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1. 发明授权

US08796253B2 Heteroaryl substituted pyrazole derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权
标题翻译：用于治疗高增殖性疾病和与血管生成相关的疾病的杂芳基取代的吡唑衍生物
公开(公告)号：US08796253B2
公开(公告)日：2014-08-05
申请号：US12600640
申请日：2008-05-08
申请人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
发明人： Stephen Boyer , Michael Härter , Philip Wickens , Manoj Patel , Ellalahewage Sathyajith Kumarasinghe , Ajay Kumar Bhargava , Karl-Heinz Thierauch , Hartmut Beck , Susanne Greschat , Peter Ellinghaus , Patrick Paulus , Holger Hess-Stumpp
IPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D471/04 , C07D491/04
CPC分类号： C07D413/04 , C07D403/04 , C07D413/14 , C07D471/04 , C07D491/04
摘要： This invention relates to novel heteroaryl substituted pyrazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients or therapeutic measures.
摘要翻译：本发明涉及新颖的杂芳基取代的吡唑化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用作治疗高增殖和/或血管发生障碍作为唯一试剂或与其它活性成分或治疗措施组合的用途。

2. 发明授权

US08424732B1 Child carrier having adaptive leg supports 有权
标题翻译：具有自适应腿部支撑的儿童托架
公开(公告)号：US08424732B1
公开(公告)日：2013-04-23
申请号：US13429327
申请日：2012-03-24
申请人： Lisbeth Hals Lehan , Stephen Boyer Lehan
发明人： Lisbeth Hals Lehan , Stephen Boyer Lehan
IPC分类号： A61G1/00 , A45F3/14 , A45F3/04 , A45F3/08
CPC分类号： A45F3/04 , A45F3/08 , A47D13/025
摘要： A carrier for transporting a child by a transporting individual The carrier includes a torso support part configured for supporting at least part of the torso of the child if the child is seated in the carrier, a seat support part coupled to the torso support part and configured for supporting the posterior of the child, and a hip belt coupled to the seat support part and configured for securing about the hips of the transporting individual. The seat support part is configured for enabling one or both upper legs of the child to hang substantially unsupported and in at least one alternative configuration at least one upper-leg-support part is coupled to the seat support part and to the hip belt and is configured for supporting at least part of one or both upper legs of the child.
摘要翻译：用于由运输个体运送儿童的托架运载器包括躯干支撑部分，其构造成用于在儿童坐在托架中时支撑儿童的至少一部分躯干;耦合到躯干支撑部分的座椅支撑部分，用于支撑儿童的后部，以及髋部带，其联接到座椅支撑部分并且构造成用于固定在运送个体的臀部周围。座椅支撑部分被构造成使儿童的一个或两个上腿基本上悬挂不动，并且在至少一个替代配置中，至少一个上腿支撑部分联接到座椅支撑部分和臀部带，并且是被配置为用于支撑所述儿童的一个或两个大腿的至少一部分。

3. 发明授权

US07557129B2 Cyanopyridine derivatives useful in the treatment of cancer and other disorders 有权
标题翻译：可用于治疗癌症和其他疾病的氰基吡啶衍生物
公开(公告)号：US07557129B2
公开(公告)日：2009-07-07
申请号：US10788029
申请日：2004-02-27
申请人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
发明人： William J. Scott , Jacques Dumas , Stephen Boyer , Wendy Lee , Yuanwei Chen , Barton Phillips , Sharad Verma , Jianqing Chen , Zhi Chen , Jianmei Fan , Brian Raudenbush , Aniko Redman , Lin Yi , Qingming Zhu , Lila Adnane
IPC分类号： A61K31/4433 , C07D405/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

