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1. 发明申请

US20090155372A1 METHOD OF MANUFACTURING MODIFIED RELEASE DOSAGE FORMS 有权
标题翻译：制造改良释放剂量形式的方法
公开(公告)号：US20090155372A1
公开(公告)日：2009-06-18
申请号：US12391475
申请日：2009-02-24
申请人： SHUN-POR LI , Harry S. Sowden , David Wynn , Der-Yang Lee , Martin Thomas
发明人： SHUN-POR LI , Harry S. Sowden , David Wynn , Der-Yang Lee , Martin Thomas
IPC分类号： A61K9/52 , A61K47/30 , A61P43/00
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches and combinations thereof, and the matrix is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. The dosage form may additionally comprise uncoated particles which may contain at least one active ingredient. In another embodiment, a dosage form comprises at least one active ingredient, a plurality of particles and a molded matrix, wherein at least a portion of the particles are coated. The coated particles, the matrix or both may comprise at least one active ingredient, and the coated particles or the matrix or a combination thereof is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
摘要翻译：在一个实施方案中，剂型包含至少一种活性成分和模塑基质，其包含10-100％的熔点小于约100℃的材料，其选自热塑性聚环氧烷，低熔点疏水性材料，热塑性聚合物，热塑性淀粉及其组合，并且所述基质能够在剂型与液体介质接触时提供活性成分的改性释放。剂型还可以包含可以含有至少一种活性成分的未涂覆的颗粒。在另一个实施方案中，剂型包含至少一种活性成分，多个颗粒和模制基质，其中至少一部分颗粒被涂覆。涂覆的颗粒，基质或两者可以包含至少一种活性成分，并且涂覆的颗粒或基质或其组合能够在剂型与液体介质接触时提供活性成分的改性释放。

2. 发明授权

US08545887B2 Modified release dosage forms 有权
标题翻译：改性释放剂型
公开(公告)号：US08545887B2
公开(公告)日：2013-10-01
申请号：US10476530
申请日：2002-09-28
申请人： Harry S. Sowden , David Wynn , Shun-Por Li , Der-Yang Lee , Martin Thomas
发明人： Harry S. Sowden , David Wynn , Shun-Por Li , Der-Yang Lee , Martin Thomas
IPC分类号： A61J3/06 , A61K9/20 , B30B11/00 , A61K9/24 , G06F17/30
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： A dosage form comprises: (a) at least one active ingredient: (b) a core having a first surface portion upon which resides a first coating and a second surface portion which is substantially free of the first coating; and (c) a shell which resides upon at least a portion of the second surface portion, wherein the shell comprises a different material from the first coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core comprising a center portion having an exterior surface and an annular portion having an exterior surface and an interior surface, wherein the annular portion interior surface is in contact with at least a portion of the center portion exterior surface, and a coating resides on at least a portion of the annular portion exterior surface; and (c) a shell which resides upon at least a portion of the exterior surface of the center portion, wherein the shell comprises a different material than the impermeable coating. In another embodiment, the dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface and a cavity which extends at least partially through the core such that the core outer surface has at least a first opening therein; (c) a first coating which resides on at least a portion of the core outer surface, wherein the first shell portion comprises a different material from the first coating; and (d) a first shell portion which is adjacent to the first opening and covers at least the first opening.
摘要翻译：剂型包括：（a）至少一种活性成分：（b）具有第一表面部分的核心，其上存在第一涂层和基本上不含第一涂层的第二表面部分; 和（c）位于第二表面部分的至少一部分上的外壳，其中外壳包括与第一涂层不同的材料。在另一个实施方案中，剂型包含：（a）至少一种活性成分; （b）芯部，其包括具有外表面的中心部分和具有外表面和内表面的环形部分，其中所述环形部分内表面与所述中心部分外表面的至少一部分接触，位于环形部分外表面的至少一部分上; 和（c）驻留在中心部分的外表面的至少一部分上的壳体，其中壳体包括与不可渗透涂层不同的材料。在另一个实施方案中，剂型包含：（a）至少一种活性成分; （b）具有外表面和空腔的芯体，其至少部分地穿过所述芯部，使得所述芯部外表面至少具有第一开口; （c）驻留在所述芯外表面的至少一部分上的第一涂层，其中所述第一壳部分包括与所述第一涂层不同的材料; 和（d）与第一开口相邻并且至少覆盖第一开口的第一壳体部分。

