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1. 发明申请

US20130209396A1 CHIMERIC IL-1 RECEPTOR TYPE I AGONISTS AND ANTAGONISTS 有权
标题翻译： CHIMERIC IL-1受体I型激动剂和拮抗剂
公开(公告)号：US20130209396A1
公开(公告)日：2013-08-15
申请号：US13812582
申请日：2011-07-29
申请人： Thomas M. Barnes , Jinzhao Hou , Bracken M. King
发明人： Thomas M. Barnes , Jinzhao Hou , Bracken M. King
IPC分类号： C07K14/545
CPC分类号： C07K14/545 , A61K38/00 , C07K2319/00 , Y02A50/463
摘要： Featured herein are non-naturally occurring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1 RI), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains.
摘要翻译：本文特征在于非天然存在的细胞因子结构域，其可以用于调节对白细胞介素-1受体I（IL-1RI）的响应的细胞信号传导，以治疗病症，以及检测和/或结合细胞受体，以及其他代理商。示例性细胞因子结构域可以包含来自至少两个亲本细胞因子结构域的氨基酸残基，例如受体结合特征，表面特征，β链和来自至少两个亲本细胞因子结构域的环。

2. 发明申请

US20120270219A1 NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES 审中-公开
标题翻译：编码具有预防，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20120270219A1
公开(公告)日：2012-10-25
申请号：US13540352
申请日：2012-07-02
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： C07K14/47 , C12N5/10 , C12P21/02 , C07K16/18 , C12Q1/68 , C12N5/071 , C12N15/12 , C12N15/85 , G01N33/566
CPC分类号： C07K14/705 , C07K14/70503 , G01N33/54313
摘要： The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

3. 发明申请

US20100062487A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 失效
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20100062487A1
公开(公告)日：2010-03-11
申请号：US12387959
申请日：2009-05-08
申请人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
发明人： Christopher C. Fraser , Thomas M. Barnes , John D. Sharp , Susan J. Kirst , Paul S. Myers , Kevin R. Leiby , Douglas A. Holtzman , Sean A. McCarthy , Nicholas Wrighton , Charles R. Mackay , Andrew D.J. Goodearl
IPC分类号： C12P21/02 , C07H21/04 , C12N5/00 , C12N1/00 , C07K14/00 , C07K16/00 , G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K2319/00 , Y02A50/411 , Y10T436/143333
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

4. 发明申请

US20080220495A1 DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof 审中-公开
标题翻译： DELTA3，FTHMA-070，TANGO85，TANGO77，SPOIL，NEOKINE，TANGO129和整合素α亚基蛋白和核酸分子及其用途
公开(公告)号：US20080220495A1
公开(公告)日：2008-09-11
申请号：US11974465
申请日：2007-10-12
申请人： Sean A. McCarthy , David P. Gearing , Douglas A. Holtzman , Yang Pan , Samantha J. Busfield , Thomas M. Barnes , Charles R. Mackay , Jose M. Lora
发明人： Sean A. McCarthy , David P. Gearing , Douglas A. Holtzman , Yang Pan , Samantha J. Busfield , Thomas M. Barnes , Charles R. Mackay , Jose M. Lora
IPC分类号： C12N11/00 , C07K16/00 , C07K17/00
CPC分类号： C12Q1/48 , A61K38/00 , C07K14/47 , C07K2319/00 , C12Q1/6876
摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。还提供利用本发明组合物的诊断，筛选和治疗方法。

5. 发明授权

US07033780B1 Nucleic acids corresponding to TANGO 294 a gene encoding a lipase—like protein 失效
标题翻译：对应于TANGO 294的编码脂肪酶样蛋白的基因的核酸
公开(公告)号：US07033780B1
公开(公告)日：2006-04-25
申请号：US09333159
申请日：1999-06-14
申请人： Sean A. McCarthy , Christopher C. Fraser , John D. Sharp , Thomas M. Barnes
发明人： Sean A. McCarthy , Christopher C. Fraser , John D. Sharp , Thomas M. Barnes
IPC分类号： C12N15/00
CPC分类号： C07K14/47
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了利用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

