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1. 发明申请

US20090209802A1 BALLOON BRACHYTHERAPY APPLICATOR AND METHOD 有权
标题翻译：气球加速器和方法
公开(公告)号：US20090209802A1
公开(公告)日：2009-08-20
申请号：US11871116
申请日：2007-10-11
申请人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
发明人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61M2025/1063
摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.
摘要翻译：公开了用于近距离放射治疗患者，特别是切除腔中的腔周围的组织的方法和施用装置。在需要在连续辐射治疗之间恢复时间的治疗方案中，本发明的施用器保留在皮肤下，允许皮肤至少部分愈合，并且稍后重新进行一次或多次随后的治疗。为了减少患者的不适，麻醉剂可以通过施用器输注到患者组织，用于插入，球囊充气或去除涂抹器。

2. 发明授权

US07727137B2 Balloon brachytherapy applicator and method 有权
标题翻译：气球近距离放射治疗仪及方法
公开(公告)号：US07727137B2
公开(公告)日：2010-06-01
申请号：US11871116
申请日：2007-10-11
申请人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
发明人： Darius Francescatti , David J. Hoffmann , Scott Tremberth , Michael Klein , Paul A. Lovoi , James E. Jervis
IPC分类号： A61M36/00 , A61M36/04 , A61N5/00
CPC分类号： A61N5/1015 , A61M2025/1063
摘要： Methods and applicator apparatus are disclosed for brachytherapy treatment of tissue surrounding a cavity in a patient, particularly a resection cavity. In treatment regimes requiring recovery time between successive radiation treatments, applicators of the invention are retained under the skin, with the skin allowed to at least partially heal, and are re-accessed later for one or more subsequent treatments. To reduce patient discomfort an anesthetic agent can be infused through the applicator to patient tissue, for insertion, balloon inflation or removal of the applicator.
摘要翻译：公开了用于近距离放射治疗患者，特别是切除腔中的腔周围的组织的方法和施用装置。在需要在连续辐射治疗之间恢复时间的治疗方案中，本发明的施用器保留在皮肤下，允许皮肤至少部分愈合，并且稍后重新进行一次或多次随后的治疗。为了减少患者的不适，麻醉剂可以通过施用器输注到患者组织，用于插入，球囊充气或去除涂抹器。

3. 发明授权

US07783006B2 Radiation treatment using x-ray source 有权
标题翻译：使用x射线源的放射治疗
公开(公告)号：US07783006B2
公开(公告)日：2010-08-24
申请号：US10962247
申请日：2004-10-08
申请人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
发明人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
IPC分类号： G21K5/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译：描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。

4. 发明授权

US07885382B2 Radiation treatment using x-ray source 有权
标题翻译：使用x射线源的放射治疗
公开(公告)号：US07885382B2
公开(公告)日：2011-02-08
申请号：US11820238
申请日：2007-06-18
申请人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
发明人： Daren L. Stewart , Paul A. Lovoi , Thomas W. Rusch , Alex Lim , Darius Francescatti
IPC分类号： G21K5/00
CPC分类号： A61N5/1015 , A61B90/39 , A61B2017/22051 , A61B2090/3933 , A61N2005/1003 , A61N2005/1061
摘要： Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
摘要翻译：描述了用于通过空腔或内腔照射活组织的方法和装置，使用可充气球囊施放器。在优选实施例中，施放器气球具有具有相对较低浓度的x射线造影材料的气球皮肤，使得当从外部成像时气球的轮廓将显现出明显。在另一个优选实施例中，球囊导管具有用于从空腔抽出液体的排水口，其可以包括气囊外部上的通道或纹理。描述了使用可变形的微型X射线管的方法，其可变电压和电流，以获得等剂量曲线的精度。

5. 发明授权

US07678040B2 Customized gynecological brachytherapy applicator and method 有权
公开(公告)号：US07678040B2
公开(公告)日：2010-03-16
申请号：US11809836
申请日：2007-05-31
申请人： Darius Francescatti , Paul A. Lovoi
发明人： Darius Francescatti , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.

6. 发明申请

US20080293994A1 Customized gynecological brachytherapy applicator and method 有权
标题翻译：定制妇科近距离放射治疗仪及方法
公开(公告)号：US20080293994A1
公开(公告)日：2008-11-27
申请号：US11805065
申请日：2007-05-21
申请人： Darius Francescatti , Paul A. Lovoi
发明人： Darius Francescatti , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.
摘要翻译：通过将固定在手柄上的模制气囊放置在阴道腔中，然后用可固定的液体材料填充模具球，形成定制的妇科近距离放射治疗仪。当通过化学作用，温度变化，氧化，诸如光或其它固化方式的固化手段设定时，该材料可以是膨胀泡沫体或任何其它形式的可固化材料，其变得固体，刚性或柔韧性。取决于施用器将其外表面与阴道轮廓相一致的程度，模具气囊可以是弹性的或非弹性的。提供了一个或多个灯泡以在接收辐射源的集合填充材料中，其中另外的腔可以任选地提供用于治疗剂的排出或施用。在治疗期间，施用器可以被取出并重新插入阴道，并且根据辐射处方照射与施用器相邻的选定组织。

