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1. 发明授权

US5320732A Biosensor and measuring apparatus using the same 失效
标题翻译：生物传感器和使用其的测量装置
公开(公告)号：US5320732A
公开(公告)日：1994-06-14
申请号：US75859
申请日：1993-06-11
申请人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Minoru Fukuda
发明人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Minoru Fukuda
IPC分类号： G01N27/28 , G01N33/487 , G01N27/26
CPC分类号： G01N27/3272
摘要： The subject invention provides a simple sensor and an easy to handle biosensor measuring apparatus for the purpose of making measurements easily, rapidly and with high accuracy for specific components within a biological specimen such as blood.The biosensor of the subject invention is provided with a protrusion or a depression in a portion of a base having at least a measurement electrode and an opposing electrode. Also, the biosensor measuring apparatus is so configurated to have a mating means in the main body of the measuring apparatus freely supporting this biosensor to contact the said sensor's protrusion or depression, and further having the activating switch of the driving power supply located in this mating means.By means of these, it is possible to prevent wasteful measuring operations, as noted in the prior art biosensors, such as inserting the sensor backwards and making measurements with the sensor inserted backwards.
摘要翻译：本发明提供了一种简单的传感器和易于处理的生物传感器测量装置，用于容易，快速且高度精确地测量诸如血液的生物样本内的特定组分的目的。本发明的生物传感器在至少具有测量电极和相对电极的基部的一部分中设置有突起或凹陷。此外，生物传感器测量装置被配置为具有在测量装置的主体中具有自由支撑该生物传感器的配合装置以接触所述传感器的突起或凹陷，并且还具有位于该配合中的驱动电源的启动开关手段。通过这些，可以防止浪费的测量操作，如现有技术的生物传感器中所述，例如向后插入传感器并且使传感器向后插入进行测量。

2. 发明授权

US5266179A Quantitative analysis method and its system using a disposable sensor 失效
标题翻译：定量分析方法及其使用一次性传感器的系统
公开(公告)号：US5266179A
公开(公告)日：1993-11-30
申请号：US733130
申请日：1991-07-19
申请人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Kyozo Terao , Naoki Tanimoto , Masahiro Yoshioka , Hiroshi Hyodo , Takatoshi Uchigaki
发明人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Kyozo Terao , Naoki Tanimoto , Masahiro Yoshioka , Hiroshi Hyodo , Takatoshi Uchigaki
IPC分类号： G01N27/26 , G01N27/28 , G01N27/416 , G01N27/49
CPC分类号： G01N33/48771 , G01N2035/009
摘要： A sensor 13 is inserted into a connector 14. A constant voltage required to obtain a response current is applied across the connector 14 by a voltage applying source 15 at timings required. A response current of the sensor 13 inserted into the connector 14 is converted into a voltage by a current-to-voltage converter 16, and the amount thereof is determined by a microcomputer, the analysis results being displayed onto a display unit.

3. 发明授权

US5512159A Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US5512159A
公开(公告)日：1996-04-30
申请号：US293131
申请日：1994-08-19
申请人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
发明人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
IPC分类号： G01N27/28 , C12M1/34 , C12M1/40 , C12Q1/00 , C12Q1/54 , G01N27/327 , G01N33/483
CPC分类号： C12Q1/001
摘要： A biosensor of the present invention is provided with an insulating base plate, an electrode system mainly consisting of a working electrode and a counter electrode formed on the insulating base plate, and a reaction layer on the electrode system. The counter electrode is partially a circular arc. A manufacturing method of the biosensor of the present invention is comprised of a step to form a base by arranging leads, an electrode system, and an insulating layer on an insulating base plate, and a step to form a reaction layer mainly composed of an enzyme on the electrode system. Since the counter electrode is partially in the shape of a circular arc, the reaction layer is easily formed and prevented from delaminating, whereby the measuring accuracy, preservative properties and reliability of the biosensor are improved. The present invention enables highly efficient biosensors to be mass produced at low cost.
摘要翻译：本发明的生物传感器设置有绝缘基板，主要由在绝缘基板上形成的工作电极和对电极组成的电极系统和电极系统上的反应层。对电极部分是圆弧。本发明的生物传感器的制造方法包括通过在绝缘基板上排列引线，电极系统和绝缘层形成基底的步骤，以及形成主要由酶组成的反应层的步骤在电极系统上。由于对电极部分为圆弧形状，反应层易于形成并防止分层，从而提高了生物传感器的测量精度，防腐性能和可靠性。本发明能够以低成本批量生产高效生物传感器。

