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1. 发明申请

US20080152815A1 Self-healing coating and microcapsules to make same 审中-公开
标题翻译：自愈膜和微胶囊相同
公开(公告)号：US20080152815A1
公开(公告)日：2008-06-26
申请号：US11789811
申请日：2007-02-22
申请人： Larry D. Stephenson , Curtis Thies , Ashok Kumar , Srinivasan Sarangapani
发明人： Larry D. Stephenson , Curtis Thies , Ashok Kumar , Srinivasan Sarangapani
IPC分类号： C08K9/10 , B05D3/00 , B32B5/16
CPC分类号： C09D5/086 , B05D5/005 , C08K9/10 , C09D7/69 , C09D7/70 , Y10T428/2984 , Y10T428/2985
摘要： A self-healing coating, incorporating medium-sized microcapsules filled with a liquid formulation, repairs itself upon physical compromise. In one embodiment, a commercial primer is mixed with these microcapsules and applied. After the coating has cured, any physical compromise of the cured coating results in the microcapsules bursting to release the liquid, in turn filling and sealing the compromised volume of the coating. In applications where a product is used to provide corrosion protection, the liquid contains anti-corrosion material as well as suitable diluents and film-forming compounds. In a preferred embodiment, the microcapsules are provided separately to be mixed with commercial products during preparation for application of the coating. For example, if a paint formulation is known a priori, tailored microcapsules packaged separately from the paint and designed for use with the paint formulation, are wet mixed into the paint during preparation for application.
摘要翻译：包含充满液体制剂的中等尺寸微胶囊的自修复涂层在物理妥协时自行修复。在一个实施方案中，将商业引物与这些微胶囊混合并施用。在涂层固化之后，固化涂层的任何物理损害导致微胶囊破裂以释放液体，反过来填充和密封受损的体积的涂层。在产品用于提供腐蚀保护的应用中，液体含有防腐蚀材料以及合适的稀释剂和成膜化合物。在优选的实施方案中，微胶囊单独提供以在制备涂料期间与商品混合。例如，如果涂料配方是已知的，则预先将与涂料分开包装并设计用于涂料配方的定制微胶囊在制备应用期间被湿混合到涂料中。

2. 发明授权

US07192993B1 Self-healing coating and microcapsules to make same 失效
标题翻译：自愈膜和微胶囊相同
公开(公告)号：US07192993B1
公开(公告)日：2007-03-20
申请号：US10377642
申请日：2003-03-04
申请人： Srinivasan Sarangapani , Ashok Kumar , Curtis Thies , Larry D. Stephenson
发明人： Srinivasan Sarangapani , Ashok Kumar , Curtis Thies , Larry D. Stephenson
IPC分类号： B32B5/16 , B32B9/00 , B32B15/02 , C08K9/00 , C08K9/04
CPC分类号： C09D5/086 , B05D5/005 , C08K9/10 , C09D7/69 , C09D7/70 , Y10T428/2984 , Y10T428/2985
摘要： A liquid self-healing coating, incorporating microcapsules filled with tailored repair formulations, repairs itself upon physical compromise after curing. In one embodiment, a commercially available paint primer is mixed with a pre-specified amount of these microcapsules. After the coating has cured on the substrate to which it is applied, any physical compromise of the cured coating results in the microcapsules bursting to release a liquid that fills and seals the compromised volume of the coating. In applications where paint is used to provide corrosion protection, the liquid contains anti-corrosion material as well as suitable diluents and film-forming compounds. In another embodiment, the microcapsules may be provided separately to enhance commercially available products. For example, if a paint formulation is known a priori, specifically configured microcapsules packaged separately from the paint and designed for use with the paint formulation, may be added to the commercially available product just prior to application.
摘要翻译：液体自修复涂层，包含充满定制修复配方的微胶囊，在固化后的物理折磨下自行修复。在一个实施方案中，将市售的油漆底漆与预定量的这些微胶囊混合。涂层在其所施加的基材上固化之后，固化涂层的任何物理损害导致微胶囊爆裂以释放填充并密封受损的涂层体积的液体。在使用涂料提供防腐蚀保护的应用中，液体含有防腐蚀材料以及合适的稀释剂和成膜化合物。在另一个实施方案中，可以分开提供微胶囊以增强市售产品。例如，如果涂料配方是已知的，则可以在施用之前将先前专门配置的与涂料分开包装且设计用于涂料配方的微胶囊加入市售产品中。

