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1. 发明申请

US20070231399A1 COATED FINE PARTICLES CONTAINING DRUG FOR INTRABUCCALLY FAST DISINTEGRATING DOSAGE FORMS 失效
标题翻译：含有药物的含有精细颗粒的快速消毒剂型
公开(公告)号：US20070231399A1
公开(公告)日：2007-10-04
申请号：US11458582
申请日：2006-07-19
申请人： Yuki Kasashima , Ippei Kurimoto , Hitoshi Kawai
发明人： Yuki Kasashima , Ippei Kurimoto , Hitoshi Kawai
IPC分类号： A61K9/52
CPC分类号： A61K9/5078 , A61K9/5047
摘要： Regarding an object of sufficient suppression of unpleasant taste in the oral cavity and quick dissolution in the gastrointestinal tract, which is generated when a drug having a strong unpleasant taste such as bitterness, astringency and the like is applied to a quickly disintegrating preparations in the oral cavity, this invention has achieved the aforementioned object for the first time by employing a constitution of coating a coat of a water-soluble polymer and a specified ratio of a pH-independent water-insoluble polymer and hydroxypropylcellulose.
摘要翻译：关于在口腔中充分抑制不愉快味道和快速溶解在胃肠道中的目的，当将具有强烈令人不快的味道（例如苦味，涩味等）的药物施用于口服的快速崩解制剂时产生本发明通过使用涂布水溶性聚合物的涂层和与pH无关的水不溶性聚合物和羟丙基纤维素的规定比例的结构第一次实现了上述目的。

2. 发明申请

US20050175689A1 Coated fine particles containing drug for intrabuccally fast disintegrating tablet 审中-公开
标题翻译：含有药物的包衣微粒含有快速崩解片剂
公开(公告)号：US20050175689A1
公开(公告)日：2005-08-11
申请号：US10975210
申请日：2004-10-27
申请人： Ippei Kurimoto , Yuki Kasashima , Hitoshi Kawai , Yuuki Takaishi , Masataka Katsuma , Hiroshi Ohi , Takayuki Yoshida , Hiroaki Tasaki
发明人： Ippei Kurimoto , Yuki Kasashima , Hitoshi Kawai , Yuuki Takaishi , Masataka Katsuma , Hiroshi Ohi , Takayuki Yoshida , Hiroaki Tasaki
IPC分类号： A61K9/14 , A61K9/20
CPC分类号： A61K9/0056 , A61K9/2081
摘要： The present invention makes it possible to provide drug-containing coated microparticles for quick-disintegrating oral tablets wherein microparticles containing a drug with an unpleasant taste are coated with a film composed of (1) a pH-independent water-insoluble polymer accounting for 60% or more but less than 80% of the film and (2) a pH-independent water-soluble substance accounting for more than 20% to 40% or less of the film, these microparticles being characterized in that the rate of dissolution of the drug from the drug-containing microparticles is 0% to 10% in one minute and 80% to 100% in 30 minutes, and the average particle diameter is 350 μm or less, in order to realize sufficient control of oral drug dissolution and fast gastrointestinal drug dissolution.
摘要翻译：本发明使得可以提供用于快速崩解口服片剂的药物包衣微粒，其中含有具有令人不快的味道的药物的微粒被包被（1）不含pH的水不溶性聚合物占60％或更多但小于80％的膜，（2）占pH超过20％至40％以下的pH不依赖性水溶性物质，这些微粒的特征在于药物的溶解速率含药微粒在1分钟内为0％〜10％，30分钟为80％〜100％，平均粒径为350μm以下，为了实现口服药物溶解和快速胃肠药物的充分控制溶解

