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1. 发明授权

US09770280B2 Implantable thermal treatment method and apparatus 有权
公开(公告)号：US09770280B2
公开(公告)日：2017-09-26
申请号：US14197107
申请日：2014-03-04
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Chris J. Diederich , Jeffrey C. Lotz , William H. Nau, Jr. , David S. Bradford
IPC分类号： A61N7/00 , A61B18/04 , A61N7/02 , A61B17/00 , A61B18/00 , A61B8/00 , A61B90/00
CPC分类号： A61B18/04 , A61B8/56 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2018/00339 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0078
摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints.

2. 发明申请

US20150289767A1 TEMPERATURE SENSOR, TEMPERATURE MEASURING DEVICE AND MEDICAL ENGINEERING SYSTEMS COMPRISING A TEMPERATURE SENSOR OR A TEMPERATURE MEASURING DEVICE 审中-公开
标题翻译：温度传感器，温度测量装置和包含温度传感器或温度测量装置的医疗工程系统
公开(公告)号：US20150289767A1
公开(公告)日：2015-10-15
申请号：US14345486
申请日：2012-09-19
申请人： Aesculap AG
发明人： Anton Keller , Stefan Eick , Thomas Maser , Christoph Rothweiler , Sebastian Langen , Raimund Hibst , Olivier Fugger , Detlef Russ
IPC分类号： A61B5/01 , A61B18/20 , A61B18/14 , A61B5/00
CPC分类号： A61B5/01 , A61B5/6847 , A61B5/6887 , A61B5/742 , A61B18/1442 , A61B18/18 , A61B18/20 , A61B2017/00101 , A61B2018/00589 , A61B2018/00601 , A61B2018/00619 , A61B2018/0066 , A61B2018/00714 , A61B2018/00797 , A61B2018/00809 , A61B2562/0271 , A61B2562/0276 , G01K11/3213 , G01K13/002
摘要： In order to provide a temperature sensor or a temperature measuring apparatus having a temperature sensor, which enables direct temperature measurement, in particular even during treatment, in particular even with HF surgical devices, it is proposed that the temperature sensor includes a sensor element with a medium which can be excited to luminescence, in particular fluorescence, and an optical waveguide which is optically connected to the sensor element and is intended to supply light to the medium at an excitation wavelength and/or to pick up and conduct light at a luminescence wavelength of the medium which can be excited to luminescence.
摘要翻译：为了提供具有温度传感器的温度传感器或温度测量装置，其能够直接进行温度测量，特别是即使在处理期间，特别是甚至在HF手术装置中，也提出了温度传感器包括具有可以被激发以发光的介质，特别是荧光，和光学连接到传感器元件并且旨在以激发波长向介质提供光和/或拾取和传导发光波长的光的光波导可以激发发光的培养基。

3. 发明申请

US20150141876A1 METHOD FOR PROVIDING DIRECTIONAL THERAPY TO SKELETAL JOINTS 审中-公开
标题翻译：用于向骨骼接合提供方向治疗的方法
公开(公告)号：US20150141876A1
公开(公告)日：2015-05-21
申请号：US14540017
申请日：2014-11-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Chris J. Diederich , Jeffrey C. Lotz , Will Nau , David S. Bradford
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61B18/04 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2090/374 , A61N7/022 , A61N2007/0021 , A61N2007/003 , A61N2007/0056 , A61N2007/0078
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.
摘要翻译：提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现其他响应而没有明显的重塑。

4. 发明授权

US08518095B2 Interstitial energy treatment probe holders 有权
公开(公告)号：US08518095B2
公开(公告)日：2013-08-27
申请号：US13326051
申请日：2011-12-14
申请人： Anthony J. Tomasello , William Graveman , Kambiz Dowlatshahi , Henry R. Appelbaum
发明人： Anthony J. Tomasello , William Graveman , Kambiz Dowlatshahi , Henry R. Appelbaum
IPC分类号： A61N5/06
CPC分类号： A61B18/20 , A61B18/24 , A61B90/11 , A61B2017/00101 , A61B2018/2005 , A61N5/0601
摘要： An interstitial laser energy treatment apparatus having co-acting movable probe holders which facilitate positioning of a laser probe and thermal probe in different positions relative to a tissue mass such as the tumor to be treated and relative to each other to facilitate treating tissue masses based on the exact position, size and shape of the tissue mass.

