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1. 发明申请

US20190198309A1 MASS SPECTROMETRY SYSTEM AND WORKING METHOD AND APPLICATION THEREOF, AND SAMPLING DEVICE 审中-公开
公开(公告)号：US20190198309A1
公开(公告)日：2019-06-27
申请号：US16286574
申请日：2019-02-26
申请人： NINGBO UNIVERSITY , CHINA INNOVATION INSTRUMENT CO., LTD.
发明人： Luhong WEN , Peng ZHAO , Ruiqiang CHEN , Huanhuan HONG , Feng ZHOU
IPC分类号： H01J49/42 , G01N27/64 , H01J49/04 , G01N33/543 , H01J49/06
CPC分类号： H01J49/426 , G01N27/64 , G01N33/543 , H01J49/0031 , H01J49/0409 , H01J49/0431 , H01J49/062
摘要： A mass spectrometry system and a working method and an application thereof, and a sampling device. The mass spectrometry system includes an ion source, a sampling device and a mass spectrometer. The sampling device includes: a guide rail; a support adapted to move on the guide rail; a bearing member made from a hydrophobic material with two ends being fixed to the support; a plurality of containers for containing samples arranged on the support; a plurality of transport members made from a hydrophilic material and including a first portion provided on the bearing member and a second portion connected to the first portion and extending into each container; adjacent transport members being not in contact; and a drive module configured to drive the support to move on the guide rail such that a central axis of an exit port of the ion source passes through the first portion.

2. 发明申请

US20190035616A1 METHOD AND APPARATUS FOR IMAGING SINGLE MOLECULES 审中-公开
公开(公告)号：US20190035616A1
公开(公告)日：2019-01-31
申请号：US16068672
申请日：2016-06-29
申请人： UNIVERSITAET ZUERICH
发明人： Jean-Nicolas LONGCHAMP , Hans-Werner FINK , Conrad ESCHER
IPC分类号： H01J49/16 , H01J49/04
CPC分类号： H01J49/165 , G01N23/2251 , H01J37/26 , H01J49/0409 , H01J49/40 , H01J2237/2614
摘要： A method of imaging single molecules, comprises the steps of: a) providing an assembly comprising a carrier substrate having a substrate face with an aperture, the aperture being covered with a receiving layer attached to the substrate face, the receiving layer being substantially transparent for low-energy electrons with a kinetic energy of 5 to 1,000 eV; b) depositing single molecules onto said receiving layer by means of soft-landing electrospray ion deposition, whereby a single molecule loaded receiving layer is formed; c) acquiring an in-line low-energy electron transmission pattern of said single molecule loaded receiving layer, said single molecule loaded receiving layer. The above steps a) to c) are conducted under vacuum conditions.

3. 发明授权

US10008374B2 Systems and methods for transfer of ions for analysis 有权
公开(公告)号：US10008374B2
公开(公告)日：2018-06-26
申请号：US15340355
申请日：2016-11-01
申请人： Purdue Research Foundation
发明人： Zheng Ouyang , Robert Graham Cooks , Sandilya Venkata Garimella , Jason David Harper , Nicholas Alan Charipar
IPC分类号： H01J49/04 , H01J49/26 , H01J49/10
CPC分类号： H01J49/0404 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/04 , H01J49/0409 , H01J49/0422 , H01J49/0459 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/4215
摘要： The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device.

4. 发明申请

US20180047552A1 REACTION MONITORING 审中-公开
公开(公告)号：US20180047552A1
公开(公告)日：2018-02-15
申请号：US15672862
申请日：2017-08-09
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Xin Yan , Christopher Pulliam , Ryan M. Bain , Tawnya Flick
IPC分类号： H01J49/00 , H01J49/04 , G01N33/68 , H01J49/16
CPC分类号： H01J49/0031 , G01N33/6848 , H01J49/0409 , H01J49/165
摘要： The invention generally relates to systems and methods for on-line reaction monitoring. In certain embodiments, the invention provides systems that include a reaction vessel having an outlet, a quantitation unit coupled to the outlet and configured to introduce internal standard and solvent into reaction solution flowed from the reaction vessel, one or more ion generating devices that receive flow from the quantitation unit, and a mass spectrometer. In certain embodiments, the invention provides systems for multiple reaction monitoring that include a plurality of reaction vessels, a plurality of ion generating devices, a plurality of channels, each channel coupling a reaction vessel to an ion generating device, an actuator coupled to the plurality of ion generating devices to thereby allow movement of the plurality of ion generating devices, and a mass spectrometer

