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1. 发明申请

US20050266084A1 Modified release dosage forms 有权
标题翻译：改性释放剂型
公开(公告)号：US20050266084A1
公开(公告)日：2005-12-01
申请号：US10477334
申请日：2002-09-28
申请人： Shun-Por Li , Harry Sowden , David Wynn , Der-Yang Lee
发明人： Shun-Por Li , Harry Sowden , David Wynn , Der-Yang Lee
IPC分类号： A23G3/34 , A23G1/00 , A23G1/54 , A23G3/00 , A23G3/04 , A23G3/36 , A23G3/54 , A23L1/00 , A23L1/09 , A23L1/30 , A61J3/00 , A61J3/06 , A61J3/10 , A61K9/00 , A61K9/14 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/26 , A61K9/28 , A61K9/30 , A61K9/32 , A61K9/34 , A61K9/36 , A61K9/38 , A61K9/48 , A61K9/50 , A61K31/136 , A61K31/137 , A61K31/277 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61K47/46 , A61P11/00 , B30B11/08 , B30B11/34 , B30B15/30 , G06F17/30
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches and combinations thereof, and the matrix is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. The dosage form may additionally comprise uncoated particles which may contain at least one active ingredient. In another embodiment, a dosage form comprises at least one active ingredient, a plurality of particles and a molded matrix, wherein at least a portion of the particles are coated. The coated particles, the matrix or both may comprise at least one active ingredient, and the coated particles or the matrix or a combination thereof is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
摘要翻译：在一个实施方案中，剂型包含至少一种活性成分和模塑基质，其包含10-100％的熔点小于约100℃的材料，其选自热塑性聚环氧烷，低熔点疏水性材料，热塑性聚合物，热塑性淀粉及其组合，并且所述基质能够在剂型与液体介质接触时提供活性成分的改性释放。剂型还可以包含可以含有至少一种活性成分的未涂覆的颗粒。在另一个实施方案中，剂型包含至少一种活性成分，多个颗粒和模制基质，其中至少一部分颗粒被涂覆。涂覆的颗粒，基质或两者可以包含至少一种活性成分，并且涂覆的颗粒或基质或其组合能够在剂型与液体介质接触时提供活性成分的改性释放。

2. 发明申请

US20050281876A1 Solid dosage form for acid-labile active ingredient 审中-公开
标题翻译：酸性不稳定活性成分的固体剂型
公开(公告)号：US20050281876A1
公开(公告)日：2005-12-22
申请号：US10871851
申请日：2004-06-18
申请人： Shun-Por Li , David Wynn , Harry Sowden
发明人： Shun-Por Li , David Wynn , Harry Sowden
IPC分类号： A61K9/14 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/36 , A61M31/00
CPC分类号： A61K9/2886 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/209 , A61K9/2826 , A61K9/284 , A61K9/2853 , A61K9/286 , A61K9/2866
摘要： The present invention relates to solid, orally administrable dosage forms for acid-labile actives having at least one molded insert or core containing an acid-labile active ingredient, such as a proton pump inhibitor that is surrounded by barrier layer that is subsequently coated with an enteric layer. The present invention also relates to a dosage form that combines the barrier coated active ingredient containing insert with a second active ingredient.
摘要翻译：本发明涉及用于酸不稳定活性物质的固体，可口服给药的剂型，其具有至少一个含有酸不稳定活性成分的模制插入物或核心，所述酸性不稳定活性成分例如由阻挡层包围的质子泵抑制剂，其随后涂覆有肠溶层本发明还涉及将包含阻屏的活性成分含有插入物与第二活性成分组合的剂型。

3. 发明申请

US20050019376A1 Dosage form containing a confectionery composition 审中-公开
标题翻译：含有糖果组合物的剂型
公开(公告)号：US20050019376A1
公开(公告)日：2005-01-27
申请号：US10476503
申请日：2002-09-28
申请人： Gerard McNally , Frank Bunick , Harry Sowden , Gus LaBella , Timothy Gilmor , Der-Yang Lee , Martin Thomas
发明人： Gerard McNally , Frank Bunick , Harry Sowden , Gus LaBella , Timothy Gilmor , Der-Yang Lee , Martin Thomas
IPC分类号： A61K9/36 , A23G3/00 , A23G3/04 , A23G3/36 , A61J3/00 , A61J3/10 , A61K9/00 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/30 , A61K9/40 , A61K9/42 , A61K9/50 , A61K31/167 , A61K47/06 , A61K47/26 , A61K47/42 , A61P29/00 , A61P29/02 , B30B11/08 , B30B11/34 , A61K9/68
CPC分类号： A61J3/10 , A23G3/04 , A23G3/368 , A61J3/005 , A61K9/2853 , A61K9/2873 , A61K9/2893 , B30B11/08 , B30B11/34
摘要： A dosage form comprises an active ingredient and a confectionery composition. In one embodiment the relative standard deviation of the weight of the dosage form is less than 1%, and the dosage form has at least one face. In another embodiment, a dosage form comprising an active ingredient and a confectionery composition wherein the dosage form has at least one face, does not have a free formed surface, and has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission. The active ingredient may be a pharmaceutically active agent.
摘要翻译：剂型包含活性成分和糖食组合物。在一个实施方案中，剂型的重量的相对标准偏差小于1％，并且剂型具有至少一个面。在另一个实施方案中，包含活性成分和糖食组合物的剂型，其中所述剂型具有至少一个面，不具有自由形成的表面，并且具有不大于最大消光角的平均偏振光透射率比最大传播角度的剂型的平均偏振光透射。活性成分可以是药物活性剂。

