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1. 发明申请

US20050222247A1 Chroman derivatives 审中-公开
标题翻译：色原衍生物
公开(公告)号：US20050222247A1
公开(公告)日：2005-10-06
申请号：US10996230
申请日：2004-11-23
申请人： Stephen Boyer , Kentaro Hashimoto , Thomas Rolle , Peter Sandner , Beatrix Stelte-Ludwig , Hanna Tinel , Kerstin Henninger , Arnel Concepcion , Osamu Sakurai , Kanako Hirai , Tadashi Inoue , Yuki Mochizuki , Noriko Nunami , Masaomi Tajimi , Noriyuki Yamamoto , Yasuhiro Tsukimi
发明人： Stephen Boyer , Kentaro Hashimoto , Thomas Rolle , Peter Sandner , Beatrix Stelte-Ludwig , Hanna Tinel , Kerstin Henninger , Arnel Concepcion , Osamu Sakurai , Kanako Hirai , Tadashi Inoue , Yuki Mochizuki , Noriko Nunami , Masaomi Tajimi , Noriyuki Yamamoto , Yasuhiro Tsukimi
IPC分类号： A61K31/353 , A61K31/403 , A61K31/4192 , C07D311/58 , C07D405/12 , C07D311/74
CPC分类号： C07D311/58 , C07D405/12
摘要： This invention relates to chroman derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The chroman derivatives of the present invention have an excellent activity as BETA 3 antagonists and are useful for the prophylaxis and treatment of diseases associated with BETA 3 activity, in particular for the treatment of urological disorder or disease, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor oeractivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; and inflammatory disorders, such as asthma and COPD.
摘要翻译：本发明涉及可用作药物制剂的活性成分的苯并二氢吡喃衍生物及其盐。本发明的苯并二氢吡喃衍生物作为BETA 3拮抗剂具有优异的活性，可用于预防和治疗与BETA 3活性相关的疾病，特别是用于治疗泌尿系统疾病或疾病，如逼尿肌过度活动（膀胱过度活动症），尿失禁，神经源性逼尿肌反应性（逼尿肌hyperflexia），特发性逼尿肌过度活动（逼尿肌不稳定），良性前列腺增生和下尿路症状; 和炎症性疾病，如哮喘和COPD。

2. 发明授权

US08637553B2 Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions 有权
标题翻译：氟取代的ω-羧基芳基二苯脲用于治疗和预防疾病和病症
公开(公告)号：US08637553B2
公开(公告)日：2014-01-28
申请号：US10895985
申请日：2004-07-22
申请人： Stephen Boyer , Jacques Dumas , Bernd Riedl , Scott Wilhelm
发明人： Stephen Boyer , Jacques Dumas , Bernd Riedl , Scott Wilhelm
IPC分类号： A61K31/4412 , C07D213/62
CPC分类号： A61K31/4412 , C07D213/62 , C07D213/81
摘要： A compound of Formula (I): salts thereof, prodrugs thereof, metabolites thereof, pharmaceutical compositions containing such a compound, and use of such compound and compositions to treat diseases mediated by raf, VEGFR, PDGFR, p38 and flt-3.
摘要翻译：式（I）的化合物：其盐，其前药，其代谢物，含有这种化合物的药物组合物，以及这些化合物和组合物用于治疗由raf，VEGFR，PDGFR，p38和flt-3介导的疾病的用途。

3. 发明授权

US07928227B2 2-oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders 失效
标题翻译：可用于治疗高增殖性，血管生成和炎症性疾病的2-氧代-1,3,5-三氢三氮杂衍生物
公开(公告)号：US07928227B2
公开(公告)日：2011-04-19
申请号：US10788405
申请日：2004-03-01
申请人： Stephen Boyer , Jacques Dumas , Barton Phillips , William J. Scott , Roger A. Smith , Jianqing Chen , Benjamin Jones , Gan Wang
发明人： Stephen Boyer , Jacques Dumas , Barton Phillips , William J. Scott , Roger A. Smith , Jianqing Chen , Benjamin Jones , Gan Wang
IPC分类号： C07D251/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/53 , A61P19/02
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

