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1. 发明申请

US20070249659A1 Imidazopyridine Compound 失效
标题翻译：咪唑并吡啶化合物
公开(公告)号：US20070249659A1
公开(公告)日：2007-10-25
申请号：US11579570
申请日：2005-05-09
申请人： Shunji Sakuraba , Minoru Moriya , Hidekazu Takahashi , Hiroyuki Kishino , Makoto Jitsuoka , Minoru Kameda , Akio Kanatani
发明人： Shunji Sakuraba , Minoru Moriya , Hidekazu Takahashi , Hiroyuki Kishino , Makoto Jitsuoka , Minoru Kameda , Akio Kanatani
IPC分类号： A61K31/44 , C07D471/02
CPC分类号： A61K31/501 , A61K31/437 , A61K31/444 , A61K31/506 , C07D471/04
摘要： The present invention provides an imidazopyridine compound represented by formula (I), wherein R1 and R2 each independently represent a C1-6 alkyl group et al; R3 and R4 each independently represent a hydrogen atom, a methyl et al; Ar1 is a divalent substituent representing a monocyclic or bicyclic, 3- to 8-membered aromatic or aliphatic heterocyclic group et al; Ar2 represents an aromatic carbocyclic group, or an aromatic heterocyclic group; W represents —(CH2)m et al, and m indicates an integer of from 0 to 10. This compound acts as a melanin concentrating hormone receptor antagonist, and is useful as treating agents for obesity.
摘要翻译：本发明提供由式（I）表示的咪唑并吡啶化合物，其中R 1和R 2各自独立地表示C 1-6烷基集团等 R 3和R 4各自独立地表示氢原子，甲基等; Ar 1是表示单环或双环的3至8元芳族或脂族杂环基等的二价取代基; Ar 2表示芳族碳环基或芳族杂环基; W表示 - （CH 2）2，m表示0〜10的整数。该化合物作为黑色素浓缩激素受体拮抗剂起作用，作为肥胖症的治疗剂。

2. 发明授权

US07566781B2 Imidazopyridine compound 失效
标题翻译：咪唑并吡啶化合物
公开(公告)号：US07566781B2
公开(公告)日：2009-07-28
申请号：US11579570
申请日：2005-05-09
申请人： Shunji Sakuraba , Minoru Moriya , Hidekazu Takahashi , Hiroyuki Kishino , Makoto Jitsuoka , Minoru Kameda , Akio Kanatani
发明人： Shunji Sakuraba , Minoru Moriya , Hidekazu Takahashi , Hiroyuki Kishino , Makoto Jitsuoka , Minoru Kameda , Akio Kanatani
IPC分类号： C07D491/02 , C07D237/02 , C07F9/02 , A61K31/519
CPC分类号： A61K31/501 , A61K31/437 , A61K31/444 , A61K31/506 , C07D471/04
摘要： The present invention provides an imidazopyridine compound represented by formula (I), wherein R1 and R2 each independently represent a C1-6 alkyl group et al; R3 and R4 each independently represent a hydrogen atom, a methyl et al; Ar1 is a divalent substituent representing a monocyclic or bicyclic, 3- to 8-membered aromatic or aliphatic heterocyclic group et al; Ar2 represents an aromatic carbocyclic group, or an aromatic heterocyclic group; W represents —(CH2)m et al, and m indicates an integer of from 0 to 10. This compound acts as a melanin concentrating hormone receptor antagonist, and is useful as treating agents for obesity.
摘要翻译：本发明提供由式（I）表示的咪唑并吡啶化合物，其中R 1和R 2各自独立地表示C 1-6烷基等; R3和R4各自独立地表示氢原子，甲基等; Ar 1是代表单环或双环的3-至8-元芳族或脂族杂环基团的二价取代基; Ar 2表示芳香族碳环基或芳香族杂环基; W表示 - （CH 2）m等，m表示0〜10的整数。该化合物作为黑色素浓缩激素受体拮抗剂起作用，可用作肥胖症的治疗剂。

