专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08530681B2 Pharmaceutical compositions of O-nitro compounds 有权
标题翻译： O-硝基化合物的药物组合物
公开(公告)号：US08530681B2
公开(公告)日：2013-09-10
申请号：US13484138
申请日：2012-05-30
申请人： Susan Knox , Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde , Shoucheng Ning , Lynn M. Oehler
发明人： Mark D. Bednarski , Susan Knox , Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde , Shoucheng Ning
IPC分类号： C07D303/00 , C07D331/02 , A61K33/24
CPC分类号： C07D303/22 , A61K31/21 , A61K31/336 , A61K31/38 , A61K31/395 , A61K45/06
摘要： The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供O-硝基化合物，O-硝基化合物的药物组合物和使用O-硝基化合物和/或其药物组合物的方法来治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫性疾病。

2. 发明申请

US20110130572A1 METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS 有权
标题翻译：合成环状化合物的方法
公开(公告)号：US20110130572A1
公开(公告)日：2011-06-02
申请号：US12788014
申请日：2010-05-26
申请人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
发明人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

3. 发明授权

US07745643B2 Methods of synthesizing cyclic nitro compounds 有权
标题翻译：环状硝基化合物的合成方法
公开(公告)号：US07745643B2
公开(公告)日：2010-06-29
申请号：US12252278
申请日：2008-10-15
申请人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
发明人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

4. 发明申请

US20090093644A1 METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS 有权
标题翻译：合成环状化合物的方法
公开(公告)号：US20090093644A1
公开(公告)日：2009-04-09
申请号：US12252278
申请日：2008-10-15
申请人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
发明人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

5. 发明授权

US08178698B2 Methods of synthesizing cyclic nitro compounds 有权
标题翻译：环状硝基化合物的合成方法
公开(公告)号：US08178698B2
公开(公告)日：2012-05-15
申请号：US12788014
申请日：2010-05-26
申请人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
发明人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

6. 发明申请

US20090088506A1 SYNTHESIS OF ENERGETIC THERMOPLASTIC ELASTOMERS CONTAINING BOTH POLYOXIRANE AND POLYOXETANE BLOCKS 审中-公开
标题翻译：含有多氟聚合物和聚氧乙烯嵌段的能量热塑性弹性体的合成
公开(公告)号：US20090088506A1
公开(公告)日：2009-04-02
申请号：US12137962
申请日：2008-06-12
申请人： Andrew J. Sanderson , Wayne Edwards , Louis F. Cannizzo , Robert B. Wardle
发明人： Andrew J. Sanderson , Wayne Edwards , Louis F. Cannizzo , Robert B. Wardle
IPC分类号： C08G65/333 , C08K5/33 , C08K5/17 , C08K5/22 , C08K5/11
CPC分类号： C08G18/3206 , C06B45/105 , C08G18/48 , C08G18/4833 , C08G18/5021 , C08G18/7621 , C08G65/18 , C08G65/22
摘要： This thermoplastic elastomer is present in a substantially solid state suitable for use as a binder for a propellant, explosive, and/or gas generant of a supplemental restraint system. The thermoplastic elastomer is formed from a composition including A blocks which are crystalline at temperatures below about 75° C. and B blocks which are amorphous at temperatures above about −20° C. The A blocks are derived from oxetane derivatives and the B blocks are derived from oxiranes and derivatives thereof. The A blocks and B blocks are end-capped with a diisocyanate having a first isocyanate moiety that is substantially more reactive with the terminal groups of the blocks than the second isocyanate moiety, whereby the more reactive first isocyanate moiety is capable of reacting with the terminal groups of the blocks, leaving the less reactive second isocyanate moiety free and unreacted. The end-capped A blocks and the end-capped B blocks are linked together with a linking compound having two isocyanate-reactive groups which are sufficiently unhindered to react with the free and unreacted isocyanate moieties of the end-capped polymers.
摘要翻译：该热塑性弹性体以基本固态的形式存在，适合用作补充约束系统的推进剂，爆炸物和/或气体发生剂的粘合剂。热塑性弹性体由包括在低于约75℃的温度下结晶的A嵌段的组合物形成，以及在高于约-20℃的温度下是无定形的B嵌段.A嵌段衍生自氧杂环丁烷衍生物，B嵌段是衍生自环氧乙烷及其衍生物。 A嵌段和B嵌段用具有第一异氰酸酯部分的二异氰酸酯封端，所述第一异氰酸酯部分与第二异氰酸酯部分的嵌段端基基本上更具反应性，由此反应性较高的第一异氰酸酯部分能够与末端反应使得较少反应性的第二异氰酸酯部分游离且未反应。封端的A嵌段和封端的B嵌段与具有两个异氰酸酯反应性基团的连接化合物连接在一起，这两个异氰酸酯反应性基团充分地不受阻碍地与封端的聚合物的游离的和未反应的异氰酸酯部分反应。