3. 发明授权

US07968120B2 Modified release dosage forms 有权
标题翻译：改性释放剂型
公开(公告)号：US07968120B2
公开(公告)日：2011-06-28
申请号：US10477334
申请日：2002-09-28
申请人： Shun-Por Li , Harry S Sowden , David Wynn , Der-Yang Lee , Martin Thomas
发明人： Shun-Por Li , Harry S Sowden , David Wynn , Der-Yang Lee , Martin Thomas
IPC分类号： A61K9/22 , A61K9/16
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches and combinations thereof, and the matrix is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. The dosage form may additionally comprise uncoated particles which may contain at least one active ingredient. In another embodiment, a dosage form comprises at least one active ingredient, a plurality of particles and a molded matrix, wherein at least a portion of the particles are coated. The coated particles, the matrix or both may comprise at least one active ingredient, and the coated particles or the matrix or a combination thereof is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
摘要翻译：在一个实施方案中，剂型包含至少一种活性成分和模塑基质，其包含10-100％的熔点小于约100℃的材料，其选自热塑性聚环氧烷，低熔点疏水性材料，热塑性聚合物，热塑性淀粉及其组合，并且所述基质能够在剂型与液体介质接触时提供活性成分的改性释放。剂型还可以包含可以含有至少一种活性成分的未涂覆的颗粒。在另一个实施方案中，剂型包含至少一种活性成分，多个颗粒和模制基质，其中至少一部分颗粒被涂覆。涂覆的颗粒，基质或两者可以包含至少一种活性成分，并且涂覆的颗粒或基质或其组合能够在剂型与液体介质接触时提供活性成分的改性释放。

4. 发明授权

US07972624B2 Method of manufacturing modified release dosage forms 有权
标题翻译：制备改性释放剂型的方法
公开(公告)号：US07972624B2
公开(公告)日：2011-07-05
申请号：US12391475
申请日：2009-02-24
申请人： Shun-Por Li , Harry S. Sowden , David Wynn , Der-Yang Lee , Martin Thomas
发明人： Shun-Por Li , Harry S. Sowden , David Wynn , Der-Yang Lee , Martin Thomas
IPC分类号： A61K9/22 , A23G3/02
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low melting hydrophobic materials, thermoplastic polymers, thermoplastic starches and combinations thereof, and the matrix is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium. The dosage form may additionally comprise uncoated particles which may contain at least one active ingredient. In another embodiment, a dosage form comprises at least one active ingredient, a plurality of particles and a molded matrix, wherein at least a portion of the particles are coated. The coated particles, the matrix or both may comprise at least one active ingredient, and the coated particles or the matrix or a combination thereof is capable of providing modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
摘要翻译：在一个实施方案中，剂型包含至少一种活性成分和模塑基质，其包含10-100％的熔点小于约100℃的材料，其选自热塑性聚环氧烷，低熔点疏水性材料，热塑性聚合物，热塑性淀粉及其组合，并且所述基质能够在剂型与液体介质接触时提供活性成分的改性释放。剂型还可以包含可以含有至少一种活性成分的未涂覆的颗粒。在另一个实施方案中，剂型包含至少一种活性成分，多个颗粒和模制基质，其中至少一部分颗粒被涂覆。涂覆的颗粒，基质或两者可以包含至少一种活性成分，并且涂覆的颗粒或基质或其组合能够在剂型与液体介质接触时提供活性成分的改性释放。