4. 发明授权

US5229282A Preparation of biosensor having a layer containing an enzyme, electron acceptor and hydrophilic polymer on an electrode system 失效
标题翻译：具有包含酶的生物传感器的制备，电子接受体和亲水聚合物在电极系统上的制备
公开(公告)号：US5229282A
公开(公告)日：1993-07-20
申请号：US617886
申请日：1990-11-26
申请人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai
发明人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , Y10S435/817
摘要： The present invention relates to a process of preparation of a biosensor comprising forming an electrode system mainly containing carbon on an insulating base plate, treating the surface of electrode system with an organic solvent, and then arranging a reaction layer on the electrode system to give a unified element. The reaction layer contains an enzyme, electron acceptor and a hydrophilic polymer. Treatment with the organic solvent improves adhesion of the reaction layer to the electrode system. The electrode system contains a working electrode and a counter electrode. The electrode system is formed from a carbon paste containing a resin binder. Treatment is preferably carried out by wiping the surface of the electrodes with a material impregnated by the organic solvent.

5. 发明授权

US5582697A Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 失效
标题翻译：生物传感器，以及使用其进行样品液体中的基板的定量的方法和装置
公开(公告)号：US5582697A
公开(公告)日：1996-12-10
申请号：US425820
申请日：1995-04-20
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/005 , C12Q1/001 , Y10S435/817
摘要： The biosensor of this invention can quantify a substrate in a sample liquid by electrochemically measuring the amount of an electron acceptor that has been reduced by electrons generated in a reaction between the substrate and an oxidoreductase. The biosensor has an electrically insulating substrate and an electrode system formed on the substrate including a working electrode, a counter electrode and a third electrode used for detecting a liquid junction. The third electrode can be used merely for detecting a liquid junction, or can be used as both a reference electrode and a liquid junction detecting electrode.
摘要翻译：本发明的生物传感器可以通过电化学测量由底物和氧化还原酶之间的反应中产生的电子而减少的电子受体的量来量化样品液体中的底物。生物传感器具有电绝缘基板和形成在基板上的电极系统，该基板包括工作电极，对电极和用于检测液体接合点的第三电极。第三电极可以仅用于检测液体接点，也可以用作参考电极和液体接点检测电极。

6. 发明授权

US5565085A Method for quantifying specific compound 失效
标题翻译：定量化合物的方法
公开(公告)号：US5565085A
公开(公告)日：1996-10-15
申请号：US428040
申请日：1995-04-25
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno
IPC分类号： G01N27/416 , C12Q1/00 , G01N27/30 , G01N27/327 , G01N27/26
CPC分类号： C12Q1/001 , Y10S435/817
摘要： A biosensor for quantifying a specific compound has a reaction layer containing at least an enzyme, and an electrode system having a working electrode and a counter electrode formed on an insulating base plate; the biosensor detects the specific compound contained in a sample on the basis of an electrochemical response. In quantifying, the working electrode and the counter electrode are short-circuited before the voltage is applied therebetween. The short-circuiting eliminates measuring errors that may occur due to nonuniform dissolution of the reaction layer in a sample, and achieves highly reliable quantification of a specific compound.
摘要翻译：用于定量特定化合物的生物传感器具有至少含有酶的反应层和在绝缘基板上形成有工作电极和对电极的电极系统; 生物传感器基于电化学响应来检测样品中包含的特定化合物。在量化之前，工作电极和对电极在施加电压之前短路。短路消除了由于反应层在样品中的不均匀溶解而可能发生的测量误差，并且实现了特定化合物的高度可靠的定量。

