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    • 4. 发明授权
    • Biological indicator for sterilization processes with double buffer system
    • 双缓冲系统灭菌过程的生物指标
    • US06436659B1
    • 2002-08-20
    • US09699728
    • 2000-10-27
    • Henry K. HuiLeslie A. FeldmanRichard A. Gorham
    • Henry K. HuiLeslie A. FeldmanRichard A. Gorham
    • C12Q122
    • C12Q1/22A61L2/28G01N31/226
    • A method and an apparatus for preventing reversion of the color of an indicator dye in a biological indicator is disclosed. The indicator dye changes color if viable microorganisms are present after sterilization, because acidic byproducts are formed when the microorganisms metabolize the growth medium. It has been found that the dye can change color back to the original color after the completion of the sterilization due to leaching or diffusion of basic impurities into the growth medium. The method and the apparatus employ a dual buffer system with one buffer which operates at high pH to moderate pH fluctuations at the start of the sterilization and a second buffer which operates at low pH to minimize pH fluctuations after the sterilization is complete. Less high pH buffer than low pH buffer is used in order to maximize the speed and sensitivity of the biological indicator.
    • 公开了一种用于防止生物指示剂中指示剂染料的颜色反转的方法和装置。 如果活菌在灭菌后存在,则指示剂染料会变色,因为当微生物代谢生长培养基时会形成酸性副产物。 已经发现,由于碱性杂质浸入或扩散到生长介质中,染料可以在灭菌完成之后将颜色改变回原色。 该方法和装置采用具有一个缓冲液的双缓冲系统,该缓冲液在高pH值下操作以缓解灭菌开始时的pH波动,以及在灭菌完成后使pH波动最小的第二缓冲液。 使用比低pH缓冲液低的pH缓冲液以使生物指示剂的速度和灵敏度最大化。
    • 9. 发明授权
    • Method of protecting and sterilizing aluminum surfaces on medical
instruments
    • 在医疗器械上保护和消毒铝表面的方法
    • US5658529A
    • 1997-08-19
    • US614705
    • 1996-03-13
    • Leslie A. FeldmanHenry Hui
    • Leslie A. FeldmanHenry Hui
    • A61L2/20C25D11/22C25D11/24A61L2/08
    • A61L2/20C25D11/22C25D11/24
    • A process for color anodizing and sterilizing aluminum surfaces on medical instruments without fading the anodized color comprises the steps of: anodizing an aluminum surface on a medical instrument to form an oxide film; immersing the surface in a salt bath of a coloring metal and electrolytically depositing the coloring metal onto the oxide film; and repeatedly sterilizing the medical instrument and its surface by exposing it to an oxidizing sterilant, whereby the electrolytically deposited coloring metal remains adhered to the surface and the color of the surface is not adversely affected by the repeated exposure to the oxidizing sterilant. Preferably, the sterilant comprises hydrogen peroxide, the coloring metal comprises tin and the surface remains non-cytotoxic after the anodizing, coloring steps and sterilizing steps.
    • 用于在医疗仪器上对铝表面进行彩色阳极氧化和灭菌的方法,而不会使阳极化颜色褪色的步骤包括以下步骤:阳极氧化医疗器械上的铝表面以形成氧化膜; 将表面浸渍在着色金属的盐浴中,并将着色金属电解沉积到氧化物膜上; 并通过将其暴露于氧化性灭菌剂而使医疗器械及其表面反复灭菌,由此电解沉积的着色金属保持粘附到表面,并且表面的颜色不会受到反复暴露于氧化消毒剂的不利影响。 优选地,灭菌剂包含过氧化氢,着色金属包含锡,并且在阳极氧化,着色步骤和灭菌步骤之后表面保持非细胞毒性。