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1. 发明申请

US20190201703A1 SYSTEMS AND METHODS FOR FAST AND REVERSIBLE NERVE BLOCK 审中-公开
公开(公告)号：US20190201703A1
公开(公告)日：2019-07-04
申请号：US16296617
申请日：2019-03-08
申请人： Case Western Reserve University
发明人： Hillel Chiel , Niloy Bhadra , Mike Jenkins , Emilie Lothet , Tina Vrabec , Kevin Kilgore , Narendra Bhadra , Eric Duco Jansen
IPC分类号： A61N1/40 , A61F7/00 , A61N7/02 , A61N1/06 , A61N1/28 , A61N5/06 , A61N1/36
CPC分类号： A61N1/403 , A61F7/007 , A61F2007/0071 , A61N1/06 , A61N1/28 , A61N1/36067 , A61N1/36071 , A61N5/0622 , A61N5/0625 , A61N7/02 , A61N2005/0659 , A61N2005/067 , A61N2007/0021
摘要： One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.

2. 发明申请

US20180361144A1 APPARATUS FOR APPLICATION OF A PULSED RADIO FREQUENCY THERAPY IN A VASCULAR SYSTEM OR ANOTHER CAVITY OR TISSUE OF THE HUMAN OR ANIMAL BODY 审中-公开
公开(公告)号：US20180361144A1
公开(公告)日：2018-12-20
申请号：US16011106
申请日：2018-06-18
申请人： Omar OMAR-PASHA
发明人： Omar OMAR-PASHA
IPC分类号： A61N1/05 , A61N1/36 , A61M5/14 , A61N1/06 , A61N1/32 , A61B18/14 , A61B18/00
CPC分类号： A61N1/0551 , A61B18/1492 , A61B2018/00434 , A61B2018/00791 , A61B2018/00827 , A61B2018/00839 , A61B2018/00875 , A61B2018/00892 , A61B2218/002 , A61M5/14 , A61N1/05 , A61N1/06 , A61N1/32 , A61N1/36071 , A61N1/36103 , A61N1/36167 , A61N1/36175
摘要： The invention relates to an apparatus for application of a pulsed radio frequency therapy in a vascular system or another cavity or tissue of the human or animal body comprising a catheter with at least one electrode disposed thereon for insertion into the vascular system or another cavity or the tissue of the human or animal body; a probe with at least one further electrode disposed thereon, wherein the probe is insertable via the catheter into the vascular system or the other cavity or the tissue of the human or animal body; and a generator electrically connected with the electrodes for generating a pulsed electro-magnetic field between the electrodes.

3. 发明申请

US20180243553A1 TREATMENT DEVICE USING HIGH FREQUENCY 审中-公开
公开(公告)号：US20180243553A1
公开(公告)日：2018-08-30
申请号：US15965626
申请日：2018-04-27
申请人： LUTRONIC CORPORATION
发明人： Kwang Chon KO
IPC分类号： A61N1/06 , A61N1/32 , A61B18/14 , A61B18/00 , A61F7/00 , A61B18/12
CPC分类号： A61N1/06 , A61B18/1477 , A61B2018/00452 , A61B2018/128 , A61F2007/0052 , A61N1/328
摘要： A treatment device using a high frequency according to the present invention includes: a plurality of electrodes which transfers high frequency energy to the skin; a plurality of pads each of which is provided on one surface thereof with at least one of the electrodes; and a plurality of elastic members which independently and elastically support the other surfaces of the plurality of pads, respectively, so that plurality of electrodes can be three-dimensionally and closely attached to the curved surface of the skin. Accordingly, even when treating a body region having many curves, the attachment of the electrodes is efficiently maintained. In addition, although a hand piece moves in a state in which the plurality of pads are attached to skin, the plurality of pads can be maintained in the skin attached state while actively coping with the curves.

