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1. 发明申请

US20130123122A1 SECRETED PROTEINS AND USES THEREOF 有权
标题翻译：分泌蛋白及其用途
公开(公告)号：US20130123122A1
公开(公告)日：2013-05-16
申请号：US13462600
申请日：2012-05-02
申请人： Christopher C. Fraser
发明人： Christopher C. Fraser
IPC分类号： C07K14/47 , C07K16/28 , G01N33/53 , C12Q1/68 , C12Q1/02 , C07K16/18 , C07K14/705 , G01N33/68
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

2. 发明申请

US20120270219A1 NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES 审中-公开
标题翻译：编码具有预防，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20120270219A1
公开(公告)日：2012-10-25
申请号：US13540352
申请日：2012-07-02
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： C07K14/47 , C12N5/10 , C12P21/02 , C07K16/18 , C12Q1/68 , C12N5/071 , C12N15/12 , C12N15/85 , G01N33/566
CPC分类号： C07K14/705 , C07K14/70503 , G01N33/54313
摘要： The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

3. 发明申请

US20110081656A1 Secreted proteins and uses thereof 有权
标题翻译：分泌蛋白及其用途
公开(公告)号：US20110081656A1
公开(公告)日：2011-04-07
申请号：US12386835
申请日：2009-04-23
申请人： Christopher C. Fraser
发明人： Christopher C. Fraser
IPC分类号： G01N33/53 , C07H21/04 , C12N15/63 , C12N5/071 , C07K14/00 , C07K16/00 , C12P21/00 , G01N33/50
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

4. 发明申请

US20100062487A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 失效
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20100062487A1
公开(公告)日：2010-03-11
申请号：US12387959
申请日：2009-05-08
申请人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
发明人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
IPC分类号： C12P21/02 , C07H21/04 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K2319/00 , Y02A50/411 , Y10T436/143333
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

5. 发明授权

US07459530B2 Tango 405 polypeptides and uses thereof 失效
标题翻译： Tango 405多肽及其用途
公开(公告)号：US07459530B2
公开(公告)日：2008-12-02
申请号：US11491318
申请日：2006-07-21
申请人： Christopher C. Fraser
发明人： Christopher C. Fraser
IPC分类号： C07K14/00
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

6. 发明授权

US07282209B2 Tango 240 polypeptides and uses thereof 有权
标题翻译： Tango 240多肽及其用途
公开(公告)号：US07282209B2
公开(公告)日：2007-10-16
申请号：US10929150
申请日：2004-08-27
申请人： Christopher C. Fraser
发明人： Christopher C. Fraser
IPC分类号： A61K39/00 , C07K14/47
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

7. 发明授权

US07033780B1 Nucleic acids corresponding to TANGO 294 a gene encoding a lipase—like protein 失效
标题翻译：对应于TANGO 294的编码脂肪酶样蛋白的基因的核酸
公开(公告)号：US07033780B1
公开(公告)日：2006-04-25
申请号：US09333159
申请日：1999-06-14
申请人： Sean A. McCarthy , Christopher C. Fraser , John D. Sharp , Thomas M. Barnes
发明人： Sean A. McCarthy , Christopher C. Fraser , John D. Sharp , Thomas M. Barnes
IPC分类号： C12N15/00
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

8. 发明授权

US06635750B1 B7-H2 nucleic acids, members of the B7 family 有权
标题翻译： B7-H2核酸，B7家族成员
公开(公告)号：US06635750B1
公开(公告)日：2003-10-21
申请号：US09620461
申请日：2000-07-20
申请人： Anthony J. Coyle , Christopher C. Fraser , Stephen Manning
发明人： Anthony J. Coyle , Christopher C. Fraser , Stephen Manning
IPC分类号： C07H2104
CPC分类号： C07K14/70532 , Y10S435/81
摘要： B7-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also provides B7-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了B7样多肽，蛋白质和核酸分子。除了分离的全长B7样蛋白之外，本发明还提供分离的B7样融合蛋白，抗原肽和抗B7样抗体。本发明还提供了B7样核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入或破坏了B7样基因的非人类转基因动物。还提供了利用本发明组合物的诊断，筛选和治疗方法。

9. 发明授权

US08187819B2 Methods of identifying compounds that bind TANGO240 有权
标题翻译：识别结合TANGO240的化合物的方法
公开(公告)号：US08187819B2
公开(公告)日：2012-05-29
申请号：US12386835
申请日：2009-04-23
申请人： Christopher C. Fraser
发明人： Christopher C. Fraser
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： C07K14/475 , A61K38/00 , A61K39/00 , C07H21/04 , C07K14/47 , C07K14/4705 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/22 , C07K16/28 , C12N15/86 , C12N2800/10 , C12Q1/025 , C12Q1/6813 , C12Q1/686 , G01N33/53 , G01N33/68 , G01N33/6872 , Y10T436/143333
摘要： The invention provides isolated nucleic acid molecules, designated TANGO 228 nucleic acid molecules, which encode secreted proteins with homology to the rat MCA-32 protein, isolated nucleic acid molecules, designated TANGO 240 nucleic acid molecules, which encode secreted proteins with homology to the Mycobacterium tuberculosis hypothetical protein Rv0712, and isolated nucleic acid molecules, designated TANGO 243 nucleic acid molecules, which encode proteins with homology to human PLAP (phospholipase A2-activating protein).The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为TANGO 228核酸分子，其编码与大鼠MCA-32蛋白同源的分泌蛋白，分离的核酸分子，称为TANGO 240核酸分子，其编码与分枝杆菌具有同源性的分泌蛋白结核分枝杆菌假想蛋白Rv0712和分离的核酸分子，命名为TANGO 243核酸分子，其编码与人PLAP（磷脂酶A2激活蛋白）具有同源性的蛋白质。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

10. 发明申请

US20120045777A1 NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES 审中-公开
标题翻译：编码具有预防，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20120045777A1
公开(公告)日：2012-02-23
申请号：US13169686
申请日：2011-06-27
申请人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
发明人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
IPC分类号： G01N33/53 , C12Q1/37 , C12P21/02 , C12N9/99 , C12N9/64 , C12N15/57 , C12N5/00 , C12N15/63 , G01N33/50 , C07K14/00 , C07K16/18 , C07H21/04 , G01N33/573 , C12N5/10
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K2319/00 , Y02A50/411 , Y10T436/143333
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

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