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1. 发明申请

US20050058747A1 Proteases 有权
标题翻译：蛋白酶
公开(公告)号：US20050058747A1
公开(公告)日：2005-03-17
申请号：US10873593
申请日：2004-06-21
申请人： Soeren Lassen , Carsten Sjoeholm , Peter Oestergaard , Carsten Andersen , Morten Fischer
发明人： Soeren Lassen , Carsten Sjoeholm , Peter Oestergaard , Carsten Andersen , Morten Fischer
IPC分类号： A23K3/00 , C07H21/04 , C11D3/386 , C12N9/08 , C12N9/52 , C12N9/54 , C12N9/58 , C12N15/57 , C12N15/74
CPC分类号： C12N9/52 , A01K2217/05 , C12N9/58 , C12N2310/111
摘要： The present invention relates to thermostable proteases homologous to proteases derived from Nocardiopsis, and the production thereof by the wild-type, and in recombinant host cells including transgenic plants and non-human transgenic animals. The proteases are effective in animal feed, in particular fish feed, and detergents. The proteases are capable of degrading the soybean Bowman-Birk inhibitor, and other antinutritional factors such as soybean agglutinin and the Kunitz trypsin inhibitor, as well as the isolated soy storage proteins glycinin and beta-conglycinin. Characteristic structural features of relevance for the thermostability of these proteases of peptidase family S2A or S1E are disclosed.
摘要翻译：本发明涉及与来源于诺卡氏菌属的蛋白酶同源的热稳定蛋白酶，以及野生型的生产，以及包含转基因植物和非人转基因动物的重组宿主细胞。蛋白酶在动物饲料，特别是鱼饲料和洗涤剂中是有效的。蛋白酶能够降解大豆Bowman-Birk抑制剂和其他抗营养因子如大豆凝集素和Kunitz胰蛋白酶抑制剂，以及分离的大豆贮存蛋白大豆球蛋白和β-伴大豆球蛋白。公开了与肽酶家族S2A或S1E的这些蛋白酶的热稳定性相关的特征性结构特征。

2. 发明授权

US07179630B2 Thermostable proteases 有权
标题翻译：热稳定蛋白酶
公开(公告)号：US07179630B2
公开(公告)日：2007-02-20
申请号：US10873593
申请日：2004-06-21
申请人： Soeren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Oestergaard , Carsten Andersen , Morten Fischer
发明人： Soeren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Oestergaard , Carsten Andersen , Morten Fischer
IPC分类号： C12N9/48 , C07H21/04 , A21D2/00 , A21D8/02 , C11C3/00
CPC分类号： C12N9/52 , A01K2217/05 , C12N9/58 , C12N2310/111
摘要： The present invention relates to thermostable proteases having an amino acid sequence which homologous to the amino acid sequence of proteases derived from Nocardiopsis, and the production thereof by wild-type and recombinant host cells including transgenic plants and non-human transgenic animals. The proteases are effective in animal feed, in particular fish feed, and detergents. The proteases are capable of degrading the soybean Bowman-Birk inhibitor, and other antinutritional factors such as soybean agglutinin and the Kunitz trypsin inhibitor, as well as the isolated soy storage proteins glycinin and beta-conglycinin. Characteristic structural features of relevance for the thermostability of these proteases of peptidase family S2A or S1E are disclosed.
摘要翻译：本发明涉及具有与来自诺卡氏菌属（Nocardiopsis）的蛋白酶的氨基酸序列同源的氨基酸序列的热稳定蛋白酶，以及包含转基因植物和非人转基因动物的野生型和重组宿主细胞的生产。蛋白酶在动物饲料，特别是鱼饲料和洗涤剂中是有效的。蛋白酶能够降解大豆Bowman-Birk抑制剂和其他抗营养因子如大豆凝集素和Kunitz胰蛋白酶抑制剂，以及分离的大豆贮存蛋白大豆球蛋白和β-伴大豆球蛋白。公开了与肽酶家族S2A或S1E的这些蛋白酶的热稳定性相关的特征性结构特征。

