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1. 发明申请

US20080132602A1 MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 有权
标题翻译：含聚-4-羟基丁酸酯和共聚物的靶向膜的医疗装置
公开(公告)号：US20080132602A1
公开(公告)日：2008-06-05
申请号：US11931850
申请日：2007-10-31
申请人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
发明人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
IPC分类号： A61F2/02 , A61F2/82
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2， 2℃，断裂伸长率为10-500％，其中该膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个膜中定向至超过膜的原始长度的25％方向。这些可以用于各种目的，包括制造医疗器械。

2. 发明授权

US08753555B2 Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers 有权
标题翻译：包含聚-4-羟基丁酸取代膜和共聚物的医疗器械
公开(公告)号：US08753555B2
公开(公告)日：2014-06-17
申请号：US13084388
申请日：2011-04-11
申请人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
发明人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
IPC分类号： B29C55/04 , B29C55/12 , A61L27/18 , A61L27/58 , C08L67/04 , C08G63/08
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2，断裂伸长率为10-500％其中所述膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个方向上定向至超过膜的原始长度的25％。这些可以用于各种目的，包括制造医疗器械。

3. 发明申请

US20090162276A1 MEDICAL DEVICES CONTAINING MELT-BLOWN NON-WOVENS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 有权
标题翻译：含有聚-4-羟基丁酸酯及其共聚物的熔融非织造物的医疗装置
公开(公告)号：US20090162276A1
公开(公告)日：2009-06-25
申请号：US12336755
申请日：2008-12-17
申请人： David P. Martin , Said Rizk , Kicherl Ho , Simon F. Williams
发明人： David P. Martin , Said Rizk , Kicherl Ho , Simon F. Williams
IPC分类号： A61K51/00 , D04H13/00 , B32B27/02 , A61F2/02 , A61K49/00 , D04H3/16
CPC分类号： A61L29/06 , A61L15/26 , A61L15/44 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , D04H1/4382 , D04H1/56 , Y10T442/608 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 μm to 50 μm, and thickness from 10 μm to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly-4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non-woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：已经开发了用于制造具有以下特性中的一种或多种的可吸收聚合非织造物的连续加工方法：高破裂强度，平均直径为1μm至50μm的细纤维和厚度为10um至50mm。通过允许无纺布的纤维在网收集期间最初保持熔融，可以实现改进的纤维内聚力。在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的无纺布，其中无纺布具有大于0.1Kgff的破裂强度，其中无纺织物通过连续熔喷法得到。无纺布可以用于各种目的，包括制造医疗装置。

4. 发明申请

US20070182041A1 Toughened Polylactic Acid Polymers and Copolymers 审中-公开
标题翻译：增韧的聚乳酸聚合物和共聚物
公开(公告)号：US20070182041A1
公开(公告)日：2007-08-09
申请号：US11671544
申请日：2007-02-06
申请人： Said Rizk , David P. Martin , Kicherl Ho , Amit Ganatra , Simon F. Williams
发明人： Said Rizk , David P. Martin , Kicherl Ho , Amit Ganatra , Simon F. Williams
IPC分类号： B29B9/08 , C08G63/08
CPC分类号： C08L67/04 , A61K47/34 , A61L15/26 , A61L17/105 , A61L17/12 , A61L27/18 , A61L27/26 , A61L29/049 , A61L29/06 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/18 , C08G63/06 , C08K3/014 , C08K5/0016 , C08K5/005 , C08K5/0083 , C08L2666/18
摘要： Toughened compositions of PLA and PLA copolymers are disclosed, which also have low tensile modulus values and greater elongation to break. These toughened compositions are prepared by blending PLA and PLA copolymers with poly-4-hydroxybutyrate, and copolymers thereof. Blending of poly-4-hydroxybutyrate with PLA and its copolymers has been found to impart advantageous properties to the resulting blend. These compositions, and objects formed from these compositions, have improved toughness and lower stiffness than polylactic acid polymers or copolymers alone.
摘要翻译：公开了PLA和PLA共聚物的增韧组合物，其也具有低拉伸模量值和较大的断裂伸长率。这些增韧的组合物通过将PLA和PLA共聚物与聚-4-羟基丁酸酯及其共聚物共混来制备。已经发现聚-4-羟基丁酸酯与PLA及其共聚物的混合赋予所得共混物有利的性质。这些组合物和由这些组合物形成的物体比单独的聚乳酸聚合物或共聚物具有改善的韧性和较低的刚度。

