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1. 发明授权

US07909817B2 Lateral laser fiber for high average power and peak pulse energy 有权
标题翻译：横向激光光纤，具有较高的平均功率和峰值脉冲能量
公开(公告)号：US07909817B2
公开(公告)日：2011-03-22
申请号：US11148817
申请日：2005-06-08
申请人： Stephen E. Griffin , Teresanne Griffin
发明人： Stephen E. Griffin , Teresanne Griffin
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61B18/22 , A61B2018/00023 , A61B2018/00029 , A61B2018/2272
摘要： An improved optical fiber comprising a waveguide with an input for coupling focused laser energy into the waveguide and communicating electromagnetic radiation in a propagation direction to an internally reflective tip of the waveguide, a tissue contacting surface wherein the light path from the reflecting surface to the transmitting surface in substantially homogenous in refractive index and cooled by fluid flow. In minimizing the variations in refractive index within the lateral light path, while providing active cooling directly below the tissue contact surface, the invention prevents internal reflections and beam distortion and greatly improves the efficiency and durability of the laterally directing probe. Free rotation of the tissue contact surface, about the lateral tip, may be provided and tissue vaporization efficiency may be improved by providing a morcellating tool on the tissue contact surface.
摘要翻译：一种改进的光纤，包括具有输入的波导，所述输入用于将聚焦的激光能量耦合到所述波导中并将传播方向上的电磁辐射传送到所述波导的内反射尖端，组织接触表面，其中从所述反射表面到所述透射表面基本上具有均匀的折射率并且通过流体流冷却。在使侧光路径内的折射率的变化最小化的同时，在组织接触表面的正下方提供主动冷却的同时，本发明可防止内部反射和光束变形，并大大提高了侧向引导探针的效率和耐久性。可以提供组织接触表面围绕侧向末端的自由旋转，并且可以通过在组织接触表面上设置一个脱毛工具来改善组织蒸发效率。

2. 发明授权

US08529561B2 Lateral laser fiber for high average power and peak pulse energy 有权
标题翻译：横向激光光纤，具有较高的平均功率和峰值脉冲能量
公开(公告)号：US08529561B2
公开(公告)日：2013-09-10
申请号：US13028867
申请日：2011-02-16
申请人： Stephen E. Griffin , Teresanne Griffin
发明人： Stephen E. Griffin , Teresanne Griffin
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61B18/22 , A61B2018/00023 , A61B2018/00029 , A61B2018/2272
摘要： An improved optical fiber comprising a waveguide with an input for coupling focused laser energy into the waveguide and communicating electromagnetic radiation in a propagation direction to an internally reflective tip of the waveguide, a tissue contacting surface wherein the light path from the reflecting surface to the transmitting surface in substantially homogenous in refractive index and cooled by fluid flow. In minimizing the variations in refractive index within the lateral light path, while providing active cooling directly below the tissue contact surface, the invention prevents internal reflections and beam distortion and greatly improves the efficiency and durability of the laterally directing probe. Free rotation of the tissue contact surface, about the lateral tip, may be provided and tissue vaporization efficiency may be improved by providing a morcellating tool on the tissue contact surface.
摘要翻译：一种改进的光纤，包括具有输入的波导，所述输入用于将聚焦的激光能量耦合到所述波导中并将传播方向上的电磁辐射传送到所述波导的内反射尖端，组织接触表面，其中从所述反射表面到所述透射表面基本上具有均匀的折射率并且通过流体流冷却。在使侧光路径内的折射率的变化最小化的同时，在组织接触表面的正下方提供主动冷却的同时，本发明可防止内部反射和光束变形，并大大提高了侧向引导探针的效率和耐久性。可以提供组织接触表面围绕侧向末端的自由旋转，并且可以通过在组织接触表面上设置一个脱毛工具来改善组织蒸发效率。

3. 发明授权

US07469557B2 Method for forming a capillary column for filtering, separation and concentration 失效
标题翻译：形成用于过滤，分离和浓缩的毛细管柱的方法
公开(公告)号：US07469557B2
公开(公告)日：2008-12-30
申请号：US10866626
申请日：2004-06-12
申请人： Teresanne Griffin , Stephen E. Griffin
发明人： Teresanne Griffin , Stephen E. Griffin
IPC分类号： C03B23/207
CPC分类号： G01N30/52 , G01N30/6052 , G01N30/6082 , G01N2030/528
摘要： The column according to the present invention provides greatly increased effective length and tortuosity, per unit length of column material, by providing a smooth or textured, tight radius helical channel or channels within a silica monolith. The capillary according to the present invention is useful in enabling fully automated massively parallel analyses, syntheses, separations and concentrations at reduced costs and higher speed as well as in immobilization, filtration, and miniaturization/acceleration/automation of classical instrumentation for practicality of general deployment in environmental threat monitoring and other applications.
摘要翻译：根据本发明的柱通过在二氧化硅整体中提供光滑或纹理紧密的半径螺旋形通道或通道来提供每单位长度的柱材料的有效长度和弯曲度。根据本发明的毛细管可用于实现全面自动化的大规模并行分析，合成，分离和浓缩，降低成本和更高的速度以及固定，过滤以及经典仪器的小型化/加速/自动化，以实现普遍部署在环境威胁监测等应用中。

