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    • 2. 发明授权
    • Colon-specific drug release system
    • 结肠特异性药物释放系统
    • US06368629B1
    • 2002-04-09
    • US09183339
    • 1998-10-30
    • Shunsuke WatanabeHitoshi KawaiMasataka KatsumaMuneo Fukui
    • Shunsuke WatanabeHitoshi KawaiMasataka KatsumaMuneo Fukui
    • A61K932
    • A61K9/2886A61K9/2018A61K9/2826A61K9/2846A61K9/4808
    • A system for releasing a drug specifically in the colon of the gastrointestinal tract, which comprises a drug (b) coated with an organic acid-soluble polymer material (a), and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract; a colon-specific drug release oral preparation, which comprises a composition comprising a drug (b) coated with an organic acid-soluble polymer material (a) and a saccharide (c) which rapidly generates an organic acid by the action of enterobacteria in the lower part of the gastrointestinal tract, said composition being coated with an enteric coating polymer material (d). The invention provides a drug release system and a preparation which utilize enterobacteria, which do not form harmful substances due to the release-starting mechanism, show rapid degradation, and have higher colon specificity.
    • 一种用于特别在胃肠道结肠中释放药物的系统,其包括用有机酸溶性聚合物材料(a)涂覆的药物(b)和通过动作快速产生有机酸的糖(c) 的胃肠道下部的肠细菌; 一种结肠特异性药物释放口服制剂,其包含包含有机酸溶性聚合物材料(a)的药物(b)和通过肠杆菌的作用快速产生有机酸的糖(c)的组合物 所述组合物涂覆有肠溶衣聚合物材料(d)。本发明提供一种药物释放系统和利用肠杆菌的制剂,其不会由于释放启动机制而形成有害物质 快速降解,并具有更高的结肠特异性。