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    • 1. 发明授权
    • Treating urinary and other body strictures
    • 治疗尿液和其他身体狭窄
    • US06338726B1
    • 2002-01-15
    • US08795656
    • 1997-02-06
    • Stuart D. EdwardsMuta M. Issa
    • Stuart D. EdwardsMuta M. Issa
    • A61M2900
    • A61F2/82A61B17/00491A61B18/14A61B18/1485A61B18/1492A61B2017/005A61B2018/0022A61B2018/00404A61B2018/00553A61F2/07A61F2/90A61F2/94A61F2/958A61F2002/3008A61F2002/5015A61F2002/5052A61F2250/0098
    • The invention provides a method and system for treatment of body strictures to restore luminal diameter to within a normal diameter range, in which the stricture is dilated to stretch its lumen to a desired diameter, collagen is exuded near to existing tissue of the stricture so as to be absorbed by that tissue or adhere to that tissue, making a collagen-enhanced tissue structure, and energy is emitted to affect the collagen-enhanced tissue, such as by ablation or by hardening. Ablation and hardening may be repeated so as to create a set of layers of hardened collagen in the form of a supporting frame, preferably having a hollow cylindrical shape. Dilation of the stricture is achieved by expanding one or more balloons, or by the pressure of exuded collagen, until the stricture is larger than a normal diameter range. When energy is emitted into the collagen, the stricture contracts back to the normal diameter range, either by ablation of excess tissue or by plating of the stricture wall. The stricture's tissue is also isolated by a set of balloons at either or both ends of the stricture, so as to isolate the stricture and restrict the collagen to the stricture's tissue. The stricture's tissue is also supported by a stent, which is preferably tackwelded onto the stricture's tissue using collagen. Collagen adheres to the stent, which supports the stricture's tissue until the stent is absorbed into that tissue.
    • 本发明提供了一种用于治疗身体狭窄的方法和系统,以将管腔直径恢复到正常直径范围内,其中狭窄被扩张以将其内腔拉伸至期望的直径,胶原蛋白渗透到狭窄的现有组织附近,以便 被该组织吸收或粘附到该组织,形成胶原增强的组织结构,并且发射能量以影响胶原增强组织,例如通过消融或硬化。 可以重复消融和硬化,以便产生一组支撑框架形式的硬化胶原层,优选具有中空圆柱形状。 通过扩张一个或多个气囊或通过渗出的胶原的压力来扩张狭窄,直到狭窄大于正常直径范围为止。 当能量发射到胶原中时,通过消融多余的组织或通过电镀狭窄壁,狭窄可缩回到正常直径范围。 狭窄的组织也通过一组气囊在狭窄的两端或两端分离,以隔离狭窄并将胶原限制在狭窄的组织上。 狭窄的组织也由支架支撑,支架优选使用胶原粘合到狭窄组织上。 胶原蛋白粘附到支架上,其支持狭窄的组织,直到支架被吸收到该组织中。
    • 6. 发明授权
    • Treatment of tissue in sphincters, sinuses and orifices
    • 治疗括约肌,鼻窦和孔的组织
    • US07022105B1
    • 2006-04-04
    • US09356110
    • 1999-07-16
    • Stuart D. Edwards
    • Stuart D. Edwards
    • A61M31/00
    • A61N1/06A61N1/403
    • The invention provides a method and system for ablation of body structures or tissue in a sphincter, sinus or orifice such as the rectum, colon, esophagus, vagina, penis, larynx or pharynx. In one aspect of the invention, the environment surrounding the targeted ablation region can be isolated or controlled by blocking the flow of gases or liquids using an inflatable balloon positioned immediately adjacent to the tissue that is to be ablated. In a preferred embodiment, the inflatable balloon also serves to anchor the catheter in place and prevent the catheter from being expelled from the body. The inflatable balloon also insures that locally administered drug remain in the area where most needed. In a second aspect of the invention, positive pressure is used to inflate the balloon. Inflation of balloon triggers the extension of at least one curvilinear electrode into the targeted tissue. Negative pressure deflates the air sac and helps retract the curvilinear electrodes so as to allow the catheter to be removed from the body without damaging adjacent body structures. In a third aspect of the invention, the electrodes are coupled to sensors that measure properties of the target region such as temperature and impedance. Measurement of these properties permits the use of feedback technique to control delivery of the RF energy and administration of fluids for cooling and hydrating the affected tissues. In a fourth aspect of the invention, the catheter includes an optical path that can be coupled to external viewing apparatus. In this way, the position of the electrodes in the body can be determined by fluoroscopic or fiber optic techniques.
    • 本发明提供了一种用于消融括约肌,窦或孔如直肠,结肠,食管,阴道,阴茎,喉或咽部中的身体结构或组织的方法和系统。 在本发明的一个方面,围绕目标消融区域的环境可以通过使用紧邻待烧伤组织定位的可充气气囊来阻止气体或液体的流动而被隔离或控制。 在优选实施例中,可膨胀气囊还用于将导管锚定在适当位置并防止导管从身体排出。 充气气囊还确保局部给药的药物保留在最需要的区域。 在本发明的第二方面中,使用正压使气囊膨胀。 球囊的充气触发了至少一个曲线电极延伸到目标组织中。 负压使气囊缩小并帮助缩回曲线电极,以便允许导管从身体移除而不损坏邻近的身体结构。 在本发明的第三方面中,电极耦合到测量目标区域的性质(诸如温度和阻抗)的传感器。 这些性质的测量允许使用反馈技术来控制RF能量的传递和给予流体以冷却和保湿受影响的组织。 在本发明的第四方面中,导管包括可以连接到外部观察装置的光路。 以这种方式,电极在体内的位置可以通过荧光镜或光纤技术来确定。