6. 发明授权

US4105439A Method for production of refined steel 失效
标题翻译：精炼钢生产方法
公开(公告)号：US4105439A
公开(公告)日：1978-08-08
申请号：US801786
申请日：1977-05-31
申请人： Thomas M. Barnes
发明人： Thomas M. Barnes
IPC分类号： C21C5/56 , C21B3/04 , C21C5/28 , C21C5/32 , C21C5/36 , C21C7/072 , C21C5/00
CPC分类号： C21C5/28 , C21B3/04 , C21C5/32 , Y02W30/542
摘要： In a method of producing successive heats of refined steel wherein successive charges of molten, impure iron are refined by oxygen in the presence of at least one flux to form molten, refined steel and liquid slag, followed by the separation of said molten, refined steel and liquid slag, the improvement wherein a liquid slag from one of said refining operations is brought into contact with and caused to react with a batch of molten, impure iron which comprises a charge for a subsequent refining operation other than the immediate next successive refining operation to that from which the said liquid slag was obtained, such that at least some of the free and combined iron contained in said slag is substantially reduced and dissolved into said molten, impure iron, and such that the molten, impure iron is at least partially refined.
摘要翻译：在制造连续的精炼钢的方法中，其中在存在至少一种助熔剂的情况下，熔融的不纯铁的连续电荷被氧气精炼以形成熔融，精炼的钢和液态炉渣，然后将所述熔融精炼钢和液体炉渣，其中来自所述精炼操作之一的液体炉渣与一批熔融的不纯铁接触并引起与一批熔融的不纯铁反应的改进，其包括除了即时下一个连续精炼操作之外的后续精炼操作的装料获得所述液体渣的原料，使得所述炉渣中所含的游离和组合铁中的至少一些基本上被还原并溶解到所述熔融的不纯铁中，并且使得熔融的不纯铁至少部分地精制。

7. 发明授权

US08853150B2 Chimeric IL-1 receptor type I antagonists 有权
标题翻译：嵌合IL-1受体I型拮抗剂
公开(公告)号：US08853150B2
公开(公告)日：2014-10-07
申请号：US13812582
申请日：2011-07-29
申请人： Thomas M. Barnes , Jinzhao Hou , Bracken M. King
发明人： Thomas M. Barnes , Jinzhao Hou , Bracken M. King
IPC分类号： A61K38/17 , C07K14/715 , C07K14/545 , A61K38/00
CPC分类号： C07K14/545 , A61K38/00 , C07K2319/00 , Y02A50/463
摘要： Featured herein are non-naturally occurring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1 RI), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains.
摘要翻译：本文特征在于非天然存在的细胞因子结构域，其可以用于调节对白细胞介素-1受体I（IL-1RI）的响应的细胞信号传导，以治疗病症，以及检测和/或结合细胞受体，以及其他代理商。示例性细胞因子结构域可以含有至少两个亲本细胞因子结构域的氨基酸残基，例如受体结合特征，表面特征，链和环，其来自至少两个亲本细胞因子结构域。

8. 发明授权

US08003334B2 Methods for identifying compounds which bind to TANGO294 失效
标题翻译：识别与TANGO294结合的化合物的方法
公开(公告)号：US08003334B2
公开(公告)日：2011-08-23
申请号：US12387959
申请日：2009-05-08
申请人： Thomas M. Barnes , John D. Sharp
发明人： Thomas M. Barnes , John D. Sharp
IPC分类号： G01N33/53
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C07K14/705 , C07K2319/00 , Y02A50/411 , Y10T436/143333
摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
摘要翻译：本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供了使用本发明组合物的诊断，筛选和治疗方法。本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

9. 发明申请

US20110065124A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 有权
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20110065124A1
公开(公告)日：2011-03-17
申请号：US12800681
申请日：2010-05-20
申请人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
发明人： Douglas A. Holtzman , John D. Sharp , Kevin R. Leiby , Steven Bossone , Yang Pan , Thomas M. Barnes , Christopher C. Fraser , Nicholas Wrighton , Paul S. Myers , Gillian Kingsbury
IPC分类号： G01N33/53 , C12N15/12 , C12N5/07 , C07K14/435 , C07K16/18 , C12P21/00 , G01N33/68 , G01N33/00
CPC分类号： C07K14/7151 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/78 , C07K2319/00 , Y10T436/143333
摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

10. 发明申请

US20090220977A1 Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 审中-公开
标题翻译：编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因
公开(公告)号：US20090220977A1
公开(公告)日：2009-09-03
申请号：US12319689
申请日：2009-01-09
申请人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
发明人： Christopher C. Fraser , Sean Anthony McCarthy , John D. Sharp , Thomas M. Barnes , Nicholas C. Wrighton , Charles R. Mackay , Kevin R. Leiby , Douglas A. Holtzman
IPC分类号： C12Q1/68 , G01N33/53 , C12N5/10 , C12N15/63 , C07K14/435 , C07K16/00 , C07H21/04
CPC分类号： C07K16/18
摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子和多肽分子。本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或中断了本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。还提供利用本发明组合物的诊断，筛选和治疗方法。

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