专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090270269A1 NANO-SCALE FLUORO-BIOSENSORS EXHIBITING A LOW FALSE ALARM RATE FOR RAPID DETECTION OF BIOLOGICAL CONTAMINANTS 审中-公开
标题翻译：展示生物污染物快速检测的低错误报警率的纳米级荧光生物传感器
公开(公告)号：US20090270269A1
公开(公告)日：2009-10-29
申请号：US12110386
申请日：2008-04-28
申请人： Ashok Kumar , Larry D. Stephenson , Jeremy A. Hale , Elizabeth J. Norton
发明人： Ashok Kumar , Larry D. Stephenson , Jeremy A. Hale , Elizabeth J. Norton
IPC分类号： C12M1/34 , G01N33/50 , C40B30/04
CPC分类号： G01N33/542 , G01N21/6428 , G01N33/54366 , G01N2021/6432
摘要： A sensing system incorporating a nano-scale fluoro-biosensor for detection of specifically targeted bio-contaminants (targets). Select embodiments use fluorescent nanoparticles such as quantum dots (QD) conjugated to antibody fragments to form a sensor for a specific bio-contaminant based on fluorescent resonance energy transfer (FRET). A quenching dye may be used to label an analog, while a specific antibody is covalently bonded to a hydrophilic QD. Coupling of QD labeled antibodies and quencher labeled analogs provides enough proximity to produce appreciable FRET-based quenching. Any addition of the target displaces the dye-labeled bacteria, eliminating FRET-based quenching and results in a concentration-dependent increase in QD photoluminescence. Applications include rapid detection and identification, with a high degree of specificity and sensitivity, of a broad range of targets, including viral contaminants, e.g., in less than about three minutes. By using QDs of varying wavelengths the system may be adapted into a multiplexing immuno-assay.
摘要翻译：包含用于检测特异性靶向生物污染物（靶）的纳米级氟生物传感器的感测系统。选择实施方案使用与抗体片段缀合的荧光纳米颗粒例如量子点（QD），以形成基于荧光共振能量转移（FRET）的特定生物污染物的传感器。可以使用淬灭染料来标记类似物，而特异性抗体与亲水性QD共价结合。 QD标记的抗体和猝灭标记的类似物的偶联提供足够的接近度以产生明显的基于FRET的淬灭。目标的任何添加取代了染料标记的细菌，消除了基于FRET的猝灭，并导致QD光致发光的浓度依赖性增加。应用包括快速检测和鉴定，具有高度特异性和灵敏度的广泛靶标，包括病毒污染物，例如在少于约3分钟内。通过使用不同波长的量子点，该系统可以适应多路复用免疫测定。

2. 发明授权

US06258364B1 Purified sperm surface antigen, monoclonal antibody therefor and application therefor 失效
标题翻译：纯化精子表面抗原，单克隆抗体及其应用
公开(公告)号：US06258364B1
公开(公告)日：2001-07-10
申请号：US09027673
申请日：1998-02-23
申请人： John C. Herr , Alan B. Diekman , V. Anne Westbrook-Case , Elizabeth J. Norton
发明人： John C. Herr , Alan B. Diekman , V. Anne Westbrook-Case , Elizabeth J. Norton
IPC分类号： A61K4500
CPC分类号： C07K16/28 , A61K38/00 , A61K39/00 , C07K14/705 , G01N33/6854 , G01N33/689 , G01N2800/367
摘要： S19 mAb, deposited under Accession Number HB-12144 at the ATCC, binds to a carbohydrate epitope of a glycoprotein found distributed over the surface of sperm. The carbohydrate nature of the epitope, its distribution over the entire sperm surface, and the fact that it is epididymal/sperm specific and not naturally found in any of the tissues of the female reproductive tract, make the glycoprotein, SAGA-1, a desirable immunogen as the active agent for a contraceptive vaccine, as well as a test standard for monitoring antibody titer. The antibody provides a diagnostic for the presence of sperm, as well as a topical spermistatic.
摘要翻译： S19 mAb以ATCC号保藏号HB-12144保藏，结合到分布在精子表面上的糖蛋白的碳水化合物表位。表位的碳水化合物性质，其在整个精子表面上的分布，以及其是附睾/精子特异性而不是天然存在于女性生殖道的任何组织中的事实使得糖蛋白SAGA-1是所需的免疫原作为避孕疫苗的活性剂，以及用于监测抗体滴度的测试标准。抗体提供精子存在的诊断以及局部精子。

3. 发明授权

US4211549A Substituted oxirane compounds 失效
标题翻译：取代的环氧乙烷化合物
公开(公告)号：US4211549A
公开(公告)日：1980-07-08
申请号：US925487
申请日：1978-07-17
申请人： Lowell D. Markley , Elizabeth J. Norton
发明人： Lowell D. Markley , Elizabeth J. Norton
IPC分类号： A01N43/20 , C07D303/08 , A01N9/00
CPC分类号： C07D303/08 , A01N43/20
摘要： Novel substituted oxirane compounds of the formula ##STR1## wherein R is Cl, Br or --CH.sub.3 are useful as herbicidal agents useful in the control of green foxtail in the presence of corn, sorghum and soybeans.
摘要翻译：其中R为Cl，Br或-CH 3的新型取代的环氧乙烷化合物可用作在玉米，高粱和大豆存在下用于控制绿色狐尾草的除草剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式