5. 发明授权

US08506589B2 Nasogastric tube for use during an ablation procedure 有权
标题翻译：鼻胃管在消融过程中使用
公开(公告)号：US08506589B2
公开(公告)日：2013-08-13
申请号：US11932196
申请日：2007-10-31
申请人： James D. Maloney
发明人： James D. Maloney
IPC分类号： A61M29/00 , A61M31/00 , A61M37/00
CPC分类号： A61B18/1492 , A61B2017/00101 , A61B2018/00214 , A61B2018/00267
摘要： Embodiments of the present invention provide a nastogastric tube for deflecting an esophagus during an ablation procedure. According to one embodiment, the nasogastric tube includes a tube comprising at least one lumen having proximal and distal ends, and an esophageal deflector positioned within the at least one lumen and configured to deflect a portion of the tube between the proximal and distal ends. The esophageal deflector is configured to deflect the portion of the tube proximate to a retrocardiac portion of the esophagus such that the retrocardiac portion of the esophagus is deflected away from an ablation site.
摘要翻译：本发明的实施例提供了一种用于在消融过程中偏转食道的胃胃管。根据一个实施例，鼻胃管包括管，其包括具有近端和远端的至少一个内腔，以及定位在至少一个内腔内的构造成使管的一部分偏转在近端和远端之间的食管偏转器。食管偏转器构造成使管的部分靠近食道的逆心部分偏转，使得食道的逆心部分偏离消融部位。

6. 发明授权

US08241276B2 RF ablation device with jam-preventing electrical coupling member 有权
标题翻译：射频消融装置，具有阻塞电耦合构件
公开(公告)号：US08241276B2
公开(公告)日：2012-08-14
申请号：US11940289
申请日：2007-11-14
申请人： Gordon Epstein , Bruce Lee , Jeffrey M. Cohen , Adam Hagmann , Richard Spero
发明人： Gordon Epstein , Bruce Lee , Jeffrey M. Cohen , Adam Hagmann , Richard Spero
IPC分类号： A61B18/14
CPC分类号： A61N1/06 , A61B18/1477 , A61B2017/00101 , A61B2018/143 , A61B2018/1475
摘要： The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen within the cannula and a cannula axis. A plurality of conductors contained within the lumen, each of the conductors has a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled at the respective proximal end of the stylet to the distal end of a respective conductor, the stylets comprise a deflectable material, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula. A deflection surface positioned between the trocar point and the proximal end of the cannula, the deflection surface being configured and positioned to deflect, in response to axial movement of the stylets in a direction from the proximate end of the cannula to the distal end of the cannula, at least some of the stylets laterally with respect to the cannula axis in different directions along substantially straight paths, the paths defining an ablation volume.
摘要翻译：本发明的消融元件包括具有近端和远端的细长插管。套管限定插管内的内腔和插管轴线。包含在内腔内的多个导体，每个导体具有靠近插管的近端的近端，以及靠近套管远端的远端。多个消融模具各自具有近端和远端，并且每个消融模具各自在相应的导管的相应近端处连接到相应导体的远端，所述模式包括可偏转材料，所述导体与它们各自的形式安装用于轴向移动。定位在套管远端附近的套针针点。定位在套管针点和套管近端之间的偏转表面，所述偏转表面被构造和定位成响应于沿着插管的近端到所述插管的远端的方向的轴向移动而偏转插管，沿着基本上直的路径在不同方向上相对于插管轴线横向的至少一些样式，所述路径限定消融体积。

