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1. 发明授权

US12130255B2 High-throughput label-free enzymatic bioassays using DESI-MS 有权
公开(公告)号：US12130255B2
公开(公告)日：2024-10-29
申请号：US18084827
申请日：2022-12-20
申请人： Purdue Research Foundation
发明人： Robert Graham Cooks , Nicolás M. Morato , Dylan T. Holden
IPC分类号： G01N27/64 , G01N27/622 , G01N27/626 , H01J49/04
CPC分类号： G01N27/622 , G01N27/626 , G01N27/64 , H01J49/0409
摘要： The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization-mass spectrometry (DESI-MS).

2. 发明公开

US20240230661A1 OPERATING A MASS SPECTROMETER UTILIZING MASS SPECTRAL DATABASE SEARCH 审中-公开
公开(公告)号：US20240230661A1
公开(公告)日：2024-07-11
申请号：US18540423
申请日：2023-12-14
申请人： Thermo Finnigan LLC
发明人： Derek J. Bailey
IPC分类号： G01N33/68 , H01J49/00 , H01J49/04 , H01J49/42
CPC分类号： G01N33/6848 , H01J49/0036 , H01J49/0409 , H01J49/4295
摘要： Real-time search (RTS) for mass spectrometry is described. In one aspect, a mass spectrometer can identify a candidate peptide for a product ion spectrum by searching a mass spectral database. While executing the search of the mass spectral database, the elapsed search time can be monitored. If the elapsed search time of the identification of the candidate peptide is completed before reaching a maximum value, then the mass spectrometer can perform further actions.

3. 发明公开

US20240059432A1 SAMPLE COLLECTION SYSTEM FOR INTERPLANETARY VEHICLE 审中-公开
公开(公告)号：US20240059432A1
公开(公告)日：2024-02-22
申请号：US18495357
申请日：2023-10-26
申请人： HONEYBEE ROBOTICS, LLC
发明人： Philip Chu , Justin Spring , Kris Zacny
IPC分类号： B64G1/66 , G01N1/14
CPC分类号： B64G1/66 , G01N1/14 , H01J49/0409
摘要： A sample collection system for an extraterrestrial vehicle and method of operating is provided. The system includes an inlet conduit configured to receive a gas stream. A chamber having an inlet is fluidly coupled to the inlet conduit, the inlet and chamber configured to induce cyclonic flow. A container is removably disposed within the chamber, the container having a first opening fluidly coupled to the inlet and an outlet. An exhaust conduit is fluidly coupled to the outlet. A filter is disposed between the exhaust conduit and the chamber.

4. 发明公开

US20230395364A1 METHOD AND APPARATUS FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：US20230395364A1
公开(公告)日：2023-12-07
申请号：US18035668
申请日：2021-11-05
申请人： Ohio State Innovation Foundation
发明人： Abraham Badu-Tawiah , Dmytro Kulyk , Kavyasree Chintalapudi , Enoch Amoah
IPC分类号： H01J49/04 , H01J49/16
CPC分类号： H01J49/0409 , H01J49/165 , H01J49/168
摘要： Disclosed herein are apparatuses comprising a panoptic ion sources capable of ionizing organic compounds. Also disclosed are methods for analyzing complex organic compounds using the disclosed herein apparatuses. The methods and systems are suitable for high throughput screening of samples, including biofluids. The methods and systems are suitable for the rapid evaluation of chemical reactions, permitting the discovery of novel organic reaction pathways.