5. 发明授权

US10227718B2 Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers 有权
公开(公告)号：US10227718B2
公开(公告)日：2019-03-12
申请号：US13160942
申请日：2011-06-15
申请人： Ryan Cahil , Kai Guo , David P. Martin , Said Rizk , Kicherl Ho , Simon F. Williams
发明人： Ryan Cahil , Kai Guo , David P. Martin , Said Rizk , Kicherl Ho , Simon F. Williams
IPC分类号： D04H1/42 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L31/16 , D04H1/56 , D04H3/16
摘要： Continuous processing methods for making absorbable polymeric dry spun non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 0.01 μm to 50 μm, and thickness from 10 μm to 10 mm, have been developed. Improved fiber cohesion is made possible by controlling the tackiness of the fibers of the non-woven during web collection. The polymer is preferably a polyhydroxyalkanoate, more preferably, a 4-hydroxybutyrate polymer or copolymer. A non-woven of poly-4-hydroxybutyrate is most preferred. The non-wovens have fine fibers with average diameters ranging from 0.01 μm to 50 μm, and are derived by dry spun processing, during which a solution of polymer(s) is injected into a stream of high velocity air with a pressure of 1 to 500 psi for solvent stripping and polymer strand attenuation. The non-wovens can be used for a variety of purposes including fabrication of medical devices.

6. 发明授权

US07943683B2 Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers 有权
标题翻译：包含聚-4-羟基丁酸取代膜和共聚物的医疗器械
公开(公告)号：US07943683B2
公开(公告)日：2011-05-17
申请号：US11931850
申请日：2007-10-31
申请人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
发明人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
IPC分类号： C08G63/06 , B29C47/00
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2，断裂伸长率为10-500％其中所述膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个方向上定向至超过膜的原始长度的25％。这些可以用于各种目的，包括制造医疗器械。

7. 发明授权

US08287909B2 Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof 有权
标题翻译：含有聚-4-羟基丁酸酯的熔喷非织造物及其共聚物的医疗装置
公开(公告)号：US08287909B2
公开(公告)日：2012-10-16
申请号：US12336755
申请日：2008-12-17
申请人： David P. Martin , Said Rizk , Kicherl Ho , Simon F. Williams
发明人： David P. Martin , Said Rizk , Kicherl Ho , Simon F. Williams
IPC分类号： A61K9/14 , A61K13/00 , A61B18/18 , A61B17/56
CPC分类号： A61L29/06 , A61L15/26 , A61L15/44 , A61L27/18 , A61L27/54 , A61L29/16 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , D04H1/4382 , D04H1/56 , Y10T442/608 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric non-wovens with one or more of the following properties: high burst strength, fine fibers of average diameter from 1 μm to 50 μm, and thickness from 10 μm to 50 mm, have been developed. Improved fiber cohesion is made possible by allowing the fibers of the non-woven to initially remain molten during web collection. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a non-woven of poly-4-hydroxybutyrate or copolymer thereof, wherein the non-woven has a burst strength greater than 0.1 Kgf, wherein the non-woven is derived by a continuous melt-blown process. The non-wovens can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：已经开发了用于制造具有以下特性中的一种或多种的可吸收聚合非织造物的连续加工方法：高爆裂强度，平均直径为1μm至50μm的细纤维和厚度为10μm至50mm。通过允许无纺布的纤维在网收集期间最初保持熔融，可以实现改进的纤维内聚力。在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的无纺布，其中无纺布具有大于0.1Kgff的破裂强度，其中无纺织物通过连续熔喷法得到。无纺布可以用于各种目的，包括制造医疗装置。

8. 发明申请

US20110189475A1 MEDICAL DEVICES CONTAINING ORIENTED FILMS OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS 有权
标题翻译：含聚-4-羟基丁酸酯和共聚物的靶向膜的医疗装置
公开(公告)号：US20110189475A1
公开(公告)日：2011-08-04
申请号：US13084388
申请日：2011-04-11
申请人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
发明人： Said Rizk , David P. Martin , Kicherl Ho , Simon F. Williams
IPC分类号： B32B3/00 , C08G63/06 , A61L27/44 , B29D7/01
CPC分类号： A61L27/34 , A61L27/18 , A61L31/10 , B29C55/005 , B29C55/04 , B29C55/12 , B29K2067/00 , B29K2067/046 , B29K2995/006 , C08L67/04
摘要： Continuous processing methods for making absorbable polymeric films with one or more of the following properties: high toughness, low modulus, high tensile strength, and thickness less than 10 mm, more preferably less than 1 mm, and more preferably less than 100 μm, have been developed. In the preferred embodiment, the polymer is a polyhydroxyalkanoate, and in the most preferred embodiment, the polymer comprises 4-hydroxybutyrate. A particularly preferred embodiment is a film of poly-4-hydroxybutyrate or copolymer thereof, wherein the film has a tensile strength greater than 5.5 kgf/mm2, tensile modulus less than 181 kgf/mm2, and elongation at break from 10-500%, wherein the film is derived by a continuous process such as melt extrusion or solvent casting, followed by orientation to more than 25% of the film's original length in one or more directions. These can be used for a variety of purposes including fabrication of medical devices.
摘要翻译：用于制造具有以下特性中的一种或多种的可吸收聚合物膜的连续加工方法：高韧性，低模量，高拉伸强度和小于10mm，更优选小于1mm，更优选小于100μm的厚度具有已经开发在优选的实施方案中，聚合物是聚羟基链烷酸酯，并且在最优选的实施方案中，聚合物包含4-羟基丁酸酯。特别优选的实施方案是聚-4-羟基丁酸酯或其共聚物的膜，其中所述膜的拉伸强度大于5.5kgf / mm 2，拉伸模量小于181kgf / mm 2，断裂伸长率为10-500％其中所述膜通过连续方法如熔体挤出或溶剂浇铸得到，然后在一个或多个方向上定向至超过膜的原始长度的25％。这些可以用于各种目的，包括制造医疗器械。