3. 发明申请

US20080200494A1 Imidazopyridine Derivatives 失效
标题翻译：咪唑并吡啶衍生物
公开(公告)号：US20080200494A1
公开(公告)日：2008-08-21
申请号：US10567269
申请日：2004-08-13
申请人： Hiroyuki Kishino , Minoru Moriya , Toshihiro Sakamoto , Hidekazu Takahashi , Shunji Sakuraba , Takao Suzuki , Akio Kanatani
发明人： Hiroyuki Kishino , Minoru Moriya , Toshihiro Sakamoto , Hidekazu Takahashi , Shunji Sakuraba , Takao Suzuki , Akio Kanatani
IPC分类号： A61K31/437 , A61P3/10 , C07D471/04
CPC分类号： C07D471/04
摘要： The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R1 and R2 may be the same or different and stand for C1-6 alkyl or the like, R3 and R4 stand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.
摘要翻译：本发明提供由通式[I]表示的咪唑并吡啶衍生物[其中R 1'和R 2'可以相同或不同，代表C 1〜 6个烷基等，R 3和R 4代表氢原子，甲基等，W代表单环或双环3 - 至8-元芳族或脂族杂环等，Ar表示任选取代的芳族杂环等〕。这些化合物作为黑色素浓缩激素受体拮抗剂起作用，可用作中枢神经系统疾病，心血管系统疾病和代谢紊乱的药物。

4. 发明授权

US07504412B2 Imidazopyridine derivatives 失效
标题翻译：咪唑并吡啶衍生物
公开(公告)号：US07504412B2
公开(公告)日：2009-03-17
申请号：US10567269
申请日：2004-08-13
申请人： Hiroyuki Kishino , Minoru Moriya , Toshihiro Sakamoto , Hidekazu Takahashi , Shunji Sakuraba , Takao Suzuki , Akio Kanatani
发明人： Hiroyuki Kishino , Minoru Moriya , Toshihiro Sakamoto , Hidekazu Takahashi , Shunji Sakuraba , Takao Suzuki , Akio Kanatani
IPC分类号： A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R1 and R2 may be the same or different and stand for C1-6 alkyl or the like, R3 and R4 stand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.
摘要翻译：本发明提供由通式[I]表示的咪唑并吡啶衍生物[其中R 1和R 2可以相同或不同，代表C 1-6烷基等，R 3和R 4代表氢原子，甲基等， W代表单环或双环3-至8-元芳族或脂族杂环等，Ar代表任选取代的芳族杂环等〕。这些化合物作为黑色素浓缩激素受体拮抗剂，可用作中枢神经系统疾病，心血管系统疾病和代谢紊乱的药物。

5. 发明申请

US20090264426A1 Bicyclic aromatic substituted pyridone derivative 审中-公开
标题翻译：双环芳族取代吡啶酮衍生物
公开(公告)号：US20090264426A1
公开(公告)日：2009-10-22
申请号：US11991334
申请日：2006-09-05
申请人： Shunji Sakuraba , Minoru Kameda , Hiroyuki Kishino , Yuji Haga , Norikazu Otake , Minoru Moriya
发明人： Shunji Sakuraba , Minoru Kameda , Hiroyuki Kishino , Yuji Haga , Norikazu Otake , Minoru Moriya
IPC分类号： A61K31/5377 , C07D401/10 , C07D413/14 , A61K31/47 , A61P9/10
CPC分类号： C07D401/14 , C07D401/04 , C07D405/04 , C07D471/04
摘要： Disclosed is a compound represented by the formula (I): Wherein R1 and R2 independently represent a hydrogen atom, a lower alkyl group or the like; X1, X2 and X3 independently represent a methine group or a nitrogen atom; Y1 and Y3 independently represent a single bond, —O— or the like; Y2 represents a lower alkylene group or the like; W1 to W4 independently represent a single bond, a methylene group or the like; L represents a single bond, a methylene group or the like; Z1 and Z2 independently represent a single bond, a C1-4 alkylene group or the like; Ar1 represents an aromatic carbocyclic ring or the like; and Ar2 represents a bicyclic aromatic carbocyclic ring or the like. The compound is useful as a pharmaceutical for a central disease, a cardiovascular disease or a metabolic disease.
摘要翻译：公开了由式（I）表示的化合物：其中R1和R2独立地表示氢原子，低级烷基等; X1，X2和X3独立地表示次甲基或氮原子; Y1和Y3独立地表示单键，-O-等; Y2表示低级亚烷基等; W1至W4独立地表示单键，亚甲基等; L表示单键，亚甲基等; Z 1和Z 2独立地表示单键，C 1-4亚烷基等; Ar 1表示芳香族碳环等， Ar 2表示双环芳香族碳环等。该化合物可用作中枢性疾病，心血管疾病或代谢性疾病的药物。