4. 发明申请

US20180169405A1 LEADS FOR EXTRAFORAMINAL STIMULATION OF DORSAL ROOTS AND DORSAL ROOT GANGLIA AND RELATED METHODS 审中-公开
公开(公告)号：US20180169405A1
公开(公告)日：2018-06-21
申请号：US15386981
申请日：2016-12-21
申请人： Pacesetter, Inc.
发明人： Alexander Kent , William Cusack , Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61N1/05 , A61N1/06 , A61N1/36
CPC分类号： A61N1/0551 , A61N1/0504 , A61N1/0553 , A61N1/0558 , A61N1/06 , A61N1/36071 , A61N1/36171 , A61N1/36175
摘要： The present disclosure generally relates to extraforaminal electrical stimulation systems and leads for electrical stimulation of the dorsal root and dorsal root ganglion (DRG), minimally invasive implantation methods therefore, and related methods of providing extraforaminal electrical stimulation of the dorsal root and DRG for the treatment of a medical condition. In accordance with certain aspects, the extraforaminal electrical stimulation leads and methods are particularly suited for stimulation of dorsal roots and DRG of the cervical and thoracic spine.

5. 发明授权

US09993645B2 Devices for controlling high frequency spinal cord modulation for inhibiting pain, and associated systems and methods, including simplified program selection 有权
公开(公告)号：US09993645B2
公开(公告)日：2018-06-12
申请号：US15008391
申请日：2016-01-27
申请人： Nevro Corporation
发明人： Andre B. Walker , Jon Parker , Konstantinos Alataris , James R. Thacker
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05 , A61N1/06 , A61N1/378
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/0553 , A61N1/06 , A61N1/36021 , A61N1/3605 , A61N1/36157 , A61N1/36164 , A61N1/36167 , A61N1/36171 , A61N1/36175 , A61N1/36182 , A61N1/37235 , A61N1/37241 , A61N1/37247 , A61N1/37264 , A61N1/3787
摘要： Selective high-frequency spinal chord modulation for inhibiting pain with reduced side affects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal chord region to address low back pain without creating unwanted sensory and/or motor side affects. In other embodiments, modulation in accordance with similar parameters can be applied to other spinal or peripheral locations to address other indications. In particular embodiments, aspects of the foregoing modulation therapies may be implemented by systems and devices that have simplified functionalities.

6. 发明授权

US09987487B2 Swallowable capsule and method for stimulating incretin production within the intestinal tract 有权
公开(公告)号：US09987487B2
公开(公告)日：2018-06-05
申请号：US15485031
申请日：2017-04-11
申请人： Incube Labs, LLC
发明人： Mir A. Imran , Mir Hashim , Emily Arnsdorf
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372
CPC分类号： A61N1/36007 , A61K38/26 , A61N1/05 , A61N1/0507 , A61N1/0509 , A61N1/06 , A61N1/37217
摘要： Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.

7. 发明申请

US20180133469A1 NON-INVASIVE SKIN TREATMENT DEVICE USING R.F. ELECTRICAL CURRENT WITH A TREATMENT SETTINGS DETERMINER 审中-公开
公开(公告)号：US20180133469A1
公开(公告)日：2018-05-17
申请号：US15563982
申请日：2016-03-29
申请人： KONINKLIJKE PHILIPS N.V.
发明人： JONATHAN ALAMBRA PALERO , RALPH TIMOTHEUS HUIJGEN , MARTIN JURNA , BABU VARGHESE , MARCO BARAGONA , HENDRIK HALLING VAN AMERONGEN
IPC分类号： A61N1/32 , A61N1/06 , A61N1/40
CPC分类号： A61N1/328 , A61B2018/0047 , A61N1/06 , A61N1/403
摘要： The invention provides a non-invasive skin treatment device (100) comprising an r.f. treatment electrode (10); a return electrode (40); an r.f. generator (20) configured and arranged such that, during treatment, an r.f. treatment signal is applied between the r.f. treatment electrode (10) and the return electrode (40) for heating an inner region (15) of skin; an impedance measurement circuit (35) configured and arranged to measure, before treatment of the inner region, an initial skin impedance (Zo) between the r.f. treatment electrode (10) and the return electrode (40); and a treatment settings determiner (30) configured and arranged to determine, before treatment of the inner region (15), treatment settings associated with the r.f. treatment signal depending on the initial skin impedance (Zo) and on a dimension of the r.f. treatment electrode (10) in the contact plane, the treatment settings comprising at least one of a treatment duration (TD) associated with a desired treatment result, and an r.f. electrical parameter associated with the r.f. treatment signal. The skin treatment device (100) further comprises a controller (25) configured and arranged to consecutively activate the impedance measurement circuit (35) and the treatment settings determiner (30) before treatment of the inner region (15), configure the r.f. generator (20) to provide the r.f. treatment signal according to the treatment settings, and activate the r.f. generator (20) to apply the r.f. treatment signal to the inner region (15) for the treatment duration (TD). The invention is based on the insight obtained from multiple measurements made during the creation of microscopic thermal lesions in an inner region of skin by applying r.f. measurement and treatment signals. By analyzing the histological and heating results, a relationship was obtained between the initial impedance (Zo), the dimension of the r.f. treatment electrode (10), and the treatment settings required to obtain a particular skin treatment result. This relationship has been found to be relatively constant for different subjects, different treatment locations on the body and different skin moisture contents. The invention makes it possible to preset or predetermine, i.e. in advance, the treatment duration (TD) and/or the r.f. electrical parameters associated with the r.f. treatment signal accurately enough to avoid undesired skin damage during the treatment. The device can be simpler, as it is no longer essential to continuously monitor the impedance during treatment to determine the onset of undesired skin damage, such as ablation, which is the safety feature known from conventional devices.