4. 发明申请

US20050019407A1 Composite dosage forms 审中-公开
标题翻译：复合剂型
公开(公告)号：US20050019407A1
公开(公告)日：2005-01-27
申请号：US10476529
申请日：2002-09-28
申请人： Harry Sowden , Frank Bunick , Gerard McNally , Der-Yang Lee , Martin Thomas
发明人： Harry Sowden , Frank Bunick , Gerard McNally , Der-Yang Lee , Martin Thomas
IPC分类号： A23G3/34 , A23G1/00 , A23G1/54 , A23G3/00 , A23G3/04 , A23G3/36 , A23G3/54 , A23L1/00 , A23L1/09 , A23L1/30 , A61J3/00 , A61J3/06 , A61J3/10 , A61K9/00 , A61K9/14 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/26 , A61K9/28 , A61K9/30 , A61K9/32 , A61K9/34 , A61K9/36 , A61K9/38 , A61K9/48 , A61K9/50 , A61K31/136 , A61K31/137 , A61K31/277 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61K47/46 , A61P11/00 , B30B11/08 , B30B11/34 , B30B15/30 , G06F17/30
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： A composite dosage form comprises at least one active ingredient, a first portion comprising a first molded material, and a second portion comprising a second material which is compositionally different from the first material. The first and second portions are joined at an interface, and a surface of the first portion at the interface resides substantially conformally upon a surface of the second portion of the interface. Either the first portion, the second portion, or a combination thereof may contain at least one active ingredient. The first portion, second portion or both may also each comprise an insert which may contain at least one active ingredient. The dosage form may also comprise a third portion which is located between the first and second portions.
摘要翻译：复合剂型包含至少一种活性成分，第一部分包括第一模制材料，第二部分包含与第一材料成分不同的第二材料。第一部分和第二部分在界面处接合，并且界面处的第一部分的表面基本上保形地驻留在界面的第二部分的表面上。第一部分，第二部分或其组合可以含有至少一种活性成分。第一部分，第二部分或两者也可各自包含可包含至少一种活性成分的插入物。剂型还可以包括位于第一和第二部分之间的第三部分。

5. 发明申请

US20100330169A1 Pharmaceutical Tablet Containing A Liquid Filled Capsule 审中-公开
标题翻译：含有液体填充胶囊的药片
公开(公告)号：US20100330169A1
公开(公告)日：2010-12-30
申请号：US12824311
申请日：2010-06-28
申请人： Frank Bunick , Leo B. Kriksunov , Joseph Luber , Harry Sowden
发明人： Frank Bunick , Leo B. Kriksunov , Joseph Luber , Harry Sowden
IPC分类号： A61K9/48 , A61P11/10 , A61P11/02 , A61P37/08 , A61P23/00
CPC分类号： A61K9/2081 , A61K9/0053 , A61K9/28 , A61K31/137 , A61K31/167 , A61K45/06 , A61K2300/00
摘要： In one aspect, the present invention features a tablet including a compressed core and a liquid filled capsule, wherein the compressed core includes a first pharmaceutically active agent, the compressed core has a cavity exposed on the surface of the core, and the capsule is contained within the cavity such that a portion of the capsule is visible on the surface of the tablet, wherein the capsule has a diameter of at least 500 microns.
摘要翻译：在一个方面，本发明的特征在于包括压缩芯和液体填充胶囊的片剂，其中所述压缩芯包括第一药物活性剂，所述压缩芯具有暴露在所述芯的表面上的空腔，并且所述胶囊被包含在腔内使得胶囊的一部分在片剂的表面上可见，其中胶囊具有至少500微米的直径。

6. 发明申请

US20060118991A1 System and process for providing at least one opening in dosage forms 有权
公开(公告)号：US20060118991A1
公开(公告)日：2006-06-08
申请号：US11006038
申请日：2004-12-07
申请人： Harry Sowden
发明人： Harry Sowden
IPC分类号： B30B11/08
CPC分类号： A61K9/2072 , A61J3/005 , A61J3/10 , A61K9/2873 , B26D3/08 , B26F1/3846 , Y10T83/0333 , Y10T83/0363
摘要： The present invention relates to apparatus, methods, and processes for making solid dosage forms comprising at least one active ingredient, a core and shell configuration, wherein the shell comprises a hardenable material, such as a thermal-gelling polymer, for example gelatin; and the shell is provided with at least one opening. The opening(s) are formed while the shell is still in a softened state.

