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1. 发明授权

US11328823B2 Wearable device for reducing exposure to pathogens of possible contagion 有权
公开(公告)号：US11328823B2
公开(公告)日：2022-05-10
申请号：US16949088
申请日：2020-10-13
申请人： Steven W. Goldstein
发明人： Steven W. Goldstein
IPC分类号： G16H50/30 , A61B5/00 , A61B5/117 , G16H50/20 , G06N20/00 , G16H50/80
摘要： A wearable device for reducing exposure to pathogens of possible contagion includes a detection component configured to detect a proximate subject in relation to a user wherein the user is in possession of the wearable device, a data input component configured to capture data relating to the proximate subject, wherein the data relating to the currently proximate subject further comprises an inoculation status of the currently proximate subject, a processor configured to calculate a degree of transmission threat between the user and the proximate subject, wherein calculating the degree of transmission threat further comprises identifying a pathogen of possible contagion, locating a reproduction rate for the pathogen of possible contagion, calculating the degree of transmission threat as a function of the data input component and the reproduction rate, and a user-signaling component configured to generate an output as a function of the degree of transmission threat.

2. 发明授权

US09763003B2 Automotive constant signal-to-noise ratio system for enhanced situation awareness 有权
公开(公告)号：US09763003B2
公开(公告)日：2017-09-12
申请号：US13978983
申请日：2012-01-12
申请人： John Usher , Steven W. Goldstein , John G. Casall
发明人： John Usher , Steven W. Goldstein , John G. Casall
IPC分类号： H04R29/00 , H04R3/00
CPC分类号： H04R3/005 , H04R29/00 , H04R2420/01 , H04R2499/13
摘要： Audio systems for a vehicle and methods for increasing auditory situation awareness in a vehicle are provided. An audio system includes at least one ambient microphone disposed on the vehicle, a processor and at least one loudspeaker. The at least one ambient microphone is configured to capture ambient sound external to the vehicle and to produce an ambient sound signal. The processor is configured to receive the ambient sound signal and an audio content signal, and to mix the ambient sound signal with the audio content signal to generate a mixed output signal. The at least one loudspeaker is configured to reproduce the mixed output signal in the vehicle cabin.

3. 发明申请

US20140010380A1 SOUND LEVEL DOSEAGE SYSTEM FOR VEHICLES 有权
标题翻译：声级系统
公开(公告)号：US20140010380A1
公开(公告)日：2014-01-09
申请号：US13979005
申请日：2012-01-12
申请人： John Usher , Steven W. Goldstein
发明人： John Usher , Steven W. Goldstein
IPC分类号： H04R29/00
CPC分类号： H04R29/00 , H03G3/3005 , H03G3/3089 , H03G3/32
摘要： Audio systems for a vehicle and methods of operating an audio device in a vehicle cabin are provided. A method of operating an audio device directs an acoustic signal to at least one vehicle cabin receiver (VCR) of the audio device; measures sound pressure levels (SPLVCM) for acoustic energy received by at least one vehicle cabin microphone (VCM) of the audio device during a time period Δt; calculates a sound pressure level (SPL) dose (SPL_DoseΔt) during the time period Δt using the sound pressure levels SPLVCM of the at least one VCM; combines the SPL dose (SPL_DoseΔt) with an SPL dose of a previous time period to form a total SPL dose (SPL_Dosetotal); and performs an action to modify operation of the audio device when the total SPL dose is greater than a predetermined threshold.
摘要翻译：提供了用于车辆的音频系统以及在车厢中操作音频设备的方法。操作音频设备的方法将声信号引导到音频设备的至少一个车厢接收器（VCR）; 测量在一段时间内由音频设备的至少一个车厢麦克风（VCM）接收的声能的声压级（SPLVCM）; 使用所述至少一个VCM的声压级SPLVCM在所述时间段Deltat期间计算声压级（SPL_DoseDeltat）; 将SPL剂量（SPL_DoseDeltat）与前一时间段的SPL剂量组合以形成总SPL剂量（SPL-糖值）; 并且当总SPL剂量大于预定阈值时，执行修改音频设备的操作的动作。

4. 发明申请

US20080212787A1 EARHEALTH MONITORING SYSTEM AND METHOD I 有权
标题翻译：神经监测系统和方法I
公开(公告)号：US20080212787A1
公开(公告)日：2008-09-04
申请号：US11928290
申请日：2007-10-30
申请人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
发明人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
IPC分类号： H04R29/00
CPC分类号： A61B5/6817 , A61B5/121 , G01H3/14
摘要： At least one exemplary embodiment is directed to a method of operating an audio device comprising: calculating estimated sound pressure levels for drive signals directed to an ear canal receiver (ECR) during a time increment Δt; calculating an estimated SPL_Dose during the time increment Δt using the estimated sound pressure levels; and calculating a total SPL_Dose at the time t of the audio device using the estimated SPL_Dose.
摘要翻译：至少一个示例性实施例涉及一种操作音频设备的方法，包括：在时间增量Deltat期间计算针对耳道接收器（ECR）的驱动信号的估计声压级; 在使用估计声压级的时间增量Deltat期间计算估计的SPL_Dose; 以及使用所估计的SPL_Dose在音频设备的时间t计算总SPL_Dose。

