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1. 发明授权

US08871668B2 Immobilized lewis acid catalysts coated with ionic liquids and use thereof 有权
标题翻译：用离子液体涂覆的固定的路易斯酸催化剂及其用途
公开(公告)号：US08871668B2
公开(公告)日：2014-10-28
申请号：US12282444
申请日：2007-03-12
申请人： Shu Kobayashi , Yuichiro Mori , Gu Yanlong
发明人： Shu Kobayashi , Yuichiro Mori , Gu Yanlong
IPC分类号： B01J31/22 , B01J31/02 , B01J31/16 , C07C327/22 , C07C29/40 , C07C221/00
CPC分类号： C07C29/40 , B01J31/0252 , B01J31/0254 , B01J31/0284 , B01J31/0288 , B01J31/0292 , B01J31/1633 , B01J31/2256 , B01J2231/32 , B01J2231/342 , B01J2231/346 , B01J2531/35 , B01J2531/36 , B01J2531/38 , B01J2531/54 , B01J2531/96 , C07C221/00 , C07C327/22 , Y02P20/588 , C07C225/18 , C07C33/30
摘要： The invention provides a novel immobilized Lewis acid catalyst which exhibits high catalytic activity in an aqueous solution and which permits recovery and reuse or long-term continuous use. The invention relates to an immobilized Lewis acid catalyst comprising a solid substance and a Lewis acid supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are coated with an ionic liquid, more specifically, an immobilized Lewis acid catalyst comprising a solid substance such as silica gel or an organic polymer and a Lewis acid stable even in water which is supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are completely or partially coated with a hydrophobic ionic liquid; a process for the production of the catalyst; use thereof; and a process for the preparation of compounds with the catalyst.
摘要翻译：本发明提供了一种在水溶液中显示出高催化活性并且允许回收和再利用或长期连续使用的新型固定化路易斯酸催化剂。本发明涉及一种固定化的路易斯酸催化剂，其包含通过化学键合负载在固体物质的表面上的固体物质和路易斯酸，其中固体物质的表面和路易斯酸的外围被离子液体包覆，更具体地，包含固体物质如硅胶或有机聚合物的固化的路易斯酸催化剂和即使在水中稳定的路易斯酸，其通过化学键合负载在固体物质的表面上，其中固体物质的表面和路易斯酸的外围部分被完全或部分地涂覆有疏水性离子液体; 催化剂的生产方法; 使用; 以及用催化剂制备化合物的方法。

2. 发明申请

US20090318729A1 IMMOBILIZED LEWIS ACID CATALYSTS COATED WITH IONIC LIQUIDS AND USE THEREOF 有权
标题翻译：用离子液体涂覆的固化的LEWIS酸催化剂及其用途
公开(公告)号：US20090318729A1
公开(公告)日：2009-12-24
申请号：US12282444
申请日：2007-03-12
申请人： Shu Kobayashi , Yuichiro Mori , Gu Yanlong
发明人： Shu Kobayashi , Yuichiro Mori , Gu Yanlong
IPC分类号： B01J31/12 , C07C327/04 , C07C215/20 , C07C33/30
CPC分类号： C07C29/40 , B01J31/0252 , B01J31/0254 , B01J31/0284 , B01J31/0288 , B01J31/0292 , B01J31/1633 , B01J31/2256 , B01J2231/32 , B01J2231/342 , B01J2231/346 , B01J2531/35 , B01J2531/36 , B01J2531/38 , B01J2531/54 , B01J2531/96 , C07C221/00 , C07C327/22 , Y02P20/588 , C07C225/18 , C07C33/30
摘要： The invention provides a novel immobilized Lewis acid catalyst which exhibits high catalytic activity in an aqueous solution and which permits recovery and reuse or long-term continuous use. The invention relates to an immobilized Lewis acid catalyst comprising a solid substance and a Lewis acid supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are coated with an ionic liquid, more specifically, an immobilized Lewis acid catalyst comprising a solid substance such as silica gel or an organic polymer and a Lewis acid stable even in water which is supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are completely or partially coated with a hydrophobic ionic liquid; a process for the production of the catalyst; use thereof; and a process for the preparation of compounds with the catalyst.
摘要翻译：本发明提供了一种在水溶液中显示出高催化活性并且允许回收和再利用或长期连续使用的新型固定化路易斯酸催化剂。本发明涉及一种固定化的路易斯酸催化剂，其包含通过化学键合负载在固体物质的表面上的固体物质和路易斯酸，其中固体物质的表面和路易斯酸的外围被离子液体包覆，更具体地，包含固体物质例如硅胶或有机聚合物的固定化路易斯酸催化剂和即使在水中稳定的路易斯酸，其通过化学键合负载在固体物质的表面上，其中固体物质的表面和路易斯酸的外围部分被完全或部分地涂覆有疏水性离子液体; 催化剂的生产方法; 使用; 以及用催化剂制备化合物的方法。

