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1. 发明授权

US4897173A Biosensor and method for making the same 失效
标题翻译：生物传感器和制作方法
公开(公告)号：US4897173A
公开(公告)日：1990-01-30
申请号：US27204
申请日：1987-02-20
申请人： Shiro Nankai , Mariko Kawaguri , Tashi Iijima
发明人： Shiro Nankai , Mariko Kawaguri , Tashi Iijima
IPC分类号： C12Q1/00 , G01N27/30 , G01N27/416
CPC分类号： C12Q1/004 , Y10S435/817
摘要： This invention relates to a biosensor which comprises an insulative base, an electrode system formed on the substrate and primarily made of carbon, and a perforated body having an enzyme and an electron acceptor and integrally combined with the electrode system whereby a concentration of a specific component in a biological liquid sample can be electrochemically measured rapidly and accurately by a simple procedure of mere addition of the liquid sample. Several simple biosensors for measuring a specific component in a liquid sample are known including a sensor of the type in which a change of a dye formed by an enzyme reaction is optically detected and a sensor of the type using an enzyme electrode. These sensors, respectively, involve an interference with colored matters in liquid sample and necessity of washing of an electrode system every measuring procedure. In addition, the sensors are complicated in structure and materials therefor are expensive. In the present invention, the electrode system is formed mainly of carbon and is integrally combined with the perforated body, so that washing of the electrode system is unnecessary. Thus, an inexpensive, simply-operated biosensor of the disposable type can be provided.
摘要翻译： PCT No.PCT / JP86 / 00311 Sec。 371日期1987年2月20日 102（e）1987年2月20日PCT PCT 1986年6月19日PCT公布。出版物WO86 / 07632 日本公开日1986年12月31日。本发明涉及一种生物传感器，其包括绝缘基底，形成在基底上并主要由碳制成的电极系统，以及具有酶和电子受体的穿孔体，并与电极系统从而可以通过简单地加入液体样品的简单程序，快速准确地对生物液体样品中的特定成分的浓度进行电化学测定。用于测量液体样品中的特定组分的几种简单生物传感器是已知的，包括其中光学检测由酶反应形成的染料变化的类型的传感器和使用酶电极的类型的传感器。这些传感器分别涉及对液体样品中的有色物质的干扰和每个测量程序洗涤电极系统的必要性。此外，传感器结构复杂，材料昂贵。在本发明中，电极系主要由碳形成，与多孔体一体地组合，不需要电极系的清洗。因此，可以提供廉价的简单操作的一次性型的生物传感器。

2. 发明授权

US5320732A Biosensor and measuring apparatus using the same 失效
标题翻译：生物传感器和使用其的测量装置
公开(公告)号：US5320732A
公开(公告)日：1994-06-14
申请号：US75859
申请日：1993-06-11
申请人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Minoru Fukuda
发明人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Minoru Fukuda
IPC分类号： G01N27/28 , G01N33/487 , G01N27/26
CPC分类号： G01N27/3272
摘要： The subject invention provides a simple sensor and an easy to handle biosensor measuring apparatus for the purpose of making measurements easily, rapidly and with high accuracy for specific components within a biological specimen such as blood.The biosensor of the subject invention is provided with a protrusion or a depression in a portion of a base having at least a measurement electrode and an opposing electrode. Also, the biosensor measuring apparatus is so configurated to have a mating means in the main body of the measuring apparatus freely supporting this biosensor to contact the said sensor's protrusion or depression, and further having the activating switch of the driving power supply located in this mating means.By means of these, it is possible to prevent wasteful measuring operations, as noted in the prior art biosensors, such as inserting the sensor backwards and making measurements with the sensor inserted backwards.
摘要翻译：本发明提供了一种简单的传感器和易于处理的生物传感器测量装置，用于容易，快速且高度精确地测量诸如血液的生物样本内的特定组分的目的。本发明的生物传感器在至少具有测量电极和相对电极的基部的一部分中设置有突起或凹陷。此外，生物传感器测量装置被配置为具有在测量装置的主体中具有自由支撑该生物传感器的配合装置以接触所述传感器的突起或凹陷，并且还具有位于该配合中的驱动电源的启动开关手段。通过这些，可以防止浪费的测量操作，如现有技术的生物传感器中所述，例如向后插入传感器并且使传感器向后插入进行测量。