5. 发明公开

US20230238229A1 MASS SPECTROMETER 审中-公开
公开(公告)号：US20230238229A1
公开(公告)日：2023-07-27
申请号：US17999280
申请日：2021-05-18
申请人： ASCEND DIAGNOSTICS LIMITED
发明人： Simone PANTALEI , Alex GWEN-HAM HO
IPC分类号： H01J49/00 , H01J49/04 , G01N27/622
CPC分类号： H01J49/0031 , H01J49/0409 , G01N27/622
摘要： A mass spectrometer, MS, 100 is described. A mass spectrometer comprises: a set of chambers, for receiving sample plate holders therein and/or therethrough, wherein the sample plate holders are arranged to hold respective subsets of sample plates therein and/or thereon and wherein the sample plate holders include respective identifiers, wherein the set of chambers is fluidically coupled to and/or comprises an ion source, an analyser and an ion detector, for mass spectrometry of samples included on the sample plates received therein; a reader configured to read a first identifier, of a set of identifiers, included on a first sample plate holder, of a set of sample plate holders, optionally including a first sample plate, of a set of sample plates, held therein and/or thereon, received in the set of chambers; and a controller configured to control the reader to read the first identifier of the first sample plate holder received in the set of chambers.

6. 发明公开

US20230238228A1 MASS SPECTROMETER 审中-公开
公开(公告)号：US20230238228A1
公开(公告)日：2023-07-27
申请号：US17999270
申请日：2021-05-18
申请人： ASCEND DIAGNOSTICS LIMITED
发明人： Simone PANTALEI , Alex GWEN-HAM HO
IPC分类号： H01J49/00 , H01J49/04 , G01N27/622
CPC分类号： H01J49/0031 , H01J49/0409 , G01N27/622 , H01J49/0004
摘要： A mass spectrometer, MS, 100 is described. The MS 100 comprises: a first chamber 110, comprising a set of ports P close able by respective doors, for receiving sample plates including respective unique device identifiers, UDIs, therein and/or there through, wherein the set of ports P includes a first port P1 having a first door D1 and a second port P2 having a second door D2; a second chamber 120, fluidically couple able with the first chamber 110 via the second port P2, wherein the second chamber 120 is fluidically coupled to and/or comprises an ion source 130, an analyser 140 and an ion detector 150, for mass spectrometry of samples included on the sample plates received therein; and an imager 160, coupled to the second chamber 120, configured to image the UDIs of the sample plates; a controller 170 configured to control the imager 160; wherein the MS 100 is arrangeable in: a first arrangement, wherein a first sample plate 1A of a set of sample plates 1 is received in the first chamber 110 via the first port P1, wherein the first door D1 is open and wherein the second door D2 is closed, and wherein the first sample plate 1A includes a first UDI U1A of a set of UDIs; a second arrangement, wherein the first sample plate 1A is in the first chamber 110, wherein the first door D1 is closed and wherein the second door D2 is closed; and a third arrangement, wherein the first sample plate 1A is received in the second chamber 120 via the second port P2, wherein the second door D2 is closed; wherein the controller 170 is configured to control the imager 160 to image the first UDI U1A of the first sample plate 1A, when the MS 100 is arranged in the third arrangement.

7. 发明公开

US20230143849A1 SPECTROMETRIC ANALYSIS OF MICROBES 审中-公开
公开(公告)号：US20230143849A1
公开(公告)日：2023-05-11
申请号：US18149468
申请日：2023-01-03
申请人： Micromass UK Limited
发明人： Zoltán TAKÁTS , Frances BOLT , Tamás KARANCSI , Emrys JONES , Keith RICHARDSON , Lajos GODORHAZY , Daniel SZALAY , Julia BALOG , Steven Derek PRINGLE , Daniel SIMON
IPC分类号： H01J49/04 , A61B10/02 , A61B17/32 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/68 , H01J49/00 , H01J49/06 , H01J49/16 , G01N27/623 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B17/00 , A61B18/04 , A61B18/18 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/92 , H01J49/02 , H01J49/10 , H01J49/14 , H01J49/24 , H01J49/26
CPC分类号： H01J49/049 , A61B10/0233 , A61B10/0283 , A61B17/320068 , A61B18/00 , A61B18/14 , A61B18/20 , G01N3/00 , G01N9/00 , G01N33/6848 , H01J49/0036 , H01J49/0404 , H01J49/0459 , H01J49/068 , H01J49/16 , H01J49/044 , G01N27/623 , A61B90/13 , A61B1/041 , A61B1/2736 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B17/00 , A61B18/04 , A61B18/042 , A61B18/1445 , A61B18/1815 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/6851 , G01N33/92 , H01J49/0004 , H01J49/0027 , H01J49/0031 , H01J49/025 , H01J49/0409 , H01J49/0422 , H01J49/0445 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/10 , H01J49/14 , H01J49/164 , H01J49/24 , H01J49/26 , G16B20/00
摘要： A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.