3. 发明申请

US20050148060A1 Use of acid stable protease in animal feed 有权
标题翻译：在动物饲料中使用酸稳定蛋白酶
公开(公告)号：US20050148060A1
公开(公告)日：2005-07-07
申请号：US11074491
申请日：2005-03-08
申请人： Carsten Sjoeholm , Peter Oestergaard , Anna-Marie Kluenter
发明人： Carsten Sjoeholm , Peter Oestergaard , Anna-Marie Kluenter
IPC分类号： A23J3/16 , A23J3/34 , A23K1/14 , A23K1/165 , C12N9/52 , C12N9/54
CPC分类号： C12N9/52 , A23J3/16 , A23J3/346 , A23K10/30 , A23K20/189
摘要： The present invention relates to acid-stable proteases of the subtilisin family, their use in animal feed, feed-additives and feed compositions containing such proteases, and methods for the treatment of vegetable proteins using such proteases.
摘要翻译：本发明涉及枯草杆菌蛋白酶家族的酸稳定蛋白酶，它们在动物饲料中的应用，饲料添加剂和含有这种蛋白酶的饲料组合物，以及使用这种蛋白酶处理植物蛋白质的方法。

4. 发明申请

US20080286415A1 Proteases 有权
标题翻译：蛋白酶
公开(公告)号：US20080286415A1
公开(公告)日：2008-11-20
申请号：US11570913
申请日：2005-06-17
申请人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Oestergaard , Morten Fischer
发明人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Oestergaard , Morten Fischer
IPC分类号： A23K1/165 , C12N9/50 , C12N15/11 , C12N15/00 , C12N5/06 , C12N5/04 , A01H5/00 , A01K67/027 , C12P21/04 , C12N1/20
CPC分类号： C12N9/52 , A23J3/346 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , C11D3/38609 , C11D3/38618
摘要： Proteases derived from Nocardiopsis dassonvillei subsp. dassonvillei DSM 43235, Nocardiopsis prasina DSM 15649, Nocardiopsis prasina (previously alba) DSM 14010 Nocardiopsis sp. DSM 16424, Nocardiopsis alkaliphila DSM 44657 and Nocardiopsis lucentensis DSM 44048, as well as homologous proteases; their recombinant production in various hosts, including transgenic plants and non-human animals, and their use in animal feed and detergents. The proteases are acid-stable, alkali-stable, and/or thermostable.
摘要翻译：衍生自Nocardiopsis dassonvillei subsp。 dassonvillei DSM 43235，Nocardiopsis prasina DSM 15649，Nocardiopsis prasina（以前的alba）DSM 14010 Nocardiopsis sp。 DSM 16424，Nocardiopsis alkaliphila DSM 44657和Nocardiopsis lucentensis DSM 44048以及同源蛋白酶; 其在各种宿主中的重组生产，包括转基因植物和非人类动物，以及它们在动物饲料和洗涤剂中的应用。蛋白酶是酸稳定的，碱稳定的和/或热稳定的。

5. 发明授权

US09279114B2 Proteases 有权
公开(公告)号：US09279114B2
公开(公告)日：2016-03-08
申请号：US13490559
申请日：2012-06-07
申请人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Øestergaard , Morten Fischer
发明人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Øestergaard , Morten Fischer
IPC分类号： C12N9/52 , A23J3/34 , A23K1/165 , A23K1/18 , C11D3/386
CPC分类号： C12N9/52 , A23J3/346 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , C11D3/38609 , C11D3/38618
摘要： Proteases derived from Nocardiopsis dassonvillei subsp. dassonvillei DSM 43235, Nocardiopsis prasina DSM 15649, Nocardiopsis prasina (previously alba) DSM 14010 Nocardiopsis sp. DSM 16424, Nocardiopsis alkaliphila DSM 44657 and Nocardiopsis lucentensis DSM 44048, as well as homologous proteases; their recombinant production in various hosts, including transgenic plants and non-human animals, and their use in animal feed and detergents. The proteases are acid-stable, alkali-stable, and/or thermostable.

