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1. 发明授权

US5795764A Enzyme exhibiting mannanase activity 失效
标题翻译：展示甘露聚糖酶活性的酶
公开(公告)号：US5795764A
公开(公告)日：1998-08-18
申请号：US525697
申请日：1995-09-21
申请人： Stephan Christgau , Lene Venke Kofod , Lene Nonboe Andersen , Sakari Kauppinen , Hans Peter Heldt-Hansen , Henrik Dalboege
发明人： Stephan Christgau , Lene Venke Kofod , Lene Nonboe Andersen , Sakari Kauppinen , Hans Peter Heldt-Hansen , Henrik Dalboege
IPC分类号： A23L2/80 , C09K8/90 , C12N9/24 , C12N15/56 , C07H21/04 , C12N1/14 , C12N15/00
CPC分类号： C09K8/905 , A23L2/80 , C12N9/2488 , C12Y302/01025 , C12Y302/01078
摘要： An enzyme exhibiting mannanase activity, which enzyme i) is immunologically reactive with an antibody raised against a purified mannanase derived from Aspergillus aculeatus, CBS 101.43; ii) is encoded by the DNA sequences shown in SEQ ID No. 1 or an analogue of said sequence, and/or; iii) comprises the amino acid sequence shown in SEQ ID No. 2 or a sequence being an least 70% homologous thereto. The enzyme may be used for various purposes for which degradation or modification of a plant or algal cell wall material is desirable.
摘要翻译： PCT No.PCT / DK94 / 00174 Sec。 371 1995年9月21日第 102（e）1995年9月21日PCT PCT 1994年4月28日PCT公布。出版物WO94 / 25576 日期1994年11月10日具有甘露聚糖酶活性的酶，该酶i）与针对源自Aspergillus aculeatus的纯化甘露聚糖酶产生的抗体具有免疫反应性，CBS 101.43; ii）由SEQ ID No.1所示的DNA序列或所述序列的类似物编码，和/或; iii）包含SEQ ID No.2所示的氨基酸序列或与其至少70％同源的序列。该酶可用于各种目的，其中期望降解或修饰植物或藻类细胞壁材料。

2. 发明授权

US5707847A Enzyme exhibiting pectin methylesterase activity 失效
标题翻译：酶显示果胶甲酯酶活性
公开(公告)号：US5707847A
公开(公告)日：1998-01-13
申请号：US535230
申请日：1995-11-02
申请人： Stephan Christgau , Lene Venke Kofod , Lene Nonboe Andersen , Sakari Kauppinen , Hans Peter Heldt-Hansen , Gitte Budolfsen , Henrik Dalb.o slashed.ge
发明人： Stephan Christgau , Lene Venke Kofod , Lene Nonboe Andersen , Sakari Kauppinen , Hans Peter Heldt-Hansen , Gitte Budolfsen , Henrik Dalb.o slashed.ge
IPC分类号： C12N9/18 , C12N15/55 , C12N9/16
CPC分类号： C12N9/18
摘要： An enzyme exhibiting pectin methyl esterase activity, wherein the enzyme a) is derived from Aspergillus aculeatus; b) is encoded by Seq ID No:1; or c) has the amino acid sequence of Seq ID No:2 or a sequence which is at least 95% homologous thereto. An enzyme can be used for the modification of plant cell wall components.
摘要翻译： PCT No.PCT / DK94 / 00173 Sec。 371日期：1995年11月2日 102（e）1995年11月2日PCT PCT 1994年4月28日PCT公布。第WO94 / 25575号公报日期：1994年11月10日显示果胶甲酯酶活性的酶，其中所述酶a）源自棘孢曲霉; b）由Seq ID No：1编码; 或c）具有Seq ID No.2的氨基酸序列或与其至少95％同源的序列。酶可用于植物细胞壁组分的修饰。