5. 发明授权

US09733234B2 Probe for extraction of molecules of interest from a sample 有权
公开(公告)号：US09733234B2
公开(公告)日：2017-08-15
申请号：US14738688
申请日：2015-06-12
申请人： Janusz B. Pawliszyn , German Augusto Gomez Rios
发明人： Janusz B. Pawliszyn , German Augusto Gomez Rios
IPC分类号： G01N1/02 , G01N30/00 , H01J49/16 , G01N33/50 , G01N1/40 , H01J49/04 , B01J20/286 , A61B10/00 , G01N30/06 , G01N30/72
CPC分类号： G01N33/50 , A61B10/0045 , B01J20/286 , G01N1/405 , G01N30/7233 , G01N2030/009 , G01N2030/062 , G01N2560/00 , H01J49/0409 , H01J49/168 , Y10T428/2933
摘要： A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer. The solid substrate may have at least two edges that meet at an angle from about 8° to about 180°. Mass spectrometry systems that include such a device are also described. Methods of analyzing a molecule previously extracted from a sample onto the device are also described.

6. 发明申请

US20170219502A1 METHOD FOR CHARACTERIZING A SAMPLE COMBINING AN X-RAY CHARACTERIZATION TECHNIQUE AND A SECONDARY IONIZATION MASS SPECTROMETRY CHARACTERIZATION TECHNIQUE 审中-公开
公开(公告)号：US20170219502A1
公开(公告)日：2017-08-03
申请号：US15421660
申请日：2017-02-01
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： Agnieszka PRIEBE , Guillaume AUDOIT , Jean-Paul BARNES
IPC分类号： G01N23/20 , G01N23/083 , H01J49/00 , H01J49/40 , H01J49/04
CPC分类号： G01N23/20025 , G01N23/046 , G01N23/083 , G01N23/2204 , G01N23/2206 , G01N23/2258 , G01N2223/045 , G01N2223/0816 , G01N2223/307 , H01J49/0072 , H01J49/0409 , H01J49/40
摘要： A method for characterizing a sample combining an X-ray tomography characterization technique and a secondary ionization mass spectrometry characterization technique, includes: a step of providing a tip that includes first and second end surfaces, a first cylindrical region bearing the first end surface and a second region in contact with the first cylindrical region and becoming slimmer towards the second end surface; a step of machining the second region to obtain a sample holder including a flat surface, the flat surface forming an end surface of the sample holder, the area of the flat surface being less than the area of the first end surface; a step of placing the sample on the flat surface of the sample holder; a first step of characterization of the sample using an X-ray characterization technique; a second step of characterization of the sample using a secondary ionization mass spectrometry characterization technique.

7. 发明申请

US20170045425A1 SAMPLE HOLDERS AND METHODS OF USING THEM 有权
标题翻译：样品持有人及其使用方法
公开(公告)号：US20170045425A1
公开(公告)日：2017-02-16
申请号：US15197194
申请日：2016-06-29
申请人： PERKINELMER HEALTH SCIENCES, INC.
发明人： Paul L St. Cyr , Michael L. DelVecchio , Leonard J. Weisgable , John T. Buturla , Steve M Pignataro
IPC分类号： G01N1/28 , B01L9/00
CPC分类号： G01N1/36 , B01L9/50 , B01L9/52 , B01L2200/025 , B01L2300/043 , B01L2300/0681 , B01L2300/0829 , G01N1/28 , G01N2001/368 , H01J49/0409
摘要： Certain embodiments described herein are directed to sample holders that can be used to retain a sample support effective for use in direct sample analysis. In some embodiments, the sample support can include a first and a second plate with apertures to permit a sample to be analyzed using direct sample analysis.
摘要翻译：本文描述的某些实施例涉及可用于保持有效用于直接样品分析的样品支架的样品保持器。在一些实施例中，样品支架可以包括具有孔的第一和第二板，以允许使用直接样品分析分析样品。