6. 发明申请

US20120321746A1 Proteases 审中-公开
标题翻译：蛋白酶
公开(公告)号：US20120321746A1
公开(公告)日：2012-12-20
申请号：US13490559
申请日：2012-06-07
申请人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Ostergaard , Morten Fischer
发明人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Ostergaard , Morten Fischer
IPC分类号： C12N9/52 , C12N15/57 , C12N15/63 , A23K1/165 , C12N5/10 , C12N1/15 , C12N1/19 , C12S3/14 , C12N1/21
CPC分类号： C12N9/52 , A23J3/346 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , C11D3/38609 , C11D3/38618
摘要： Proteases derived from Nocardiopsis dassonvillei subsp. dassonvillei DSM 43235, Nocardiopsis prasina DSM 15649, Nocardiopsis prasina (previously alba) DSM 14010 Nocardiopsis sp. DSM 16424, Nocardiopsis alkaliphila DSM 44657 and Nocardiopsis lucentensis DSM 44048, as well as homologous proteases; their recombinant production in various hosts, including transgenic plants and non-human animals, and their use in animal feed and detergents. The proteases are acid-stable, alkali-stable, and/or thermostable.
摘要翻译：衍生自Nocardiopsis dassonvillei subsp。 dassonvillei DSM 43235，Nocardiopsis prasina DSM 15649，Nocardiopsis prasina（以前的alba）DSM 14010 Nocardiopsis sp。 DSM 16424，Nocardiopsis alkaliphila DSM 44657和Nocardiopsis lucentensis DSM 44048以及同源蛋白酶; 其在各种宿主中的重组生产，包括转基因植物和非人类动物，以及它们在动物饲料和洗涤剂中的应用。蛋白酶是酸稳定的，碱稳定的和/或热稳定的。

7. 发明授权

US09279115B2 Proteases 有权
公开(公告)号：US09279115B2
公开(公告)日：2016-03-08
申请号：US13490566
申请日：2012-06-07
申请人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Øestergaard , Morten Fischer
发明人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Øestergaard , Morten Fischer
IPC分类号： C12N9/52 , A23J3/34 , A23K1/165 , A23K1/18 , C11D3/386
CPC分类号： C12N9/52 , A23J3/346 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , C11D3/38609 , C11D3/38618
摘要： Proteases derived from Nocardiopsis dassonvillei subsp. dassonvillei DSM 43235, Nocardiopsis prasina DSM 15649, Nocardiopsis prasina (previously alba) DSM 14010 Nocardiopsis sp. DSM 16424, Nocardiopsis alkaliphila DSM 44657 and Nocardiopsis lucentensis DSM 44048, as well as homologous proteases; their recombinant production in various hosts, including transgenic plants and non-human animals, and their use in animal feed and detergents. The proteases are acid-stable, alkali-stable, and/or thermostable.

8. 发明申请

US20120321747A1 Proteases 审中-公开
公开(公告)号：US20120321747A1
公开(公告)日：2012-12-20
申请号：US13490566
申请日：2012-06-07
申请人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Oestergaard , Morten Fischer
发明人： Soren Flensted Lassen , Carsten Sjoeholm , Peter Rahbek Oestergaard , Morten Fischer
IPC分类号： C12N9/52 , C12N15/63 , C12S3/14 , C12N1/15 , C12N1/19 , A23K1/165 , C12N15/57 , C12N1/21
CPC分类号： C12N9/52 , A23J3/346 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , C11D3/38609 , C11D3/38618
摘要： Proteases derived from Nocardiopsis dassonvillei subsp. dassonvillei DSM 43235, Nocardiopsis prasina DSM 15649, Nocardiopsis prasina (previously alba) DSM 14010 Nocardiopsis sp. DSM 16424, Nocardiopsis alkaliphila DSM 44657 and Nocardiopsis lucentensis DSM 44048, as well as homologous proteases; their recombinant production in various hosts, including transgenic plants and non-human animals, and their use in animal feed and detergents. The proteases are acid-stable, alkali-stable, and/or thermostable.