3. 发明申请

US20090270269A1 NANO-SCALE FLUORO-BIOSENSORS EXHIBITING A LOW FALSE ALARM RATE FOR RAPID DETECTION OF BIOLOGICAL CONTAMINANTS 审中-公开
标题翻译：展示生物污染物快速检测的低错误报警率的纳米级荧光生物传感器
公开(公告)号：US20090270269A1
公开(公告)日：2009-10-29
申请号：US12110386
申请日：2008-04-28
申请人： Ashok Kumar , Larry D. Stephenson , Jeremy A. Hale , Elizabeth J. Norton
发明人： Ashok Kumar , Larry D. Stephenson , Jeremy A. Hale , Elizabeth J. Norton
IPC分类号： C12M1/34 , G01N33/50 , C40B30/04
CPC分类号： G01N33/542 , G01N21/6428 , G01N33/54366 , G01N2021/6432
摘要： A sensing system incorporating a nano-scale fluoro-biosensor for detection of specifically targeted bio-contaminants (targets). Select embodiments use fluorescent nanoparticles such as quantum dots (QD) conjugated to antibody fragments to form a sensor for a specific bio-contaminant based on fluorescent resonance energy transfer (FRET). A quenching dye may be used to label an analog, while a specific antibody is covalently bonded to a hydrophilic QD. Coupling of QD labeled antibodies and quencher labeled analogs provides enough proximity to produce appreciable FRET-based quenching. Any addition of the target displaces the dye-labeled bacteria, eliminating FRET-based quenching and results in a concentration-dependent increase in QD photoluminescence. Applications include rapid detection and identification, with a high degree of specificity and sensitivity, of a broad range of targets, including viral contaminants, e.g., in less than about three minutes. By using QDs of varying wavelengths the system may be adapted into a multiplexing immuno-assay.
摘要翻译：包含用于检测特异性靶向生物污染物（靶）的纳米级氟生物传感器的感测系统。选择实施方案使用与抗体片段缀合的荧光纳米颗粒例如量子点（QD），以形成基于荧光共振能量转移（FRET）的特定生物污染物的传感器。可以使用淬灭染料来标记类似物，而特异性抗体与亲水性QD共价结合。 QD标记的抗体和猝灭标记的类似物的偶联提供足够的接近度以产生明显的基于FRET的淬灭。目标的任何添加取代了染料标记的细菌，消除了基于FRET的猝灭，并导致QD光致发光的浓度依赖性增加。应用包括快速检测和鉴定，具有高度特异性和灵敏度的广泛靶标，包括病毒污染物，例如在少于约3分钟内。通过使用不同波长的量子点，该系统可以适应多路复用免疫测定。

