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1. 发明申请

US20120328523A1 POLYHYDROXYALKANOATES FOR IN VIVO APPLICATIONS 失效
标题翻译：用于生殖器官应用的聚羟基烷酸酯
公开(公告)号：US20120328523A1
公开(公告)日：2012-12-27
申请号：US13545663
申请日：2012-07-10
申请人： Simon F. Williams , David P. Martin , Tiliman Gerngross , Daniel M. Horowitz
发明人： Simon F. Williams , David P. Martin , Tiliman Gerngross , Daniel M. Horowitz
IPC分类号： C08G63/06 , C08G63/91 , A61K47/34 , A61K38/02 , C04B24/28 , A61K31/70 , A61K31/715 , A61K49/00 , A61K35/12 , A61K9/00 , A61K31/7052
CPC分类号： C12P7/625 , A61B17/06166 , A61B42/00 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L27/18 , A61L27/34 , A61L29/06 , A61L31/06 , C08G63/06 , C08G63/6852 , C08G63/6882 , C08G63/912 , C12N5/0068 , C12N2533/30 , Y10S977/775 , Y10T428/139 , C08L67/04
摘要： Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. The PHAs are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone, other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses.
摘要翻译：提供已经除去热原的聚羟基链烷酸酯（PHA）。已经化学改性以增强物理和/或化学性质的PHA用于通过网状内皮系统（RES）靶向或修饰生物降解性或清除的PHA。还提供了通过细菌发酵方法制备的去氢原位PHA聚合物的方法，其中热原从聚合物中除去而不会不利地影响聚合物固有的化学结构和物理性质。还描述了具有有利处理特性的PHA，包括低熔点和/或在无毒溶剂中的溶解度。 PHAs适用于体内应用，例如组织涂层，支架，缝线，管，骨，其他假体，骨或组织水泥，组织再生装置，伤口敷料，药物递送以及用于诊断和预防用途。

2. 发明授权

US06245537B1 Removing endotoxin with an oxdizing agent from polyhydroxyalkanoates produced by fermentation 失效
标题翻译：用氧化剂从发酵产生的聚羟基链烷酸酯中去除内毒素
公开(公告)号：US06245537B1
公开(公告)日：2001-06-12
申请号：US09076198
申请日：1998-05-12
申请人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
发明人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
IPC分类号： C12P762
CPC分类号： C12P7/625 , A61B17/06166 , A61B42/00 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L27/18 , A61L27/34 , A61L29/06 , A61L31/06 , C08G63/06 , C08G63/6852 , C08G63/6882 , C08G63/912 , C12N5/0068 , C12N2533/30 , Y10S977/775 , Y10T428/139 , C08L67/04
摘要： Polyhydroxyalkanoate (PHA) that contains a pyrogen such as endotoxin due to a process of producing the PHA is treated to remove the pyrogen by a process that does not affect the inherent chemical and physical properties of the PHA to obtain a biocompatible PHA. PHA produced by fermentation with a Gram negative bacteria can be treated with an oxidizing agent such as hydrogen peroxide or benzoyl peroxide to reduce the endotoxin content to less than 20 endotoxin units/gram of PHA to produce PHA that does not elicit an acute inflammatory response when implanted in an animal. The PHA may have a melting point or glass transition temperature less than 136° C., and can be chemically modified or derivatized such as by covalently coupling an attachment or targeting molecule. The PHA may be used to form various medical devices, and can be used for in vivo applications including tissue coatings, stents, sutures, tubing, bone and other prostheses, bone and tissue cements, tissue regenerating devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses.
摘要翻译：处理由于产生PHA的过程而含有热原如内毒素的聚羟基链烷酸酯（PHA），以通过不影响PHA固有的化学和物理性能以获得生物相容性PHA的方法除去热原。通过用革兰氏阴性细菌发酵产生的PHA可以用氧化剂如过氧化氢或过氧化苯甲酰处理以将内毒素含量降低到小于20个内毒素单位/克的PHA，以产生不引起急性炎症反应的PHA 植入动物。 PHA可以具有低于136℃的熔点或玻璃化转变温度，并且可以通过共价偶联附着物或靶向分子进行化学修饰或衍生化。 PHA可以用于形成各种医疗装置，并且可以用于体内应用，包括组织涂层，支架，缝线，管，骨和其他假体，骨和组织水泥，组织再生装置，伤口敷料，药物递送和用于诊断和预防用途。

