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1. 发明授权

US09017937B1 Nanopore sequencing using ratiometric impedance 有权
标题翻译：使用比例阻抗进行纳孔测序
公开(公告)号：US09017937B1
公开(公告)日：2015-04-28
申请号：US13083320
申请日：2011-04-08
申请人： Stephen Turner , Nathaniel McCaffrey , Jeffrey Wegener , Adrian Fehr
发明人： Stephen Turner , Nathaniel McCaffrey , Jeffrey Wegener , Adrian Fehr
IPC分类号： G01N33/487 , C12Q1/68
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2563/116 , C12Q2565/631 , C12Q2537/165
摘要： The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. The invention includes devices having sample and reference pores connecting sample, measurement and reference chambers, wherein potential measurements in each chamber is used to provide an accurate determination of current through a sample nanopore, improving nanopore sequencing.
摘要翻译：本发明涉及纳米孔测序的装置和方法。本发明包括纳入电子电路的纳米孔阵列，例如在CMOS中。本发明包括具有连接样品，测量和参考室的样品和参考孔的装置，其中每个室中的电位测量用于提供通过样品纳米孔的电流的精确测定，改进纳米孔测序。

2. 发明授权

US09410891B2 Optics collection and detection system and method 有权
标题翻译：光学收集和检测系统及方法
公开(公告)号：US09410891B2
公开(公告)日：2016-08-09
申请号：US13031146
申请日：2011-02-18
申请人： Adrian Fehr , Nathaniel Joseph McCaffrey , Stephen Turner
发明人： Adrian Fehr , Nathaniel Joseph McCaffrey , Stephen Turner
IPC分类号： G01N21/64 , G01N21/77 , B01L3/00 , G01N21/75 , B82Y20/00 , G01N33/543 , G02B6/122 , G01N21/03 , G01N21/05 , C12Q1/68 , H01L27/144
CPC分类号： C12Q1/6874 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0663 , B01L2300/0816 , B01L2300/168 , B82Y20/00 , C12Q1/6825 , C12Q1/6869 , G01N21/03 , G01N21/0303 , G01N21/05 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6454 , G01N21/6456 , G01N21/648 , G01N21/75 , G01N21/77 , G01N33/54373 , G01N2021/0346 , G01N2021/6434 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/757 , G01N2021/7786 , G01N2201/067 , G01N2201/068 , G01N2201/08 , G02B6/1226 , Y10T436/143333
摘要： Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.
摘要翻译：提供光学收集和检测系统，用于随着时间的推移从光源阵列测量光信号。还描述了使用光学器件收集和检测系统的方法。

3. 发明申请

US20100331194A1 NANOPORE SEQUENCING DEVICES AND METHODS 有权
标题翻译： NANOPORE顺序设备和方法
公开(公告)号：US20100331194A1
公开(公告)日：2010-12-30
申请号：US12757789
申请日：2010-04-09
申请人： Stephen Turner , Benjamin Flusberg , Mathieu Foquet , Hans Callebaut , Robert Sebra , Bidhan Chaudhuri , Jon Sorenson , Keith Bjornson , Adrian Fehr , Jonas Korlach , Robin Emig
发明人： Stephen Turner , Benjamin Flusberg , Mathieu Foquet , Hans Callebaut , Robert Sebra , Bidhan Chaudhuri , Jon Sorenson , Keith Bjornson , Adrian Fehr , Jonas Korlach , Robin Emig
IPC分类号： C40B20/00 , C40B60/10 , H01L21/30
CPC分类号： G01N33/48721 , B82Y5/00 , B82Y15/00 , C12Q1/6869 , C12Q1/6874 , C12Q2565/631 , G01N27/447 , G01N27/44791 , C12Q2563/116 , C12Q2527/113
摘要： The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed.
摘要翻译：本发明涉及纳米孔测序的装置和方法。本发明包括纳入电子电路的纳米孔阵列，例如在CMOS中。在一些情况下，纳米孔阵列包括用于隔离电子信号的电阻开口以改善测序。公开了通过纳米孔控制易位的方法。