7. 发明申请

US20110208180A1 System and Method for Monitoring Ablation Size 审中-公开
标题翻译：监测消融尺寸的系统和方法
公开(公告)号：US20110208180A1
公开(公告)日：2011-08-25
申请号：US12712864
申请日：2010-02-25
申请人： Joseph D. Brannan
发明人： Joseph D. Brannan
IPC分类号： A61B18/18
CPC分类号： A61B18/1815 , A61B2017/00084 , A61B2017/00101 , A61B2018/00023 , A61B2018/00666 , A61B2018/1869
摘要： A system for monitoring ablation size is provided. The system includes a power source including a microprocessor for executing at least one control algorithm. A microwave antenna is configured to deliver microwave energy from the power source to tissue to form an ablation zone. A series of thermal sensors is operably disposed adjacent a radiating section of the microwave antenna and extends proximally therefrom. The thermal sensors corresponding to a radius of the ablation zone, wherein each thermal sensor generates a voltage when a predetermined threshold tissue temperature is reached corresponding to the radius of the ablation zone.
摘要翻译：提供了一种用于监测消融尺寸的系统。该系统包括电源，该电源包括用于执行至少一个控制算法的微处理器。微波天线被配置为将微波能量从电源传送到组织以形成消融区域。一系列热传感器可操作地设置在微波天线的辐射部分附近并从其向近侧延伸。所述热传感器对应于所述消融区域的半径，其中当达到对应于所述消融区域的半径的预定阈值组织温度时，每个热传感器产生电压。

8. 发明申请

US20110087314A1 IMPLANTABLE THERMAL TREATMENT METHOD AND APPARATUS 有权
标题翻译：可植入热处理方法和装置
公开(公告)号：US20110087314A1
公开(公告)日：2011-04-14
申请号：US12898401
申请日：2010-10-05
申请人： Chris J. Diederich , Jeffrey C. Lotz , Will H. Nau, JR. , David S. Bradford
发明人： Chris J. Diederich , Jeffrey C. Lotz , Will H. Nau, JR. , David S. Bradford
IPC分类号： A61F7/12
CPC分类号： A61B18/04 , A61B8/56 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2018/00339 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0078
摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译：提供了一种长期植入式超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。

9. 发明申请

US20100152722A1 Cryoprobe with reduced adhesion to frozen tisssue 审中-公开
标题翻译：冷冻组织对冷冻组织的粘附力降低
公开(公告)号：US20100152722A1
公开(公告)日：2010-06-17
申请号：US11990659
申请日：2006-08-16
申请人： Paul Kleinberger
发明人： Paul Kleinberger
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/1815 , A61B2017/00101 , A61B2018/00041 , A61B2018/0019 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： The present invention relates to devices and methods for cryosurgery. More particularly, the present invention relates to a cryoprobe which does not form strong adhesive or mechanical bonds with body tissues when such tissues are frozen by cooling action of the probe. Embodiments of the present invention include a cryoprobe having a distal cooling module with an outer surface layer of non-polar molecules, a probe having a distal cooling module with a microscopically smooth outer surface, a cryoprobe comprising a mechanism for coating a distal cooling module thereof with non-polar lubricant during movement of the cryoprobe within body tissues of a patient, and a non-cooling cryosurgery probe with non-adhesive features. Also presented are methods utilizing disclosed cryoprobes to facilitate cryosurgery and to enhance accuracy of cryoablation of user-selected cryoablation targets.
摘要翻译：本发明涉及冷冻手术的装置和方法。更具体地说，本发明涉及一种冷冻探针，当这些组织被探针的冷却作用冻结时，它不会与身体组织形成强烈的粘合或机械结合。本发明的实施例包括具有远端冷却模块和非极性分子的外表面层的冷冻探针，探针具有具有微观光滑的外表面的远侧冷却模块，冷冻探针包括用于涂覆远端冷却模块的机构在冷冻探针在患者的身体组织内运动期间具有非极性润滑剂，以及具有非粘合特征的非冷却冷冻手术探针。还提出了利用所公开的冷冻探针的方法来促进冷冻手术并提高用户选择的冷冻消融靶标的冷冻消融的准确性。