3. 发明授权

US07906135B2 Medical device comprising polyhydroxyalkanoate having pyrogen removed 有权
标题翻译：包含去除热原原虫的聚羟基链烷酸酯的医疗装置
公开(公告)号：US07906135B2
公开(公告)日：2011-03-15
申请号：US11748723
申请日：2007-05-15
申请人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
发明人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
IPC分类号： A61F2/00 , A61F13/00 , C12P7/62 , C12N11/08 , C12N5/07
CPC分类号： C12P7/625 , A61B17/06166 , A61B42/00 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L27/18 , A61L27/34 , A61L29/06 , A61L31/06 , C08G63/06 , C08G63/6852 , C08G63/6882 , C08G63/912 , C12N5/0068 , C12N2533/30 , Y10S977/775 , Y10T428/139 , C08L67/04
摘要： Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. PHAs are provided which are suitable for use in vivo applications such as in tissue coatings, stents, sutures, tubing, bone and other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses. Properties which are selected for include degradability, elasticity, inclusion of functional groups or derivatized groups, which can in turn be used to attach targeting agents, and bioadhesion.
摘要翻译：已经除去热原的聚羟基链烷酸酯（PHA）被提供用于许多生物医学应用。已经化学改性以增强物理和/或化学性质的PHA用于通过网状内皮系统（RES）靶向或修饰生物降解性或清除的PHA。还提供了通过细菌发酵方法制备的去氢原位PHA聚合物的方法，其中热原从聚合物中除去而不会不利地影响聚合物固有的化学结构和物理性质。还描述了具有有利处理特性的PHA，包括低熔点和/或在无毒溶剂中的溶解度。提供适用于体内应用的PHA，例如在组织包衣，支架，缝线，管，骨和其他假体，骨或组织水泥，组织再生装置，伤口敷料，药物递送以及诊断和预防用途中。选择的性质包括降解性，弹性，包含官能团或衍生基团，其又可用于附着靶向剂，以及生物粘附。

4. 发明授权

US06623749B2 Medical device containing polyhydroxyalkanoate treated with oxidizing agent to remove endotoxin 有权
标题翻译：包含用氧化剂处理以除去内毒素的聚羟基链烷酸酯的医疗装置
公开(公告)号：US06623749B2
公开(公告)日：2003-09-23
申请号：US09819447
申请日：2001-03-28
申请人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
发明人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
IPC分类号： A61F200
CPC分类号： C12P7/625 , A61B17/06166 , A61B42/00 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L27/18 , A61L27/34 , A61L29/06 , A61L31/06 , C08G63/06 , C08G63/6852 , C08G63/6882 , C08G63/912 , C12N5/0068 , C12N2533/30 , Y10S977/775 , Y10T428/139 , C08L67/04
摘要： Polyhydroxyalkanoate (PHA) that contains a pyrogen such as an endotoxin due to a process of producing the PHA is treated to remove the pyrogen by a process that does not affect the inherent chemical and physical properties of the PHA to obtain a biocompatible PHA. PHA produced by fermentation with a Gram negative bacteria can be treated with an oxidizing agent such as hydrogen peroxide or benzoyl peroxide to reduce the endotoxin content to less than 20 endotoxin units/gram of PHA to produce PHA that does not elicit an acute inflammatory response when implanted in an animal. The PHA may have a melting point or glass transition temperature less than 136° C., and can be chemically modified or derivatized such as by covalently coupling an attachment or targeting molecule. The PHA may be used to form various medical devices, and can be used for in vivo applications including tissue coatings, stents, sutures, tubing, bone and other prostheses, bone and tissue cements, issue regenerating devices, wound dressings, drug delivery, and diagnostic and prophylactic uses.
摘要翻译：通过不影响PHA的固有化学和物理性能以获得生物相容性PHA的方法，处理含有由热生物引起的热源（例如内毒素）的聚羟基链烷酸酯（PHA），由此产生PHA。通过用革兰氏阴性细菌发酵产生的PHA可以用氧化剂如过氧化氢或过氧化苯甲酰处理以将内毒素含量降低到小于20个内毒素单位/克的PHA，以产生不引起急性炎症反应的PHA 植入动物。 PHA可以具有低于136℃的熔点或玻璃化转变温度，并且可以通过共价偶联附着物或靶向分子进行化学修饰或衍生化。 PHA可以用于形成各种医疗装置，并且可以用于体内应用，包括组织涂层，支架，缝线，管，骨和其他假体，骨和组织水泥，发行再生装置，伤口敷料，药物递送和诊断和预防用途。