7. 发明授权

US5650062A Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same 失效
标题翻译：生物传感器，以及使用其进行样品液体中的基板的定量的方法和装置
公开(公告)号：US5650062A
公开(公告)日：1997-07-22
申请号：US526557
申请日：1995-09-12
申请人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
发明人： Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Syoji Miyazaki
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/001 , Y10S435/817
摘要： The biosensor of this invention can quantify a substrate in a sample liquid by electrochemically measuring the amount of an electron acceptor that has been reduced by electrons generated in a reaction between the substrate and an oxidoreductase. The biosensor has an electrically insulating substrate and an electrode system formed on the substrate including a working electrode, a counter electrode and a third electrode used for detecting a liquid junction. The third electrode can be used merely for detecting a liquid junction, or can be used as both a reference electrode and a liquid junction detecting electrode.
摘要翻译：本发明的生物传感器可以通过电化学测量由底物和氧化还原酶之间的反应中产生的电子而减少的电子受体的量来量化样品液体中的底物。生物传感器具有电绝缘基板和形成在基板上的电极系统，该基板包括工作电极，对电极和用于检测液体接合点的第三电极。第三电极可以仅用于检测液体接点，也可以用作参考电极和液体接点检测电极。

8. 发明授权

US5171689A Solid state bio-sensor 失效
标题翻译：固态生物传感器
公开(公告)号：US5171689A
公开(公告)日：1992-12-15
申请号：US339698
申请日：1989-04-18
申请人： Mariko Kawaguri , Shiro Nankai , Takashi Iijima
发明人： Mariko Kawaguri , Shiro Nankai , Takashi Iijima
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , Y10S435/817
摘要： As the conventional simple bio-sensors for measuring the particular component in living bodies, there are those in which a change in dye caused by enzyme reaction is detected optically, but such bio-sensors had a problem that precision is low owing to disturbance of the color of liquid samples. With bio-sensors using an enzyme electrode, the precision was high, but operation of measurement was troublesome. The present invention made it possible to detect the concentration of the particular component electromechanically with rapidity, simplicity and high precision by merely putting a porous substrate containing at least enzyme on the electrode system and impregnating the body with a liquid sample.
摘要翻译：作为用于测量活体中特定成分的传统简单生物传感器，存在其中由酶反应引起的染料变化被光学检测的那些，但是这样的生物传感器具有由于干扰而导致的精度低的问题液体样品颜色。使用酶电极的生物传感器，精度高，但测量操作麻烦。本发明通过仅将至少含有酶的多孔底物放置在电极系统上并用液体样品浸渍身体，可以快速，简便和高精度地机电地检测特定成分的浓度。

