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1. 发明申请

US20120326022A1 MASS SPECTROMETER AND MASS ANALYZING METHOD 有权
标题翻译：质谱仪和质谱分析方法
公开(公告)号：US20120326022A1
公开(公告)日：2012-12-27
申请号：US13527627
申请日：2012-06-20
申请人： Shun KUMANO , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hidetoshi Morokuma , Shuhei Hashiba
发明人： Shun KUMANO , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hidetoshi Morokuma , Shuhei Hashiba
IPC分类号： H01J49/04
CPC分类号： H01J49/0409 , H01J49/0495
摘要： A mass spectrometer including a sample attaching member of attaching a sample, an ionizing chamber including an introductory port of the sample attaching member and an ionization source of generating a sample ion, a vacuumed chamber having a mass analyzer of analyzing the sample ion, and an opening/closing mechanism provided between the ionizing chamber and the vacuumed chamber, in which the opening/closing mechanism is controlled from a closed state to an open state after introducing the sample attaching member into the ionizing chamber to thereby enable to perform ionization with inconsiderable fragmentation at a high sensitivity with a high throughput
摘要翻译：一种质谱仪，包括附着样品的样品附着构件，包括样品附着构件的入口的电离室和产生样品离子的离子源，具有分析样品离子的质量分析器的真空室，以及设置在离子化室和真空室之间的开/关机构，其中将样品附着构件引入电离室之后，将开/关机构从关闭状态控制到打开状态，从而能够以不可分割的碎片进行电离灵敏度高，吞吐量高

2. 发明授权

US09184037B2 Mass spectrometer and mass analyzing method 有权
标题翻译：质谱仪和质量分析方法
公开(公告)号：US09184037B2
公开(公告)日：2015-11-10
申请号：US13527627
申请日：2012-06-20
申请人： Shun Kumano , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hidetoshi Morokuma , Shuhei Hashiba
发明人： Shun Kumano , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hidetoshi Morokuma , Shuhei Hashiba
IPC分类号： H01J49/00 , H01J49/04
CPC分类号： H01J49/0409 , H01J49/0495
摘要： A mass spectrometer including a sample attaching member of attaching a sample, an ionizing chamber including an introductory port of the sample attaching member and an ionization source of generating a sample ion, a vacuumed chamber having a mass analyzer of analyzing the sample ion, and an opening/closing mechanism provided between the ionizing chamber and the vacuumed chamber, in which the opening/closing mechanism is controlled from a closed state to an open state after introducing the sample attaching member into the ionizing chamber to thereby enable to perform ionization with inconsiderable fragmentation at a high sensitivity with a high throughput.
摘要翻译：一种质谱仪，包括附着样品的样品附着构件，包括样品附着构件的入口的电离室和产生样品离子的离子源，具有分析样品离子的质量分析器的真空室，以及设置在离子化室和真空室之间的开/关机构，其中将样品附着构件引入电离室之后，将开/关机构从关闭状态控制到打开状态，从而能够以不可分割的碎片进行电离灵敏度高，吞吐量高。

3. 发明授权

US09076638B2 Mass spectrometer method and mass spectrometer 有权
标题翻译：质谱仪和质谱仪
公开(公告)号：US09076638B2
公开(公告)日：2015-07-07
申请号：US13365355
申请日：2012-02-03
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Shuhei Hashiba , Shun Kumano
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Shuhei Hashiba , Shun Kumano
IPC分类号： H01J49/26 , H01J49/00
CPC分类号： H01J49/0031 , H01J49/0045
摘要： A variation in an ionization efficiency and the amount of sample which is introduced into an ion trap is corrected and quantified. Ions of an internal standard and ions of a sample are trapped in the ion trap at the same time, and a concentration of the sample is quantified according to an intensity of the ions of the internal standard which are mass-selectively ejected, and an intensity of fragment ions of the sample.
摘要翻译：电离效率的变化和引入离子阱的样品量被校正和量化。将内标的离子和样品的离子同时捕获在离子阱中，并且根据质量选择性地喷射的内标的离子的强度来量化样品的浓度，强度的样品的碎片离子。

4. 发明申请

US20120298852A1 SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR MASS SPECTROMETRY 有权
标题翻译：用于质谱分析的系统和计算机程序产品
公开(公告)号：US20120298852A1
公开(公告)日：2012-11-29
申请号：US13468967
申请日：2012-05-10
申请人： Yohei Kawaguchi , Yuichiro Hashimoto , Masuyuki Sugiyama , Shun Kumano , Shuhei Hashiba , Masahito Togami
发明人： Yohei Kawaguchi , Yuichiro Hashimoto , Masuyuki Sugiyama , Shun Kumano , Shuhei Hashiba , Masahito Togami
IPC分类号： H01J49/26
CPC分类号： H01J49/0031 , H01J49/004
摘要： A mass spectrometry system is mounted with (1) an action planning module for determining a measurement schedule provided by a combination of an MS analysis and an MSn analysis (where n≧2) according to a measuring time provided previously; and (2) a mass spectrometry unit having a tandem mass spectrometry function for outputting a mass spectrum obtained by performing each measurement action constructing the measurement schedule.
摘要翻译：一种质谱系统安装有（1）动作计划模块，用于根据先前提供的测量时间确定由MS分析和MSn分析（其中n≥2）的组合提供的测量计划; 和（2）具有串联质谱分析功能的质谱分析装置，用于输出通过进行构成测定时间表的每个测定动作而得到的质谱。

