
CPC分类号： C07C235/74 , C07D277/36
摘要： What are disclosed are cephem compounds of the formula ##STR1## useful for combating bacterial infections, and methods of making and using the same.
摘要翻译：所公开的是用于对抗细菌感染的具有式（IMAGE）+ TR＆lt; IMAGE＆gt;的头孢烯化合物及其制备和使用方法。

8. 再颁专利

USRE34865E Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：USRE34865E
公开(公告)日：1995-02-21
申请号：US978980
申请日：1992-11-19
申请人： Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
发明人： Friedhelm Adam , Jurgen Blumbach , Walter Durckheimer , Gerd Fischer , Burghard Mencke , Dieter Isert , Gerhard Seibert
IPC分类号： A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/00 , C07D501/32 , C07D501/34
CPC分类号： C07D501/34 , C07D501/00
摘要： Cephemcarboxylic acid esters of the general formula ##STR1## pharmaceutical preparations which are active against bacterial infections, which contain such cephem derivatives, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and also the use of the cephem derivatives for combating bacterial infections.
摘要翻译：具有抗细菌感染活性的含有此类头孢烯衍生物的通式 + TR 药物制剂的头孢霉羧酸酯，制备头孢烯衍生物和药物制剂的方法，以及使用头孢烯衍生物用于对抗细菌感染。

9. 发明授权

US5362721A Corticoid-17-alkyl-carbonates substituted in the 17-position, process for their preparation and pharmaceuticals containing them 失效
标题翻译：在17位取代的皮质类固醇-17-烷基 - 碳酸酯，其制备方法和含有它们的药物
公开(公告)号：US5362721A
公开(公告)日：1994-11-08
申请号：US015041
申请日：1993-02-08
申请人： Ulrich Stache , Walter Durckheimer , Hans G. Alpermann , Walter Petri
发明人： Ulrich Stache , Walter Durckheimer , Hans G. Alpermann , Walter Petri
IPC分类号： A61K31/57 , A61P29/00 , A61P37/08 , C07J5/00 , C07J7/00 , C07J21/00 , C07J31/00 , C07J9/00
CPC分类号： C07J7/0085 , C07J21/00 , C07J31/006 , C07J5/0053 , C07J5/0076
摘要： The disclosed invention includes corticoid-17-alkylcarbonates substituted in the 17-position, a process for their preparation and pharmaceuticals containing them. These corticoid-17-alkylcarbonates have the following formula I ##STR1## where A is CHOH in any desired steric arrangement, C.dbd.O or CH.sub.2 ; Y is H, F, or Cl; Z is H, F or CH.sub.3 ; R(1) is O-acyl, carbonylalkyl, alkylsulfonate or arylsulfonate;R(2) is branched alkyl or (CH.sub.2).sub.2-4 --OCH.sub.3 andR(3) is H or methyl. They have excellent local and topical antiinflammatory action. They are distinguished by a particularly good ratio of local to systemic antiinflammatory activity and in some cases also show stronger local antiinflammatory activities than their isomeric corticoid-17-alkylcarbonates having a linear alkyl group in the 17-alkylcarbonate moiety.
摘要翻译：所公开的发明包括在17位取代的皮质类固醇-17-烷基碳酸酯，其制备方法和含有它们的药物。这些皮质激素-17-烷基碳酸酯具有以下分子式I，其中A是任何所需空间排列中的CHOH，C = O或CH 2; Y是H，F或Cl; Z是H，F或CH 3; R（1）是O-酰基，羰基烷基，烷基磺酸酯或芳基磺酸酯; R（2）是支链烷基或（CH2）2-4-OCH3，R（3）是H或甲基。他们具有优异的局部和局部抗炎作用。它们的区别在于局部与系统性抗炎活性的比例特别好，并且在某些情况下也显示出比其在17-烷基碳酸酯部分具有直链烷基的异构的类皮质激素-17-烷基碳酸酯更强的局部抗炎活性。

10. 发明授权

US4845087A Crystallized cephem-acid addition salts, and a process for the preparation thereof 失效
标题翻译：结晶头孢烯酸加成盐及其制备方法
公开(公告)号：US4845087A
公开(公告)日：1989-07-04
申请号：US159395
申请日：1988-02-23
申请人： Rudolf Lattrell , Walter Durckheimer , Reiner Kirrstetter
发明人： Rudolf Lattrell , Walter Durckheimer , Reiner Kirrstetter
IPC分类号： C07D501/00 , A61K20060101 , A61K31/54 , A61K31/545 , A61K31/546 , A61K31/70 , A61P31/04 , C07D20060101 , C07D501/02 , C07D501/04 , C07D501/46 , C07D501/56
CPC分类号： C07D501/46
摘要： Crystallized cephem-acid addition salts of the general formula ##STR1## pharmaceutical preparations which contain such cephem derivatives and are active against bacterial infections, a process for the preparation of the cephem derivatives and the pharmaceutical preparations, and the use of the cephem derivatives for combating bacterial infections.
摘要翻译：包含这种头孢烯衍生物并且对细菌感染具有活性的药物制剂的结晶头孢甲酸加成盐，制备头孢烯衍生物和药物制剂的方法，以及使用用于对抗细菌感染的头孢烯衍生物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式