9. 发明授权

US4897173A Biosensor and method for making the same 失效
标题翻译：生物传感器和制作方法
公开(公告)号：US4897173A
公开(公告)日：1990-01-30
申请号：US27204
申请日：1987-02-20
申请人： Shiro Nankai , Mariko Kawaguri , Tashi Iijima
发明人： Shiro Nankai , Mariko Kawaguri , Tashi Iijima
IPC分类号： C12Q1/00 , G01N27/30 , G01N27/416
CPC分类号： C12Q1/004 , Y10S435/817
摘要： This invention relates to a biosensor which comprises an insulative base, an electrode system formed on the substrate and primarily made of carbon, and a perforated body having an enzyme and an electron acceptor and integrally combined with the electrode system whereby a concentration of a specific component in a biological liquid sample can be electrochemically measured rapidly and accurately by a simple procedure of mere addition of the liquid sample. Several simple biosensors for measuring a specific component in a liquid sample are known including a sensor of the type in which a change of a dye formed by an enzyme reaction is optically detected and a sensor of the type using an enzyme electrode. These sensors, respectively, involve an interference with colored matters in liquid sample and necessity of washing of an electrode system every measuring procedure. In addition, the sensors are complicated in structure and materials therefor are expensive. In the present invention, the electrode system is formed mainly of carbon and is integrally combined with the perforated body, so that washing of the electrode system is unnecessary. Thus, an inexpensive, simply-operated biosensor of the disposable type can be provided.
摘要翻译： PCT No.PCT / JP86 / 00311 Sec。 371日期1987年2月20日 102（e）1987年2月20日PCT PCT 1986年6月19日PCT公布。出版物WO86 / 07632 日本公开日1986年12月31日。本发明涉及一种生物传感器，其包括绝缘基底，形成在基底上并主要由碳制成的电极系统，以及具有酶和电子受体的穿孔体，并与电极系统从而可以通过简单地加入液体样品的简单程序，快速准确地对生物液体样品中的特定成分的浓度进行电化学测定。用于测量液体样品中的特定组分的几种简单生物传感器是已知的，包括其中光学检测由酶反应形成的染料变化的类型的传感器和使用酶电极的类型的传感器。这些传感器分别涉及对液体样品中的有色物质的干扰和每个测量程序洗涤电极系统的必要性。此外，传感器结构复杂，材料昂贵。在本发明中，电极系主要由碳形成，与多孔体一体地组合，不需要电极系的清洗。因此，可以提供廉价的简单操作的一次性型的生物传感器。

10. 发明授权

US5185256A Method for making a biosensor 失效
标题翻译：制作生物传感器的方法
公开(公告)号：US5185256A
公开(公告)日：1993-02-09
申请号：US774129
申请日：1991-10-15
申请人： Shiro Nankai , Mariko Kawaguri , Takashi Iijima
发明人： Shiro Nankai , Mariko Kawaguri , Takashi Iijima
IPC分类号： C12Q1/00 , G01N27/30
CPC分类号： C12Q1/004 , G01N27/3272 , Y10S435/817
摘要： This invention relates to a biosensor which comprises an insulative base, an electrode system formed on the substrate and primarily made of carbon, and a perforated body having an enzyme and an electron acceptor and integrally combined with the electrode system whereby a concentration of a specific component in a biological liquid sample can be electrochemically measured rapidly and accurately by a simple procedure of mere addition of the liquid sample. Several simple biosensors for measuring a specific component in a liquid sample are known including a sensor of the type in which a change of a dye formed by an enzyme reaction is optically detected and a sensor of the type using an enzyme electrode. These sensors, respectively, involve an interference with colored matters in liquid sample and necessity of washing of an electrode system every measuring procedure. In addition, the sensors are complicated in structure and materials therefor are expensive. In the present invention, the electrode system is formed mainly of carbon and is integrally combined with the perforated body, so that washing of the electrode system is unnecessary. Thus, an inexpensive, simply-operated biosensor of the disposable type can be provided.
摘要翻译：本发明涉及一种生物传感器，其包括绝缘基底，形成在基底上并主要由碳制成的电极系统，以及具有酶和电子受体的穿孔体，与电极系统整体结合，由此使特定成分在生物液体样品中，可以通过仅添加液体样品的简单方法快速且准确地进行电化学测量。用于测量液体样品中的特定组分的几种简单的生物传感器是已知的，包括其中光学检测由酶反应形成的染料变化的类型的传感器和使用酶电极的类型的传感器。这些传感器分别涉及对液体样品中的有色物质的干扰和每个测量程序洗涤电极系统的必要性。此外，传感器结构复杂，材料昂贵。在本发明中，电极系主要由碳形成，与多孔体一体地组合，不需要电极系的清洗。因此，可以提供廉价的简单操作的一次性型的生物传感器。

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