6. 发明申请

US20070299070A1 2-Arylcarboxamide-Nitrogenous Heterocycle Compound 失效
标题翻译： 2-芳基甲酰胺 - 含氮杂环化合物
公开(公告)号：US20070299070A1
公开(公告)日：2007-12-27
申请号：US11663038
申请日：2005-09-30
申请人： Takao Suzuki , Minoru Moriya , Shunji Sakuraba , Sayaka Mizutani , Hisashi Iwaasa , Akio Kanatani
发明人： Takao Suzuki , Minoru Moriya , Shunji Sakuraba , Sayaka Mizutani , Hisashi Iwaasa , Akio Kanatani
IPC分类号： A61K31/5377 , A61K31/4025 , A61K31/4045 , A61P1/00 , A61P13/00 , A61P21/00 , A61P27/00 , A61P37/00 , A61P5/00 , C07D413/14 , C07D413/10 , C07D403/10 , C07D401/12 , C07D401/10 , C07D401/02 , C07D209/04 , A61P9/00 , A61P7/00 , A61P43/00 , A61P3/00 , A61P25/00 , A61P15/00 , A61P11/00 , A61K31/4439 , A61K31/454
CPC分类号： C07D209/42 , C07D235/24 , C07D401/12
摘要： A compound represented by the formula [I]: [wherein R1 and R2 are the same or different and each represents C1-6 alkyl, C3-8 cycloalkyl, et al; R3a, R3b, and R4 are the same or different and each represents hydrogen, C1-6 alkyl, et al; X represents —N—, —CH—, et al; Y, represents a single bond, C1-3 alkylene, et al; Y2 represents C1-4 alkylene, oxy(C1-4 alkylene), et al; Ar1 represents a monocyclic aromatic carbocyclic group, monocyclic aromatic heterocyclic group, et al; and Ar2 represents a 5- or 6-membered aromatic carbocyclic group, aromatic heterocyclic group, et al]. This compound functions as a melanin-concentrating hormone receptor antagonist and is useful as, e.g., a therapeutic agent for obesity, et al.
摘要翻译：由式[I]表示的化合物：其中R 1和R 2相同或不同，各自表示C 1-6烷基，烷基，C 3-8环烷基等; R 3a，R 3b和R 4相同或不同，各自表示氢，C 1-6 烷基等; X表示-N-，-CH-等; Y表示单键，C 1-3亚烷基等; Y 2表示C 1-4亚烷基，氧（C 1-4烷基亚烷基）等; Ar 1表示单环芳族碳环基团，单环芳族杂环基团等; 和Ar 2代表5或6元芳族碳环基团，芳族杂环基团等。该化合物起着黑色素浓缩激素受体拮抗剂的作用，可用作例如肥胖症的治疗剂等。