9. 发明授权

US08016883B2 Methods and devices for rotator cuff repair 有权
标题翻译：肩袖修复方法及装置
公开(公告)号：US08016883B2
公开(公告)日：2011-09-13
申请号：US11671102
申请日：2007-02-05
申请人： Struan Coleman , David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
发明人： Struan Coleman , David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/0642 , A61B2017/00893 , A61L27/18 , A61L2430/10 , C08L67/04
摘要： Interposition and augmentation devices for tendon and ligament repair, including rotator cuff repair, have been developed as well as methods for their delivery using arthroscopic methods. The devices are preferably derived from biocompatible polyhydroxyalkanoates, and preferably from copolymers or homopolymers of 4-hydroxybutyrate. The devices may be delivered arthroscopically, and offer additional benefits such as support for the surgical repair, high initial strength, prolonged strength retention in vivo, flexibility, anti-adhesion properties, improved biocompatibility, an ability to remodel in vivo to healthy tissue, minimal risk for disease transmission or to potentiate infection, options for fixation including sufficiently high strength to prevent suture pull out or other detachment of the implanted device, eventual absorption eliminating future risk of foreign body reactions or interference with subsequent procedures, competitive cost, and long-term mechanical stability. The devices are also particularly suitable for use in pediatric populations where their eventual absorption should not hinder growth.
摘要翻译：已经开发了用于肌腱和韧带修复的包括肩袖修复的插入和增大装置以及使用关节镜方法进行递送的方法。所述装置优选衍生自生物相容性聚羟基链烷酸酯，优选衍生自4-羟基丁酸酯的共聚物或均聚物。这些装置可以关节镜地传送，并且提供额外的益处，例如支持手术修复，高初始强度，在体内延长的强度保持力，柔韧性，抗粘连性，改善的生物相容性，体内重塑健康组织的能力，最小化疾病传播的风险或增强感染的选择，包括足够高的强度的选项，以防止缝合线拔出或植入装置的其他脱离，最终吸收消除异物反应的未来风险或干扰后续程序，竞争性成本，长期机械稳定性。这些装置还特别适用于儿科人群，其最终吸收不应阻碍生长。

10. 发明授权

US09125719B2 Polyhydroxyalkanoate medical textiles and fibers 有权
标题翻译：聚羟基链烷酸酯医用纺织品和纤维
公开(公告)号：US09125719B2
公开(公告)日：2015-09-08
申请号：US13228056
申请日：2011-09-08
申请人： David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
发明人： David P. Martin , Said Rizk , Ajay Ahuja , Simon F. Williams
IPC分类号： A61K9/00 , A61F2/00 , A61L27/18 , A61L31/06 , D01F6/62 , D01F6/84 , D01D5/088 , D01D5/16 , D02G3/02 , A61L27/48 , D01D5/098
CPC分类号： A61F2/0063 , A61F2002/0068 , A61L27/18 , A61L27/48 , A61L31/06 , B29C47/0004 , B29C47/0014 , B29C71/0072 , B29K2067/00 , B29L2031/753 , D01D5/088 , D01D5/098 , D01D5/16 , D01F6/62 , D01F6/625 , D01F6/84 , D02G3/02 , Y10T428/1362 , Y10T428/1369 , Y10T428/249922 , Y10T442/10 , Y10T442/183 , Y10T442/184 , Y10T442/2525 , C08L67/04
摘要： Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate. These devices provide a wider range of in vivo strength retention properties than are currently available, and could offer additional benefits such as anti-adhesion properties, reduced risks of infection or other post-operative problems resulting from absorption and eventual elimination of the device, and competitive cost. The devices may also be particularly suitable for use in pediatric populations where their absorption should not hinder growth, and provide in all patient populations wound healing with long-term mechanical stability. The devices may additionally be combined with autologous, allogenic and/or xenogenic tissues to provide implants with improved mechanical, biological and handling properties.
摘要翻译：已经开发了具有延长的强度保持性的可吸收聚酯纤维，辫子和外科网。这些装置优选衍生自生物相容性共聚物或4-羟基丁酸酯的均聚物。这些装置提供比目前可获得的更广泛的体内强度保持性能，并且可以提供额外的益处，例如抗粘附性质，降低的感染风险或由于吸收和最终消除装置而导致的其他手术后问题，以及有竞争力的成本。这些装置还可以特别适用于儿科人群，其吸收不应阻碍生长，并在所有患者群体中提供长期机械稳定性的伤口愈合。所述装置可以另外与自体，同种异体和/或异种组织组合，以提供具有改进的机械，生物和处理性质的植入物。

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