5. 发明申请

US20080144841A1 EARHEALTH MONITORING SYSTEM AND METHOD III 有权
标题翻译：神经监测系统及方法III
公开(公告)号：US20080144841A1
公开(公告)日：2008-06-19
申请号：US11930938
申请日：2007-10-31
申请人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
发明人： Steven W. Goldstein , John Usher , Brian Fligor , John P. Keady
IPC分类号： H04R29/00
CPC分类号： G01H3/14
摘要： A system for monitoring sound pressure levels at the ear includes an ambient sound microphone for receiving ambient sounds and an ear canal microphone for producing audio signals as a function of ambient sound received at the ambient sound microphone and sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECR calculates a total SPL_Dose experienced by the ear at a time t. In one exemplary embodiment the total SPL_Dose is calculated by determining estimated SPL_Dose for periods Δt. The logic circuit then may then select an action parameter in response to the Total SPL_Dose.
摘要翻译：用于监测耳朵的声压级的系统包括用于接收环境声音的环境声麦克风和用于产生作为在环境声音麦克风处接收的环境声音和从相关联的个人音频设备接收的声音信号的函数的音频信号的耳道麦克风。逻辑电路与ASM可操作地相关联，并且ECR在时间t计算耳朵经历的总SPL_Dose。在一个示例性实施例中，通过确定周期Deltat的估计SPL_Dose来计算总SPL_Dose。然后逻辑电路可以响应于总SPL_Dose来选择动作参数。

6. 发明授权

US07220760B2 Quinoline derivatives as CRTH2 antagonists 失效
标题翻译：喹啉衍生物作为CRTH2拮抗剂
公开(公告)号：US07220760B2
公开(公告)日：2007-05-22
申请号：US10688566
申请日：2003-10-17
申请人： Mohamed M. Ali Awad , Marc J. Bazin , Frederic Feru , Steven W. Goldstein , Cyrille F. Kuhn
发明人： Mohamed M. Ali Awad , Marc J. Bazin , Frederic Feru , Steven W. Goldstein , Cyrille F. Kuhn
IPC分类号： A61K31/47 , C07D215/02
CPC分类号： C07D315/00 , C07D215/42 , C07D215/44 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D471/04
摘要： The invetion relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the description, their use as medicament, pharmaceutical compositions containing them and processes for their preparation.
摘要翻译：这种侵袭与式（I）的化合物相关，其中R 1，R 2，R 3，R 4，R 4， R 5，R 6，R 7和R 8如在说明书中所定义，它们的用途如药物，含有它们的药物组合物及其制备方法。

7. 发明授权

US06319915B1 Benzazepine derivatives as inhibitors of hyperproliferation diseases 失效
标题翻译：苯扎西平衍生物作为过度增生疾病的抑制剂
公开(公告)号：US06319915B1
公开(公告)日：2001-11-20
申请号：US09548194
申请日：2000-04-13
申请人： Steven W. Goldstein , Kelly P. Longo , Arthur A. Nagel , John A. Lowe, III
发明人： Steven W. Goldstein , Kelly P. Longo , Arthur A. Nagel , John A. Lowe, III
IPC分类号： A61K3155
CPC分类号： A61K31/55 , A61K31/553 , A61K31/554
摘要： A method of treating hyperproliferation diseases in mammals in need of such treatment which method includes administering to said mammal a therapeutically effective amount of a compound of the formula: or a pharmaceutically acceptable salt, hydrate or prodrug thereof, wherein R1, R2, R3, R4, W, X, Y, Z and t are as defined herein.
摘要翻译：一种在需要这种治疗的哺乳动物中治疗过度增生性疾病的方法，该方法包括向所述哺乳动物施用治疗有效量的下式化合物或其药学上可接受的盐，水合物或前药，其中R1，R2，R3，R4 ，W，X，Y，Z和t如本文所定义。