7. 发明授权

US07531668B2 2-arylcarboxamide-nitrogenous heterocycle compound 失效
标题翻译： 2-芳基羧酰胺 - 含氮杂环化合物
公开(公告)号：US07531668B2
公开(公告)日：2009-05-12
申请号：US11663038
申请日：2005-09-30
申请人： Takao Suzuki , Minoru Moriya , Shunji Sakuraba , Sayaka Mizutani , Hisashi Iwaasa , Akio Kanatani
发明人： Takao Suzuki , Minoru Moriya , Shunji Sakuraba , Sayaka Mizutani , Hisashi Iwaasa , Akio Kanatani
IPC分类号： C07D235/12 , C07D209/12 , C07D211/06 , C07D401/12 , C07D291/04 , C07D291/06 , C07D279/02 , C07D279/06 , C07D279/12 , C07D265/02 , C07D265/06 , C07D265/30 , C07D257/04 , C07D257/08 , C07D251/04 , C07D237/04
CPC分类号： C07D209/42 , C07D235/24 , C07D401/12
摘要： A compound represented by the formula [I]: [wherein R1 and R2 are the same or different and each represents C1-6 alkyl, C3-8 cycloalkyl, et al; R3a, R3b, and R4 are the same or different and each represents hydrogen, C1-6 alkyl, et al; X represents —N—, —CH—, et al; Y1 represents a single bond, C1-3 alkylene, et al; Y2 represents C1-4 alkylene, oxy(C1-4 alkylene), et al; Ar1 represents a monocyclic aromatic carbocyclic group, monocyclic aromatic heterocyclic group, et al; and Ar2 represents a 5- or 6-membered aromatic carbocyclic group, aromatic heterocyclic group, et al]. This compound functions as a melanin-concentrating hormone receptor antagonist and is useful as, e.g., a therapeutic agent for obesity, et al.
摘要翻译：由式[I]表示的化合物：其中R 1和R 2相同或不同，各自表示C 1-6烷基，C 3-8环烷基等; R3a，R3b和R4相同或不同，各自表示氢，C1-6烷基等; X表示-N-，-CH-等; Y1表示单键，C1-3亚烷基等; Y2代表C1-4亚烷基，氧基（C1-4亚烷基）等; Ar 1表示单环芳族碳环基团，单环芳族杂环基团等; 和Ar 2表示5或6元芳族碳环基团，芳族杂环基团等。该化合物起着黑色素浓缩激素受体拮抗剂的作用，可用作例如肥胖症的治疗剂等。

8. 发明申请

US20060287340A1 2-Aminoquinoline derivatives 失效
标题翻译： 2-氨基喹啉衍生物
公开(公告)号：US20060287340A1
公开(公告)日：2006-12-21
申请号：US10556932
申请日：2004-05-20
申请人： Minoru Moriya , Takao Suzuki , Akane Ishihara , Hisashi Iwaasa , Akio Kanatani
发明人： Minoru Moriya , Takao Suzuki , Akane Ishihara , Hisashi Iwaasa , Akio Kanatani
IPC分类号： A61K31/506 , C07D403/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D487/04 , C07D487/10
摘要： This invention provides 2-aminoquinoline derivatives represented by a general formula [I] [in which R1 and R2 either stand for lower alkyl, lower cycloalkyl, etc., or R1 and R2 together form an aliphatic nitrogen-containing heterocycle with the nitrogen atom to which they bind; R3, R4, R5, R6 and R7 stand for hydrogen, lower alkyl, etc.; R8 stands for lower alkyl, lower alkyloxy, etc.; and n stands for an integer of 0-4]. The compounds act as melanin concentrating hormone receptor antagonist, and are useful as medicines for central nervous system disorders, cardiovascular disorders and metabolic disorders.
摘要翻译：本发明提供由通式[I]表示的2-氨基喹啉衍生物[其中R 1和R 2代表低级烷基，低级环烷基等，或 R 1和R 2一起形成与它们结合的氮原子的脂族含氮杂环; R 3，R 4，R 5，R 6和R 7，R 3，氢，低级烷基等; R 8代表低级烷基，低级烷氧基等; 并且n表示0-4的整数]。该化合物作为黑色素浓缩激素受体拮抗剂，可用作中枢神经系统疾病，心血管疾病和代谢紊乱的药物。