4. 发明申请

US20100249085A1 HETEROARYL SUBSTITUTED PYRAZOLE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权
标题翻译：用于治疗与促血细胞生成相关的高血压疾病和疾病的异氟醚取代的吡唑衍生物
公开(公告)号：US20100249085A1
公开(公告)日：2010-09-30
申请号：US12600640
申请日：2008-05-08
申请人： Stephen Boyer , Michael Härter , Philip L. Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
发明人： Stephen Boyer , Michael Härter , Philip L. Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
IPC分类号： A61K31/4245 , C12N5/02 , A61K31/5377 , A61K31/496 , A61K31/437 , A61K31/454 , A61K31/4439 , A61K31/422 , A61K31/423 , A61K31/4184 , A61K31/4178 , C07D403/14 , C07D471/04 , C07D401/14 , C07D413/14 , C07D413/04 , C07D491/048 , C07D487/04 , C07D403/04 , A61K31/4188 , C07D491/056 , A61P35/00 , A61P9/10 , A61P11/00 , A61P13/12 , A61P25/00 , A61P29/00 , A61P17/06 , A61P27/02
CPC分类号： C07D413/04 , C07D403/04 , C07D413/14 , C07D471/04 , C07D491/04
摘要： This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
摘要翻译：本发明涉及新颖的杂芳基取代的吡唑化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用作治疗高增殖和/或血管发生障碍作为唯一试剂或与其它活性成分或治疗措施组合的用途。

5. 发明申请

US20050209261A1 Rho-kinase inhibitors 审中-公开
公开(公告)号：US20050209261A1
公开(公告)日：2005-09-22
申请号：US11111704
申请日：2005-04-22
申请人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Hans Pluempe
发明人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Hans Pluempe
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/517 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/06 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07D401/12 , C07D401/14 , C07D43/14
CPC分类号： C07D401/12 , C07D401/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

6. 发明申请

US20050176155A1 Well plate reactor 有权
标题翻译：井板反应器
公开(公告)号：US20050176155A1
公开(公告)日：2005-08-11
申请号：US10777581
申请日：2004-02-11
申请人： David Klein , Stephen Boyer , Gregory Andronaco
发明人： David Klein , Stephen Boyer , Gregory Andronaco
IPC分类号： B01L3/00 , C12M1/20 , C12M1/36 , G01N33/00
CPC分类号： C12M23/12 , B01L3/50851 , B01L3/50853 , B01L2200/143 , B01L2300/049 , B01L2300/0663 , B01L2300/0829 , B01L2300/10 , B01L2300/1822 , B01L2300/1827 , C12M23/38 , C12M41/26 , C12M41/34 , Y10T436/209163
摘要： A well plate and its supporting devices provide capabilities found in larger fermenters, such as controlling the oxygen level, the pH level, and temperature of the contents of the well. The well plate includes a plurality of wells, each of which can be independently controlled. Apertures in the wells, for example, provide access for a gas supply and sensors within each well provide data relating to, e.g., oxygen and/or pH level in the well. A control system controls the gas supply for each well based on the information provided by the sensor within the well. Similarly, temperature control elements, such as a heater or cooler, is placed in thermal contact with the interior of the well, as is a temperature measurement element. A control system can independently control the temperature of the contents of the well based on information provided by the temperature measurement element for that well.
摘要翻译：井板及其支撑装置提供在较大发酵罐中发现的能力，例如控制井的内容物的氧气含量，pH值和温度。井板包括多个井，每个井可独立控制。例如，孔中的孔径为气体供应提供通路，并且每个井内的传感器提供与井中的氧气和/或pH水平有关的数据。控制系统根据由井内的传感器提供的信息来控制每个井的气体供应。类似地，诸如加热器或冷却器的温度控制元件也被放置成与井的内部热接触，温度测量元件也是如此。控制系统可以根据井的温度测量元件提供的信息独立地控制井的内部温度。