5. 发明申请

US20110135707A1 POLYHYDROXYALKANOATES FOR IN VIVO APPLICATIONS 有权
标题翻译：用于生殖器官应用的聚羟基烷酸酯
公开(公告)号：US20110135707A1
公开(公告)日：2011-06-09
申请号：US13021419
申请日：2011-02-04
申请人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
发明人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
IPC分类号： A61F2/28 , C12N5/07 , A61F2/00 , A61K9/00 , A61K49/00 , A61K38/02 , A61K31/7088 , A61K31/715 , A61K31/70 , A61K31/20 , A61K9/70 , A61P17/02 , A61P19/08 , A61P9/00 , C08G63/91 , B32B1/08
CPC分类号： C12P7/625 , A61B17/06166 , A61B42/00 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L27/18 , A61L27/34 , A61L29/06 , A61L31/06 , C08G63/06 , C08G63/6852 , C08G63/6882 , C08G63/912 , C12N5/0068 , C12N2533/30 , Y10S977/775 , Y10T428/139 , C08L67/04
摘要： Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. PHAs are provided which are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone and other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses. Properties which are selected for include degradability, elasticity, inclusion of functional groups or derivatized groups, which can in turn be used to attach targeting agents, and bioadhesion.
摘要翻译：已经除去热原的聚羟基链烷酸酯（PHA）被提供用于许多生物医学应用。已经化学改性以增强物理和/或化学性质的PHA用于通过网状内皮系统（RES）靶向或修饰生物降解性或清除的PHA。还提供了通过细菌发酵方法制备的PHA聚合物去热原化方法，其中热原从聚合物中除去而不会不利地影响聚合物固有的化学结构和物理性质。还描述了具有有利处理特性的PHA，包括低熔点和/或在无毒溶剂中的溶解度。提供适用于体内应用的PHA，例如在组织涂层，支架，缝线，管，骨和其他假体，骨或组织水泥，组织再生装置，伤口敷料，药物递送以及用于诊断和预防用途。选择的性质包括降解性，弹性，包含官能团或衍生基团，其又可用于附着靶向剂，以及生物粘附。

6. 发明授权

US08771720B2 Medical device comprising polyhydroxyalkanoate having pyrogen removed using oxidizing agent 失效
标题翻译：包含使用氧化剂除去热原性的聚羟基链烷酸酯的医疗装置
公开(公告)号：US08771720B2
公开(公告)日：2014-07-08
申请号：US13545663
申请日：2012-07-10
申请人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
发明人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
IPC分类号： A61F2/00 , A61F2/02 , A61F13/00 , C12P7/62 , C12P1/04 , C12N11/08 , C12N11/04 , C12N5/07 , C07K17/04 , C07K17/08
CPC分类号： C12P7/625 , A61B17/06166 , A61B42/00 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L27/18 , A61L27/34 , A61L29/06 , A61L31/06 , C08G63/06 , C08G63/6852 , C08G63/6882 , C08G63/912 , C12N5/0068 , C12N2533/30 , Y10S977/775 , Y10T428/139 , C08L67/04
摘要： Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. The PHAs are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone, other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses.
摘要翻译：提供已经除去热原的聚羟基链烷酸酯（PHA）。已经化学改性以增强物理和/或化学性质的PHA用于通过网状内皮系统（RES）靶向或修饰生物降解性或清除的PHA。还提供了通过细菌发酵方法制备的去氢原位PHA聚合物的方法，其中热原从聚合物中除去而不会不利地影响聚合物固有的化学结构和物理性质。还描述了具有有利处理特性的PHA，包括低熔点和/或在无毒溶剂中的溶解度。 PHAs适用于体内应用，例如组织涂层，支架，缝线，管，骨，其他假体，骨或组织水泥，组织再生装置，伤口敷料，药物递送以及用于诊断和预防用途。

7. 发明授权

US08231889B2 Method of forming medical devices having pyrogen removed for in vivo application 有权
标题翻译：形成用于体内应用除去热原的医疗装置的方法
公开(公告)号：US08231889B2
公开(公告)日：2012-07-31
申请号：US13021419
申请日：2011-02-04
申请人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
发明人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
IPC分类号： A61F2/00 , A61F13/00 , C12P7/62 , C12P1/04 , C12N11/08 , C12N11/04 , C12N5/07
CPC分类号： C12P7/625 , A61B17/06166 , A61B42/00 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L27/18 , A61L27/34 , A61L29/06 , A61L31/06 , C08G63/06 , C08G63/6852 , C08G63/6882 , C08G63/912 , C12N5/0068 , C12N2533/30 , Y10S977/775 , Y10T428/139 , C08L67/04
摘要： Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. PHAs are provided which are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone and other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses. Properties which are selected for include degradability, elasticity, inclusion of functional groups or derivatized groups, which can in turn be used to attach targeting agents, and bioadhesion.
摘要翻译：已经除去热原的聚羟基链烷酸酯（PHA）被提供用于许多生物医学应用。已经化学改性以增强物理和/或化学性质的PHA用于通过网状内皮系统（RES）靶向或修饰生物降解性或清除的PHA。还提供了通过细菌发酵方法制备的PHA聚合物去热原化方法，其中热原从聚合物中除去而不会不利地影响聚合物固有的化学结构和物理性质。还描述了具有有利处理特性的PHA，包括低熔点和/或在无毒溶剂中的溶解度。提供适用于体内应用的PHA，例如在组织涂层，支架，缝线，管，骨和其他假体，骨或组织水泥，组织再生装置，伤口敷料，药物递送以及用于诊断和预防用途。选择的性质包括降解性，弹性，包含官能团或衍生基团，其又可用于附着靶向剂，以及生物粘附。

