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1. 发明授权

US06319915B1 Benzazepine derivatives as inhibitors of hyperproliferation diseases 失效
标题翻译：苯扎西平衍生物作为过度增生疾病的抑制剂
公开(公告)号：US06319915B1
公开(公告)日：2001-11-20
申请号：US09548194
申请日：2000-04-13
申请人： Steven W. Goldstein , Kelly P. Longo , Arthur A. Nagel , John A. Lowe, III
发明人： Steven W. Goldstein , Kelly P. Longo , Arthur A. Nagel , John A. Lowe, III
IPC分类号： A61K3155
CPC分类号： A61K31/55 , A61K31/553 , A61K31/554
摘要： A method of treating hyperproliferation diseases in mammals in need of such treatment which method includes administering to said mammal a therapeutically effective amount of a compound of the formula: or a pharmaceutically acceptable salt, hydrate or prodrug thereof, wherein R1, R2, R3, R4, W, X, Y, Z and t are as defined herein.
摘要翻译：一种在需要这种治疗的哺乳动物中治疗过度增生性疾病的方法，该方法包括向所述哺乳动物施用治疗有效量的下式化合物或其药学上可接受的盐，水合物或前药，其中R1，R2，R3，R4 ，W，X，Y，Z和t如本文所定义。

2. 发明授权

US06576632B1 Biaryl compounds useful as anticancer agents 失效
标题翻译：用作抗癌剂的二芳基化合物
公开(公告)号：US06576632B1
公开(公告)日：2003-06-10
申请号：US09548460
申请日：2000-04-13
申请人： Steven W. Goldstein , Kelly P. Longo , James F. Blake , Mohamed M. A. Awad , Kenneth P. Raiche , Kevin W. Kramer
发明人： Steven W. Goldstein , Kelly P. Longo , James F. Blake , Mohamed M. A. Awad , Kenneth P. Raiche , Kevin W. Kramer
IPC分类号： C07C23305
CPC分类号： C07C233/51 , C07C233/11 , C07C233/83 , C07C311/51 , C07C2601/14 , C07C2602/10
摘要： The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b, m, n, p and v are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and methods of treating hyperproliferative disorders in mammals by administering the above compounds.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物和前药，其中R1，R2，R3，R4，R5，R10，R11，b，m，n，p和v如本文所定义。本发明还涉及含有上述化合物的药物组合物和通过施用上述化合物治疗哺乳动物中过度增殖性疾病的方法。

3. 发明授权

US06541495B1 Carboxylic acid derivatives as inhibitors of hyperproliferation diseases 失效
标题翻译：羧酸衍生物作为过度增生疾病的抑制剂
公开(公告)号：US06541495B1
公开(公告)日：2003-04-01
申请号：US09548937
申请日：2000-04-13
申请人： Steven W. Goldstein , Kelly P. Longo , Bernard Hulin
发明人： Steven W. Goldstein , Kelly P. Longo , Bernard Hulin
IPC分类号： A61K3142
CPC分类号： A61K31/343
摘要： A method of treating hyperproliferation diseases in mammals in need of such treatment, which method includes administering to said mammal a therapeutically effective amount of a compound of the formula: or a pharmaceutically acceptable salt, hydrate or prodrug thereof, wherein R1, R2, R3, R4, W, X, Y, Z and t are as defined herein.
摘要翻译：一种在需要这种治疗的哺乳动物中治疗过度增生疾病的方法，该方法包括向所述哺乳动物施用治疗有效量的下式化合物或其药学上可接受的盐，水合物或前药，其中R1，R2，R3， R4，W，X，Y，Z和t如本文所定义。

4. 发明授权

US6020335A (N-(pyridinylmethyl)-heterocyclic)ylideneamine compounds as nicotinic acetylcholine receptor binding agents 失效
标题翻译：（N-（吡啶基甲基） - 杂环）亚基胺化合物作为烟碱乙酰胆碱受体结合剂
公开(公告)号：US6020335A
公开(公告)日：2000-02-01
申请号：US963852
申请日：1997-11-04
申请人： Arthur A. Nagel , Steven W. Goldstein , Stanley Jung , Peter H. Dorff
发明人： Arthur A. Nagel , Steven W. Goldstein , Stanley Jung , Peter H. Dorff
IPC分类号： C07D401/12 , A61K31/44 , A61K31/4427 , A61K31/4439 , A61K31/444 , A61K31/50 , A61K31/501 , A61P1/00 , A61P3/04 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P25/34 , C07D401/06 , C07D417/06 , C07D417/12 , C07D471/04 , C07D213/62 , C07D213/36 , C07D213/44 , C07D213/79
CPC分类号： C07D401/06 , C07D417/06 , C07D471/04
摘要： An (N-(pyridinylmethyl)-heterocyclic)ylideneamine compound of the formula ##STR1## wherein R.sup.3, A, and B are as described below, and its pharmaceutically acceptable salts and prodrugs. Compounds of the formula I and their pharmaceutically acceptable salts and prodrugs are useful in the treatment of addictive disorders, such as the use of tobacco or other nicotine containing products, neurological and mental disorders such as senile dementia of the Alzheimer's type, Parkinson's disease, attentional hyperactivity disorder, anxiety, obesity, Tourette's Syndrome and ulcerative colitis.
摘要翻译：具有下式的（N-（吡啶基甲基） - 杂环）亚基胺化合物及其药学上可接受的盐和前药其中R 3，A和B如下所述。式I化合物及其药学上可接受的盐和前药可用于治疗成瘾性疾病，例如使用烟草或其他含有尼古丁的产品，神经和精神障碍，例如老年痴呆型老年痴呆，帕金森病，注意多动障碍，焦虑症，肥胖，Tourette综合征和溃疡性结肠炎。