5. 发明授权

US08686352B2 Systems and computer program products for mass spectrometry 有权
标题翻译：用于质谱的系统和计算机程序产品
公开(公告)号：US08686352B2
公开(公告)日：2014-04-01
申请号：US13468967
申请日：2012-05-10
申请人： Yohei Kawaguchi , Yuichiro Hashimoto , Masuyuki Sugiyama , Shun Kumano , Shuhei Hashiba , Masahito Togami
发明人： Yohei Kawaguchi , Yuichiro Hashimoto , Masuyuki Sugiyama , Shun Kumano , Shuhei Hashiba , Masahito Togami
IPC分类号： H01J49/26
CPC分类号： H01J49/0031 , H01J49/004
摘要： A mass spectrometry system is mounted with (1) an action planning module for determining a measurement schedule provided by a combination of an MS analysis and an MSn analysis (where n≧2) according to a measuring time provided previously; and (2) a mass spectrometry unit having a tandem mass spectrometry function for outputting a mass spectrum obtained by performing each measurement action constructing the measurement schedule.
摘要翻译：一种质谱系统安装有（1）动作计划模块，用于根据先前提供的测量时间确定由MS分析和MSn分析（其中n≥2）的组合提供的测量计划; 和（2）具有串联质谱分析功能的质谱分析装置，用于输出通过进行构成测定时间表的每个测定动作而得到的质谱。

6. 发明授权

US07626162B2 Mass spectrometry system and mass spectrometry method 失效
标题翻译：质谱系统和质谱法
公开(公告)号：US07626162B2
公开(公告)日：2009-12-01
申请号：US12038829
申请日：2008-02-28
申请人： Shuhei Hashiba , Takeshi Sakamoto
发明人： Shuhei Hashiba , Takeshi Sakamoto
IPC分类号： B01D59/44 , H01J49/26 , H01J49/42
CPC分类号： H01J49/0027 , G01N30/724 , Y10T436/13
摘要： When a liquid mixture of two samples such as biological samples labeled with stable isotopes is subjected to a relative quantitative analysis using a liquid chromatography-tandem mass spectrometry system, various constituents are simultaneously ionized. Accordingly, sufficient time required for second mass spectrometry is not ensured, whereby some ions remain unanalyzed after measurement. To address this problem, after second mass spectrometry, amino acid sequencing is performed using the analysis data of the second mass spectrometry, which enables determination on the presence/absence of a specific amino acid labeled with a stable isotope. When the specific amino acid is present, the m/z value of an isotopically-labeled-paired ion in an MS spectrum is calculated, and non-target information for use in second mass spectrometry is created using the calculated m/z information. This avoids redundant second mass spectrometry on sample components derived from the same peptide while allowing second mass spectrometry to be efficiently performed.
摘要翻译：当使用液相色谱 - 串联质谱系统进行相对定量分析，将诸如用稳定同位素标记的生物样品的两个样品的液体混合物进行相对定量分析时，同时电离各种成分。因此，不能确保第二质谱所需的足够的时间，从而在测量之后一些离子保持未分析。为了解决这个问题，在第二次质谱法之后，使用第二质谱分析数据进行氨基酸测序，其能够确定用稳定同位素标记的特定氨基酸的存在/不存在。当存在特定氨基酸时，计算MS谱中同位素标记配对离子的m / z值，并使用所计算的m / z信息产生用于第二质谱的非目标信息。这避免了来自相同肽的样品组分的冗余第二质谱，同时允许有效地进行第二质谱。

7. 发明申请

US20050084839A1 Method for selecting oocytes by using a response to LPA stimulation 审中-公开
标题翻译：通过使用对LPA刺激的反应来选择卵母细胞的方法
公开(公告)号：US20050084839A1
公开(公告)日：2005-04-21
申请号：US10876551
申请日：2004-06-28
申请人： Tomoko Takeshita , Takako Mizoguchi , Shuhei Hashiba , Jun Otomo
发明人： Tomoko Takeshita , Takako Mizoguchi , Shuhei Hashiba , Jun Otomo
IPC分类号： C12N15/09 , A01N1/02 , C12N5/00 , C12N5/075 , C12N5/10 , C12Q1/02
CPC分类号： C12N5/0612 , C12N5/0609
摘要： The selection of oocytes has largely relied on manual procedures, resulting in their lack of uniformity. Groups of oocytes are prepared and sorted, the current responses of these groups of oocytes upon exposure to lysophosphatidic acid (LPA) are measured, the response of G protein-coupled receptor (GPCR) is determined for each group of oocytes, and desirable groups of oocytes are selected on the basis of the response of GPCR. In this way, oocytes having a uniformly high response of GPCR can be selected.
摘要翻译：卵母细胞的选择在很大程度上取决于手工程序，导致其缺乏一致性。卵母细胞的组成和分选，测定了这些卵母细胞群暴露于溶血磷脂酸（LPA）后的当前反应，测定每组卵母细胞G蛋白偶联受体（GPCR）的反应，基于GPCR的反应选择卵母细胞。以这种方式，可以选择具有GPCR均匀高响应的卵母细胞。

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