5. 发明申请

US20090186082A1 METHOD OF MANUFACTURING MODIFIED RELEASE DOSAGE FORMS 审中-公开
标题翻译：制造改良释放剂量形式的方法
公开(公告)号：US20090186082A1
公开(公告)日：2009-07-23
申请号：US12360579
申请日：2009-01-27
申请人： Shun-Por LI , David Wynn , Narendra Parikh , Dan McTeigue , Harry S. Sowden , Martin Thomas , Der-Yang Lee
发明人： Shun-Por LI , David Wynn , Narendra Parikh , Dan McTeigue , Harry S. Sowden , Martin Thomas , Der-Yang Lee
IPC分类号： A61K9/22
CPC分类号： A61J3/10 , A23G3/04 , A23G3/368 , A61J3/005 , A61K9/2853 , A61K9/2873 , A61K9/2893 , B30B11/08 , B30B11/34
摘要： In one embodiment, a dosage form comprises: (a) at least one active ingredient; (b) a molded core which is solid at room temperature; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium. In another embodiment of this invention, a dosage form comprises: (a) at least one active ingredient; (b) a molded core comprising a plurality of particles; and (c) a shell which is in contact with at least a portion of the core, wherein the dosage form provides modified release of the active ingredient upon contacting of the dosage form with a liquid medium.
摘要翻译：在一个实施方案中，剂型包含：（a）至少一种活性成分; （b）在室温下为固体的模制芯; 和（c）与芯的至少一部分接触的壳，其中所述剂型在剂型与液体介质接触时提供活性成分的改性释放。在本发明的另一个实施方案中，剂型包含：（a）至少一种活性成分; （b）包含多个颗粒的成型芯; 和（c）与芯的至少一部分接触的壳，其中所述剂型在剂型与液体介质接触时提供活性成分的改性释放。

6. 发明授权

US07807197B2 Composite dosage forms having an inlaid portion 有权
标题翻译：具有镶嵌部分的复合剂型
公开(公告)号：US07807197B2
公开(公告)日：2010-10-05
申请号：US10476388
申请日：2002-09-28
申请人： Der-Yang Lee , Harry S. Sowden , Martin Thomas
发明人： Der-Yang Lee , Harry S. Sowden , Martin Thomas
IPC分类号： A61K9/20 , A61K9/28 , A61K9/24
CPC分类号： A61K9/209 , A61K9/2072 , A61K9/2086 , A61K9/2095 , A61K9/2893
摘要： A dosage form comprises at least one active ingredient, a first portion which comprises an exterior surface and one or more cavities defining at least one interior surface having indentations and an exterior surface, and a second molded portion which is inlaid into the cavities of the first portion and has an exterior surface. The first and second portions are in contact at an interface, the second portion comprises a solidified thermoplastic material, and the second portion resides substantially conformally upon the indentations of the first portion. In another embodiment, a dosage form comprises at least one active ingredient, a core having an outer surface and a shell residing on at least a portion of the core outer surface, wherein the shell comprises a first shell portion and a second molded shell portion which is inlaid into the first shell portion. In another embodiment, a dosage form comprises at least one active ingredient, a core, and a shell having a first molded shell portion which is discontinuous, and a second molded shell portion which is continuous, such that the discontinuities of the first shell portion are due to the presence of the second molded shell portion, and the first and second shell portions are compositionally different.
摘要翻译：剂型包括至少一种活性成分，第一部分包括外表面和限定至少一个具有凹痕和外表面的内表面的一个或多个空腔，以及第二模制部分，其嵌入第一并具有外表面。第一部分和第二部分在界面处接触，第二部分包括凝固的热塑性材料，第二部分基本上保持在第一部分的凹陷上。在另一个实施方案中，剂型包含至少一种活性成分，具有外表面的芯和位于芯外表面的至少一部分上的壳，其中所述壳包括第一壳部分和第二模制壳部分，嵌入第一壳部分。在另一个实施方案中，剂型包含至少一种活性成分，核心和壳，其具有不连续的第一模塑壳部分和连续的第二模制壳部分，使得第一壳部分的不连续性为由于存在第二模制壳体部分，并且第一和第二壳部分在组成上是不同的。