4. 发明授权

US07342057B2 Self-healing coatings using microcapsules to suppress lead dust 失效
标题翻译：使用微胶囊抑制铅尘的自愈涂层
公开(公告)号：US07342057B2
公开(公告)日：2008-03-11
申请号：US10923890
申请日：2004-08-24
申请人： Ashok Kumar , Larry D. Stephenson
发明人： Ashok Kumar , Larry D. Stephenson
IPC分类号： C08J3/00 , C08K9/00 , C08L75/00 , C08G18/80 , B32B5/16
CPC分类号： C09D5/002 , C04B20/1037 , C04B26/02 , C04B2111/00482 , C08K9/10 , C09D7/40 , C09D7/69 , Y10T428/2985 , C04B22/002 , C04B22/064 , C04B24/2611 , C04B40/0641 , C04B40/0675 , C04B2103/0075
摘要： Self-healing coatings incorporate microcapsules of about 60-150 microns diameter that contain film formers and dust suppression compounds suitable for controlling spalling of lead dust, for example. In one embodiment, a primer paint is mixed with these microcapsules and applied by brushing or rolling. After the coating has cured, any physical compromise of the coating results in microcapsules bursting to release liquid that fills and seals the compromised volume. The microcapsule contents protect the underlying substrate from damage and repair some of the outer coating. In one application, embodiments of these self-healing coatings seal existing lead-based paint for suppression of lead dust. In another embodiment, microcapsules are provided separately to enhance commercially available products. For example, if a paint formulation is known a priori, specifically configured microcapsules, packaged separately from the paint and designed for use with the paint formulation, are added to the paint just prior to application.
摘要翻译：自修复涂层包含约60-150微米直径的微胶囊，其包含适用于控制铅粉尘剥落的成膜剂和粉尘抑制化合物。在一个实施方案中，将底漆与这些微胶囊混合并通过刷涂或滚涂进行涂布。在涂层固化之后，涂层的任何物理损害导致微胶囊破裂以释放填充并密封受损体积的液体。微胶囊内容物保护底层基材免受损坏并修复一些外涂层。在一个应用中，这些自修复涂层的实施例密封现有的铅基涂料以抑制铅尘。在另一个实施方案中，单独提供微胶囊以增强市售产品。例如，如果涂料配方是已知的，则在施涂前将先前，特别配置的微胶囊与涂料分开包装并设计用于涂料配方，加入到涂料中。

5. 发明授权

US09345773B2 PVA-boronic acid containing copolymer compositions for protein delivery 有权
标题翻译：含有PVA-硼酸的蛋白质递送共聚物组合物
公开(公告)号：US09345773B2
公开(公告)日：2016-05-24
申请号：US13880299
申请日：2011-08-08
申请人： Ashok Kumar , Rachamalla Maheedhar Reddy
发明人： Ashok Kumar , Rachamalla Maheedhar Reddy
IPC分类号： A61K47/32 , A61K9/50 , A61K9/51 , A61K31/78 , C08F220/56 , C08L33/24
CPC分类号： A61K47/32 , A61K9/5026 , A61K9/5138 , A61K31/78 , C08F220/56 , C08L33/24 , C08F220/54 , C08F220/34 , C08L29/04
摘要： Provided herein are phenylboronate containing co-polymers (PCC), compositions containing PCC and polyvinyl alcohol (PVA), such compositions further including proteins, methods of making these compositions by water in oil polymerization, and methods of using the protein containing compositions for releasing proteins. Such phenylboronate containing co-polymers are of Formula I: where m, n, p, x, R1-R5, L, X1 and X2 are defined in the application.
摘要翻译：本文提供含苯基硼酸盐的共聚物（PCC），含有PCC和聚乙烯醇（PVA）的组合物，此类组合物还包括蛋白质，通过水中油聚合制备这些组合物的方法，以及使用含蛋白质组合物释放蛋白质的方法。这种苯基硼酸酯的共聚物具有式I：其中m，n，p，x，R 1 -R 5，L，X 1和X 2在本申请中定义。