7. 发明申请

US20050038080A1 Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions 有权
标题翻译：氟取代的ω-羧基芳基二苯脲用于治疗和预防疾病和病症
公开(公告)号：US20050038080A1
公开(公告)日：2005-02-17
申请号：US10895985
申请日：2004-07-22
申请人： Stephen Boyer , Jacques Dumas , Bernd Riedl , Scott Wilhelm
发明人： Stephen Boyer , Jacques Dumas , Bernd Riedl , Scott Wilhelm
IPC分类号： A61K31/44 , A61K31/4415 , A61K31/675 , A61P35/00 , C07D213/78 , C07D213/81
CPC分类号： A61K31/4412 , C07D213/62 , C07D213/81
摘要： A compound of Formula (I): salts thereof, prodrugs thereof, metabolites thereof, pharmaceutical compositions containing such a compound, and use of such compound and compositions to treat diseases mediated by raf, VEGFR, PDGFR, p38 and flt-3.
摘要翻译：式（I）的化合物：其盐，其前药，其代谢物，含有这种化合物的药物组合物，以及这些化合物和组合物用于治疗由raf，VEGFR，PDGFR，p38和flt-3介导的疾病的用途。

8. 发明申请

US20050032798A1 2-Oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders 失效
标题翻译：可用于治疗高增殖性，血管生成和炎性疾病的2-氧代-1,3,5-全氢三氮杂衍生物
公开(公告)号：US20050032798A1
公开(公告)日：2005-02-10
申请号：US10788405
申请日：2004-03-01
申请人： Stephen Boyer , Jacques Dumas , Barton Phillips , William Scott , Roger Smith , Jianqing Chen , Benjamin Jones , Gan Wang
发明人： Stephen Boyer , Jacques Dumas , Barton Phillips , William Scott , Roger Smith , Jianqing Chen , Benjamin Jones , Gan Wang
IPC分类号： A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

9. 发明授权

US07899827B2 System and method for the indexing of organic chemical structures mined from text documents 失效
标题翻译：从文本文件开采有机化学结构索引的系统和方法
公开(公告)号：US07899827B2
公开(公告)日：2011-03-01
申请号：US10797359
申请日：2004-03-09
申请人： Stephen Boyer , Anna Rosa Coden , James William Cooper
发明人： Stephen Boyer , Anna Rosa Coden , James William Cooper
IPC分类号： G06F17/30
CPC分类号： G06F19/707
摘要： Disclosed is a method, a computer program product and a system for processing documents that contain chemical names. The system has a unit to partition document text and to assign semantic meaning to words; a unit to recognize any substructures present in the chemical name fragments; and a unit to determine structural connectivity information of the chemical name fragments and recognized substructures and to store the determined structural connectivity information in a searchable index. The system further includes a unit to search a text index using at least one of a fragment name and a substructure name and to search the structure index by at least one of fragment connectivity and substructure connectivity. At an intersection of the search results from the structure index and the text index, the system operates to identify at least one document that contains a reference to a corresponding chemical compound.
摘要翻译：公开了一种用于处理含有化学名称的文件的方法，计算机程序产品和系统。该系统具有分隔文档文本并为语义分配语义的单位; 识别化学名称片段中存在的任何亚结构的单元; 以及用于确定化学名称片段和识别的子结构的结构连接性信息并将确定的结构连接性信息存储在可搜索的索引中的单元。该系统还包括使用片段名称和子结构名称中的至少一个来搜索文本索引的单元，并且通过片段连接性和子结构连接性中的至少一个来搜索结构索引。在结构索引和文本索引的搜索结果的交集处，系统操作以识别包含对相应化合物的引用的至少一个文档。

10. 发明申请

US20060142313A1 Rho-kinase inhibitors 审中-公开
公开(公告)号：US20060142313A1
公开(公告)日：2006-06-29
申请号：US11354977
申请日：2006-02-16
申请人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
发明人： Dhanaphalan Nagarathnam , Davoud Asgari , Jianxing Shao , Xiao-Gao Liu , Uday Khire , Chunguang Wang , Barry Hart , Stephen Boyer , Olaf Weber , Mark Lynch
IPC分类号： A61K31/517 , A61K31/4709 , C07D403/02
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

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