3. 发明授权

US07663008B2 Method of catalytic reaction using micro-reactor 失效
标题翻译：使用微反应器的催化反应方法
公开(公告)号：US07663008B2
公开(公告)日：2010-02-16
申请号：US10587895
申请日：2005-01-26
申请人： Shu Kobayashi , Yuichiro Mori , Takehiko Kitamori , Masaharu Ueno , Kuniaki Okamoto
发明人： Shu Kobayashi , Yuichiro Mori , Takehiko Kitamori , Masaharu Ueno , Kuniaki Okamoto
IPC分类号： C07C5/52 , C10G45/00
CPC分类号： C07C5/03 , B01J19/0093 , B01J23/44 , B01J31/1633 , B01J35/0013 , B01J37/0219 , B01J2219/00831 , B01J2219/00835 , B01J2231/641 , B01J2231/643 , B01J2231/645 , B01J2531/62 , B01J2531/64 , B01J2531/66 , B01J2531/72 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/825 , B01J2531/827 , C07C5/08 , C07C29/175 , C07C45/62 , C07C209/36 , C07C2601/14 , Y02P20/588 , C07C15/12 , C07C15/18 , C07C33/20 , C07C211/46
摘要： A method of catalytic reaction uses a micro-reactor (1) with a metal catalyst (5) or a metal complex catalyst (5) as a solid phase supported on the inner wall (4c) of a channel (4), a solution (7) dissolving a reactant as a liquid phase and hydrogen (9) as a gas phase are flown through the channel (4) in pipe flow state, and the reaction of the solution (7) and the gas (9) accelerated by the metal catalyst (5) or the metal complex catalyst (5) is conducted by three phase catalytic reaction of solid-liquid-gas phases. The metal catalyst (5) or the metal complex catalyst (5) is incorporated in a polymer, and hydrogenation reaction by three phase catalytic reductive reaction of a substance to be reduced can be conducted in short time at good yield. For hydrogenation reaction of unsaturated organics, the rate of reaction and yield are high when palladium catalyst is used, and carbonylation reaction can be conducted if carbon monoxide is used instead of hydrogen.
摘要翻译：催化反应的方法使用具有金属催化剂（5）或金属络合物催化剂（5）的微反应器（1）作为支撑在通道（4）的内壁（4c）上的固相，溶液（ 7）溶解作为液相的反应物和作为气相的氢（9）以管流状态流过通道（4），并且溶液（7）和气体（9）被金属加速的反应催化剂（5）或金属络合物催化剂（5）通过固 - 液 - 气相的三相催化反应进行。将金属催化剂（5）或金属络合物催化剂（5）引入到聚合物中，并且可以在短时间内以良好的收率进行要还原的物质的三相催化还原反应的氢化反应。对于不饱和有机物的氢化反应，当使用钯催化剂时，反应速率和产率高，如果使用一氧化碳代替氢气，则可进行羰基化反应。