6. 发明授权

US08916343B2 DNA biochip and methods of use 有权
标题翻译： DNA生物芯片和使用方法
公开(公告)号：US08916343B2
公开(公告)日：2014-12-23
申请号：US12931116
申请日：2011-01-24
申请人： Arun Kumar , Ashok Kumar , Shree R. Singh , Souheil Zekri
发明人： Arun Kumar , Ashok Kumar , Shree R. Singh , Souheil Zekri
IPC分类号： C12Q1/68 , C12M1/36 , G01N15/06 , C07H21/04 , G01N33/569 , G01N33/53
CPC分类号： G01N33/56983 , C12Q1/6825 , C12Q1/6837 , G01N33/5308 , C12Q2527/125 , C12Q2565/501 , C12Q2565/607
摘要： The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based “biochip” comprising nucleic acid immobilized thereon. In one embodiment, the silicon comprises microcavities. The nucleic acid to be assayed for the presence of one or more target nucleic acid sequences is immobilized on the silicon. A nucleic acid, such as an oligonucleotide probe, having a sequence substantially complementary to the target nucleic acid sequence can be used to detect the immobilized nucleic acid on the silicon. If the nucleic acid used for detection hybridizes with a target nucleic acid sequence, the hybridized sequences can be detected directly or indirectly. In an exemplified embodiment, the oligonucleotide probe can be labeled with a detectable label, for example, a fluorescent molecule. The subject invention also concerns methods for detecting a target nucleic acid using a silicon-based biochip of the invention.
摘要翻译：本发明涉及用于检测核酸序列的材料和方法。本发明的一个方面涉及包含固定在其上的核酸的硅基“生物芯片”。在一个实施例中，硅包括微腔。要测定的一种或多种靶核酸序列的存在的核酸被固定在硅上。可以使用具有与靶核酸序列基本上互补的序列的核酸，例如寡核苷酸探针，以检测硅上的固定化核酸。如果用于检测的核酸与靶核酸序列杂交，则可以直接或间接检测杂交的序列。在示例性实施方案中，寡核苷酸探针可以用可检测标记，例如荧光分子标记。本发明还涉及使用本发明的硅基生物芯片检测靶核酸的方法。

7. 发明授权

US08668938B2 Composition and manufacturing processes of a toxicity free botanical drug for curative treatment of chronic diseases 有权
标题翻译：无毒性植物药物用于治疗慢性疾病的组成和制造过程
公开(公告)号：US08668938B2
公开(公告)日：2014-03-11
申请号：US13575807
申请日：2010-01-29
申请人： Ashok Kumar , Aditi Kumar , Prakrati Kumar , Priti Kumar
发明人： Ashok Kumar , Aditi Kumar , Prakrati Kumar , Priti Kumar
IPC分类号： A01N65/00
CPC分类号： A61K36/23 , A61K36/88 , A61K2300/00
摘要： This invention discloses composition and manufacturing processes of a toxicity free botanical drug formulation for curative treatment of chronic diseases. It is manufactured from plants Crinum asiaticum and Crocus sativus. This drug was administered to human volunteers by oral and intranasal routes in effective amount for an effective time period. Effective amount and effective time of administration varies from one human volunteer to another depending upon age, body weight, length of disease, severity of disease, type of the disease. In vitro experiments show that this botanical drug causes proliferation and differentiation of stem cells.
摘要翻译：本发明公开了用于治疗慢性疾病的无毒性植物药物制剂的组合物和制造方法。它由植物Crinum asiaticum和Crocus sativus制成。该药物通过口服和鼻内途径以有效的时间段施用于人类志愿者。根据年龄，体重，疾病长度，疾病的严重程度，疾病的类型，有效量和有效的给药时间因人类志愿者而异。体外实验表明，这种植物药物引起干细胞的增殖和分化。

8. 发明申请

US20130179833A1 APPLICATION SHORTCUT USER INTERFACE SYSTEMS AND METHODS 有权
标题翻译：应用更快的用户界面系统和方法
公开(公告)号：US20130179833A1
公开(公告)日：2013-07-11
申请号：US13343909
申请日：2012-01-05
申请人： Heath Stallings , Omar Abou-Khamis , Nathan J. Maxfield , Ashok Kumar , Andrien J. Wang , Don G. Archer , Aravind Perumandla
发明人： Heath Stallings , Omar Abou-Khamis , Nathan J. Maxfield , Ashok Kumar , Andrien J. Wang , Don G. Archer , Aravind Perumandla
IPC分类号： G06F3/048
CPC分类号： G06F3/0482
摘要： An exemplary method includes a user computing device 1) determining current states, such as current integration states and/or current operational states, of software applications included in a suite of software applications relative to the user computing device, 2) identifying, based on the current states, access options for the software applications included in the suite of software applications, and 3) providing, by the user computing device for display, a graphical user interface that includes the access options configured to be selected by a user of the user computing device to access the software applications included in the suite of software applications. Corresponding methods and systems are also disclosed.
摘要翻译：一种示例性方法包括用户计算设备1）确定包括在相对于用户计算设备的软件应用套件中的软件应用的当前状态，例如当前集成状态和/或当前操作状态，2）基于当前状态，软件应用程序包括的软件应用程序的访问选项，以及3）由用户计算设备提供用于显示的图形用户界面，其包括被配置为由用户计算的用户选择的访问选项设备访问软件应用程序套件中包含的软件应用程序。还公开了相应的方法和系统。

