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    • 6. 发明申请
    • Compositions and methods for the treatment and diagnosis of immune disorders
    • 用于治疗和诊断免疫疾病的组合物和方法
    • US20050119209A1
    • 2005-06-02
    • US10838852
    • 2004-05-03
    • Douglas LevinsonClare LloydSean McCarthy
    • Douglas LevinsonClare LloydSean McCarthy
    • A01K67/027A61K38/00C07K14/47C07K14/705C07K19/00C12N9/64C12N15/85C12Q1/68A61K48/00C07H21/04
    • C12N15/8509A01K67/0275A01K67/0278A01K2207/15A01K2217/00A01K2217/05A01K2217/075A01K2227/105A01K2267/03A01K2267/0325A01K2267/0368A01K2267/0375A01K2267/0381A01K2267/0387A01K2267/0393A61K38/00C07K14/47C07K14/70503C07K19/00C07K2319/00C12N9/6467C12N9/6472C12Q1/6809
    • The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials. Methods are also provided for the treatment of symptoms associated with mast cell-related processes or disorders and ischemic disorders and injuries using the genes, gene products and antibodies of the invention.
    • 本发明涉及用于治疗和诊断免疫疾病,特别是T辅助淋巴细胞相关病症的方法和组合物,还涉及治疗肥大细胞相关过程和病症,缺血性疾病和损伤,包括缺血性肾病和损伤 。 例如,识别在T辅助细胞(TH)细胞和TH细胞亚群内部和之间差异表达的基因,其包括但不限于TH0,TH1和TH2细胞亚群。 基因也通过其基因产物与涉及TH细胞和TH细胞亚群的分化,维持和效应子功能的基因产物相互作用的能力进行鉴定。 所鉴定的基因可以诊断使用或作为治疗干预的靶标。 在这方面,本发明提供了用于鉴定和治疗性使用化合物作为免疫疾病,特别是TH细胞亚群相关病症治疗的方法。 另外,提供了用于TH细胞亚群相关病症的诊断评估和预后的方法,用于鉴定表现出对这些病症倾向的受试者,用于监测接受临床评估治疗这种病症的患者,以及用于监测 化合物用于临床试验。 还提供了使用本发明的基因,基因产物和抗体治疗与肥大细胞相关过程或病症相关的症状以及缺血性疾病和损伤的方法。
    • 7. 发明申请
    • PASSIVE MAGNETIC BEARING
    • 被动磁性轴承
    • US20110001379A1
    • 2011-01-06
    • US12829457
    • 2010-07-02
    • Sean McCarthySeamus FlanaganAlan SimpsonMaxime Sorin
    • Sean McCarthySeamus FlanaganAlan SimpsonMaxime Sorin
    • H02K7/09
    • F16C32/0425F16C19/10F16C32/0402
    • A passive magnetic bearing which has an exceptionally low friction couple. Radial and axial restraint is achieved through magnetic and mechanical means. The embodiment of the passive magnetic bearing has two axially magnetized rings, which each exhibit at least one pair of north and south poles. The magnetized rings are positioned in a manner where the poles are in a repulsive magnetic interaction such that the plane of symmetry which separates the like poles lies perpendicular to the axis of the rotation of a shaft and this radially constrains the movement of the shaft. Axial rigidity is added to the system by the use of ceramic bearings and related axial retaining mechanisms on one of the ring magnets thus maintaining the magnetic bearing in an otherwise unstable axial plane.
    • 一种具有极低摩擦力的无源磁轴承。 通过磁力和机械方式实现径向和轴向约束。 无源磁轴承的实施例具有两个轴向磁化的环,每个环表现出至少一对北极和南极。 磁化环以这样的方式定位,其中磁极处于排斥磁相互作用,使得分离相同磁极的对称平面垂直于轴的旋转轴线,并且这径向地限制轴的运动。 通过在其中一个环形磁体上使用陶瓷轴承和相关的轴向保持机构将轴向刚度加到系统上,从而将磁轴承保持在另外不稳定的轴向平面。