5. 发明授权

US10051356B2 Methods and devices for occluding an ear canal having a predetermined filter characteristic 有权
公开(公告)号：US10051356B2
公开(公告)日：2018-08-14
申请号：US13805833
申请日：2011-06-24
申请人： Steven W. Goldstein
发明人： Steven W. Goldstein
IPC分类号： H04R25/00 , H04R1/10 , A61F11/08 , A61F11/10 , A61F11/14 , H04R29/00
摘要： Occlusion devices, earpiece devices and methods of forming occlusion devices are provided. An occlusion device is configured to occlude an ear canal. The occlusion device includes an insertion element and at least one expandable element disposed on the insertion element. The expandable element is configured to receive a medium via the insertion element and is configured to expand, responsive to the medium, to contact the ear canal. Physical parameters of the occlusion device are selected to produce a predetermined sound attenuation characteristic over a frequency band, such that sound is attenuated more in a first frequency range of the frequency band than in a second frequency range of the frequency band.

6. 发明授权

US08917880B2 Earhealth monitoring system and method I 有权
标题翻译：耳风监测系统及方法I
公开(公告)号：US08917880B2
公开(公告)日：2014-12-23
申请号：US13425743
申请日：2012-03-21
申请人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
发明人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
IPC分类号： G01C3/08 , H04R29/00 , A61F11/06 , A61B5/00 , A61B5/12 , G01H3/14
CPC分类号： A61B5/6817 , A61B5/121 , G01H3/14
摘要： Methods of operating an audio device are provided. A method includes calculating estimated sound pressure levels (SPLs) for drive signals directed to an ear canal receiver (ECR) during a time increment Δt; calculating an estimated SPL_Dose during the time increment Δt using the estimated sound pressure levels; and calculating a total SPL_Dose at a time t of the audio device using the estimated SPL_Dose.
摘要翻译：提供操作音频设备的方法。一种方法包括在时间增量＆Dgr; t期间计算针对耳道接收器（ECR）的驱动信号的估计声压级（SPL）; 使用估计的声压级在时间增量＆Dgr; t期间计算估计的SPL_Dose; 以及使用估计的SPL_Dose在音频设备的时间t计算总SPL_Dose。

7. 发明授权

US08774433B2 Method and device for personalized hearing 有权
标题翻译：个性化听觉的方法和装置
公开(公告)号：US08774433B2
公开(公告)日：2014-07-08
申请号：US11942370
申请日：2007-11-19
申请人： Steven W. Goldstein
发明人： Steven W. Goldstein
IPC分类号： H04R25/00
CPC分类号： H04R1/1083 , H04R1/1016 , H04R1/1041 , H04R3/002 , H04R29/00 , H04R29/001 , H04R29/008 , H04R2410/05 , H04R2420/07 , H04R2430/03 , H04R2460/15
摘要： An earpiece is provided that can include an Ambient Sound Microphone (ASM) to measure ambient sound, an Ear Canal Receiver (ECR) to deliver audio to an ear canal, an Ear Canal Microphone (ECM) to measure a sound pressure level within the ear canal, and a processor to produce the audio from at least in part the ambient sound, actively monitor a sound exposure level inside the ear canal, and adjust a level of the audio to within a safe and subjectively optimized listening level range based on the sound exposure level. An audio interface can deliver audio content from a media player. The processor can selectively mix the audio content with the ambient sound to produce the audio in accordance with a personalized hearing level (PHL) to permit environmental awareness of at least one distinct sound in the ambient sound. Other embodiments are disclosed.
摘要翻译：提供一种耳机，其可以包括用于测量环境声音的环境声音麦克风（ASM），用于向耳道传送音频的耳道接收器（ECR），耳道麦克风（ECM）以测量耳朵内的声压级运河和处理器以至少部分地从环境声音产生音频，主动地监测耳道内的声音曝光水平，并且基于声音将音频的水平调整到安全和主观优化的听力水平范围内暴露水平音频接口可以从媒体播放器传送音频内容。处理器可以根据个性化听觉水平（PHL）选择性地混合音频内容与环境声音以产生音频，以允许环境声音中至少一个不同声音的环境意识。公开了其他实施例。