9. 发明申请

US20060205750A1 Novel benzimidazole derivatives 失效
公开(公告)号：US20060205750A1
公开(公告)日：2006-09-14
申请号：US11431274
申请日：2006-05-10
申请人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
发明人： Norikazu Otake , Minoru Moriya , Yoshio Ogino , Kenji Matsuda , Yoshikazu Nagae , Akio Kanatani , Takehiro Fukami
IPC分类号： A61K31/4747 , A61K31/4184 , C07D487/10
CPC分类号： C07D473/30 , C07D405/04 , C07D471/04 , C07D471/10 , C07D473/00 , C07D491/04
摘要： The present invention relates to a compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is 0 or 1; T, U, V and W are independently nitrogen or optionally substituted methine; X is —N(SO2R4)—, —N(COR5)— or —CO—; Y is —C(R6)(R7)—, —O— or —N(R8)—, provided that the compound (I) when E is nitrogen, n is 0, X is —CO—, and Y is —O— is excluded) and the like, which are useful as an agent for the treatment of various diseases related to NPY, for example cardiovascular disorders such as angina, acute or congestive heart failure, myocardial infarction, hypertension, nephropathy, electrolyte abnormality, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, memory impairment, sleep disorders, cognitive impairment, etc., metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, gout, fatty liver, etc., genital or reproductive disorders such as infertility, preterm labor, sexual dysfunction, etc., gastro-intestinal disorders, respiratory disorder, inflammatory diseases or glaucoma, and the like, also for example, atherosclerosis, hypogonadism, hyperandrogenism, polycystic ovary syndrome (Pickwickian syndrome), hirsutism, gastro-intestinal motility disorder, obesity-related gastro-esophageal reflux, obesity hypoventilation, sleep apnea, inflammation, systemic inflammation of the vasculature, osteoarthritis, insulin resistance, bronchoconstriction, alcohol preference, metabolic syndrome, Alzheimer's disease, cardiac hypertrophy, left ventricular hypertrophy, hypertriglyceridemia, low HDL cholesterol, cardiovascular disorders such as coronary heart disease (CHD), cerebrovascular disease, stroke, peripheral vascular disease, sudden death, gallbladder diseases, cancer (breast, endometrial, colon), breathlessness, hyperuricemia, impaired fertility, low back pain, or increased anesthetic risk, and the like.

10. 发明授权

US07727998B2 Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient 失效
标题翻译：黑色素浓缩激素受体拮抗剂含有哌啶衍生物作为活性成分
公开(公告)号：US07727998B2
公开(公告)日：2010-06-01
申请号：US10544261
申请日：2004-02-09
申请人： Minoru Moriya , Toshihiro Sakamoto , Makoto Ishikawa , Akio Kanatani , Takehiro Fukami
发明人： Minoru Moriya , Toshihiro Sakamoto , Makoto Ishikawa , Akio Kanatani , Takehiro Fukami
IPC分类号： A61K31/4545 , C07D491/10
CPC分类号： C07D401/04 , A61K31/438 , A61K31/4439 , A61K31/445 , C07D211/26 , C07D491/10
摘要： The invention provides melanin-concentrating hormone receptor antagonists containing as the active ingredient piperidine derivatives represented by the general formula [I]: [wherein R1 is hydrogen, hydroxyl, lower alkyl, or the like; R2, R3a, R3b, R4a, R4b, R5a, R5b and R6 each stands for hydrogen, halogen, or the like; W1 and W2 each independently stands for —O—, —CH2—, or the like; Y1, Y2, Y3 and Y4 stand for —CH—, —CF—, —N—, or the like; Z stands for lower alkyl, an aliphatic heterocyclic group, or the like; Ar is a mono- or bi-cyclic aliphatic heterocycle or an aromatic heterocycle; and n is an integer of 1 to 8]. The compounds act as antagonist against melanin-concentrating hormone receptor and are useful as drugs for central diseases, circulatory diseases, or metabolic diseases.
摘要翻译：本发明提供了含有作为活性成分的通式[I]表示的哌啶衍生物的黑色素浓缩激素受体拮抗剂：其中R1是氢，羟基，低级烷基等; R2，R3a，R3b，R4a，R4b，R5a，R5b和R6各自代表氢，卤素等; W1和W2各自独立地代表-O-，-CH2-等; Y1，Y2，Y3和Y4代表-CH-，-CF-，-N-等; Z代表低级烷基，脂族杂环基等; Ar是单环或双环脂族杂环或芳族杂环; n为1〜8的整数]。该化合物作为拮抗黑素浓缩激素受体的拮抗剂，可用作中枢疾病，循环系统疾病或代谢疾病的药物。

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