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1. 发明申请

US20090030258A1 Method and apparatus for modifying distance from a brachytherapy radiation source to sensitive anatomical structures 有权
标题翻译：用于修改从近距离放射治疗辐射源到敏感解剖结构的距离的方法和装置
公开(公告)号：US20090030258A1
公开(公告)日：2009-01-29
申请号：US11881835
申请日：2007-07-28
申请人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
发明人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
IPC分类号： A61M36/06
CPC分类号： A61M25/1011 , A61B2017/22069 , A61M25/1002 , A61M2025/1061 , A61N5/1015
摘要： A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue, such as skin or bone, farther away from a radiation source within a source guide inside the balloon. In one case a secondary balloon or secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber, primarily of inelastic or fairly rigidly elastic wall material, but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape (which may be approximately spherical), and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.
摘要翻译：气球近距离放射治疗器具有单室或双室，在气球一侧的指定区域处具有“起泡”的能力。这对于将敏感组织（例如皮肤或骨骼）移动离气囊内的源引导件内的辐射源更远是有用的。在一种情况下，次级球囊或次级隔室形成在主气囊上，并且可分开地充气，以便在需要时根据需要允许起泡。在另一种形式中，气囊包括主要为非弹性或相当刚性弹性的壁材料的单个腔室，但具有球囊壁具有弹性或比主气囊壁基本上更有弹性的“窗口”或区域，从而使气球直到某一点形成基本上规则的气球形状（其可以近似为球形），并且增加进一步的压力将使弹性区域起泡以增加轴和敏感组织之间的距离，气球。

2. 发明申请

US20080214887A1 Brachytherapy apparatus and method using off-center radiation source 审中-公开
标题翻译：近距离放射治疗仪和使用偏心辐射源的方法
公开(公告)号：US20080214887A1
公开(公告)日：2008-09-04
申请号：US12082492
申请日：2008-04-10
申请人： Joseph A. Heanue , Paul A. Lovoi , Steve Axelrod , James E. Jervis
发明人： Joseph A. Heanue , Paul A. Lovoi , Steve Axelrod , James E. Jervis
IPC分类号： A61M36/04
CPC分类号： A61N5/1014 , A61M2025/1063 , A61N5/1015 , A61N5/1048 , A61N2005/1018
摘要： A brachytherapy applicator and method of use involve source guides that assume a desired curving, non-linear configuration. A flexible source catheter follows the shape of the source guides when inserted therein. Radiation dose received in various tissue areas can be better controlled using the invention, and the ratio of cavity surface dose to prescription depth dose can be lowered. With sequential manipulation of the source via movement of the catheter, the applicator can deliver radiotherapy to a treatment plan with local variation to prevent overdose, through either stepped or continuous movement of the source. Source guides can be fixed in position and arranged in bowed configuration around a generally central balloon axis, either attached to the balloon wall or not, and the series of off-center guides can be used to shape the dose delivered.
摘要翻译：近距离放射疗法施加器和使用方法包括采用期望的弯曲非线性构造的源引导件。当插入其中时，柔性源导管遵循源极引导件的形状。可以使用本发明更好地控制在各组织区域中接收的辐射剂量，并且可以降低腔表面剂量与处方深度剂量的比例。通过导管的运动对源进行顺序操作，施用器可以将放射治疗递送到具有局部变化的治疗计划，以通过源的逐步或连续运动来防止过量。源引导件可以被固定在适当位置并且围绕一般中心的气球轴线以弓形的形式布置，或者附接到球囊壁，并且可以使用一系列偏心导向器来调整所输送的剂量。