10. 发明授权

US07572251B1 Systems and methods for electrosurgical tissue treatment 有权
标题翻译：电外科组织治疗的系统和方法
公开(公告)号：US07572251B1
公开(公告)日：2009-08-11
申请号：US09457201
申请日：1999-12-06
申请人： Terry S. Davison , Jean Woloszko , Michael A. Baker , Hira V. Thapliyal , Philip E. Eggers
发明人： Terry S. Davison , Jean Woloszko , Michael A. Baker , Hira V. Thapliyal , Philip E. Eggers
IPC分类号： A61M31/00 , A61B17/20
CPC分类号： A61B18/12 , A61B18/1206 , A61B18/1402 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/149 , A61B18/1492 , A61B2017/00026 , A61B2017/00084 , A61B2017/00097 , A61B2017/00101 , A61B2017/00106 , A61B2017/00247 , A61B2017/00292 , A61B2017/003 , A61B2017/22001 , A61B2017/22038 , A61B2018/00029 , A61B2018/00083 , A61B2018/00119 , A61B2018/0016 , A61B2018/00178 , A61B2018/00196 , A61B2018/00327 , A61B2018/00392 , A61B2018/00505 , A61B2018/00565 , A61B2018/00577 , A61B2018/00583 , A61B2018/00601 , A61B2018/00642 , A61B2018/0066 , A61B2018/00678 , A61B2018/00702 , A61B2018/00726 , A61B2018/00738 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00886 , A61B2018/00982 , A61B2018/1213 , A61B2018/124 , A61B2018/1246 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1407 , A61B2018/1467 , A61B2018/1472 , A61B2018/162 , A61B2018/165 , A61B2090/378 , A61B2090/3782 , A61B2218/002 , A61B2218/007 , A61F2/2493 , A61F2/95 , A61M3/0283 , A61M25/0133
摘要： Systems and methods are provided for applying a high frequency voltage in the presence of an electrically conductive fluid to create a relatively low-temperature plasma for ablation of tissue adjacent to, or in contact with, the plasma. In one embodiment, an electrosurgical probe or catheter is positioned adjacent the target site so that one or more active electrode(s) are brought into contact with, or close proximity to, a target tissue in the presence of electrically conductive fluid. High frequency voltage is then applied between the active electrode(s) and one or more return electrode(s) to non-thermally generate a plasma adjacent to the active electrode(s), and to volumetrically remove or ablate at least a portion of the target tissue. The high frequency voltage generates electric fields around the active electrode(s) with sufficient energy to ionize the conductive fluid adjacent to the active electrode(s). Within the ionized gas or plasma, free electrons are accelerated, and electron-atoms collisions liberate more electrons, and the process cascades until the plasma contains sufficient energy to break apart the tissue molecules, causing molecular dissociation and ablation of the target tissue.
摘要翻译：提供的系统和方法用于在存在导电流体的情况下施加高频电压以产生相对低温的等离子体，以消除与等离子体相邻或与其接触的组织。在一个实施例中，电外科探针或导管邻近靶位置定位，使得在存在导电流体的情况下使一个或多个有效电极与目标组织接触或接近。然后将高频电压施加在有源电极和一个或多个返回电极之间，以非热生成邻近有源电极的等离子体，并且对体积方法移除或消除至少一部分目标组织。高频电压以足够的能量产生有源电极周围的电场，以使邻近有源电极的导电流体离子化。在电离气体或等离子体中，自由电子被加速，并且电子 - 原子碰撞释放出更多的电子，并且该过程直到等离子体含有足够的能量来分解组织分子，导致靶组织的分子解离和消融。

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