4. 发明申请

US20070161834A1 Method of catalytic reaction using micro-reactor 失效
标题翻译：使用微反应器的催化反应方法
公开(公告)号：US20070161834A1
公开(公告)日：2007-07-12
申请号：US10587895
申请日：2005-01-26
申请人： Shu Kobayashi , Yuichiro Mori , Takehiko Kitamaori , Masaharu Ueno , Kuniaki Okamoto
发明人： Shu Kobayashi , Yuichiro Mori , Takehiko Kitamaori , Masaharu Ueno , Kuniaki Okamoto
IPC分类号： C07C5/10 , C07C13/465
CPC分类号： C07C5/03 , B01J19/0093 , B01J23/44 , B01J31/1633 , B01J35/0013 , B01J37/0219 , B01J2219/00831 , B01J2219/00835 , B01J2231/641 , B01J2231/643 , B01J2231/645 , B01J2531/62 , B01J2531/64 , B01J2531/66 , B01J2531/72 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/825 , B01J2531/827 , C07C5/08 , C07C29/175 , C07C45/62 , C07C209/36 , C07C2601/14 , Y02P20/588 , C07C15/12 , C07C15/18 , C07C33/20 , C07C211/46
摘要： A method of catalytic reaction uses a micro-reactor (1) with a metal catalyst (5) or a metal complex catalyst (5) as a solid phase supported on the inner wall (4c) of a channel (4), a solution (7) dissolving a reactant as a liquid phase and hydrogen (9) as a gas phase are flown through the channel (4) in pipe flow state, and the reaction of the solution (7) and the gas (9) accelerated by the metal catalyst (5) or the metal complex catalyst (5) is conducted by three phase catalytic reaction of solid-liquid-gas phases. The metal catalyst (5) or the metal complex catalyst (5) is incorporated in a polymer, and hydrogenation reaction by three phase catalytic reductive reaction of a substance to be reduced can be conducted in short time at good yield. For hydrogenation reaction of unsaturated organics, the rate of reaction and yield are high when palladium catalyst is used, and carbonylation reaction can be conducted if carbon monoxide is used instead of hydrogen.
摘要翻译：催化反应的方法使用具有负载在通道（4）的内壁（4c）上的金属催化剂（5）或金属络合物催化剂（5）作为固相的微反应器（1），溶液（7）溶解作为液相的反应物和作为气相的氢（9）以管流状态流过通道（4），并且溶液（7）和气体（9）的反应被金属催化剂（5）或金属络合物催化剂（5）通过固 - 液 - 气相的三相催化反应进行。将金属催化剂（5）或金属络合物催化剂（5）引入到聚合物中，并且可以在短时间内以良好的收率进行要还原的物质的三相催化还原反应的氢化反应。对于不饱和有机物的氢化反应，当使用钯催化剂时，反应速率和产率高，如果使用一氧化碳代替氢气，则可进行羰基化反应。

5. 发明授权

US08563765B2 Diamino acid derivative starting material, manufacturing method thereof, and diamino acid derivative manufacturing method 有权
公开(公告)号：US08563765B2
公开(公告)日：2013-10-22
申请号：US12922008
申请日：2009-02-27
申请人： Shu Kobayashi , Yasuhiro Yamashita , Kazutaka Seki
发明人： Shu Kobayashi , Yasuhiro Yamashita , Kazutaka Seki
IPC分类号： C07C229/00
CPC分类号： C07F9/4056 , B01J31/0222 , B01J31/0237 , B01J31/0251 , B01J31/0271 , B01J31/1805 , B01J2231/346 , B01J2531/20 , B01J2531/21 , B01J2531/22 , B01J2531/23 , B01J2531/24 , B01J2531/25 , C07B53/00 , C07B2200/07 , C07C251/24 , C07C271/22 , C07C2601/14 , C07C2603/18 , C07D307/52 , C07F9/4006 , C07F9/65515 , C07F9/655345
摘要： Provided is an efficient technology for synthesizing diamino acids (diamino acid derivatives). Disclosed is a manufacturing method for diamino acid derivatives wherein the fluorenyl groups of the diamino acid derivative starting materials represented by General Formula [II] or [IV] are removed.