8. 发明授权

US5334604A Hypoglycemic hydroxyurea derivatives 失效
标题翻译：低血糖羟基脲衍生物
公开(公告)号：US5334604A
公开(公告)日：1994-08-02
申请号：US983538
申请日：1993-02-22
申请人： Steven W. Goldstein , Ruth E. McDermott
发明人： Steven W. Goldstein , Ruth E. McDermott
IPC分类号： A61K31/42 , A61K31/421 , A61P3/06 , A61P3/08 , C07D20060101 , C07D213/12 , C07D213/14 , C07D263/32 , C07D263/34 , C07D263/38 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D413/00
CPC分类号： C07D413/04 , C07D263/32 , C07D413/10 , C07D413/12 , C07D413/14
摘要： There are disclosed preparative processes and hypoglycemic compounds of the formula ##STR1## wherein R is hydrogen or C1 to C3 alkyl;R.sup.1 and R.sup.2 are taken together and are carbonyl; or R.sup.1 and R.sup.2 are taken separately, wherein R.sup.1 is hydrogen or R.sup.4 and R.sup.2 is--COR.sup.5 and COOR.sup.5 ;R.sup.3, R.sup.4 and R.sup.5 are each independently C1 to C9 alkyl, C3 to C7 cycloalkyl, phenyl, naphthyl, furyl, benzofuryl or thienyl or one of said groups mono- or disubstituted with C1 to C3 alkyl, C1 to C3 alkoxy, C1 to C3 alkoxy-carbonyl, trifluoromethyl, fluoro or chloro; and n is 0 or 1; or pharmaceutically acceptable cationic salts thereof.
摘要翻译： PCT No.PCT / US91 / 04352 Sec。 371日期：1993年2月22日 102（e）日期1993年2月22日PCT 1991年6月26日PCT公开。公开了制备方法和式“IMAGE”的降血糖化合物，其中R是氢或C 1至C 3烷基; R 1和R 2一起并且是羰基; 或R1和R2分别取代，其中R1是氢或R4，R2是-Co5和COOR5; R 3，R 4和R 5各自独立地为C 1至C 9烷基，C 3至C 7环烷基，苯基，萘基，呋喃基，苯并呋喃基或噻吩基或被C1至C3烷基，C1至C3烷氧基，C1至C3单取代或二取代的一个基团烷氧羰基，三氟甲基，氟或氯; 并且n为0或1; 或其药学上可接受的阳离子盐。

9. 发明授权

US5330998A Thiazolidinedione derivatives as hypoglycemic agents 失效
标题翻译：噻唑烷二酮衍生物作为降血糖药
公开(公告)号：US5330998A
公开(公告)日：1994-07-19
申请号：US566437
申请日：1990-08-14
申请人： David A. Clark , Steven W. Goldstein , Bernard Hulin
发明人： David A. Clark , Steven W. Goldstein , Bernard Hulin
IPC分类号： C07D263/44 , C07D417/12 , A61K31/425
CPC分类号： C07D263/44 , C07D417/12
摘要： Hypoglycemic thiazolidine-2,4-dione derivatives of the formula ##STR1## wherein the dotted line represents a bond or no bond;V is --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N--, S, O or NR;W is S, SO, SO.sub.2, SO.sub.2 NR.sup.1, NR.sup.1 SO.sub.2, CONR.sup.1 or NR.sup.1 CO;X is S, O, NR.sup.2, --CH.dbd.N-- or --N.dbd.CH;Y is CH or N;Z is hydrogen, (C.sub.1 -C.sub.7)alkyl, (C.sub.3 -C.sub.7)cycloalkyl, phenyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C.sub.1 -C.sub.3)alkyl, trifluoromethyl, (C.sub.1 -C.sub.3)alkoxy, fluoro, chloro or bromo;Z.sup.1 is hydrogen or (C.sub.1 -C.sub.3)alkyl;R, R.sup.1 and R.sup.2 are each independently hydrogen or (C.sub.1 -C.sub.4); andn is 1, 2 or 3;a pharmaceutically acceptable cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains a basic nitrogen.
摘要翻译： PCT No.PCT / US88 / 00745 Sec。 371日期1990年8月14日（I）的低血糖噻唑烷-2,4-二酮衍生物，其中虚线表示键或无键;（e）日本1990年8月14日PCT。 V是-CH = CH-，-N = CH-，-CH = N-，S，O或NR; W是S，SO，SO2，SO2NR1，NR1SO2，CONR1或NR1CO; X是S，O，NR2，-CH = N-或-N = CH; Y是CH或N; Z是氢，（C 1 -C 7）烷基，（C 3 -C 7）环烷基，苯基，吡啶基，呋喃基，噻吩基或被相同或不同的基团（C 1 -C 3）烷基，三氟甲基，（C 1 -C 3） -C 3）烷氧基，氟，氯或溴; Z1为氢或（C1-C3）烷基; R，R 1和R 2各自独立地为氢或（C 1 -C 4）; n为1,2或3; 其药学上可接受的阳离子盐; 或其药学上可接受的酸加成盐时，该化合物含有碱性氮。

10. 发明授权

US10051356B2 Methods and devices for occluding an ear canal having a predetermined filter characteristic 有权
公开(公告)号：US10051356B2
公开(公告)日：2018-08-14
申请号：US13805833
申请日：2011-06-24
申请人： Steven W. Goldstein
发明人： Steven W. Goldstein
IPC分类号： H04R25/00 , H04R1/10 , A61F11/08 , A61F11/10 , A61F11/14 , H04R29/00
摘要： Occlusion devices, earpiece devices and methods of forming occlusion devices are provided. An occlusion device is configured to occlude an ear canal. The occlusion device includes an insertion element and at least one expandable element disposed on the insertion element. The expandable element is configured to receive a medium via the insertion element and is configured to expand, responsive to the medium, to contact the ear canal. Physical parameters of the occlusion device are selected to produce a predetermined sound attenuation characteristic over a frequency band, such that sound is attenuated more in a first frequency range of the frequency band than in a second frequency range of the frequency band.

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