3. 发明授权

US5827719A Enzyme with lipolytic activity 失效
标题翻译：具有脂肪分解活性的酶
公开(公告)号：US5827719A
公开(公告)日：1998-10-27
申请号：US817997
申请日：1997-04-25
申请人： Thomas Sandal , Sakari Kauppinen , Lene Venke Kofod
发明人： Thomas Sandal , Sakari Kauppinen , Lene Venke Kofod
IPC分类号： C12N15/09 , C11D3/386 , C12N1/15 , C12N9/20 , C12N15/00 , C12R1/645 , C12R1/865 , C12N15/55 , C12N15/63 , C12P21/02
CPC分类号： C12N9/20
摘要： The invention relates, inter alia, to a DNA construct comprising a DNA sequence which encodes an enzyme exhibiting lipolytic activity and which comprises: a) the DNA sequence shown in SEQ ID No. 1, or b) an analogue of the DNA sequence shown in SEQ ID No. 1 which i) is homologous with the DNA sequence shown in SEQ ID No. 1, and/or ii) hybridizes with the same oligonucleotide probe as the DNA sequence shown in SEQ ID No. 1, and/or iii) encodes a polypeptide which is homologous with the polypeptide encoded by a DNA sequence comprising the DNA sequence shown in SEQ ID No. 1, and/or iv) encodes a polypeptide which is immunologically reactive with an antibody raised against a purified lipolytic enzyme which is encoded by the DNA sequence shown in SEQ ID No. 1 and/or which is derived from Humicola insolens DSM 1800. Also disclosed, inter alia, are: lipolytic enzymes encoded by such DNA constructs; and enzyme preparations, detergent additives and detergent compositions comprising such lipolytic enzymes.
摘要翻译： PCT No.PCT / DK95 / 00427 Sec。 371日期1997年04月25日 102（e）日期1997年4月25日PCT提交1995年10月26日PCT公布。公开号WO96 / 13580 日期1996年5月9日本发明尤其涉及包含编码表现出脂肪分解活性的酶的DNA序列的DNA构建体，其包含：a）SEQ ID No.1所示的DNA序列，或b）序列号1所示的DNA序列，其i）与SEQ ID No.1所示的DNA序列同源，和/或ii）与与SEQ ID No.1所示的DNA序列相同的寡核苷酸探针杂交， /或iii）编码与由包含SEQ ID No.1所示的DNA序列的DNA序列编码的多肽同源的多肽，和/或iv）编码与针对纯化的脂肪分解产生的抗体具有免疫反应性的多肽由SEQ ID No.1所示的DNA序列和/或源自Humicola insolens DSM 1800的DNA序列编码的酶。特别地，还公开了由这些DNA构建体编码的脂肪分解酶。和酶制剂，洗涤剂添加剂和包含这种脂肪分解酶的洗涤剂组合物。

4. 发明授权

US08729250B2 Antisense oligonucleotides for inhibition of microRNA-21 有权
标题翻译：用于抑制microRNA-21的反义寡核苷酸
公开(公告)号：US08729250B2
公开(公告)日：2014-05-20
申请号：US13415685
申请日：2012-03-08
申请人： Joacim Elmén , Phil Kearney , Sakari Kauppinen
发明人： Joacim Elmén , Phil Kearney , Sakari Kauppinen
IPC分类号： C07H21/04 , C12N15/11
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3515 , C12N2310/3521 , C12N2310/3533
摘要： The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from the group consisting of miR19b, miR21, miR122a, miR155 and miR375. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC.
摘要翻译：本发明提供包含长度为8至26个核碱基的短单链寡核苷酸的药物组合物，其与选自miR19b，miR21，miR122a，miR155和miR375的人微小RNA互补。短的寡核苷酸在减轻体内抑制miRNA方面特别有效。发现将高亲和力核苷酸类似物并入寡核苷酸导致高度有效的抗微小RNA分子，其似乎通过与miRNA靶标形成几乎不可逆的双链体起作用，而不是基于RNA切割的机制，例如与 RNaseH或RISC。

5. 发明申请

US20100010072A1 MICRORNA BIOMARKERS FOR HUMAN BREAST AND LUNG CANCER 有权
标题翻译： MICRORNA生物标记用于人类乳腺癌和肺癌
公开(公告)号：US20100010072A1
公开(公告)日：2010-01-14
申请号：US12436576
申请日：2009-05-06
申请人： Ethan DMITROVSKY , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
发明人： Ethan DMITROVSKY , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
IPC分类号： A61K31/7088 , C07H21/00 , A61P35/00
CPC分类号： A61K45/06 , A61K31/7105 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于诊断和分类人乳腺癌和肺癌的新型分子标志物。

6. 发明申请

US20070117144A1 Oligonucleotides useful for detecting and analyzing nucleic acids of interest 审中-公开
标题翻译：可用于检测和分析感兴趣的核酸的寡核苷酸
公开(公告)号：US20070117144A1
公开(公告)日：2007-05-24
申请号：US11643615
申请日：2006-12-21
申请人： Sakari Kauppinen , Carsten Alsbo , Peter Nielsen , Daniel Jeffares , Tobias Mourier , Soren Mork , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing
发明人： Sakari Kauppinen , Carsten Alsbo , Peter Nielsen , Daniel Jeffares , Tobias Mourier , Soren Mork , Peter Arctander , Niels Tommerup , Niels Tolstrup , Henrik Vissing
IPC分类号： C12Q1/68
CPC分类号： C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00
摘要： The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a biological sample or a patient sample.
摘要翻译：本发明的特征在于改进的核酸和用于mRNA表达谱的方法，特异性mRNA剪接变体的鉴定和分析，以及检测特定外显子或其他剪接变体的突变，缺失或重复，例如与疾病如癌症相关的改变，在核酸样品中，例如生物样品或患者样品。