6. 发明授权

US08318967B2 Polysilane-supported transition metal catalyst for liquid phase reaction 有权
标题翻译：用于液相反应的聚硅烷负载的过渡金属催化剂
公开(公告)号：US08318967B2
公开(公告)日：2012-11-27
申请号：US12224636
申请日：2007-02-27
申请人： Shu Kobayashi , Hidekazu Oyamada , Ryo Akiyama , Takeshi Naito
发明人： Shu Kobayashi , Hidekazu Oyamada , Ryo Akiyama , Takeshi Naito
IPC分类号： C07F7/08 , C07F7/02 , C07F7/00
CPC分类号： C07C67/303 , B01J23/40 , B01J23/70 , B01J31/124 , B01J31/127 , B01J31/165 , B01J31/26 , B01J31/28 , B01J35/006 , B01J37/0219 , B01J2231/4261 , B01J2231/641 , B01J2531/824 , B01J2531/828 , C07B2200/11 , C07C2/861 , C07C5/03 , C07C5/08 , C07C67/343 , C07C205/19 , C07C2523/42 , C07C2523/44 , C07C2523/72 , C07F15/0066 , C07F15/0086 , C07F15/0093 , C07C15/54 , C07C15/18 , C07C69/612 , C07C69/618
摘要： The present invention provides a polysilane-supported transition metal catalysts or a polysilane/inorganic compound-supported transition metal catalysts, wherein various types of transition metals are supported by polysilane compounds, or combination of polysilanes and inorganic compounds. The catalysts of the present invention are hardly soluble in hydrocarbons and alcohols and are useful as catalysts in heterogeneous system for various organic synthetic reactions using the above solvents. Polysilanes supporting transition metals are easily crosslinkable by thermal treatment, microwave irradiation, UV irradiation or chemical methods such as hydrosilylation reaction and are changed to be insoluble in various solvents keeping high catalytic activity. Moreover, the stability and operability of polysilane-supported transition metal catalysts will be improved by the support thereof on inorganic compounds. These polysilane-supported transition metal catalysts show a high catalytic activity in hydrogenation reaction, hydrosilylation reaction, Heck reaction, Suzuki-Miyaura coupling reactions and the like. The catalyst is easily recoverable and reusable and the leakage of metals is extremely few.
摘要翻译：本发明提供一种聚硅烷负载的过渡金属催化剂或聚硅烷/无机化合物负载的过渡金属催化剂，其中各种类型的过渡金属由聚硅烷化合物或聚硅烷和无机化合物的组合负载。本发明的催化剂几乎不溶于烃和醇，并且可用作用于使用上述溶剂的各种有机合成反应的异相体系中的催化剂。支撑过渡金属的聚硅烷通过热处理，微波照射，UV照射或氢化硅烷化反应等化学方法易于交联，并且改变为不溶于保持高催化活性的各种溶剂。此外，通过其对无机化合物的支持，聚硅烷负载的过渡金属催化剂的稳定性和可操作性将得到改善。这些聚硅烷负载的过渡金属催化剂在氢化反应，氢化硅烷化反应，Heck反应，Suzuki-Miyaura偶联反应等中显示出高的催化活性。催化剂易于回收和再利用，金属的泄漏极少。