4. 发明申请

US20060000238A1 Capillary column for filtering, separation and concentration 失效
标题翻译：用于过滤，分离和浓缩的毛细管柱
公开(公告)号：US20060000238A1
公开(公告)日：2006-01-05
申请号：US10866626
申请日：2004-06-12
申请人： Teresanne Griffin , Stephen Griffin
发明人： Teresanne Griffin , Stephen Griffin
IPC分类号： C03B23/207
CPC分类号： G01N30/52 , G01N30/6052 , G01N30/6082 , G01N2030/528
摘要： The column according to the present invention provides greatly increased effective length and tortuosity, per unit length of column material, by providing a smooth or textured, tight radius helical channel or channels within a silica monolith. The capillary according to the present invention is useful in enabling fully automated massively parallel analyses, syntheses, separations and concentrations at reduced costs and higher speed as well as in immobilization, filtration, and miniaturization/acceleration/automation of classical instrumentation for practicality of general deployment in environmental threat monitoring and other applications.
摘要翻译：根据本发明的柱通过在二氧化硅整体中提供光滑或纹理紧密的半径螺旋形通道或通道来提供每单位长度的柱材料的有效长度和弯曲度。根据本发明的毛细管可用于实现全面自动化的大规模并行分析，合成，分离和浓缩，降低成本和更高的速度以及固定，过滤以及经典仪器的小型化/加速/自动化，以实现普遍部署在环境威胁监测等应用中。

5. 发明申请

US20060282068A1 Lateral laser fiber for high average power and peak pulse energy 有权
公开(公告)号：US20060282068A1
公开(公告)日：2006-12-14
申请号：US11148817
申请日：2005-06-08
申请人： Stephen Griffin , Teresanne Griffin
发明人： Stephen Griffin , Teresanne Griffin
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61B18/22 , A61B2018/00023 , A61B2018/00029 , A61B2018/2272
摘要： An improved optical fiber comprising a waveguide with an input for coupling focused laser energy into the waveguide and communicating electromagnetic radiation in a propagation direction to an internally reflective tip of the waveguide, a tissue contacting surface wherein the light path from the reflecting surface to the transmitting surface in substantially homogenous in refractive index and cooled by fluid flow. In minimizing the variations in refractive index within the lateral light path, while providing active cooling directly below the tissue contact surface, the invention prevents internal reflections and beam distortion and greatly improves the efficiency and durability of the laterally directing probe. Free rotation of the tissue contact surface, about the lateral tip, may be provided and tissue vaporization efficiency may be improved by providing a morcellating tool on the tissue contact surface.

6. 发明申请

US20110230872A1 Lateral Laser Fiber for High Average Power and Peak Pulse Energy 有权
标题翻译：用于高平均功率和峰值脉冲能量的横向激光光纤
公开(公告)号：US20110230872A1
公开(公告)日：2011-09-22
申请号：US13028867
申请日：2011-02-16
申请人： Stephen Edward Griffin , Teresanne Griffin
发明人： Stephen Edward Griffin , Teresanne Griffin
IPC分类号： A61B18/22
CPC分类号： A61B18/20 , A61B18/22 , A61B2018/00023 , A61B2018/00029 , A61B2018/2272
摘要： An improved optical fiber comprising a waveguide with an input for coupling focused laser energy into the waveguide and communicating electromagnetic radiation in a propagation direction to an internally reflective tip of the waveguide, a tissue contacting surface wherein the light path from the reflecting surface to the transmitting surface in substantially homogenous in refractive index and cooled by fluid flow. In minimizing the variations in refractive index within the lateral light path, while providing active cooling directly below the tissue contact surface, the invention prevents internal reflections and beam distortion and greatly improves the efficiency and durability of the laterally directing probe. Free rotation of the tissue contact surface, about the lateral tip, may be provided and tissue vaporization efficiency may be improved by providing a morcellating tool on the tissue contact surface.
摘要翻译：一种改进的光纤，包括具有输入的波导，所述输入用于将聚焦的激光能量耦合到所述波导中并将传播方向上的电磁辐射传送到所述波导的内反射尖端，组织接触表面，其中从所述反射表面到所述透射表面基本上具有均匀的折射率并且通过流体流冷却。在使侧光路径内的折射率的变化最小化的同时，在组织接触表面的正下方提供主动冷却的同时，本发明可防止内部反射和光束变形，并大大提高了侧向引导探针的效率和耐久性。可以提供组织接触表面围绕侧向末端的自由旋转，并且可以通过在组织接触表面上设置一个脱毛工具来改善组织蒸发效率。

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