7. 发明申请

US20050019376A1 Dosage form containing a confectionery composition 审中-公开
标题翻译：含有糖果组合物的剂型
公开(公告)号：US20050019376A1
公开(公告)日：2005-01-27
申请号：US10476503
申请日：2002-09-28
申请人： Gerard McNally , Frank Bunick , Harry Sowden , Gus LaBella , Timothy Gilmor , Der-Yang Lee , Martin Thomas
发明人： Gerard McNally , Frank Bunick , Harry Sowden , Gus LaBella , Timothy Gilmor , Der-Yang Lee , Martin Thomas
IPC分类号： A61K9/36 , A23G3/00 , A23G3/04 , A23G3/36 , A61J3/00 , A61J3/10 , A61K9/00 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/30 , A61K9/40 , A61K9/42 , A61K9/50 , A61K31/167 , A61K47/06 , A61K47/26 , A61K47/42 , A61P29/00 , A61P29/02 , B30B11/08 , B30B11/34 , A61K9/68
CPC分类号： A61J3/10 , A23G3/04 , A23G3/368 , A61J3/005 , A61K9/2853 , A61K9/2873 , A61K9/2893 , B30B11/08 , B30B11/34
摘要： A dosage form comprises an active ingredient and a confectionery composition. In one embodiment the relative standard deviation of the weight of the dosage form is less than 1%, and the dosage form has at least one face. In another embodiment, a dosage form comprising an active ingredient and a confectionery composition wherein the dosage form has at least one face, does not have a free formed surface, and has a mean polarized light transmission at the angle of maximum extinction which is not greater than the mean polarized light transmission of the dosage form at the angle of maximum transmission. The active ingredient may be a pharmaceutically active agent.
摘要翻译：剂型包含活性成分和糖食组合物。在一个实施方案中，剂型的重量的相对标准偏差小于1％，并且剂型具有至少一个面。在另一个实施方案中，包含活性成分和糖食组合物的剂型，其中所述剂型具有至少一个面，不具有自由形成的表面，并且具有不大于最大消光角的平均偏振光透射率比最大传播角度的剂型的平均偏振光透射。活性成分可以是药物活性剂。

8. 发明申请

US20050019407A1 Composite dosage forms 审中-公开
标题翻译：复合剂型
公开(公告)号：US20050019407A1
公开(公告)日：2005-01-27
申请号：US10476529
申请日：2002-09-28
申请人： Harry Sowden , Frank Bunick , Gerard McNally , Der-Yang Lee , Martin Thomas
发明人： Harry Sowden , Frank Bunick , Gerard McNally , Der-Yang Lee , Martin Thomas
IPC分类号： A23G3/34 , A23G1/00 , A23G1/54 , A23G3/00 , A23G3/04 , A23G3/36 , A23G3/54 , A23L1/00 , A23L1/09 , A23L1/30 , A61J3/00 , A61J3/06 , A61J3/10 , A61K9/00 , A61K9/14 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/26 , A61K9/28 , A61K9/30 , A61K9/32 , A61K9/34 , A61K9/36 , A61K9/38 , A61K9/48 , A61K9/50 , A61K31/136 , A61K31/137 , A61K31/277 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/30 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61K47/46 , A61P11/00 , B30B11/08 , B30B11/34 , B30B15/30 , G06F17/30
CPC分类号： A23G3/04 , A23G1/54 , A23G3/0029 , A23G3/368 , A23G3/54 , A23L29/30 , A61J3/005 , A61J3/06 , A61J3/10 , A61K9/0004 , A61K9/0056 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2072 , A61K9/2081 , A61K9/209 , A61K9/2095 , A61K9/282 , A61K9/2826 , A61K9/284 , A61K9/286 , A61K9/2873 , A61K9/2886 , A61K9/2893 , A61K9/5084 , B30B11/08 , B30B11/34 , B30B15/302 , Y10T428/1352
摘要： A composite dosage form comprises at least one active ingredient, a first portion comprising a first molded material, and a second portion comprising a second material which is compositionally different from the first material. The first and second portions are joined at an interface, and a surface of the first portion at the interface resides substantially conformally upon a surface of the second portion of the interface. Either the first portion, the second portion, or a combination thereof may contain at least one active ingredient. The first portion, second portion or both may also each comprise an insert which may contain at least one active ingredient. The dosage form may also comprise a third portion which is located between the first and second portions.
摘要翻译：复合剂型包含至少一种活性成分，第一部分包括第一模制材料，第二部分包含与第一材料成分不同的第二材料。第一部分和第二部分在界面处接合，并且界面处的第一部分的表面基本上保形地驻留在界面的第二部分的表面上。第一部分，第二部分或其组合可以含有至少一种活性成分。第一部分，第二部分或两者也可各自包含可包含至少一种活性成分的插入物。剂型还可以包括位于第一和第二部分之间的第三部分。