7. 发明授权

US07101955B1 Synthesis of energetic thermoplastic elastomers containing both polyoxirane and polyoxetane blocks 失效
公开(公告)号：US07101955B1
公开(公告)日：2006-09-05
申请号：US09436360
申请日：1999-11-09
申请人： Andrew J. Sanderson , Wayne Edwards , Louis F. Cannizzo , Robert B. Wardle
发明人： Andrew J. Sanderson , Wayne Edwards , Louis F. Cannizzo , Robert B. Wardle
IPC分类号： C08G18/48 , C08G18/50 , C08G18/10
CPC分类号： C08G18/7621 , C08G18/3206 , C08G18/48 , C08G18/4833 , C08G18/5021 , Y10S149/122
摘要： This thermoplastic elastomer is present in a substantially solid state suitable for use as a binder for a propellant, explosive, and/or gas generant of a supplemental restraint system. The thermoplastic elastomer is formed from a composition including A blocks which are crystalline at temperatures below about 75° C. and B blocks which are amorphous at temperatures above about −20° C. The A blocks are derived from oxetane derivatives and the B blocks are derived from oxiranes and derivatives thereof. The A blocks and B-blocks are end-capped with a diisocyanate having a first isocyanate moiety that is substantially more reactive with the terminal groups of the blocks than the second isocyanate moiety, whereby the more reactive first isocyanate moiety is capable of reacting with the terminal groups of the blocks, leaving the less reactive second isocyanate moiety free and unreacted. The end-capped A blocks and the end-capped B blocks are linked together with a linking compound having two isocyanate-reactive groups which are sufficiently unhindered to react with the free and unreacted isocyanate moieties of the end-capped polymers.

8. 发明授权

US5723604A Synthesis of 2,4,6,8,10,12-hexabenzyl-2,4,6,8,10,12-hexaazatetracyclo �5.5.0.05,9.03,11!dodecane 失效
标题翻译： 2,4,6,8,10,12-六苄基-2,4,6,8,10,12-六氮杂四环[5.5.0.05,9.03,11]十二烷的合成
公开(公告)号：US5723604A
公开(公告)日：1998-03-03
申请号：US493627
申请日：1995-06-22
申请人： Louis F. Cannizzo , William W. Edwards , Robert B. Wardle , Thomas K. Highsmith
发明人： Louis F. Cannizzo , William W. Edwards , Robert B. Wardle , Thomas K. Highsmith
IPC分类号： C06B25/00 , C07D487/22
CPC分类号： C07D487/22 , C06B25/00
摘要： A process of synthesizing HBIW using a mineral acid, such as perchloric acid, as the acid catalyst is disclosed. According to the process, glyoxal, adjusted to a pH from 4 to 7, and benzylamine are reacted in the presence of the mineral acid for sufficient time to form HBIW. The resulting HBIW is then isolated according to conventional separation techniques.
摘要翻译：公开了使用无机酸如高氯酸合成HBIW作为酸催化剂的方法。根据该方法，将乙醛酸调节至4至7的pH，并且在无机酸存在下使苄胺反应足够的时间以形成HBIW。然后根据常规分离技术分离得到的HBIW。

9. 发明申请

US20130309324A1 O-NITRO COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS INCLUDING SAME 有权
标题翻译： O-硝基化合物和包括其的药物组合物
公开(公告)号：US20130309324A1
公开(公告)日：2013-11-21
申请号：US13951720
申请日：2013-07-26
申请人： Lynn M. Oehler , RadioRx, Inc., c/o Interwest Venture Partners , Alliant Techsystems Inc.
发明人： Mark D. Bednarski , Susan Knox , Louis F. Cannizzo , Kristin F. Warner , Robert B. Wardle , Stephen P. Velarde , Shoucheng Ning
IPC分类号： C07D303/22 , A61K45/06 , A61K31/336
CPC分类号： C07D303/22 , A61K31/21 , A61K31/336 , A61K31/38 , A61K31/395 , A61K45/06
摘要： The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供O-硝基化合物，O-硝基化合物的药物组合物和使用O-硝基化合物和/或其药物组合物的方法来治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫性疾病。

10. 发明授权

US07129348B1 Polycyclic, polyamides as precursors for energetic polycyclic polynitramine oxidizers 失效
标题翻译：多环，聚酰胺作为能量多环多硝胺氧化剂的前体
公开(公告)号：US07129348B1
公开(公告)日：2006-10-31
申请号：US07292028
申请日：1988-12-21
申请人： Robert B. Wardle , Jerald C. Hinshaw
发明人： Robert B. Wardle , Jerald C. Hinshaw
IPC分类号： C07D487/22 , C06B25/34
CPC分类号： C06B25/34 , C07D487/22
摘要： Hexabenzylhexaazaisowurtzitane is converted to tetracetyl, dibenzyl azaisowurtzitane. The benzyl groups are removed by catalytic transfer hydrogenolysis leaving a pair of available nitrogens. The available nitrogens are acetylated, and the resulting intermediate is converted to CL-20 with a strong nitrating agent.
摘要翻译：六苄基六氮杂异纤锌矿型结构烷烃转化为四乙酰基二氮杂异纤锌矿型结构烷烃。通过催化转移氢解除去苄基，留下一对可用的氮。可用的氮被乙酰化，所得中间体用强硝化剂转化成CL-20。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式