9. 发明授权

US08101391B2 Polypeptides having phytase activity and polynucleotides encoding same 有权
标题翻译：具有植酸酶活性的多肽和编码其的多核苷酸
公开(公告)号：US08101391B2
公开(公告)日：2012-01-24
申请号：US12022221
申请日：2008-01-30
申请人： Carsten Sjoeholm , Soeren Flensted Lassen , Lars Kobberoe Skov , Leonardo De Maria
发明人： Carsten Sjoeholm , Soeren Flensted Lassen , Lars Kobberoe Skov , Leonardo De Maria
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A23L33/18 , C12N15/8243 , C12P7/06 , Y02E50/17
摘要： The present invention relates to polypeptides having phytase activity. These polypeptides have an amino acid sequence which has at least 70% identity to either of three phytases derived from the bacterium Buttiauxella, and which comprises at least one of the following amino acids at the position indicated: 119N, 120L, and/or 121E. These phytases have an improved specific activity. Additional specific amino acid substitutions are also disclosed which characterize and distinguish additional phytases of the invention having improved properties such as temperature and/or pH stability, pH activity profile, temperature activity profile, substrate profile, improved performance in animal feed in vitro or in vivo. The invention also relates to isolated polynucleotides encoding the polypeptides, nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.
摘要翻译：本发明涉及具有植酸酶活性的多肽。这些多肽具有与来自细菌Buttiauxella的三种植酸酶中的任一种具有至少70％同一性的氨基酸序列，并且其在所示位置包含至少一个以下氨基酸：119N，120L和/或121E。这些植酸酶具有改善的比活性。还公开了另外的特定氨基酸取代，其特征和区分本发明的另外的植酸酶具有改善的性质如温度和/或pH稳定性，pH活性曲线，温度活性分布，底物分布，动物饲料体外或体内改善的性能。本发明还涉及编码多肽的分离的多核苷酸，核酸构建体，载体和包含多核苷酸的宿主细胞以及产生和使用多肽的方法。

10. 发明申请

US20110154519A1 HAFNIA PHYTASE 有权
公开(公告)号：US20110154519A1
公开(公告)日：2011-06-23
申请号：US13032679
申请日：2011-02-23
申请人： Soeren Flensted Lassen , Carsten Sjoeholm , Lars Kobberoee Skov
发明人： Soeren Flensted Lassen , Carsten Sjoeholm , Lars Kobberoee Skov
IPC分类号： C12N9/14 , C12N15/11 , C12N15/55 , C12N1/00 , C12P21/02 , A01H5/00 , A01K67/00 , A23K1/16 , A23K1/165 , A23L1/302 , A23L1/305 , A23L1/304 , C12G1/00 , C12C11/00 , A23K1/06
CPC分类号： C12N9/16 , A23K20/147 , A23K20/174 , A23K20/189 , A23K50/00 , A23K50/30 , A23K50/75 , A23K50/80 , A23L33/18 , C12Y301/01004 , C12Y301/01005 , C12Y301/03008 , C12Y301/03026 , C12Y301/04003 , C12Y301/04004 , C12Y302/01001 , C12Y302/01004 , C12Y302/01006 , C12Y302/01008 , C12Y302/01022 , C12Y302/01032 , C12Y302/01089 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to isolated polypeptides having phytase activity and isolated polynucleotides encoding the polypeptides. The polypeptides are related to a phytase derived from Hafnia alvei, the amino acid sequence of which is shown in the appended sequence listing as SEQ ID NO: 10. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides, in particular within animal feed.
摘要翻译：本发明涉及具有植酸酶活性的分离的多肽和编码多肽的分离的多核苷酸。多肽与源自Hafnia alvei的植酸酶相关，其氨基酸序列在附加的序列表中显示为SEQ ID NO：10。本发明还涉及核酸构建体，载体和宿主细胞，其包含多核苷酸为以及用于产生和使用多肽的方法，特别是在动物饲料中。

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