4. 发明授权

US08465699B2 Illumination of integrated analytical systems 有权
公开(公告)号：US08465699B2
公开(公告)日：2013-06-18
申请号：US13031103
申请日：2011-02-18
申请人： Adrian Fehr , Nathaniel Joseph McCaffrey , Stephen Turner
发明人： Adrian Fehr , Nathaniel Joseph McCaffrey , Stephen Turner
IPC分类号： B82Y20/00 , G02B6/00 , G02B6/10 , G01N21/00
CPC分类号： C12Q1/6874 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0663 , B01L2300/0816 , B01L2300/168 , B82Y20/00 , C12Q1/6825 , C12Q1/6869 , G01N21/03 , G01N21/0303 , G01N21/05 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6454 , G01N21/6456 , G01N21/648 , G01N21/75 , G01N21/77 , G01N33/54373 , G01N2021/0346 , G01N2021/6434 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/757 , G01N2021/7786 , G01N2201/067 , G01N2201/068 , G01N2201/08 , G02B6/1226 , Y10T436/143333
摘要： An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.

5. 发明申请

US20100009872A1 Single molecule loading methods and compositions 有权
标题翻译：单分子加载方法和组成
公开(公告)号：US20100009872A1
公开(公告)日：2010-01-14
申请号：US12384097
申请日：2009-03-30
申请人： John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig
发明人： John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig
IPC分类号： C40B50/06 , C40B50/00 , C40B50/18 , C40B60/12
CPC分类号： B01J19/0046 , B01J2219/00596 , C12N2310/50 , C12N2310/51 , C12Q1/6869 , C12Q2535/122 , C40B40/06 , G01N33/54313 , G01N33/54366
摘要： Methods, compositions and arrays for non-random loading of single analyte molecules into array structures are provided.
摘要翻译：提供了将单一分析物分子非随机加载到阵列结构中的方法，组合物和阵列。

6. 发明授权

US08986928B2 Nanopore sequencing devices and methods 有权
标题翻译：纳米孔测序装置及方法
公开(公告)号：US08986928B2
公开(公告)日：2015-03-24
申请号：US12757789
申请日：2010-04-09
申请人： Stephen Turner , Benjamin Flusberg , Mathieu Foquet , Hans Callebaut , Robert Sebra , Bidhan Chaudhuri , Jon Sorenson , Keith Bjornson , Adrian Fehr , Jonas Korlach , Robin Emig
发明人： Stephen Turner , Benjamin Flusberg , Mathieu Foquet , Hans Callebaut , Robert Sebra , Bidhan Chaudhuri , Jon Sorenson , Keith Bjornson , Adrian Fehr , Jonas Korlach , Robin Emig
IPC分类号： C12Q1/68 , G01N27/447 , G01N33/487 , G01N33/50
CPC分类号： G01N33/48721 , B82Y5/00 , B82Y15/00 , C12Q1/6869 , C12Q1/6874 , C12Q2565/631 , G01N27/447 , G01N27/44791 , C12Q2563/116 , C12Q2527/113
摘要： The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed.
摘要翻译：本发明涉及纳米孔测序的装置和方法。本发明包括纳入电子电路的纳米孔阵列，例如在CMOS中。在一些情况下，纳米孔阵列包括用于隔离电子信号的电阻开口以改善测序。公开了通过纳米孔控制易位的方法。

7. 发明授权

US08906831B2 Single molecule loading methods and compositions 有权
标题翻译：单分子加载方法和组成
公开(公告)号：US08906831B2
公开(公告)日：2014-12-09
申请号：US12384097
申请日：2009-03-30
申请人： John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig , Jeremy Gray , Robert Sebra , Lei Sun , Stephen Dudek
发明人： John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig , Jeremy Gray , Robert Sebra , Lei Sun , Stephen Dudek
IPC分类号： C12Q1/48 , C12N11/14 , G01N33/543 , C40B20/02 , C40B60/08 , C40B40/06 , C12Q1/68
CPC分类号： B01J19/0046 , B01J2219/00596 , C12N2310/50 , C12N2310/51 , C12Q1/6869 , C12Q2535/122 , C40B40/06 , G01N33/54313 , G01N33/54366
摘要： Methods for non-random loading of single analyte molecules into array structures are provided. The methods allow for distribution of a population of target molecules into a plurality of size confined regions such as wells. Sizing moieties are linked to individual target molecules. The sizing moieties are of sufficient size, relative to the size-confined reaction or observation regions, such that only a selected number of sizing moieties will fit into the size confined regions. The confined regions and the sizing moieties or target molecules comprise a selected charge that allow for controlling the loading of the sizing moities.
摘要翻译：提供了将单一分析物分子非随机加载到阵列结构中的方法。所述方法允许将目标分子群体分配到多个尺寸的限制区域例如孔中。上限部分与单独的靶分子连接。尺寸部分相对于尺寸限制的反应或观察区域具有足够的尺寸，使得只有选定数量的施胶部分将适合尺寸限制区域。限制区域和施胶部分或靶分子包括允许控制施胶剂的载荷的选定的电荷。