3. 发明授权

US07771340B2 Method and apparatus for modifying distance from a brachytherapy radiation source to sensitive anatomical structures 有权
标题翻译：用于修改从近距离放射治疗辐射源到敏感解剖结构的距离的方法和装置
公开(公告)号：US07771340B2
公开(公告)日：2010-08-10
申请号：US11881835
申请日：2007-07-28
申请人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
发明人： Steve Axelrod , James E. Jervis , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61M25/1011 , A61B2017/22069 , A61M25/1002 , A61M2025/1061 , A61N5/1015
摘要： A balloon brachytherapy applicator has either a single or double chambers, with the capability of “blistering” outwardly at a specified area on one side of the balloon. This is useful to move sensitive tissue farther away from a radiation source within a source guide inside the balloon. In one case a secondary compartment is formed on the primary balloon, and is separately inflatable so as to allow blistering as desired when needed. In another form the balloon comprises a single chamber but with a “window” or area in which the balloon wall is elastic, or substantially more elastic than the main balloon wall, so that inflation of the balloon up to a certain point forms a substantially regular balloon shape, and the addition of further pressure will blister out the elastic area to increase the distance between the shaft and the sensitive tissue in a desired orientation of the balloon.
摘要翻译：气球近距离放射治疗器具有单室或双室，在气球一侧的指定区域处具有“起泡”的能力。这对于使敏感组织更远离辐射源在气囊内的源引导件内是有用的。在一种情况下，次级隔室形成在主气囊上，并且可分开地充气，以便在需要时允许起泡。在另一种形式中，球囊包括单个腔室，但是具有“窗口”或其中球囊壁具有弹性的区域或者比主气囊壁基本上更有弹性的区域，使得球囊到达某一点的膨胀形成基本上规则的气球形状，并且增加进一步的压力将使弹性区域膨胀，从而在气球的期望取向上增加轴与敏感组织之间的距离。

4. 发明授权

US07914435B2 Everting gynecological brachytherapy applicator and method 失效
标题翻译：永乐妇科近距离放射治疗仪及方法
公开(公告)号：US07914435B2
公开(公告)日：2011-03-29
申请号：US11811295
申请日：2007-06-07
申请人： James E. Jervis , Paul A. Lovoi
发明人： James E. Jervis , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.
摘要翻译：用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管，套筒和心轴都具有内腔。柔性套管在其远端具有分叉的开口，优选为钟形或锥形，使得当开口端被推靠在阴道口时，套筒将自身退回，逐渐展开到内侧配置，其中，完全插入，套筒完全退回到心轴的外表面上。然后将辐射源，同位素或电子插入到心轴腔中，以开始阴道组织的治疗辐射程序。

5. 发明申请

US20090209802A1 BALLOON BRACHYTHERAPY APPLICATOR AND METHOD 有权
标题翻译：气球加速器和方法
公开(公告)号：US20090209802A1
公开(公告)日：2009-08-20
申请号：US11871116
申请日：2007-10-11
申请人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
发明人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61M2025/1063
摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.
摘要翻译：公开了用于近距离放射治疗患者，特别是切除腔中的腔周围的组织的方法和施用装置。在需要在连续辐射治疗之间恢复时间的治疗方案中，本发明的施用器保留在皮肤下，允许皮肤至少部分愈合，并且稍后重新进行一次或多次随后的治疗。为了减少患者的不适，麻醉剂可以通过施用器输注到患者组织，用于插入，球囊充气或去除涂抹器。

6. 发明授权

US08262555B2 Method for adaptive radiation treatment of breast tissue surrounding a cancer resection cavity of arbitrary shape 有权
标题翻译：适合放射治疗任意形状的癌切除腔周围乳腺组织的方法
公开(公告)号：US08262555B2
公开(公告)日：2012-09-11
申请号：US11932974
申请日：2007-10-31
申请人： James E. Jervis , Paul A. Lovoi
发明人： James E. Jervis , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N5/103 , A61N5/1048
摘要： Radiation treatment methods for breast cancer following resection, both intraoperative and post operative, involve mapping preferably using an electronic x-ray source, and can include rotation of a direction source. By using a very rapid, near-instantaneous method of pathology of tissue margins following resection, the invention carries out intraoperative radiation treatment, preferably with the patient remaining anesthetized. Whether or not radiation is intraoperative, the invention preferably includes a mapping procedure using an electronic source that is progressed through the resection cavity while radiation dose is sensed at one or more points, to determine the shape of the resection cavity.
摘要翻译：切除术后，术中和术后两者的乳腺癌的放射治疗方法都涉及优选使用电子X射线源进行测绘，并且可包括方向源的旋转。通过使用切除术后组织边缘的非常快速，近瞬时的病理学方法，本发明进行术中放射治疗，优选在患者保持麻醉的情况下进行。无论辐射是否在术中，本发明优选地包括使用电子源的映射程序，该电子源在一个或多个点处感测放射剂量时进入切除腔，以确定切除腔的形状。

