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1. 发明授权

US06406884B1 Secreted proteins and uses thereof 失效
标题翻译：分泌蛋白及其用途
公开(公告)号：US06406884B1
公开(公告)日：2002-06-18
申请号：US09336536
申请日：1999-06-18
申请人： Steven Bossone
发明人： Steven Bossone
IPC分类号： C12P2102
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 281, which encode proteins downregulated in megakaryocytes that fail to express the gata-1 transcription factor (a factor critical for blood cell formulation) and can, therefore, represent direct or indirect gata-1 targets. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic polypeptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为TANGO 281，其编码在未表达gata-1转录因子（对于血细胞制剂至关重要的因子）的巨核细胞中下调的蛋白质，因此可以代表直接或间接的gata-1靶。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供了分离的多肽，融合多肽，抗原多肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

2. 发明申请

US20120270219A1 NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES 审中-公开
标题翻译：编码具有预防，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20120270219A1
公开(公告)日：2012-10-25
申请号：US13540352
申请日：2012-07-02
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： C07K14/47 , C12N5/10 , C12P21/02 , C07K16/18 , C12Q1/68 , C12N5/071 , C12N15/12 , C12N15/85 , G01N33/566
CPC分类号： C07K14/705 , C07K14/70503 , G01N33/54313
摘要： The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

3. 发明授权

US06410315B1 Genes encoding polypeptides containing signal sequences 失效
标题翻译：编码含有信号序列的多肽的基因
公开(公告)号：US06410315B1
公开(公告)日：2002-06-25
申请号：US09436183
申请日：1999-11-08
申请人： Sean A. McCarthy , Steven Bossone
发明人： Sean A. McCarthy , Steven Bossone
IPC分类号： C12N1563
CPC分类号： C12Q1/6897 , C12N15/1034 , C12N15/1051 , C12N15/81
摘要： The invention involves a method of identifying nucleic acid sequences encoding signal peptide-containing proteins. The method features chimeric constructs containing a KRE9 gene that lacks a signal sequence. Yeast containing chimeric KRE9 plasmid constructs that encode signal sequences are selected based on their ability to grow on media in which sucrose is the sole carbon source.
摘要翻译：本发明涉及鉴定编码含有信号肽的蛋白质的核酸序列的方法。该方法具有含有缺少信号序列的KRE9基因的嵌合构建体。基于它们在其中蔗糖是唯一碳源的培养基上生长的能力来选择含有编码信号序列的嵌合KRE9质粒构建体的酵母。

4. 发明申请

US20060216727A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 有权
公开(公告)号：US20060216727A1
公开(公告)日：2006-09-28
申请号：US11287573
申请日：2005-11-23
申请人： Douglas Holtzman , John Sharp , Kevin Leiby , Steven Bossone , Yang Pan , Thomas Barnes , Christopher Fraser , Nicholas Wrighton , Paul Myers , Gillian Kingsbury
发明人： Douglas Holtzman , John Sharp , Kevin Leiby , Steven Bossone , Yang Pan , Thomas Barnes , Christopher Fraser , Nicholas Wrighton , Paul Myers , Gillian Kingsbury
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/715 , C07K16/28
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K14/7151 , C07K14/78 , C07K2319/00
摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

5. 发明申请

US20110065124A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 有权
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20110065124A1
公开(公告)日：2011-03-17
申请号：US12800681
申请日：2010-05-20
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： G01N33/53 , C12N15/12 , C12N5/07 , C07K14/435 , C07K16/18 , C12P21/00 , G01N33/68 , G01N33/00
CPC分类号： C07K14/7151 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K2319/00 , Y10T436/143333
摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

6. 发明申请

US20080213778A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20080213778A1
公开(公告)日：2008-09-04
申请号：US11983233
申请日：2007-11-08
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： C12N15/11 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , C12P21/02 , G01N33/53 , C12Q1/68
CPC分类号： C07K14/7151 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K2319/00 , Y10T436/143333
摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

7. 发明申请

US20050164393A1 Method for identifying genes encoding signal sequences 审中-公开
标题翻译：识别编码信号序列的基因的方法
公开(公告)号：US20050164393A1
公开(公告)日：2005-07-28
申请号：US11048658
申请日：2005-01-25
申请人： Sean McCarthy , Steven Bossone
发明人： Sean McCarthy , Steven Bossone
IPC分类号： C12N1/19 , C12N15/10 , C12N15/81 , C12Q1/68 , C12N1/18 , C12N15/74
CPC分类号： C12Q1/6897 , C12N15/1034 , C12N15/1051 , C12N15/81
摘要： The invention involves a method of identifying nucleic acid sequences encoding signal peptide-containing proteins. The method features chimeric constructs containing a KRE9 gene that lacks a signal sequence. Yeast containing chimeric KRE9 plasmid constructs that encode signal sequences are selected based on their ability to grow on media in which sucrose is the sole carbon source.
摘要翻译：本发明涉及鉴定编码含有信号肽的蛋白质的核酸序列的方法。该方法具有含有缺少信号序列的KRE9基因的嵌合构建体。基于它们在其中蔗糖是唯一碳源的培养基上生长的能力来选择含有编码信号序列的嵌合KRE9质粒构建体的酵母。

8. 发明授权

US6046000A Method for identifying genes encoding signal sequences 失效
标题翻译：识别编码信号序列的基因的方法
公开(公告)号：US6046000A
公开(公告)日：2000-04-04
申请号：US966269
申请日：1997-11-07
申请人： Sean A. McCarthy , Michael Joseph Kuranda , Christine Ellen Bulawa , Steven Bossone
发明人： Sean A. McCarthy , Michael Joseph Kuranda , Christine Ellen Bulawa , Steven Bossone
IPC分类号： C12N1/19 , C12N15/10 , C12N15/81 , C12Q1/68 , C07H21/04 , C12N1/00 , C12P21/00
CPC分类号： C12Q1/6897 , C12N15/1034 , C12N15/1051 , C12N15/81
摘要： The invention involves a method of identifying nucleic acid sequences encoding signal peptide-containing proteins. The method features chimeric constructs containing a KRE9 gene that lacks a signal sequence. Yeast containing chimeric KRE9 plasmid constructs that encode signal sequences are selected based on their ability to grow on media in which sucrose is the sole carbon source.
摘要翻译：本发明涉及鉴定编码含有信号肽的蛋白质的核酸序列的方法。该方法具有含有缺少信号序列的KRE9基因的嵌合构建体。基于它们在其中蔗糖是唯一碳源的培养基上生长的能力来选择含有编码信号序列的嵌合KRE9质粒构建体的酵母。

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