8. 发明授权

US10636640B2 Apparatus and method for chemical phase sampling analysis 有权
公开(公告)号：US10636640B2
公开(公告)日：2020-04-28
申请号：US16029353
申请日：2018-07-06
申请人： IonSense Inc.
发明人： Brian D Musselman
IPC分类号： H01J49/10 , H01J49/04 , B01J20/281 , G01N30/72 , G01N30/12
CPC分类号： H01J49/0409 , G01N30/48 , H01J49/10 , G01N30/12 , G01N30/72
摘要： In various embodiments of the invention, a sorbent coated mesh or grid introduced into contact with a sample can be monitored at appropriate temperatures, positions and time intervals to determine species present in the sample. The monitoring utilizes reactive species produced from an atmospheric analyzer to ionize analyte molecules present on the sorbent coated mesh or grid which are then analyzed by an appropriate spectroscopy system. In an embodiment of the invention, a sorbent surface can be used to absorb, adsorb or condense analyte molecules from the sample whereafter the sorbent surface can be interrogated with the reactive species to generate analyte species characteristic of the sample.

9. 发明申请

US20190198309A1 MASS SPECTROMETRY SYSTEM AND WORKING METHOD AND APPLICATION THEREOF, AND SAMPLING DEVICE 审中-公开
公开(公告)号：US20190198309A1
公开(公告)日：2019-06-27
申请号：US16286574
申请日：2019-02-26
申请人： NINGBO UNIVERSITY , CHINA INNOVATION INSTRUMENT CO., LTD.
发明人： Luhong WEN , Peng ZHAO , Ruiqiang CHEN , Huanhuan HONG , Feng ZHOU
IPC分类号： H01J49/42 , G01N27/64 , H01J49/04 , G01N33/543 , H01J49/06
CPC分类号： H01J49/426 , G01N27/64 , G01N33/543 , H01J49/0031 , H01J49/0409 , H01J49/0431 , H01J49/062
摘要： A mass spectrometry system and a working method and an application thereof, and a sampling device. The mass spectrometry system includes an ion source, a sampling device and a mass spectrometer. The sampling device includes: a guide rail; a support adapted to move on the guide rail; a bearing member made from a hydrophobic material with two ends being fixed to the support; a plurality of containers for containing samples arranged on the support; a plurality of transport members made from a hydrophilic material and including a first portion provided on the bearing member and a second portion connected to the first portion and extending into each container; adjacent transport members being not in contact; and a drive module configured to drive the support to move on the guide rail such that a central axis of an exit port of the ion source passes through the first portion.

10. 发明申请

US20190035616A1 METHOD AND APPARATUS FOR IMAGING SINGLE MOLECULES 审中-公开
公开(公告)号：US20190035616A1
公开(公告)日：2019-01-31
申请号：US16068672
申请日：2016-06-29
申请人： UNIVERSITAET ZUERICH
发明人： Jean-Nicolas LONGCHAMP , Hans-Werner FINK , Conrad ESCHER
IPC分类号： H01J49/16 , H01J49/04
CPC分类号： H01J49/165 , G01N23/2251 , H01J37/26 , H01J49/0409 , H01J49/40 , H01J2237/2614
摘要： A method of imaging single molecules, comprises the steps of: a) providing an assembly comprising a carrier substrate having a substrate face with an aperture, the aperture being covered with a receiving layer attached to the substrate face, the receiving layer being substantially transparent for low-energy electrons with a kinetic energy of 5 to 1,000 eV; b) depositing single molecules onto said receiving layer by means of soft-landing electrospray ion deposition, whereby a single molecule loaded receiving layer is formed; c) acquiring an in-line low-energy electron transmission pattern of said single molecule loaded receiving layer, said single molecule loaded receiving layer. The above steps a) to c) are conducted under vacuum conditions.

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