7. 发明授权

US07186513B2 Methods for monitoring multiple gene expression 有权
标题翻译：多基因表达监测方法
公开(公告)号：US07186513B2
公开(公告)日：2007-03-06
申请号：US10653047
申请日：2003-08-29
申请人： Randy M. Berka , Michael W. Rey , Jeffrey R. Shuster , Sakari Kauppinen , Ib Groth Clausen , Peter Bjarke Olsen
发明人： Randy M. Berka , Michael W. Rey , Jeffrey R. Shuster , Sakari Kauppinen , Ib Groth Clausen , Peter Bjarke Olsen
IPC分类号： C12Q1/68 , C12N15/30
CPC分类号： C12Q1/6895 , C07K14/37 , C12Q1/6837 , C12Q2600/158
摘要： The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing filamentous fungal expressed sequenced tags. The present invention also relates to filamentous fungal expressed sequenced tags and to computer readable media and substrates containing such expressed sequenced tags for monitoring expression of a plurality of genes in filamentous fungal cells.
摘要翻译：本发明涉及用于使用含有丝状真菌表达的测序标签的微阵列来监测第一丝状真菌细胞中多个基因的差异表达相对于在一个或多个第二丝状真菌细胞中表达相同基因的方法。本发明还涉及丝状真菌表达的测序标签以及包含用于监测丝状真菌细胞中多种基因的表达的表达的测序标签的计算机可读介质和底物。

8. 发明授权

US09056135B2 MicroRNA biomarkers for human breast and lung cancer 有权
标题翻译：用于人乳腺癌和肺癌的微小RNA生物标志物
公开(公告)号：US09056135B2
公开(公告)日：2015-06-16
申请号：US13478408
申请日：2012-05-23
申请人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo F. Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
发明人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo F. Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
IPC分类号： C07H21/04 , A61K45/06 , C12N15/11 , C12N15/113 , C12Q1/68 , A61K31/7105
CPC分类号： A61K45/06 , A61K31/7105 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于人乳腺癌和肺癌诊断和分类的新型分子标志物。

9. 发明授权

US08163708B2 Pharmaceutical composition comprising anti-mirna antisense oligonucleotide 有权
标题翻译：包含抗mirna反义寡核苷酸的药物组合物
公开(公告)号：US08163708B2
公开(公告)日：2012-04-24
申请号：US12295960
申请日：2007-03-30
申请人： Joacim Elmén , Phil Kearney , Sakari Kauppinen
发明人： Joacim Elmén , Phil Kearney , Sakari Kauppinen
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3515 , C12N2310/3521 , C12N2310/3533
摘要： The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from the group consisting of miR19b, miR21, miR122a, miR155 and miR375. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC.
摘要翻译：本发明提供包含长度为8至26个核碱基的短单链寡核苷酸的药物组合物，其与选自miR19b，miR21，miR122a，miR155和miR375的人微小RNA互补。短的寡核苷酸在减轻体内抑制miRNA方面特别有效。发现将高亲和力核苷酸类似物并入寡核苷酸导致高度有效的抗微小RNA分子，其似乎通过与miRNA靶标形成几乎不可逆的双链体而不是基于RNA切割的机制，例如与 RNaseH或RISC。

10. 发明申请

US20090286753A1 NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF MICRORNAS AND THEIR TARGET MRNAS 审中-公开
标题翻译：新的寡核苷酸组合物和探针序列有用于检测和分析微阵列及其目标片段
公开(公告)号：US20090286753A1
公开(公告)日：2009-11-19
申请号：US12098213
申请日：2008-04-04
申请人： Sakari Kauppinen , Ronald Plasterk , Erno Wienholds , Wigard Kloosterman
发明人： Sakari Kauppinen , Ronald Plasterk , Erno Wienholds , Wigard Kloosterman
IPC分类号： A61K38/16 , C07H21/00 , A61P43/00
CPC分类号： C12N15/111 , C12N2310/141 , C12N2320/11 , C12Q1/6813 , C12Q1/6827 , C12Q1/6832 , C12Q1/6841 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , G16B25/00 , G16B30/00 , C12Q2527/107 , C12Q2525/207 , C12Q2525/101
摘要： The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs).
摘要翻译：本发明涉及可用于检测和分析微小RNA及其靶mRNA以及小干扰RNA（siRNA）的核糖核酸和寡核苷酸探针。

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