9. 发明授权

US08412720B2 Methods and apparatus for querying a relational data store using schema-less queries 有权
公开(公告)号：US08412720B2
公开(公告)日：2013-04-02
申请号：US11927305
申请日：2007-10-29
申请人： Colin P. Britton , Ashok Kumar , David Bigwood , Anthony J. DeFusco , Howard Greenblatt
发明人： Colin P. Britton , Ashok Kumar , David Bigwood , Anthony J. DeFusco , Howard Greenblatt
IPC分类号： G06F17/30
CPC分类号： G06F17/30979 , G06F17/30448 , G06F17/30463 , G06F17/30536 , G06F17/30551 , G06F17/30893 , G06F17/30917 , Y10S707/99931 , Y10S707/99932 , Y10S707/99934 , Y10S707/99936
摘要： The invention provides, in one aspect, a method of searching an RDF triples data store of the type in which the triples are maintained in accord with a first storage schema. The method includes inputting a first query specifying RDF triples that are to be identified in the data store. That first query assumes either (i) that the triples are stored in a schema-less manner (i.e., with no storage schema) or (ii) that the triples are maintained in accord with a second storage schema that differs from the first. The method further includes generating, from the first query, a second query that specifies those same RDF triples, yet, that reflects the first storage schema. That second query can be applied to the RDF triples data store in order to identify and/or retrieve the desired data.

10. 发明申请

US20120185666A1 METHOD AND APPARAUTS FOR DATA STORAGE AND ACCESS 有权
标题翻译：数据存储和访问的方法和装置
公开(公告)号：US20120185666A1
公开(公告)日：2012-07-19
申请号：US13131832
申请日：2009-11-27
申请人： M. Channabasappa , Harsha Sathyanarayana Naga , Kavita Khatawate , Sukanta Banik , Venkata Subba Raju Ganapathi Raju , Pramod (Das Pramod) Pramod Das , Ashok Kumar
发明人： M. Channabasappa , Harsha Sathyanarayana Naga , Kavita Khatawate , Sukanta Banik , Venkata Subba Raju Ganapathi Raju , Pramod (Das Pramod) Pramod Das , Ashok Kumar
IPC分类号： G06F12/02
CPC分类号： G06F17/3048 , G06F12/0875 , G06F17/30457
摘要： A query cache stores queries and corresponding results of the queries, the results of the queries being derived from a primary store. A differential store stores a pointer to data of the primary store which has changed and which affects the result of the queries stored in the query store. A new query may be satisfied by accessing the corresponding query in the query store and determining, by reference to the differential store, whether data relating to the query in the primary store has changed since the query store was compiled and, completing the new query, by accessing the corresponding data in the primary store, if applicable. Data in the differential store may be arranged and partitioned according to labels. The partitioning may be varied according to predetermined rules.
摘要翻译：查询缓存存储查询和相应的查询结果，查询的结果从主存储派生。差异存储器存储指向主存储器的数据的指针，其已经改变并且影响存储在查询存储器中的查询的结果。可以通过访问查询存储器中的对应查询来满足新查询，并且通过参考差分存储来确定自从查询存储被编译以来，与主存储中的查询相关的数据是否已经改变并且完成新查询，通过访问主存储中的相应数据（如果适用）。差分存储器中的数据可以根据标签进行排列和分区。划分可以根据预定的规则而变化。

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