8. 发明授权

US09377445B2 Ionization method, ionization apparatus, and mass analysis system 有权
标题翻译：电离法，电离装置和质量分析系统
公开(公告)号：US09377445B2
公开(公告)日：2016-06-28
申请号：US14383607
申请日：2012-08-27
申请人： Hiroyuki Satake , Hideki Hasegawa , Yuichiro Hashimoto , Masao Suga , Izumi Waki
发明人： Hiroyuki Satake , Hideki Hasegawa , Yuichiro Hashimoto , Masao Suga , Izumi Waki
IPC分类号： H01J49/16 , H01J49/04 , G01N30/72 , G01N27/62
CPC分类号： G01N30/7266 , G01N27/62 , G01N30/7233 , H01J49/0409 , H01J49/0445 , H01J49/165
摘要： In order to achieve an ionization method of high robustness with a small carry-over or less crosstalk, an ionization method is disclosed. A method includes the steps of: joining an ionization unit to a tube; sucking the sample from a sample container into a sample holder of the ionization unit to hold the sample; moving the ionization unit holding the sample to near the ionization unit using an ionization unit drive unit; and applying a voltage to the ionization unit using a power supply to ionize the sample by electrostatically spraying the sample from the holding unit.
摘要翻译：为了实现具有小的遗留或较少串扰的高鲁棒性的电离方法，公开了电离方法。一种方法包括以下步骤：将电离单元连接到管上; 将样品从样品容器吸入电离单元的样品保持器中以保持样品; 使用电离单元驱动单元将保持样品的电离单元移动到离子化单元附近; 以及使用电源向所述电离单元施加电压以通过从所述保持单元静电喷射所述样品来使样品电离。

9. 发明授权

US09362095B1 Method and apparatus for transporting samples in a mass spectrometer 有权
标题翻译：用于在质谱仪中运送样品的方法和装置
公开(公告)号：US09362095B1
公开(公告)日：2016-06-07
申请号：US14611260
申请日：2015-02-01
申请人： Virgin Instruments Corporation
发明人： Kevin Hayden , Marvin L. Vestal
IPC分类号： H01J49/04
CPC分类号： H01J49/0409 , H01J49/0495
摘要： A sample plate handling system for a time-of-flight mass spectrometer includes a transport chamber and a mass spectrometer chamber that is mechanically coupled to transport chamber. A two-dimensional translation stage is positioned in the mass spectrometer chamber. A sample plate transporter is mounted on the two-dimensional translation stage. A first portion of the sample plate transporter is mechanically attached to the two-dimensional translation stage. A second portion of the sample plate transporter defines a sample plate receiver that is positioned in the transport chamber. A sealing surface located between the first and the second portions connects the transport chamber and the mass spectrometer chamber. A motion of the two-dimensional translation stage in one direction aligns the sample plate transporter with the sealing orifice and a motion of the two-dimensional translation stage in the other direction moves the sealing surface of the sample plate transporter to engage the sealing orifice, thereby preventing gas flow between the mass spectrometer chamber and the transport chamber.
摘要翻译：用于飞行时间质谱仪的样品板处理系统包括机械耦合到运输室的运输室和质谱室。二维平移台位于质谱室中。样品板转运器安装在二维平移台上。样品板转运器的第一部分机械地附接到二维平移台。样品板传送器的第二部分限定了位于传送室中的样品板接收器。位于第一和第二部分之间的密封表面连接输送室和质谱室。二维平移台在一个方向上的运动将样品板运送器与密封孔对准，并且二维平移台在另一方向上的运动使样品板运送器的密封表面移动以接合密封孔，从而防止质谱仪室和输送室之间的气体流动。

10. 发明授权

US09184037B2 Mass spectrometer and mass analyzing method 有权
标题翻译：质谱仪和质量分析方法
公开(公告)号：US09184037B2
公开(公告)日：2015-11-10
申请号：US13527627
申请日：2012-06-20
申请人： Shun Kumano , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hidetoshi Morokuma , Shuhei Hashiba
发明人： Shun Kumano , Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Masuyoshi Yamada , Hidetoshi Morokuma , Shuhei Hashiba
IPC分类号： H01J49/00 , H01J49/04
CPC分类号： H01J49/0409 , H01J49/0495
摘要： A mass spectrometer including a sample attaching member of attaching a sample, an ionizing chamber including an introductory port of the sample attaching member and an ionization source of generating a sample ion, a vacuumed chamber having a mass analyzer of analyzing the sample ion, and an opening/closing mechanism provided between the ionizing chamber and the vacuumed chamber, in which the opening/closing mechanism is controlled from a closed state to an open state after introducing the sample attaching member into the ionizing chamber to thereby enable to perform ionization with inconsiderable fragmentation at a high sensitivity with a high throughput.
摘要翻译：一种质谱仪，包括附着样品的样品附着构件，包括样品附着构件的入口的电离室和产生样品离子的离子源，具有分析样品离子的质量分析器的真空室，以及设置在离子化室和真空室之间的开/关机构，其中将样品附着构件引入电离室之后，将开/关机构从关闭状态控制到打开状态，从而能够以不可分割的碎片进行电离灵敏度高，吞吐量高。

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