8. 发明授权

US08715930B2 Loading molecules onto substrates 有权
标题翻译：将分子加载到基材上
公开(公告)号：US08715930B2
公开(公告)日：2014-05-06
申请号：US13429019
申请日：2012-03-23
申请人： Thang Pham , Jeremy Gray , Adrian Fehr , Albert James Chmura , Yu-Chih Tsai , Arunashree Bhamidipati
发明人： Thang Pham , Jeremy Gray , Adrian Fehr , Albert James Chmura , Yu-Chih Tsai , Arunashree Bhamidipati
IPC分类号： C12Q1/68 , C40B50/06 , C40B50/18 , C40B60/12 , C40B60/14
CPC分类号： C12Q1/6874 , B01L9/523 , C12Q1/6869 , C40B60/14 , G01N33/54313 , G01N33/54353 , G01N2333/922 , C12Q2521/543 , C12Q2523/303 , C12Q2525/301
摘要： Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.
摘要翻译：公开的是通过使具有附着于其上的感兴趣分子的珠与基底相接触来将感兴趣的分子加载到基底上的组合物，装置和方法，例如通过提供使珠子接近或接触基底的场，相对于基底的珠。感兴趣的分子可以沉积在底物上用于单分子分析。

9. 发明申请

US20120322692A1 LOADING MOLECULES ONTO SUBSTRATES 有权
标题翻译：将分子装载到基材上
公开(公告)号：US20120322692A1
公开(公告)日：2012-12-20
申请号：US13429019
申请日：2012-03-23
申请人： Thang Pham , Jeremy Gray , Adrian Fehr , AJ Chmura , Yu-Chih Tsai , Arunashree Bhamidipati
发明人： Thang Pham , Jeremy Gray , Adrian Fehr , AJ Chmura , Yu-Chih Tsai , Arunashree Bhamidipati
IPC分类号： C40B50/06 , C40B60/14
CPC分类号： C12Q1/6874 , B01L9/523 , C12Q1/6869 , C40B60/14 , G01N33/54313 , G01N33/54353 , G01N2333/922 , C12Q2521/543 , C12Q2523/303 , C12Q2525/301
摘要： Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.
摘要翻译：公开的是通过使具有附着于其上的感兴趣分子的珠与基底相接触来将感兴趣的分子加载到基底上的组合物，装置和方法，例如通过提供使珠子接近或接触基底的场，相对于基底的珠。感兴趣的分子可以沉积在底物上用于单分子分析。

10. 发明申请

US20100092960A1 Helicase-assisted sequencing with molecular beacons 审中-公开
标题翻译：带有分子信标的Helicase辅助测序
公开(公告)号：US20100092960A1
公开(公告)日：2010-04-15
申请号：US12460900
申请日：2009-07-23
申请人： Adrian Fehr
发明人： Adrian Fehr
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2521/513 , C12Q2537/1376 , C12Q2565/101 , C12Q2565/107
摘要： Provided are compositions that include an at least partially single-stranded nucleic acid, at least one first molecular beacon, and an enzyme comprising a helicase activity, which enzyme is capable of removing the first molecular beacon from the single-stranded nucleic acid wherein the first molecular beacon is hybridized to a first complementary subsequence of the nucleic acid. Also provided are methods of determining the sequence of a template nucleic acid that include removing molecular beacons that are hybridized to the template from the template in a sequential manner using an enzyme that exhibits a helicase activity, detecting a sequence of fluorescent signals that is produced by the removal of a molecular beacons, and converting the sequence of fluorescent signals into nucleotide sequence information. Sequencing systems in which compositions and methods of the invention can be used are also provided.
摘要翻译：提供的是包含至少部分单链核酸，至少一个第一分子信标和包含解旋酶活性的酶的组合物，该酶能够从单链核酸中除去第一分子信标，其中第一分子信标与核酸的第一互补子序列杂交。还提供了确定模板核酸序列的方法，其包括使用显示解旋酶活性的酶以顺序的方式从模板中除去与模板杂交的分子信标，检测由下述产生的荧光信号序列：去除分子信标，并将荧光信号序列转化为核苷酸序列信息。还提供了可以使用本发明的组合物和方法的测序系统。

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