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    • 3. 发明授权
    • Implantable medical device with inter-atrial block monitoring
    • 植入式医疗器械,具有房间块监测
    • US08095207B2
    • 2012-01-10
    • US11626329
    • 2007-01-23
    • Andres BelalcazarRobert Patterson
    • Andres BelalcazarRobert Patterson
    • A61B5/0402
    • A61N1/3627A61B5/0031A61B5/04011
    • An implantable medical device includes a voltage measurement circuit to measure a potential difference between implanted electrodes in a thorax of a living being, the potential difference resulting from an electrical P-wave cardiac signal. The implantable medical device also includes a processing unit to calculate a vector corresponding to the P-wave cardiac signal, the vector comprising a magnitude and a direction, and derived from measured potential differences and orientations defined by locations of the implanted electrodes. The implantable medical device further includes a monitoring unit to track a rotation of the vector corresponding to the P-wave cardiac signal. In various implementations, the monitoring unit may use the rotation to detect an inter-atrial block condition.
    • 可植入医疗装置包括电压测量电路,用于测量生物胸部中植入的电极之间的电位差,由电P波心脏信号产生的电位差。 可植入医疗装置还包括处理单元,用于计算对应于P波心脏信号的矢量,所述矢量包括幅度和方向,并且从测量的电位差和由注入电极的位置定义的取向导出。 可植入医疗装置还包括监测单元,用于跟踪对应于P波心脏信号的矢量的旋转。 在各种实现中,监视单元可以使用旋转来检测心房间块状况。
    • 8. 发明申请
    • Genetic Data Analysis and Database Tools
    • 遗传数据分析和数据库工具
    • US20120143622A1
    • 2012-06-07
    • US13316354
    • 2011-12-09
    • Jessica OesterheldRobert PattersonHoward Coleman
    • Jessica OesterheldRobert PattersonHoward Coleman
    • G06Q50/22
    • G06F19/326G06F19/328G06F19/3456G06Q30/04G06Q50/22G06Q50/24G16B20/00G16B50/00G16C20/30G16C20/50G16C20/90
    • A computerized tool and method for delivery of pharmacogenetic and pharmacological information, comprising a core system having algorithms and databases for storing, collating, accessing, cross-referencing, and interpreting genetic and pharmacologic data, with a graphical user interface for a client network of providers of laboratory genetic testing services to access the core services under contract. The system includes “paypoints” in support of improved business models. Included are mechanisms for ‘pass through’ third party and insurance reimbursement for interpretive reports, insurance reimbursement for on-line access to pharmacogenetic information at the point of care, tools for market segmentation, and a conversion tool for capturing new subscribers. Also disclosed are tools and predictive algorithms for preventing drug-drug and drug-gene adverse drug reactions.
    • 用于递送药物遗传学和药理学信息的计算机化工具和方法,包括具有用于存储,整理,访问,交叉参考和解释遗传和药理学数据的算法和数据库的核心系统,以及用于提供者的客户端网络的图形用户界面 的实验室基因检测服务,按照合同访问核心服务。 该系统包括支持改进商业模式的“支付点”。 其中包括“通过”第三方机制,解释性报告的保险报销,在线护理药物遗传信息的在线访问保险报销,市场细分工具,以及用于捕获新用户的转换工具。 还公开了用于预防药物药物和药物基因不良药物反应的工具和预测算法。
    • 9. 发明申请
    • IMPLANTABLE MEDICAL DEVICE WITH INTER-ATRIAL BLOCK MONITORING
    • 具有椎间盘块监测的可植入医疗装置
    • US20070203420A1
    • 2007-08-30
    • US11626329
    • 2007-01-23
    • Andres BelalcazarRobert Patterson
    • Andres BelalcazarRobert Patterson
    • A61B5/04
    • A61N1/3627A61B5/0031A61B5/04011
    • An implantable medical device includes a voltage measurement circuit to measure a potential difference between implanted electrodes in a thorax of a living being, the potential difference resulting from an electrical P-wave cardiac signal. The implantable medical device also includes a processing unit to calculate a vector corresponding to the P-wave cardiac signal, the vector comprising a magnitude and a direction, and derived from measured potential differences and orientations defined by locations of the implanted electrodes. The implantable medical device further includes a monitoring unit to track a rotation of the vector corresponding to the P-wave cardiac signal. In various implementations, the monitoring unit may use the rotation to detect an inter-atrial block condition.
    • 可植入医疗装置包括电压测量电路,用于测量生物胸部中植入的电极之间的电位差,由电P波心脏信号产生的电位差。 可植入医疗装置还包括处理单元,用于计算对应于P波心脏信号的矢量,所述矢量包括幅度和方向,并且从测量的电位差和由注入电极的位置限定的取向导出。 可植入医疗装置还包括监测单元,用于跟踪对应于P波心脏信号的矢量的旋转。 在各种实现中,监视单元可以使用旋转来检测心房间块状况。
    • 10. 发明申请
    • Pathology assessment with impedance measurements using convergent bioelectric lead fields
    • 使用收敛生物电导领域进行阻抗测量的病理学评估
    • US20060184060A1
    • 2006-08-17
    • US11058123
    • 2005-02-15
    • Andres BelalcazarRobert Patterson
    • Andres BelalcazarRobert Patterson
    • A61B5/05
    • A61B5/416A61B5/0537A61B5/4519
    • A method and apparatus for measuring impedance for pathology assessment in a living being using convergent bioelectric lead fields is disclosed, including injecting a current between first and second electrodes implanted in a body of a living being, where the first and second electrodes define a first electric lead field oriented between the first and second electrodes. A potential difference is measured between third and fourth electrodes implanted in the body, where the potential difference results from the current injected between the first and second electrodes. The third and fourth electrodes define a second electric lead field oriented between the third and fourth electrodes. The first and second electric lead fields converge near an assessment site within the body, but are substantially separated otherwise. An impedance value is calculated based on the potential difference and the current injection, and is used to assess a pathology near the assessment site.
    • 公开了一种用于测量在使用会聚生物电场领域的生物中的病理学评估阻抗的方法和装置,包括在植入生物体内的第一和第二电极之间注入电流,其中第一和第二电极限定第一电 引线场定向在第一和第二电极之间。 在植入体内的第三和第四电极之间测量电位差,其中电位差由注入在第一和第二电极之间的电流产生。 第三和第四电极限定了定向在第三和第四电极之间的第二电引线场。 第一和第二电引线场在体内的评估位点附近收敛,但是基本上彼此分离。 基于电位差和电流注入计算阻抗值,并用于评估评估点附近的病理学。