4. 发明申请

US20080118403A1 Well Plate Reactor 有权
标题翻译：井板反应堆
公开(公告)号：US20080118403A1
公开(公告)日：2008-05-22
申请号：US12024973
申请日：2008-02-01
申请人： David Klein , Stephen Boyer , Gregory Andronaco
发明人： David Klein , Stephen Boyer , Gregory Andronaco
IPC分类号： G01N21/64 , B01J19/00 , G01K13/00
CPC分类号： C12M23/12 , B01L3/50851 , B01L3/50853 , B01L2200/143 , B01L2300/049 , B01L2300/0663 , B01L2300/0829 , B01L2300/10 , B01L2300/1822 , B01L2300/1827 , C12M23/38 , C12M41/26 , C12M41/34 , Y10T436/209163
摘要： A well plate and its supporting devices provide capabilities found in larger fermenters, such as controlling the oxygen level, the pH level, and temperature of the contents of the well. The well plate includes a plurality of wells, each of which can be independently controlled. Apertures in the wells, for example, provide access for a gas supply and sensors within each well provide data relating to, e.g., oxygen and/or pH level in the well. A control system controls the gas supply for each well based on the information provided by the sensor within the well. Similarly, temperature control elements, such as a heater or cooler, is placed in thermal contact with the interior of the well, as is a temperature measurement element. A control system can independently control the temperature of the contents of the well based on information provided by the temperature measurement element for that well.
摘要翻译：井板及其支撑装置提供在较大发酵罐中发现的能力，例如控制井的内容物的氧气水平，pH水平和温度。井板包括多个井，每个井可独立控制。例如，孔中的孔径为气体供应提供通路，并且每个井内的传感器提供与井中的氧气和/或pH水平有关的数据。控制系统根据由井内的传感器提供的信息来控制每个井的气体供应。类似地，诸如加热器或冷却器的温度控制元件也被放置成与井的内部热接触，温度测量元件也是如此。控制系统可以根据井的温度测量元件提供的信息独立地控制井的内部温度。

5. 发明申请

US20070112833A1 System and method for annotating patents with MeSH data 审中-公开
标题翻译：使用MeSH数据注释专利的系统和方法
公开(公告)号：US20070112833A1
公开(公告)日：2007-05-17
申请号：US11281290
申请日：2005-11-17
申请人： Robert Angell , Stephen Boyer , James Cooper , Richard Hennessy , Tapas Kanungo , Jeffrey Kreulen , David Martin , James Rhodes , W. Spangler , Herschel Weintraub
发明人： Robert Angell , Stephen Boyer , James Cooper , Richard Hennessy , Tapas Kanungo , Jeffrey Kreulen , David Martin , James Rhodes , W. Spangler , Herschel Weintraub
IPC分类号： G06F7/00
CPC分类号： G06F16/353 , G06F16/382
摘要： A system and method for enhancing patent documents. A system is disclosed that includes: an extraction system for extracting non-patent references from a patent document; a system for cross-referencing an extracted non-patent reference with a metadata database to identify metadata information associated with the extracted non-patent reference; and a system for annotating the patent document with the metadata information.
摘要翻译：一种加强专利文献的制度和方法。公开了一种系统，包括：从专利文献中提取非专利文献的提取系统; 用于使用元数据数据库交叉引用提取的非专利参考以识别与所提取的非专利参考相关联的元数据信息的系统; 以及用元数据信息注释专利文献的系统。

6. 发明申请

US20070112748A1 System and method for using text analytics to identify a set of related documents from a source document 有权
标题翻译：使用文本分析从源文档中标识一组相关文档的系统和方法
公开(公告)号：US20070112748A1
公开(公告)日：2007-05-17
申请号：US11281291
申请日：2005-11-17
申请人： Robert Angell , Stephen Boyer , James Cooper , Richard Hennessy , Tapas Kanungo , Jeffrey Kreulen , David Martin , James Rhodes , W. Spangler , Herschel Weintraub
发明人： Robert Angell , Stephen Boyer , James Cooper , Richard Hennessy , Tapas Kanungo , Jeffrey Kreulen , David Martin , James Rhodes , W. Spangler , Herschel Weintraub
IPC分类号： G06F17/30
CPC分类号： G06F17/27
摘要： A system and method for processing a document to generate a set of related documents. A system is provided that includes a textual analytics system that analyzes unstructured data contained in a source document and extracts a set of structured information about the source document; and a compare system that identifies a set of related documents by comparing the set of structured information with metadata indexed from a set of publications.
摘要翻译：一种用于处理文档以生成一组相关文档的系统和方法。提供了一种系统，其包括文本分析系统，其分析源文档中包含的非结构化数据并提取关于源文档的一组结构化信息; 以及比较系统，通过将结构化信息集与从一组出版物索引的元数据进行比较来识别一组相关文档。