9. 发明申请

US20130059222A1 Fuel Cell Stacks 有权
标题翻译：燃料电池堆
公开(公告)号：US20130059222A1
公开(公告)日：2013-03-07
申请号：US13695453
申请日：2011-05-09
申请人： Martin Thomas
发明人： Martin Thomas
IPC分类号： H01M2/38 , H01M8/04
CPC分类号： H01M8/08 , H01M8/083 , H01M8/2445 , H01M8/2459 , H01M8/2483 , Y02E60/50
摘要： A fuel cell stack (10) comprises a plurality of fuel cells each with a chamber (K) for electrolyte with at least one inlet and at least one outlet, and at least one header (30) to supply electrolyte to all the cells in parallel, and means (14) to collect electrolyte that has flowed through the cells. For each cell, the electrolyte outlets (34) feed into an electrolyte flow channel arranged such that in use there is a free surface of electrolyte within the electrolyte flow channel, the electrolyte flow channel being separate from the corresponding electrolyte flow channels for other cells, but such that the free surfaces of all the electrolyte flow channels are at a common pressure. Electrolyte is maintained at a constant depth in this open flow channel by a weir (38), and then flows over the weir to trickle or drip down the outside of the stack. This ensures uniform outlet electrolyte pressure throughout the stack (10) and across the individual cells, and avoids or reduces ionic leakage currents through the electrolyte outlets.
摘要翻译：燃料电池堆（10）包括多个燃料电池，每个燃料电池具有用于电解质的室（K），其具有至少一个入口和至少一个出口，以及至少一个头部（30），以平行地向所有电池供应电解质，以及用于收集已经流过细胞的电解质的装置（14）。对于每个电池，电解质出口（34）进入电解质流动通道，其布置使得在使用中在电解质流动通道内存在电解质的自由表面，电解质流动通道与用于其它电池的相应的电解质流动通道分开，但是使得所有电解质流动通道的自由表面处于共同的压力。电解液通过堰（38）在这个开放的流动通道中保持恒定的深度，然后流过堰，涓流或滴落在堆垛外面。这确保整个堆叠（10）和跨单独电池均匀的出口电解液压力，并避免或减少通过电解液出口的离子泄漏电流。

10. 发明授权

US08283081B2 Membrane electrode assembly with hydrogenatable material for a fuel cell 有权
标题翻译：具有用于燃料电池的可氢化材料的膜电极组件
公开(公告)号：US08283081B2
公开(公告)日：2012-10-09
申请号：US12208411
申请日：2008-09-11
申请人： Andreas Huth , Christiane Jacksch , Martin Thomas
发明人： Andreas Huth , Christiane Jacksch , Martin Thomas
IPC分类号： H01M8/02 , H01M8/04 , H01M8/10
CPC分类号： H01M8/04067 , C01B6/02 , C01B6/04 , C01B6/24 , H01M4/8605 , H01M4/8642 , H01M8/04216 , H01M8/04268 , H01M2008/1095
摘要： The invention relates to a membrane-electrode assembly for a fuel cell with a proton-conducting membrane two catalyst layers adjoining both sides of the membrane, wherein the catalyst layers have an electrically conductive base material and at least one catalytic material deposited on the base material, and two gas diffusion layers adjoining the catalyst layers. The membrane and/or at least one of the catalyst layers and/or at least one of the gas diffusion layers includes at least one hydrogenatable material capable of binding hydrogen in a reversible exothermic hydrogenation operation by forming a hydride, depending on the temperature and/or pressure. The hydrogenatable material can be distributed in the gas diffusion layer and/or in the catalyst layer or can be present as a separate layer on at least one side of the gas diffusion electrode or the membrane.
摘要翻译：本发明涉及一种用于燃料电池的膜 - 电极组件，其具有质子传导膜，两个邻近膜两侧的催化剂层，其中催化剂层具有导电基材和沉积在基材上的至少一种催化材料和与催化剂层相邻的两个气体扩散层。膜和/或至少一个催化剂层和/或至少一个气体扩散层包括至少一种能够通过形成氢化物在可逆放热加氢操作中结合氢的至少一种可氢化材料，这取决于温度和/ 或压力。可氢化材料可以分布在气体扩散层和/或催化剂层中，或者可以在气体扩散电极或膜的至少一侧作为单独的层存在。

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