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1. 发明授权

US08530681B2 Pharmaceutical compositions of O-nitro compounds 有权
标题翻译： O-硝基化合物的药物组合物
公开(公告)号：US08530681B2
公开(公告)日：2013-09-10
申请号：US13484138
申请日：2012-05-30
申请人： Susan Knox , Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde , Shoucheng Ning , Lynn M. Oehler
发明人： Mark D. Bednarski , Susan Knox , Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde , Shoucheng Ning
IPC分类号： C07D303/00 , C07D331/02 , A61K33/24
CPC分类号： C07D303/22 , A61K31/21 , A61K31/336 , A61K31/38 , A61K31/395 , A61K45/06
摘要： The present invention provides O-nitro compounds, pharmaceutical compositions of O-nitro compounds and methods of using O-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供O-硝基化合物，O-硝基化合物的药物组合物和使用O-硝基化合物和/或其药物组合物的方法来治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫性疾病。

2. 发明申请

US20090093644A1 METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS 有权
标题翻译：合成环状化合物的方法
公开(公告)号：US20090093644A1
公开(公告)日：2009-04-09
申请号：US12252278
申请日：2008-10-15
申请人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
发明人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

3. 发明申请

US20110130572A1 METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS 有权
标题翻译：合成环状化合物的方法
公开(公告)号：US20110130572A1
公开(公告)日：2011-06-02
申请号：US12788014
申请日：2010-05-26
申请人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
发明人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

4. 发明授权

US07745643B2 Methods of synthesizing cyclic nitro compounds 有权
标题翻译：环状硝基化合物的合成方法
公开(公告)号：US07745643B2
公开(公告)日：2010-06-29
申请号：US12252278
申请日：2008-10-15
申请人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
发明人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

5. 发明授权

US08178698B2 Methods of synthesizing cyclic nitro compounds 有权
标题翻译：环状硝基化合物的合成方法
公开(公告)号：US08178698B2
公开(公告)日：2012-05-15
申请号：US12788014
申请日：2010-05-26
申请人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
发明人： Louis F. Cannizzo , Kirstin F. Warner , Robert B. Wardle , Stephen P. Velarde
IPC分类号： C07D205/04
CPC分类号： A61K31/397 , A61K9/0019 , A61N5/10 , C07D205/04
摘要： The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.
摘要翻译：本发明提供了环状硝基化合物，环状硝基化合物的药物组合物和使用环状硝基化合物的方法和/或其药物组合物，用于治疗或预防以异常细胞增殖为特征的疾病或病症，例如癌症，炎症，心血管疾病和自身免疫疾病。

6. 发明授权

US07101449B2 Method for recovery of nitramines from aluminized energetic materials 失效
公开(公告)号：US07101449B2
公开(公告)日：2006-09-05
申请号：US10646419
申请日：2003-08-22
申请人： Kirstin F. Warner , Louis F. Cannizzo , Robert M. Hajik
发明人： Kirstin F. Warner , Louis F. Cannizzo , Robert M. Hajik
IPC分类号： D03D23/00
CPC分类号： C07D257/02 , Y10S149/124
摘要： Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrochloric acid, may be added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.

7. 发明授权

US06610156B2 Method for recovery of nitramines from aluminized energetic materials 失效
标题翻译：从镀铝能量材料中回收硝胺的方法
公开(公告)号：US06610156B2
公开(公告)日：2003-08-26
申请号：US09784476
申请日：2001-02-15
申请人： Kirstin F. Warner , Louis F. Cannizzo , Robert M. Hajik
发明人： Kirstin F. Warner , Louis F. Cannizzo , Robert M. Hajik
IPC分类号： C06B3308
CPC分类号： C07D257/02 , Y10S149/124
摘要： Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrochloric acid, may be added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.
摘要翻译：硝胺是在高能材料中发现的更昂贵和经常更丰富的成分之一，例如固体火箭发动机推进剂，爆炸物和烟火。通过用含有不超过55重量％的硝酸水溶液的硝酸水溶液处理镀铝的能量材料，其中硝酸水溶液与高分子材料的重量比为约4:1至约6:1，常规镀铝能量材料被消化成溶液，除了硝酸铵基本上不溶于硝酸水溶液中，并且可以回收而不需要硝酸盐的重结晶。可以加入除硝酸之外的无机酸，优选盐酸以提高铝消化速率。高能材料的处理可以在没有挥发性有机溶剂的情况下进行，从而避免使用挥发性有机溶剂引起的生态，成本和安全问题。

