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    • 1. 发明申请
    • Method and apparatus for modifying distance from a brachytherapy radiation source to sensitive anatomical structures
    • 用于修改从近距离放射治疗辐射源到敏感解剖结构的距离的方法和装置
    • US20090030258A1
    • 2009-01-29
    • US11881835
    • 2007-07-28
    • Steve AxelrodJames E. JervisPaul A. Lovoi
    • Steve AxelrodJames E. JervisPaul A. Lovoi
    • A61M36/06
    • A61M25/1011A61B2017/22069A61M25/1002A61M2025/1061A61N5/1015
    • A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue, such as skin or bone, farther away from a radiation source within a source guide inside the balloon. In one case a secondary balloon or secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber, primarily of inelastic or fairly rigidly elastic wall material, but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape (which may be approximately spherical), and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.
    • 气球近距离放射治疗器具有单室或双室,在气球一侧的指定区域处具有“起泡”的能力。 这对于将敏感组织(例如皮肤或骨骼)移动离气囊内的源引导件内的辐射源更远是有用的。 在一种情况下,次级球囊或次级隔室形成在主气囊上,并且可分开地充气,以便在需要时根据需要允许起泡。 在另一种形式中,气囊包括主要为非弹性或相当刚性弹性的壁材料的单个腔室,但具有球囊壁具有弹性或比主气囊壁基本上更有弹性的“窗口”或区域,从而使 气球直到某一点形成基本上规则的气球形状(其可以近似为球形),并且增加进一步的压力将使弹性区域起泡以增加轴和敏感组织之间的距离, 气球。
    • 2. 发明申请
    • Brachytherapy apparatus and method using off-center radiation source
    • 近距离放射治疗仪和使用偏心辐射源的方法
    • US20080214887A1
    • 2008-09-04
    • US12082492
    • 2008-04-10
    • Joseph A. HeanuePaul A. LovoiSteve AxelrodJames E. Jervis
    • Joseph A. HeanuePaul A. LovoiSteve AxelrodJames E. Jervis
    • A61M36/04
    • A61N5/1014A61M2025/1063A61N5/1015A61N5/1048A61N2005/1018
    • A brachytherapy applicator and method of use involve source guides that assume a desired curving, non-linear configuration. A flexible source catheter follows the shape of the source guides when inserted therein. Radiation dose received in various tissue areas can be better controlled using the invention, and the ratio of cavity surface dose to prescription depth dose can be lowered. With sequential manipulation of the source via movement of the catheter, the applicator can deliver radiotherapy to a treatment plan with local variation to prevent overdose, through either stepped or continuous movement of the source. Source guides can be fixed in position and arranged in bowed configuration around a generally central balloon axis, either attached to the balloon wall or not, and the series of off-center guides can be used to shape the dose delivered.
    • 近距离放射疗法施加器和使用方法包括采用期望的弯曲非线性构造的源引导件。 当插入其中时,柔性源导管遵循源极引导件的形状。 可以使用本发明更好地控制在各组织区域中接收的辐射剂量,并且可以降低腔表面剂量与处方深度剂量的比例。 通过导管的运动对源进行顺序操作,施用器可以将放射治疗递送到具有局部变化的治疗计划,以通过源的逐步或连续运动来防止过量。 源引导件可以被固定在适当位置并且围绕一般中心的气球轴线以弓形的形式布置,或者附接到球囊壁,并且可以使用一系列偏心导向器来调整所输送的剂量。
    • 3. 发明授权
    • Method and apparatus for modifying distance from a brachytherapy radiation source to sensitive anatomical structures
    • 用于修改从近距离放射治疗辐射源到敏感解剖结构的距离的方法和装置
    • US07771340B2
    • 2010-08-10
    • US11881835
    • 2007-07-28
    • Steve AxelrodJames E. JervisPaul A. Lovoi
    • Steve AxelrodJames E. JervisPaul A. Lovoi
    • A61N5/00
    • A61M25/1011A61B2017/22069A61M25/1002A61M2025/1061A61N5/1015
    • A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue farther away from a radiation source within a source guide inside the balloon. In one case a secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape, and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.
    • 气球近距离放射治疗器具有单室或双室,在气球一侧的指定区域处具有“起泡”的能力。 这对于使敏感组织更远离辐射源在气囊内的源引导件内是有用的。 在一种情况下,次级隔室形成在主气囊上,并且可分开地充气,以便在需要时允许起泡。 在另一种形式中,球囊包括单个腔室,但是具有“窗口”或其中球囊壁具有弹性的区域或者比主气囊壁基本上更有弹性的区域,使得球囊到达某一点的膨胀形成基本上规则的 气球形状,并且增加进一步的压力将使弹性区域膨胀,从而在气球的期望取向上增加轴与敏感组织之间的距离。
    • 4. 发明授权
    • Everting gynecological brachytherapy applicator and method
    • 永乐妇科近距离放射治疗仪及方法
    • US07914435B2
    • 2011-03-29
    • US11811295
    • 2007-06-07
    • James E. JervisPaul A. Lovoi
    • James E. JervisPaul A. Lovoi
    • A61N5/00
    • A61N5/1016
    • An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.
    • 用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管,套筒和心轴都具有内腔。 柔性套管在其远端具有分叉的开口,优选为钟形或锥形,使得当开口端被推靠在阴道口时,套筒将自身退回,逐渐展开到内侧 配置,其中,完全插入,套筒完全退回到心轴的外表面上。 然后将辐射源,同位素或电子插入到心轴腔中,以开始阴道组织的治疗辐射程序。
    • 9. 发明申请
    • Everting gynecological brachytherapy applicator and method
    • 永乐妇科近距离放射治疗仪及方法
    • US20080306323A1
    • 2008-12-11
    • US11811295
    • 2007-06-07
    • James E. JervisPaul A. Lovoi
    • James E. JervisPaul A. Lovoi
    • A61N5/00
    • A61N5/1016
    • An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.
    • 用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管,套筒和心轴都具有内腔。 柔性套管在其远端具有分叉的开口,优选为钟形或锥形,使得当开口端被推靠在阴道口时,套筒将自身退回,逐渐展开到内侧 配置,其中,完全插入,套筒完全退回到心轴的外表面上。 然后将辐射源,同位素或电子插入到心轴腔中,以开始阴道组织的治疗辐射程序。
    • 10. 发明申请
    • Everting gynecological brachytherapy applicator
    • 永远妇科近距离放射治疗仪
    • US20080306322A1
    • 2008-12-11
    • US11811069
    • 2007-06-07
    • James E. JervisPaul A. Lovoi
    • James E. JervisPaul A. Lovoi
    • A61N5/00
    • A61N5/1016
    • An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.
    • 用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管,套筒和心轴都具有内腔。 柔性套管在其远端具有分叉的开口,优选为钟形或锥形,使得当开口端被推靠在阴道口时,套筒将自身退回,逐渐展开到内侧 配置,其中,完全插入,套筒完全退回到心轴的外表面上。 然后将辐射源,同位素或电子插入到心轴腔中,以开始阴道组织的治疗辐射程序。