7. 发明申请

US20050192304A1 Rho-kinase inhibitors 审中-公开
标题翻译： Rho激酶抑制剂
公开(公告)号：US20050192304A1
公开(公告)日：2005-09-01
申请号：US11107793
申请日：2005-04-18
申请人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号： A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D43/02
CPC分类号： C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.
摘要翻译：公开了其化合物及其衍生物，其合成及其作为Rho-激酶抑制剂的用途。这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍和治疗由Rho-激酶介导的其它适应症，例如冠心病。

8. 发明授权

US06924290B2 Rho-kinase inhibitors 失效
公开(公告)号：US06924290B2
公开(公告)日：2005-08-02
申请号：US10349177
申请日：2003-01-23
申请人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
发明人： Dhanapalan Nagarathnam , Jacques Dumas , Holia Hatoum-Mokdad , Stephen Boyer , Chunguang Wang , Hans Pluempe , Achim Feurer , Samir Bennabi
IPC分类号： A61K31/505 , A61K31/506 , A61K31/517 , A61K31/519 , A61P7/02 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/06 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/28 , A61P27/06 , A61P35/00 , A61P43/00 , C07B57/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
CPC分类号： C07D239/48 , A61K31/506 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D471/04
摘要： Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

9. 发明申请

US20050019424A1 Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives 审中-公开
标题翻译：包含哒嗪或吡啶衍生物的抗血管生成联合疗法
公开(公告)号：US20050019424A1
公开(公告)日：2005-01-27
申请号：US10498935
申请日：2002-12-20
申请人： Paul Adams , Stephen Boyer , Jacques Dumas , James Elting , Harold Kluender
发明人： Paul Adams , Stephen Boyer , Jacques Dumas , James Elting , Harold Kluender
IPC分类号： A61K31/501 , A61K31/502 , A61K31/5025 , A61K45/06 , A61P35/00 , A61K33/24
CPC分类号： A61K45/06 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K2300/00
摘要： The invention relates generally to the use of certain substituted fused or unfused pyridazine or pyridine derivatives which are KDR inhibitors in combination with other chemotherapeutic agents for use in treatment of diseases associated with abnormal angiogenesis and/or hyperpermeability and/or hyperproliferative diseases, such as cancer.
摘要翻译：本发明一般涉及某些取代的稠合或未融合的哒嗪或吡啶衍生物，其是KDR抑制剂与其它化学治疗剂的组合，用于治疗与异常血管发生和/或高渗透性和/或过度增生性疾病如癌症相关的疾病。

10. 发明授权

US08701949B1 Child carrier having adaptive leg supports 有权
标题翻译：具有自适应腿部支撑的儿童托架
公开(公告)号：US08701949B1
公开(公告)日：2014-04-22
申请号：US13779566
申请日：2013-02-27
申请人： Lisbeth Hals Lehan , Stephen Boyer Lehan
发明人： Lisbeth Hals Lehan , Stephen Boyer Lehan
IPC分类号： A47D13/02
CPC分类号： A45F3/04 , A45F3/047 , A45F3/08 , A45F2003/144 , A47D13/025
摘要： A carrier for transporting a child by a transporting individual The carrier includes a torso support part configured for supporting at least part of the torso of the child if the child is seated in the carrier, a seat support part coupled to the torso support part and configured for supporting the posterior of the child, and a hip belt coupled to the seat support part and configured for securing about the hips of the transporting individual. The seat support part is configured for enabling one or both upper legs of the child to hang substantially unsupported and in at least one alternative configuration at least one upper-leg-support part is coupled to the seat support part and to the hip belt and is configured for supporting at least part of one or both upper legs of the child.
摘要翻译：用于由运输个体运送儿童的托架运载器包括躯干支撑部分，其构造成用于在儿童坐在托架中时支撑儿童的至少一部分躯干;耦合到躯干支撑部分的座椅支撑部分，用于支撑儿童的后部，以及髋部带，其联接到座椅支撑部分并且构造成用于固定在运送个体的臀部周围。座椅支撑部分被构造成使儿童的一个或两个上腿基本上悬挂不动，并且在至少一个替代配置中，至少一个上腿支撑部分联接到座椅支撑部分和臀部带，并且是被配置为用于支撑所述儿童的一个或两个大腿的至少一部分。

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