8. 发明授权

US08208644B2 Earhealth monitoring system and method III 有权
标题翻译：耳风监测系统及方法三
公开(公告)号：US08208644B2
公开(公告)日：2012-06-26
申请号：US11930938
申请日：2007-10-31
申请人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
发明人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
IPC分类号： H04R29/00 , H04R25/02 , G06F17/00
CPC分类号： G01H3/14
摘要： A system for monitoring sound pressure levels at the ear includes an ambient sound microphone (ASM) for receiving ambient sounds and an ear canal receiver (ECR) for producing audio signals as a function of ambient sound received at the ambient sound microphone and a sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECR and calculates a total SPL_Dose experienced by the ear for periods Δt. The logic circuit may select an action parameter in response to the Total SPL_Dose.
摘要翻译：用于监测耳朵声压级的系统包括用于接收环境声音的环境声麦克风（ASM）和用于产生作为环境声麦克风接收的环境声音的函数的音频信号的耳道接收器（ECR），以及声音信号从相关联的个人音频设备接收。逻辑电路与ASM和ECR可操作地相关联，并计算耳朵对于周期＆Dgr; t所经历的总SPL_Dose。逻辑电路可以响应于总SPL_Dose来选择动作参数。

9. 发明授权

US08194865B2 Method and device for sound detection and audio control 有权
标题翻译：用于声音检测和音频控制的方法和装置
公开(公告)号：US08194865B2
公开(公告)日：2012-06-05
申请号：US12035873
申请日：2008-02-22
申请人： Steven W. Goldstein , John Usher , Dmitry N. Zotkin
发明人： Steven W. Goldstein , John Usher , Dmitry N. Zotkin
IPC分类号： H04R29/00
CPC分类号： H04R1/1091 , H04R1/1083 , H04R3/00 , H04R3/007 , H04R2430/01 , H04R2430/03 , H04R2460/07 , H04R2460/15
摘要： Methods and devices for sound detection and audio control are provided. A listening device (100) can include a receiver (102) and a sound director for directing a sound produced by the receiver into an ear of the user, a microphone (104) and a mount for mounting the microphone so as to receive the sound in an environment, a detector for detecting an auditory signal in the sound received by the microphone, and an alerting device for alerting the user to the presence of the auditory signal. The user's personal safety is enhanced due to the user being alerted to the presence of the auditory signal, which otherwise may be unnoticed by the user due to a loud sound level created at the ear of the user by the receiver.
摘要翻译：提供了声音检测和音频控制的方法和设备。聆听装置（100）可以包括用于将由接收器产生的声音引导到用户的耳朵中的接收器（102）和声音引导器，用于安装麦克风以便接收声音的麦克风（104）和安装座在环境中，用于检测由麦克风接收的声音中的听觉信号的检测器，以及用于向用户通知听觉信号的存在的警报装置。由于用户被警告听觉信号的存在而增强了用户的个人安全性，否则由于接收机在用户耳朵处产生的大声声级，用户可能不会注意到该信号。

10. 发明授权

US08150044B2 Method and device configured for sound signature detection 有权
标题翻译：配置用于声音签名检测的方法和设备
公开(公告)号：US08150044B2
公开(公告)日：2012-04-03
申请号：US11966457
申请日：2007-12-28
申请人： Steven W. Goldstein , Mark A. Clements , Marc A. Boillot
发明人： Steven W. Goldstein , Mark A. Clements , Marc A. Boillot
IPC分类号： H03G3/20 , H04R29/00 , H04R25/00
CPC分类号： H04R25/453 , H04R1/1083 , H04R2225/023 , H04R2225/41 , H04R2420/07
摘要： Methods for personalized listening which can be used with an earpiece are provided. A method includes capturing ambient sound from an Ambient Sound Microphone (ASM) of an earpiece partially or fully occluded in an ear canal, monitoring the ambient sound for a target sound, and adjusting by way of an Ear Canal Receiver (ECR) in the earpiece a delivery of audio to an ear canal based on a detected target sound. A volume of audio content can be adjusted upon the detection of a target sound, and an audible notification can be presented to provide a warning.
摘要翻译：提供了可与耳机一起使用的个性化聆听方法。一种方法包括从耳机部分或全部闭塞的耳机的环境声音麦克风（ASM）中捕获环境声音，监测目标声音的环境声音，以及通过听筒中的耳道接收器（ECR）进行调节基于检测到的目标声音向耳道传送音频。可以在检测到目标声音时调整音量的音量，并且可以呈现可听见的通知以提供警告。

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