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1. 发明授权

US08207325B2 MicroRNA biomarkers for human breast and lung cancer 有权
标题翻译：用于人乳腺癌和肺癌的微小RNA生物标志物
公开(公告)号：US08207325B2
公开(公告)日：2012-06-26
申请号：US12436576
申请日：2009-05-06
申请人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
发明人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
IPC分类号： C07H21/04
CPC分类号： A61K45/06 , A61K31/7105 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于人乳腺癌和肺癌诊断和分类的新型分子标志物。

2. 发明授权

US07955848B2 MicroRNA biomarkers for human breast and lung cancer 有权
标题翻译：用于人乳腺癌和肺癌的微小RNA生物标志物
公开(公告)号：US07955848B2
公开(公告)日：2011-06-07
申请号：US11730570
申请日：2007-04-02
申请人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
发明人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2320/12 , C12Q1/6886 , C12Q2600/112 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于人乳腺癌和肺癌诊断和分类的新型分子标志物。

3. 发明授权

US07628382B2 Nail extractor, moulding remover and pry bar tool with indexable head 有权
标题翻译：指甲提取器，成型除去器和具有可转位头部的撬棒工具
公开(公告)号：US07628382B2
公开(公告)日：2009-12-08
申请号：US12009780
申请日：2008-01-22
申请人： Charles Cole
发明人： Charles Cole
IPC分类号： B66F15/00 , B25C11/00
CPC分类号： B25C11/00
摘要： A tool head member being a nail extractor or molding remover having a striking surface on the end opposite the nail extractor/molding remover end or a pry bar, any of the foregoing tool head members being indexably coupled to a handle member. The indexable tool head allows the user to lockably index the tool head into a more desirable position for removing nails or molding.
摘要翻译：一种工具头构件，其是指甲提取器或模制移除器，其具有在与拔钉器/模制件移除端相对的端部上的击打表面或撬棒，任何前述工具头构件可转位地联接到手柄构件。可转位工具头允许使用者将工具头可锁定地转换到更理想的位置，以去除钉子或模制件。

4. 发明申请

US20060260445A1 Adjustable tools 有权
标题翻译：可调工具
公开(公告)号：US20060260445A1
公开(公告)日：2006-11-23
申请号：US11434701
申请日：2006-05-16
申请人： Charles Cole
发明人： Charles Cole
IPC分类号： B25B23/16 , B25G3/28
CPC分类号： B25G1/063 , B25G1/06 , Y10T403/7026
摘要： Adjustable tools which may be linked through a coupling so that the tool and the handle are rotatable relative to each other in a released condition and locked relative to each other in a locked position. The tool and the handle may thus be adjusted to have the tool at any desired orientation to the handle and in a locked position in that orientation.
摘要翻译：可调整的工具，其可以通过联接件连接，使得工具和手柄在释放状态下可相对于彼此旋转并且在锁定位置相对于彼此锁定。因此，可以调整工具和手柄以使工具在手柄处于任何期望的方位并且在该取向处于锁定位置。

5. 发明授权

US09056135B2 MicroRNA biomarkers for human breast and lung cancer 有权
标题翻译：用于人乳腺癌和肺癌的微小RNA生物标志物
公开(公告)号：US09056135B2
公开(公告)日：2015-06-16
申请号：US13478408
申请日：2012-05-23
申请人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo F. Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
发明人： Ethan Dmitrovsky , Xi Liu , Sarah Freemantle , Lorenzo F. Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
IPC分类号： C07H21/04 , A61K45/06 , C12N15/11 , C12N15/113 , C12Q1/68 , A61K31/7105
CPC分类号： A61K45/06 , A61K31/7105 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于人乳腺癌和肺癌诊断和分类的新型分子标志物。

6. 发明授权

US07836620B2 Animated media and methods of construction 有权
标题翻译：动画媒体和施工方法
公开(公告)号：US07836620B2
公开(公告)日：2010-11-23
申请号：US12176805
申请日：2008-07-21
申请人： Jeffrey Charles Cole
发明人： Jeffrey Charles Cole
IPC分类号： G09F19/00
CPC分类号： G09F1/04 , A63H33/38 , B42D1/007 , B42D15/042 , B42D15/047 , G09F19/12
摘要： Animated printed media (e.g., greeting cards, books, etc.) are disclosed herein. An animated printed medium according to one embodiment includes two pages that define a pocket therebetween. At least one of the pages has a window with a plurality of spaced apart transparent sections, and a pushsleeve is coupled to an element that is rotatable relative to the two pages. The pushsleeve extends in the pocket and has a coded image positioned to move beneath the window. A fold line is between the pushsleeve and the element to allow the pushsleeve to rotate relative to the element. The pushsleeve is movable between a first position where the element is between the fold line and the window and a second position where the fold line is between the element and the window. Movement of the pushsleeve between the first and second positions causes the coded image to move beneath the window.
摘要翻译：本文公开了动画印刷媒体（例如，贺卡，书籍等）。根据一个实施例的动画打印介质包括在其间限定凹处的两个页面。页面中的至少一个具有带有多个间隔开的透明部分的窗口，并且推挽件联接到可相对于两个页面旋转的元件。推鞋延伸在口袋中，并具有定位成在窗户下方移动的编码图像。折叠线在推挽和元件之间以允许推relative相对于元件旋转。推杆可以在元件在折叠线和窗口之间的第一位置和折叠线在元件和窗口之间的第二位置之间移动。在第一和第二位置之间的推挽的移动导致编码图像在窗口下方移动。