8. 发明授权

US07244442B2 Method for making devices using polyhydroxyalkanoate having pyrogen removed 有权
标题翻译：使用除去热原原子的聚羟基链烷酸酯制造器件的方法
公开(公告)号：US07244442B2
公开(公告)日：2007-07-17
申请号：US10642026
申请日：2003-08-15
申请人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
发明人： Simon F. Williams , David P. Martin , Tillman Gerngross , Daniel M. Horowitz
IPC分类号： A61F2/00 , A61F13/00 , C12P7/62 , C12N11/08 , C12N5/00
CPC分类号： C12P7/625 , A61B17/06166 , A61B42/00 , A61K47/593 , A61K47/6957 , A61L15/26 , A61L17/10 , A61L27/18 , A61L27/34 , A61L29/06 , A61L31/06 , C08G63/06 , C08G63/6852 , C08G63/6882 , C08G63/912 , C12N5/0068 , C12N2533/30 , Y10S977/775 , Y10T428/139 , C08L67/04
摘要： Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. PHAs are provided which are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone and other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses. Properties which are selected for include degradability, elasticity, inclusion of functional groups or derivatized groups, which can in turn be used to attach targeting agents, and bioadhesion.
摘要翻译：已经除去热原的聚羟基链烷酸酯（PHA）被提供用于许多生物医学应用。已经化学改性以增强物理和/或化学性质的PHA用于通过网状内皮系统（RES）靶向或修饰生物降解性或清除的PHA。还提供了通过细菌发酵方法制备的PHA聚合物去热原化方法，其中热原从聚合物中除去而不会不利地影响聚合物固有的化学结构和物理性质。还描述了具有有利处理特性的PHA，包括低熔点和/或在无毒溶剂中的溶解度。提供适用于体内应用的PHA，例如在组织涂层，支架，缝线，管，骨和其他假体，骨或组织水泥，组织再生装置，伤口敷料，药物递送以及用于诊断和预防用途。选择的性质包括降解性，弹性，包含官能团或衍生基团，其又可用于附着靶向剂，以及生物粘附。

9. 发明申请

US20110190866A1 POLYMERIC, DEGRADABLE DRUG-ELUTING STENTS AND COATINGS 有权
标题翻译：聚合，可降解药水和涂层
公开(公告)号：US20110190866A1
公开(公告)日：2011-08-04
申请号：US13057974
申请日：2009-07-17
申请人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David P. Martin , Simon F. Williams
发明人： Klaus-Peter Schmitz , Detlef Behrend , Katrin Sternberg , Niels Grabow , David P. Martin , Simon F. Williams
IPC分类号： A61F2/84 , A61F2/82 , B05D7/00
CPC分类号： A61L31/18 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/606 , C08L67/04
摘要： Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.
摘要翻译：可吸收支架和可吸收支架涂层已经开发出具有改进的性能。这些装置优选包含4-羟基丁酸酯和任选的聚-L-乳酸和其它可吸收的聚合物和添加剂的生物相容性共聚物或均聚物。这些材料的组合物可用于制造提供有利的径向强度，抵抗反冲和蠕变的可吸收支架，可以在球囊导管上塑性膨胀，并且可以在体内迅速部署。衍生自这些材料的支架涂层提供生物相容性均匀的延展性涂层，并且可以在没有涂层开裂和/或脱胶的情况下扩展，并且可以用作药物掺入的涂层基质。

10. 发明申请

US20080132602A1 MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 有权
标题翻译：含聚-4-羟基丁酸酯和共聚物的靶向膜的医疗装置
公开(公告)号：US20080132602A1
公开(公告)日：2008-06-05
申请号：US11931850
申请日：2007-10-31
申请人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
发明人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
IPC分类号： A61F2/02 , A61F2/82
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2， 2℃，断裂伸长率为10-500％，其中该膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个膜中定向至超过膜的原始长度的25％方向。这些可以用于各种目的，包括制造医疗器械。

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