8. 发明授权

US06416601B1 Method of recovery for nitramines from aluminized energetic materials 失效
标题翻译：从镀铝能量材料中回收硝胺的方法
公开(公告)号：US06416601B1
公开(公告)日：2002-07-09
申请号：US09784475
申请日：2001-02-15
申请人： Kirstin F. Warner , Louis F. Cannizzo , Robert M. Hajik , Harold E. Johnston
发明人： Kirstin F. Warner , Louis F. Cannizzo , Robert M. Hajik , Harold E. Johnston
IPC分类号： C06B2100
CPC分类号： C07D257/02 , Y10S149/124
摘要： Nitramines are one of the more expensive and often the more plentiful ingredients found in energetic materials, such as solid rocket motor propellants, explosives, and pyrotechnics. By treating aluminized energetic material with an aqueous nitric acid solution containing not more than 55% by weight aqueous nitric acid at a weight ratio of aqueous nitric acid to energetic material of about 4:1 to about 6:1, most constituents of conventional aluminized energetic materials are digested into solution, with the exception of nitramines, which remain substantially insoluble in the aqueous nitric acid and can be recovered without requiring recrystallization of the nitramines. A mineral acid other than nitric acid, preferably hydrochloric acid, is added to increase the rate of aluminum digestion. Treatment of the energetic material can be performed without volatile organic solvents, thus obviating ecological, cost, and safety concerns raised by the use of volatile organic solvents.
摘要翻译：硝胺是在高能材料中发现的更昂贵和经常更丰富的成分之一，例如固体火箭发动机推进剂，爆炸物和烟火。通过用含有不超过55重量％的硝酸水溶液的硝酸水溶液处理镀铝的能量材料，其中硝酸水溶液与高分子材料的重量比为约4:1至约6:1，常规镀铝能量材料被消化成溶液，除了硝酸铵基本上不溶于硝酸水溶液中，并且可以回收而不需要硝酸盐的重结晶。加入硝酸以外的无机酸，优选盐酸，以提高铝的消化速度。高能材料的处理可以在没有挥发性有机溶剂的情况下进行，从而避免使用挥发性有机溶剂引起的生态，成本和安全问题。