7. 发明授权

US5864973A 3-D greeting card 失效
标题翻译： 3-D贺卡
公开(公告)号：US5864973A
公开(公告)日：1999-02-02
申请号：US250365
申请日：1994-05-27
申请人： Jeffrey Charles Cole
发明人： Jeffrey Charles Cole
IPC分类号： A63H33/38 , B42D15/04 , A63H33/00
CPC分类号： A63H33/38 , B42D15/042
摘要： An improvement is added to the existing concept of using a mirrored surface to reflect a half symmetrical image which is printed on an adjoining card. The improvement is adding a perspective drawing of a related vertical object on the mirrored surface. The vertical object is positioned to interact in a coherent manner with the reflection of the half symmetrical image. The interaction between the images provides an enhanced 3-D phenomena. Additionally objects such as a ball seem to float out of the 3-D image. One embodiment further adds a movable tab which allows modifying the overall image. The invention can be used for greeting cards, books, baseball hat peaks, and assorted novelty items.
摘要翻译：现有的使用镜像表面反映印刷在相邻卡片上的半对称图像的概念增加了一个改进。改进之处是在镜像表面上添加相关垂直对象的透视图。垂直物体定位成与半对称图像的反射以相干方式相互作用。图像之间的相互作用提供了增强的3-D现象。另外，诸如球的物体似乎漂浮在3-D图像之外。一个实施例还增加了一个允许修改整个图像的可移动片。本发明可用于贺卡，书籍，棒球帽和各种新奇物品。

8. 发明申请

US20140013620A1 RELEASABLE CONNECTION SYSTEM 审中-公开
标题翻译：可释放的连接系统
公开(公告)号：US20140013620A1
公开(公告)日：2014-01-16
申请号：US13546522
申请日：2012-07-11
申请人： Charles Cole
发明人： Charles Cole
IPC分类号： A43B13/14 , A43B1/14 , A43B13/04 , F16B11/00
CPC分类号： B62M3/086 , A43B1/10 , A43B5/14 , A43B13/04 , A43B13/22 , A43B13/223 , B29C65/56 , B29C65/64 , B29C65/76 , B29C66/1122 , B29C66/21 , B29C66/30321 , B29C66/71 , B29C66/7315 , B29K2995/0046 , B29L2031/504 , F16B2/005 , F16B5/07 , Y10T403/47 , B29K2019/00
摘要： In certain embodiments there is provided a connection system having at least one male engagement component configured to interact with a female engagement component. The female engagement component is formed of a material that, when pressure is applied, enables the at least one male engagement component to imprint into the material so that a closed connection may be formed to lock the positioning of the two components. The material is also configured to flow/float around the male engagement component so that the position of the male engagement component with respect to the female engagement component may be adjusted while the two engagement components are in contact and the male engagement component is not imprinted within the female engagement component.
摘要翻译：在某些实施例中，提供了一种连接系统，该连接系统具有被配置为与阴接合部件相互作用的至少一个阳接合部件。阴接合部件由一种材料形成，当施加压力时，能够使至少一个阳接合部件压印到材料中，使得可以形成闭合连接以锁定两个部件的定位。该材料还构造成围绕阳接合部件流动/浮动，使得阳接合部件相对于阴接合部件的位置可以在两个接合部件接触并且阳接合部件不被压印在内部的情况下被调节女性参与组件。

9. 发明申请

US20100011636A1 Animated Media And Methods Of Construction 有权
标题翻译：动画媒体和施工方法
公开(公告)号：US20100011636A1
公开(公告)日：2010-01-21
申请号：US12176805
申请日：2008-07-21
申请人： Jeffrey Charles Cole
发明人： Jeffrey Charles Cole
IPC分类号： G09F1/00
CPC分类号： G09F1/04 , A63H33/38 , B42D1/007 , B42D15/042 , B42D15/047 , G09F19/12
摘要： Animated printed media (e.g., greeting cards, books, etc.) are disclosed herein. An animated printed medium according to one embodiment includes two pages that define a pocket therebetween. At least one of the pages has a window with a plurality of spaced apart transparent sections, and a pushsleeve is coupled to an element that is rotatable relative to the two pages. The pushsleeve extends in the pocket and has a coded image positioned to move beneath the window. A fold line is between the pushsleeve and the element to allow the pushsleeve to rotate relative to the element. The pushsleeve is movable between a first position where the element is between the fold line and the window and a second position where the fold line is between the element and the window. Movement of the pushsleeve between the first and second positions causes the coded image to move beneath the window.
摘要翻译：本文公开了动画印刷媒体（例如，贺卡，书籍等）。根据一个实施例的动画打印介质包括在其间限定凹处的两个页面。页面中的至少一个具有带有多个间隔开的透明部分的窗口，并且推挽件联接到可相对于两个页面旋转的元件。推鞋延伸在口袋中，并具有定位成在窗户下方移动的编码图像。折叠线在推挽和元件之间以允许推relative相对于元件旋转。推杆可以在元件在折叠线和窗口之间的第一位置和折叠线在元件和窗口之间的第二位置之间移动。在第一和第二位置之间的推挽的移动导致编码图像在窗口下方移动。

10. 发明申请

US20100010072A1 MICRORNA BIOMARKERS FOR HUMAN BREAST AND LUNG CANCER 有权
标题翻译： MICRORNA生物标记用于人类乳腺癌和肺癌
公开(公告)号：US20100010072A1
公开(公告)日：2010-01-14
申请号：US12436576
申请日：2009-05-06
申请人： Ethan DMITROVSKY , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
发明人： Ethan DMITROVSKY , Xi Liu , Sarah Freemantle , Lorenzo Sempere , Charles Cole , Sakari Kauppinen , Mads Bak , Mette Christensen
IPC分类号： A61K31/7088 , C07H21/00 , A61P35/00
CPC分类号： A61K45/06 , A61K31/7105 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12N2320/12 , C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
摘要翻译：本发明涉及用于诊断和分类人乳腺癌和肺癌的新型分子标志物。

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