7. 发明申请

US20110054190A1 CATALYST AND REACTION PROCESS 有权
标题翻译：催化和反应过程
公开(公告)号：US20110054190A1
公开(公告)日：2011-03-03
申请号：US12865053
申请日：2009-01-28
申请人： Shu Kobayashi , Magno Agostinho , Uwe Schneider , Miyuki Yamaguchi
发明人： Shu Kobayashi , Magno Agostinho , Uwe Schneider , Miyuki Yamaguchi
IPC分类号： C07D207/02 , C07C67/00 , C07F3/00
CPC分类号： C07C311/16 , B01J31/0212 , B01J31/1805 , B01J2231/348 , B01J2531/21 , B01J2531/22 , B01J2531/23 , B01J2531/24 , B01J2531/25 , C07B53/00 , C07B2200/07 , C07C67/347 , C07C201/12 , C07C2602/10 , C07D207/325 , C07D307/54 , C07D333/24 , C07C69/738 , C07C205/56
摘要： Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time. Specifically disclosed is a catalyst which is composed of MX2 (wherein M is Be, Mg, Ca, Sr, Ba or Ra and X is an arbitrary group) and a compound represented by general formula [I]. [In the formula, R7, R8, R9 and R10 each represents a substituted cyclic group or an unsubstituted cyclic group.]
摘要翻译：公开了一种能够实现不需要大量丙二酸酯的有效的不对称迈克尔加成反应的技术，同时反应时间短。具体公开的是由MX2（其中M为Be，Mg，Ca，Sr，Ba或Ra，X为任意基团）和通式[I]表示的化合物组成的催化剂。 [式中，R 7，R 8，R 9，R 10分别表示取代的环状基团或未取代的环状基团。

8. 发明授权

US07754898B2 Method of enantioselective nucleophilic addition reaction of enamide to imine and synthesis method of α-amino-γ-keto acid ester 失效
标题翻译：酰胺对亚胺的对映选择性亲核加成反应方法及α-氨基-γ-酮酸酯的合成方法
公开(公告)号：US07754898B2
公开(公告)日：2010-07-13
申请号：US10587075
申请日：2005-01-24
申请人： Shu Kobayashi
发明人： Shu Kobayashi
IPC分类号： C07D207/14 , C07C229/00 , C07C237/00
CPC分类号： C07B53/00 , B01J31/1805 , B01J2231/341 , B01J2531/16 , C07B2200/07 , C07C231/18 , C07D207/273
摘要： An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthio-selective nucleophilic addition reaction to imine compound being a method of nucleophilic addition reaction of enamide compound accompanied by amino formation to imino group (—CH═N—) of imine compound, characterized in that the reaction is performed in the presence of a chiral copper catalyst. Further, there is provided a novel method of synthesizing an amino acid compound, etc., to which the above is applied.
摘要翻译：可用作药物，农药，香料，功能性聚合物等的原料或合成中间体的氨基酸化合物的不对称合成。提供了一种亚胺化合物的富含选择性亲核加成反应的方法，伴随氨基形成的酰胺化合物与亚胺基的亚氨基（-CH = N-）的亲核加成反应，其特征在于反应在手性铜催化剂存在下进行。此外，提供了一种合成上述应用的氨基酸化合物等的新方法。