9. 发明授权

US08282751B2 Methods of forming a sensitized explosive and a percussion primer 有权
标题翻译：形成敏化炸药和打击乐底漆的方法
公开(公告)号：US08282751B2
公开(公告)日：2012-10-09
申请号：US12559218
申请日：2009-09-14
申请人： Harold E. Johnston , Kirstin F. Warner , Reed J. Blau , Scott K. Lusk
发明人： Harold E. Johnston , Kirstin F. Warner , Reed J. Blau , Scott K. Lusk
IPC分类号： C06B45/00 , C06B45/18 , C06B25/00 , D03D23/00 , D03D43/00
CPC分类号： C06B45/34 , C06B33/08 , C06B45/00 , C06B45/18 , C06B45/24 , C06C7/00 , F42C19/0803 , F42C19/10
摘要： A sensitized explosive that comprises an explosive precipitated onto a sensitizer. The explosive is CL-20, PETN, RDX, HMX, or mixtures thereof and the sensitizer is aluminum, titanium, zirconium, magnesium, melamine, styrene, lithium aluminum hydride, or mixtures thereof. The sensitized explosive is used in a percussion primer that includes a bismuth compound and a melt binder. The bismuth compound is bismuth oxide, bismuth subnitrate, bismuth tetroxide, bismuth sulfide, or mixtures thereof and the melt binder is a wax having a melting point above ambient temperature, trinitrotoluene, poly(3,3-bis(azidomethyl)oxetane), poly(3-azidomethyl-3-methyloxetane), ethyl-3,5-dinitrobenzoate, or mixtures thereof. A gun cartridge and other primer-containing ordnance assemblies employing the percussion primer are also disclosed. Methods of forming the sensitized explosive and the percussion primer are also disclosed.
摘要翻译：包含爆炸物沉积在敏化剂上的敏化炸药。爆炸物是CL-20，PETN，RDX，HMX或其混合物，敏化剂是铝，钛，锆，镁，三聚氰胺，苯乙烯，氢化铝锂或其混合物。敏化炸药用于包括铋化合物和熔融粘合剂的冲击底漆中。铋化合物是氧化铋，碱式硝酸铋，四氧化铋，硫化铋或其混合物，熔融粘合剂是熔点高于环境温度的蜡，三硝基甲苯，聚（3,3-双（叠氮基甲基）氧杂环丁烷），聚（3-叠氮基甲基-3-甲基氧杂环丁烷），3,5-二硝基苯甲酸乙酯或其混合物。还公开了使用冲击底漆的枪筒和其它含底漆的弹药组件。还公开了形成敏化炸药和冲击底漆的方法。

10. 发明申请

US20130126057A1 PERCUSSION PRIMER COMPOSITION AND SYSTEMS INCORPORATING SAME 有权
标题翻译：与此同时引发的主要成分和体系
公开(公告)号：US20130126057A1
公开(公告)日：2013-05-23
申请号：US13477750
申请日：2012-05-22
申请人： Harold E. Johnston , Kirstin F. Warner , Reed J. Blau , Scott K. Lusk
发明人： Harold E. Johnston , Kirstin F. Warner , Reed J. Blau , Scott K. Lusk
IPC分类号： C06B45/34 , C06B45/24 , C06B45/00
CPC分类号： C06B45/34 , C06B33/08 , C06B45/00 , C06B45/18 , C06B45/24 , C06C7/00 , F42C19/0803 , F42C19/10
摘要： A percussion primer composition that comprises an explosive and a sensitizer, the explosive being a moderately insensitive explosive having an impact sensitivity in the range from about 0.3 kp m to about 0.75 kp m. The moderately insensitive explosive may comprise CL-20, PETN, RDX, HMX, or mixtures thereof. The sensitizer may comprise aluminum, titanium, zirconium, magnesium, melamine, styrene, lithium aluminum hydride, or mixtures thereof. In some instances, the percussion primer composition may comprise the moderately insensitive explosive precipitated onto the sensitizer. The percussion primer composition may contain an oxidizer, which in certain situations comprises a conventional oxidizer or a bismuth compound. The bismuth compound is bismuth trioxide, bismuth subnitrate, bismuth tetroxide, bismuth sulfide, or mixtures thereof. A gun cartridge and other primer-containing ordnance assemblies employing the percussion primer composition are also disclosed. Methods of forming the sensitized explosive and the percussion primer are also disclosed.
摘要翻译：包含炸药和致敏剂的冲击底漆组合物，该炸药是中等不敏感的炸药，其冲击灵敏度在约0.3kpm至约0.75kpm的范围内。中等不敏感的炸药可以包括CL-20，PETN，RDX，HMX或其混合物。敏化剂可以包括铝，钛，锆，镁，三聚氰胺，苯乙烯，氢化铝锂或其混合物。在一些情况下，敲击底漆组合物可以包含沉淀在敏化剂上的中度不敏感的炸药。敲击底漆组合物可以含有氧化剂，其在某些情况下包含常规的氧化剂或铋化合物。铋化合物是三氧化铋，碱式硝酸铋，四氧化铋，硫化铋或其混合物。还公开了使用冲击底漆组合物的枪筒和其它含底漆的弹药组合物。还公开了形成敏化炸药和冲击底漆的方法。

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