7. 发明授权

US07727137B2 Balloon brachytherapy applicator and method 有权
标题翻译：气球近距离放射治疗仪及方法
公开(公告)号：US07727137B2
公开(公告)日：2010-06-01
申请号：US11871116
申请日：2007-10-11
申请人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
发明人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
IPC分类号： A61M36/00 , A61M36/04 , A61N5/00
CPC分类号： A61N5/1015 , A61M2025/1063
摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.
摘要翻译：公开了用于近距离放射治疗患者，特别是切除腔中的腔周围的组织的方法和施用装置。在需要在连续辐射治疗之间恢复时间的治疗方案中，本发明的施用器保留在皮肤下，允许皮肤至少部分愈合，并且稍后重新进行一次或多次随后的治疗。为了减少患者的不适，麻醉剂可以通过施用器输注到患者组织，用于插入，球囊充气或去除涂抹器。

8. 发明申请

US20090112047A1 Brachytherapy apparatus and method for use with minimally invasive surgeries of the lung 有权
标题翻译：近距离放射治疗仪及其与微创手术相结合的方法
公开(公告)号：US20090112047A1
公开(公告)日：2009-04-30
申请号：US11978147
申请日：2007-10-26
申请人： Mark P. Carol , James E. Jervis , Paul A. Lovoi
发明人： Mark P. Carol , James E. Jervis , Paul A. Lovoi
IPC分类号： A61M36/04
CPC分类号： A61N5/1015 , A61B1/00082 , A61B1/00094 , A61B1/018 , A61B1/2676 , A61M1/0023 , A61N5/1002
摘要： Brachytherapy treatment of a patient's lung tissue following resection is effected using a balloon applicator which is inserted, normally through the same opening used for the surgery, through the chest wall and into the cavity. The lung and chest openings are closed around the applicator and generally sealed around the applicator. A suction port is provided, in a suction circuit of the applicator, to withdraw fluid from the pleural cavity, at intervals as needed, to assure that the lung can be inflated. Different embodiments of suction circuits are disclosed. A bronchial applicator and method are also disclosed.
摘要翻译：切除术后患者肺组织的近距离放射治疗使用气囊施放器进行，通常穿过用于手术的相同开口通过胸壁插入腔中。肺和胸部开口围绕涂抹器封闭，并且通常围绕敷贴器密封。在施用器的抽吸回路中设置吸入口，以便根据需要间隔地从胸膜腔中取出流体，以确保肺可以膨胀。公开了吸入电路的不同实施例。还公开了支气管施用器和方法。

9. 发明申请

US20080306323A1 Everting gynecological brachytherapy applicator and method 失效
标题翻译：永乐妇科近距离放射治疗仪及方法
公开(公告)号：US20080306323A1
公开(公告)日：2008-12-11
申请号：US11811295
申请日：2007-06-07
申请人： James E. Jervis , Paul A. Lovoi
发明人： James E. Jervis , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.
摘要翻译：用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管，套筒和心轴都具有内腔。柔性套管在其远端具有分叉的开口，优选为钟形或锥形，使得当开口端被推靠在阴道口时，套筒将自身退回，逐渐展开到内侧配置，其中，完全插入，套筒完全退回到心轴的外表面上。然后将辐射源，同位素或电子插入到心轴腔中，以开始阴道组织的治疗辐射程序。

10. 发明申请

US20080306322A1 Everting gynecological brachytherapy applicator 审中-公开
标题翻译：永远妇科近距离放射治疗仪
公开(公告)号：US20080306322A1
公开(公告)日：2008-12-11
申请号：US11811069
申请日：2007-06-07
申请人： James E. Jervis , Paul A. Lovoi
发明人： James E. Jervis , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： An everting applicator for brachytherapy of body cavities such as the vagina has a flexible sleeve secured to a distal mandrel, both the sleeve and the mandrel having internal lumens. The flexible sleeve has a diverging opening at its distal end, preferably bell-shaped or cone-shaped, such that when the open end is pushed against the mouth of a vagina, the sleeve will evert back upon itself, progressively unrolling to an inside out configuration wherein, fully inserted, the sleeve is fully everted back over the exterior surface of the mandrel. A radiation source, isotopic or electronic, is then inserted into the mandrel lumen to commence a therapeutic irradiation procedure of tissues of the vagina.
摘要翻译：用于诸如阴道的体腔近距离放射治疗的止痛器具有固定到远端心轴的柔性套管，套筒和心轴都具有内腔。柔性套管在其远端具有分叉的开口，优选为钟形或锥形，使得当开口端被推靠在阴道口时，套筒将自身退回，逐渐展开到内侧配置，其中，完全插入，套筒完全退回到心轴的外表面上。然后将辐射源，同位素或电子插入到心轴腔中，以开始阴道组织的治疗辐射程序。

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