9. 发明授权

US07659424B2 Process for the allylation of n-acylhydrazones 失效
标题翻译： N-酰基腙的烯丙基化方法
公开(公告)号：US07659424B2
公开(公告)日：2010-02-09
申请号：US10591094
申请日：2005-02-24
申请人： Shu Kobayashi , Masaharu Sugiura
发明人： Shu Kobayashi , Masaharu Sugiura
IPC分类号： C07C241/02 , C07C227/04 , C07C229/08 , C07C243/38
CPC分类号： C07C241/02 , C07B53/00 , C07C2601/14 , C07C243/38
摘要： [PROBLEMS] To provide a novel method for the allylation of N-acylhydrazones by which enantioselectively allylated N-acylhydrazines can be efficiently obtained.[MEANS FOR SOLVING PROBLEMS] A method for the production of enantioselectively allylated N-acylhydrazines represented by the general formula [3]: [wherein R0 is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or —COOR1 (wherein R1 is a hydrocarbon group); R2 is acyl; R3 and R4 are each hydrogen, or one of R3 and R4 is hydrogen and the other is a hydrocarbon group; and R5 and R6 are each independently hydrogen or a hydrocarbon group], characterized by reacting an N-acylhydrazone represented by the general formula [1]: [wherein R0 and R2 are as defined above] with an allylating agent such as allyltrichlorosilane or crotyltrichlorosilane in the presence of a chiral phosphine oxide.
摘要翻译： [问题]提供N-酰腙的烯丙基化的新方法，通过该方法可以有效地获得对映选择性烯丙化的N-酰肼。用于解决问题的方法制备由通式[3]表示的对映选择性烯丙化N-酰肼的方法：[其中R 0是任选取代的烃基，任选取代的杂环基或-COOR 1（其中R 1是烃基）; R2是酰基; R3和R4各自为氢，R3和R4中的一个为氢，另一个为烃基; R 5和R 6各自独立地为氢或烃基]，其特征在于使由通式[1]表示的N-酰腙：[其中R 0和R 2如上定义]与烯丙基化试剂如烯丙基三氯硅烷或基环丙基三氯硅烷反应存在手性氧化膦。

10. 发明申请

US20080058200A1 Polymer-Supported Metal Cluster Composition 有权
标题翻译：聚合物支持金属簇组合物
公开(公告)号：US20080058200A1
公开(公告)日：2008-03-06
申请号：US10590206
申请日：2005-03-07
申请人： Shu Kobayashi , Kuniaki Okamoto , Ryo Akiyama , Keiji Ohno , Yoshio Inagaki
发明人： Shu Kobayashi , Kuniaki Okamoto , Ryo Akiyama , Keiji Ohno , Yoshio Inagaki
IPC分类号： B01J31/06
CPC分类号： C07C67/31 , B01J31/069 , B01J31/165 , B01J2231/4261 , B01J2231/643 , B01J2531/824 , B01J2531/827 , B01J2531/828 , C07C17/14 , C07C45/68 , C07C49/796 , C07C67/343 , C08F212/08 , C08F212/14 , C07C22/04 , C07C69/732 , C07C69/618
摘要： The objective is to present compositions obtained by supporting by polymers micro clusters of transition metals and the like that are useful as catalysts in various reactions and, once used, are readily recovered and reused.A polymer-supported metal cluster composition is obtained by supporting a transition metal by a cross-linked polymer, and the polymer-supported cluster composition is characterized by the cross-linked polymer obtained by cross-linking of a cross-linkable polymer containing a hydrophilic side chain and a hydrophobic side chain group having a cross-linkable functional group. This polymer-supported metal cluster composition is, for example, preferably formed by first forming a micelle composed of the metal clusters supported by the cross-linkable polymer in a suitable solution and subsequently subjecting the cross-linkable polymer to a cross-linking reaction. The composition is useful as a catalyst and the like in hydrogenation reactions, dehydrogenation reactions, allylic substitution reactions, oxidation reactions, coupling reactions and carbonylation reactions.
摘要翻译：目的是提供通过聚合物支撑的组合物，所述过渡金属等的微簇等可用作各种反应中的催化剂，并且一旦使用，就容易回收和重复使用。聚合物负载的金属簇组合物通过用交联聚合物负载过渡金属而获得，聚合物负载的簇组合物的特征在于通过交联含有亲水性的交联聚合物而获得的交联聚合物侧链和具有可交联官能团的疏水侧链基团。该聚合物负载的金属簇组合物例如优选通过首先在合适的溶液中形成由可交联聚合物负载的金属簇构成的胶束，然后使可交联聚合物进行交联反应而形成。该组合物可用作氢化反应，脱氢反应，烯丙基取代反应，氧化反应，偶联反应和羰基化反应中的催化剂等。

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