7. 发明授权

US07744521B2 Customized gynecological brachytherapy applicator and method 有权
标题翻译：定制妇科近距离放射治疗仪及方法
公开(公告)号：US07744521B2
公开(公告)日：2010-06-29
申请号：US11805065
申请日：2007-05-21
申请人： Darius Francescatti , Paul A. Lovoi
发明人： Darius Francescatti , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.
摘要翻译：通过将固定在手柄上的模制气囊放置在阴道腔中，然后用可固定的液体材料填充模具球，形成定制的妇科近距离放射治疗仪。当通过化学作用，温度变化，氧化，诸如光或其它固化方式的固化手段设定时，该材料可以是膨胀泡沫体或任何其它形式的可固化材料，其变得固体，刚性或柔韧性。取决于施用器将其外表面与阴道轮廓相一致的程度，模具气囊可以是弹性的或非弹性的。提供了一个或多个灯泡以在接收辐射源的集合填充材料中，其中另外的腔可以任选地提供用于治疗剂的排出或施用。在治疗期间，施用器可以被取出并重新插入阴道，并且根据辐射处方照射与施用器相邻的选定组织。

8. 发明申请

US20080300445A1 Customized gynecological brachytherapy applicator and method 有权
公开(公告)号：US20080300445A1
公开(公告)日：2008-12-04
申请号：US11809836
申请日：2007-05-31
申请人： Darius Francescatti , Paul A. Lovoi
发明人： Darius Francescatti , Paul A. Lovoi
IPC分类号： A61N5/00
CPC分类号： A61N5/1016
摘要： A customized gynecological brachytherapy applicator is formed by placing a molded balloon, which is secured to a handle, into a vaginal cavity and then filling the mold balloon with a settable liquid material. The material may be an expanding foam or any other form of curable material that becomes solid, rigid or pliable, when set by chemical action, temperature change, oxidation, a curing means such as a light, or other curing regime. The mold balloon can be elastic or inelastic, depending on the degree to which the applicator is to conform its external surfaces to the vaginal contours. One or more lumina are provided in the set filler material to receive a radiation source, with additional lumina optionally provided for purposes such as drainage or administration of therapeutic agents. The applicator may be withdrawn and reinserted into the vagina during treatment, and selected tissues adjacent to the applicator are irradiated in accordance with a radiation prescription.

9. 发明申请

US20080004524A1 Endoscopic/percutaneous electronic radiation applicator and method of use 有权
标题翻译：内窥镜/经皮电子辐射施加器及其使用方法
公开(公告)号：US20080004524A1
公开(公告)日：2008-01-03
申请号：US11481242
申请日：2006-07-03
申请人： Darius Francescatti , Paul A. Lovoi
发明人： Darius Francescatti , Paul A. Lovoi
IPC分类号： A61B5/05
CPC分类号： A61B1/005 , A61B1/015 , A61B1/12 , A61N5/1001 , A61N5/1002 , A61N5/1014
摘要： Treatment of lesions in any luminal or organ system of mammalian anatomy is performed using an electronic source of ionizing radiation and aided by an endoscopic or percutaneous approach.
摘要翻译：使用电离辐射源进行哺乳动物解剖结构的任何腔内或器官系统中的损伤的治疗，并通过内窥镜或经皮方法进行辅助治疗。

10. 发明授权

US08303476B2 Applicators and methods for intraoperative treatment of proliferative diseases of the breast 有权
标题翻译：用于术中治疗乳腺增殖性疾病的应用者和方法
公开(公告)号：US08303476B2
公开(公告)日：2012-11-06
申请号：US12156298
申请日：2008-05-30
申请人： Darius Francescatti , James E. Jervis
发明人： Darius Francescatti , James E. Jervis
IPC分类号： A61N5/01
CPC分类号： A61N5/1015 , A61N5/1043 , A61N5/1083
摘要： A device for administering brachytherapy to a patient includes a vessel that may be in the form of a hollow cylindrical cup, for fleshing into and substantially filling the open-ended cavity. The vessel has a closed outer end, which may be a removable cover, and a source guide penetrates the closed outer end so as to extend deep into the vessel, to receive a radiation source in the source guide. A manipulator can be connected to the radiation source, and also to the source guide, for allowing several different types of manipulation of the source orientation and position within the vessel during the brachytherapy procedure.
摘要翻译：用于向患者施行近距离放射疗法的装置包括可以是中空圆柱形杯形式的容器，用于充满开口腔并基本上填充开口腔。容器具有封闭的外端，其可以是可移除的盖，并且源引导件穿过封闭的外端，以便深入到容器中，以在源引导件中接收辐射源。操纵器可以连接到辐射源以及源引导件，用于允许在近距离放射治疗过程期间几何不同类型的源取向和容器内的位置的操纵。

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