8. 发明申请

US20180133461A1 MODULAR STIMULATOR FOR TREATMENT OF BACK PAIN, IMPLANTABLE RF ABLATION SYSTEM AND METHODS OF USE 审中-公开
公开(公告)号：US20180133461A1
公开(公告)日：2018-05-17
申请号：US15853543
申请日：2017-12-22
申请人： MAINSTAY MEDICAL LIMITED
发明人： Peter Andrew CROSBY , Dan SACHS , Prashant Brijmohansingh RAWAT , Jason Alan SHIROFF , Johannes Petrus HEEMELS
IPC分类号： A61N1/05 , A61B18/14 , A61N1/372 , A61N1/36 , A61N1/06 , A61B18/00 , A61B17/00 , A61B34/20 , A61B18/12
CPC分类号： A61N1/0551 , A61B18/1492 , A61B2017/00221 , A61B2018/00339 , A61B2018/00577 , A61B2018/124 , A61B2018/1467 , A61B2034/2048 , A61N1/06 , A61N1/36042 , A61N1/36071 , A61N1/37211
摘要： Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and/or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.

9. 发明申请

US20180117314A1 THERAPY DELIVERY DEVICES AND METHODS FOR NON-DAMAGING NEURAL TISSUE CONDUCTION BLOCK 审中-公开
公开(公告)号：US20180117314A1
公开(公告)日：2018-05-03
申请号：US15814817
申请日：2017-11-16
申请人： Case Western Reserve University
发明人： Niloy Bhadra , Kevin L. Kilgore , Narendra Bhadra , Jesse Wainright , Tina Vrabec , Manfred Franke
IPC分类号： A61N1/05 , A61N1/36 , A61N1/20 , A61N1/06
CPC分类号： A61N1/0556 , A61N1/06 , A61N1/20 , A61N1/36064 , A61N1/36067 , A61N1/36071
摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.

10. 发明授权

US09956408B2 Method for reducing spasticity and non-transitory computer-readable medium thereof 有权
公开(公告)号：US09956408B2
公开(公告)日：2018-05-01
申请号：US15334932
申请日：2016-10-26
申请人： GiMer Medical Co., Ltd.
发明人： Wei-Tso Lin , Kuo-Hsiang Lu
IPC分类号： A61N1/36 , A61N1/05 , A61N1/06
CPC分类号： A61N1/36067 , A61N1/0551 , A61N1/06 , A61N1/36071 , A61N1/36171
摘要： A method for reducing spasticity applied with an electrical stimulation device to electrically stimulate a target zone of an organism suffering from spasticity. The electrical stimulation device comprises at least one electrical stimulation unit. The electrical stimulation unit includes at least one first electrode and at least one second electrode. The method includes the following steps. The electrical stimulation unit is placed near the target zone. The electrical stimulation unit generates an electrical stimulation signal and the electrical stimulation signal is introduced to the target zone so as to stimulate the target zone. An electric field is generated between the first electrode and the second electrode and covers the target zone. The strength of the electric field ranges from 100 V/m to 1000 V/m.

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