7. 发明授权

US5390477A System for applying a heat shrinkable sleeve to a container 失效
标题翻译：将热收缩套筒应用于容器的系统
公开(公告)号：US5390477A
公开(公告)日：1995-02-21
申请号：US794558
申请日：1991-11-19
申请人： Harry Sowden
发明人： Harry Sowden
IPC分类号： B29C61/02 , B29C63/42 , B65B53/06 , B65C3/06 , F27D19/00 , F27D21/00 , B65B53/02
CPC分类号： B65C3/065 , B29C61/02 , B29C63/423 , B65B53/063 , F27D19/00 , F27D2021/0092
摘要： A system for applying a heat-shrinkable sleeve or label to a container such as a vial for pharmaceuticals includes a novel heat tunnel assembly. The heat tunnel assembly, in a preferred embodiment, includes a conveyor for moving the sleeved containers past a heat source. The conveyor has a plurality of rollers upon which the sleeved containers are supported and rotated. The rollers turn at a first rate during initial shrinkage of the sleeve, and at a second, slower, rate after the initial shrinkage has occurred to reduce distortion and unwanted displacement of the label during its application. The heat tunnel assembly also includes a system for withdrawing the heat source from the vicinity of the conveyor should unexpected circumstances arise.
摘要翻译：将热收缩套管或标签施加到诸如用于药物的小瓶的容器的系统包括新颖的热隧道组件。在优选实施例中，热隧道组件包括用于使套筒容器移动通过热源的输送机。输送机具有多个辊子，套筒容器在该辊上被支撑和旋转。在初始收缩发生之后，辊子在初始收缩期间以第一速率转动，并且在第二次较慢的速率下转动，以减少标签在其应用期间的变形和不想要的位移。热隧道组件还包括一个系统，用于在出现意想不到的情况时从热交换器的附近退出热源。

8. 发明申请

US20050008696A1 Systems, methods and apparatuses for manufacturing dosage forms 有权
标题翻译：用于制造剂型的系统，方法和装置
公开(公告)号：US20050008696A1
公开(公告)日：2005-01-13
申请号：US10911263
申请日：2004-08-04
申请人： Harry Sowden , Bernard Plantz , Shun Li
发明人： Harry Sowden , Bernard Plantz , Shun Li
IPC分类号： A61J3/10 , A23G3/00 , A23G3/04 , A23G3/36 , A61J3/00 , A61J3/06 , A61K9/00 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/30 , A61K9/50 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , B30B11/00 , B29C45/14 , A61K9/14 , B29C45/16
CPC分类号： A23G3/368 , A23G3/04 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/2853 , A61K9/2873 , A61K9/2893 , B30B11/005
摘要： Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.
摘要翻译：提供了用于制造剂型的系统，方法和装置，以及使用这种系统，方法和装置制备的剂型。公开了新型压缩，热循环模制和热定型模制模块。一个或多个这样的模块可以优选地通过新型转移装置连接到用于制备剂型的整个系统中。

9. 发明申请

US20060233881A1 Modified release dosage form 有权
标题翻译：改性释放剂型
公开(公告)号：US20060233881A1
公开(公告)日：2006-10-19
申请号：US11107674
申请日：2005-04-15
申请人： Harry Sowden
发明人： Harry Sowden
IPC分类号： A61K9/24
CPC分类号： A61K9/2022 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K9/2077 , A61K9/2866
摘要： The present invention relates to a medicinal dosage form having a first core, a second core, and a shell that surrounds a first portion of each core and a fill material that covers a second portion of at least one core, wherein the fill material that is provided over at least one core is not in contact with any portion of the other core. e. The inventive dosage forms provide modified release of one or more active ingredients contained therein. The present invention also relates to methods for manufacturing such medicinal dosage forms.
摘要翻译：本发明涉及具有围绕每个芯的第一部分的第一芯，第二芯和壳的药物剂型和覆盖至少一个芯的第二部分的填充材料，其中填充材料是提供在至少一个芯上的芯不与另一芯的任何部分接触。 e。本发明的剂型提供其中包含的一种或多种活性成分的改性释放。本发明还涉及制备这种药物剂型的方法。

10. 发明申请

US20060121145A1 System and process for providing at least one opening in dosage forms 有权
公开(公告)号：US20060121145A1
公开(公告)日：2006-06-08
申请号：US11006288
申请日：2004-12-07
申请人： Harry Sowden
发明人： Harry Sowden
IPC分类号： B29C51/00
CPC分类号： A61J3/10 , A61J3/005 , A61K9/4833 , Y10T83/0333 , Y10T83/0363
摘要： The present invention relates to apparatus, methods, and processes for making solid dosage forms comprising at least one active ingredient, a core and shell configuration, wherein the shell comprises a hardenable material, such as a thermal-gelling polymer, for example gelatin; and the shell is provided with at least one opening. The opening(s) are formed while the shell is still in a softened state.

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