3. 发明申请

US20100062063A1 LIGHT-STABLE SOLID PHARMACEUTICAL COMPOSITION OF RAMOSETRON 审中-公开
标题翻译：光稳定的固体药物组合物
公开(公告)号：US20100062063A1
公开(公告)日：2010-03-11
申请号：US12441006
申请日：2007-09-12
申请人： Hiroyuki Umejima , Ippei Kurimoto , Atsushi Kanbayashi , Chieko Mori
发明人： Hiroyuki Umejima , Ippei Kurimoto , Atsushi Kanbayashi , Chieko Mori
IPC分类号： A61K31/4184 , A61K9/14 , A61K9/28 , A61P1/08
CPC分类号： A61K31/4184 , A61K9/0056
摘要： Provided is a preparation of ramosetron which is stable under irradiation with light. The solid pharmaceutical composition of the present invention can provide a stable preparation by blending a compound absorbing light having a specific wavelength with ramosetron which is unstable, usually under irradiation with light, or a pharmaceutically acceptable salt thereof. Particularly, this technique is useful because it is adaptable to a preparation containing ramosetron or a pharmaceutically acceptable salt thereof at a low content or an orally disintegrating tablet containing ramosetron or a pharmaceutically acceptable salt thereof. Also, the present invention relates to a method for stabilizing a solid pharmaceutical composition of ramosetron or a pharmaceutically acceptable salt thereof, which is characterized by blending a compound having characteristics of absorbing light having a specific wavelength.
摘要翻译：提供了在光照下稳定的雷莫司琼的制剂。本发明的固体药物组合物可以通过将具有特定波长的光吸收的化合物与通常在光照下不稳定的雷莫司琼或其药学上可接受的盐混合来提供稳定的制剂。特别地，该技术是有用的，因为它适用于低含量的雷莫司琼或其药学上可接受的盐或含有雷莫司琼或其药学上可接受的盐的口腔崩解片剂的制剂。另外本发明涉及一种稳定拉莫司琼固体药物组合物或其药学上可接受的盐的方法，其特征在于将具有吸收具有特定波长的光的特性的化合物混合。

4. 发明申请

US20080221047A1 Aminoakyl methacrylate copolymer E for maintaining solubility of poorly-soluble drug 审中-公开
标题翻译：用于保持难溶性药物溶解性的甲基丙烯酸甲酯共聚物E
公开(公告)号：US20080221047A1
公开(公告)日：2008-09-11
申请号：US12003473
申请日：2007-12-26
申请人： Takatsune Yoshida , Keiichi Yoshihara , Hiroyuki Umejima , Ippei Kurimoto
发明人： Takatsune Yoshida , Keiichi Yoshihara , Hiroyuki Umejima , Ippei Kurimoto
IPC分类号： A61K31/436 , A61K47/30
CPC分类号： A61K47/32 , A61K9/146 , A61K9/19 , A61K9/4858 , A61K9/4866
摘要： A pharmaceutical composition comprising aminoalkyl methacrylate copolymer E, an acidic substance, and a poorly-soluble drug, wherein the aminoalkyl methacrylate copolymer E and the acidic substance are uniformly mixed, and solubility of the poorly-soluble drug is maintained for at least 30 minutes is disclosed.
摘要翻译：一种包含甲基丙烯酸氨基烷基酯共聚物E，酸性物质和难溶性药物的药物组合物，其中甲基丙烯酸氨基烷基酯共聚物E和酸性物质均匀混合，并且难溶性药物的溶解度保持至少30分钟披露

5. 发明授权

US07815939B2 Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms 失效
标题翻译：含有药物的包被的细颗粒用于脂肪内快速崩解剂型
公开(公告)号：US07815939B2
公开(公告)日：2010-10-19
申请号：US11458582
申请日：2006-07-19
申请人： Yuki Kasashima , Ippei Kurimoto , Hitoshi Kawai
发明人： Yuki Kasashima , Ippei Kurimoto , Hitoshi Kawai
IPC分类号： A61K9/24 , A61K9/16
CPC分类号： A61K9/5078 , A61K9/5047
摘要： Regarding an object of sufficient suppression of unpleasant taste in the oral cavity and quick dissolution in the gastrointestinal tract, which is generated when a drug having a strong unpleasant taste such as bitterness, astringency and the like is applied to a quickly disintegrating preparations in the oral cavity, this invention has achieved the aforementioned object for the first time by employing a constitution of coating a coat of a water-soluble polymer and a specified ratio of a pH-independent water-insoluble polymer and hydroxypropylcellulose.
摘要翻译：关于在口腔中充分抑制不愉快味道和快速溶解在胃肠道中的目的，当将具有强烈令人不快的味道（例如苦味，涩味等）的药物施用于口服的快速崩解制剂时产生本发明通过使用涂布水溶性聚合物的涂层和与pH无关的水不溶性聚合物和羟丙基纤维素的规定比例的结构第一次实现了上述目的。

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