3. 发明授权

US5171689A Solid state bio-sensor 失效
标题翻译：固态生物传感器
公开(公告)号：US5171689A
公开(公告)日：1992-12-15
申请号：US339698
申请日：1989-04-18
申请人： Mariko Kawaguri , Shiro Nankai , Takashi Iijima
发明人： Mariko Kawaguri , Shiro Nankai , Takashi Iijima
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , Y10S435/817
摘要： As the conventional simple bio-sensors for measuring the particular component in living bodies, there are those in which a change in dye caused by enzyme reaction is detected optically, but such bio-sensors had a problem that precision is low owing to disturbance of the color of liquid samples. With bio-sensors using an enzyme electrode, the precision was high, but operation of measurement was troublesome. The present invention made it possible to detect the concentration of the particular component electromechanically with rapidity, simplicity and high precision by merely putting a porous substrate containing at least enzyme on the electrode system and impregnating the body with a liquid sample.
摘要翻译：作为用于测量活体中特定成分的传统简单生物传感器，存在其中由酶反应引起的染料变化被光学检测的那些，但是这样的生物传感器具有由于干扰而导致的精度低的问题液体样品颜色。使用酶电极的生物传感器，精度高，但测量操作麻烦。本发明通过仅将至少含有酶的多孔底物放置在电极系统上并用液体样品浸渍身体，可以快速，简便和高精度地机电地检测特定成分的浓度。

4. 发明授权

US5266179A Quantitative analysis method and its system using a disposable sensor 失效
标题翻译：定量分析方法及其使用一次性传感器的系统
公开(公告)号：US5266179A
公开(公告)日：1993-11-30
申请号：US733130
申请日：1991-07-19
申请人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Kyozo Terao , Naoki Tanimoto , Masahiro Yoshioka , Hiroshi Hyodo , Takatoshi Uchigaki
发明人： Shiro Nankai , Mariko Kawaguri , Toshihiko Yoshioka , Haruhiro Tsutsumi , Kyozo Terao , Naoki Tanimoto , Masahiro Yoshioka , Hiroshi Hyodo , Takatoshi Uchigaki
IPC分类号： G01N27/26 , G01N27/28 , G01N27/416 , G01N27/49
CPC分类号： G01N33/48771 , G01N2035/009
摘要： A sensor 13 is inserted into a connector 14. A constant voltage required to obtain a response current is applied across the connector 14 by a voltage applying source 15 at timings required. A response current of the sensor 13 inserted into the connector 14 is converted into a voltage by a current-to-voltage converter 16, and the amount thereof is determined by a microcomputer, the analysis results being displayed onto a display unit.

5. 发明授权

US5229282A Preparation of biosensor having a layer containing an enzyme, electron acceptor and hydrophilic polymer on an electrode system 失效
标题翻译：具有包含酶的生物传感器的制备，电子接受体和亲水聚合物在电极系统上的制备
公开(公告)号：US5229282A
公开(公告)日：1993-07-20
申请号：US617886
申请日：1990-11-26
申请人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai
发明人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , Y10S435/817
摘要： The present invention relates to a process of preparation of a biosensor comprising forming an electrode system mainly containing carbon on an insulating base plate, treating the surface of electrode system with an organic solvent, and then arranging a reaction layer on the electrode system to give a unified element. The reaction layer contains an enzyme, electron acceptor and a hydrophilic polymer. Treatment with the organic solvent improves adhesion of the reaction layer to the electrode system. The electrode system contains a working electrode and a counter electrode. The electrode system is formed from a carbon paste containing a resin binder. Treatment is preferably carried out by wiping the surface of the electrodes with a material impregnated by the organic solvent.

6. 发明授权

US5512159A Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US5512159A
公开(公告)日：1996-04-30
申请号：US293131
申请日：1994-08-19
申请人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
发明人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
IPC分类号： G01N27/28 , C12M1/34 , C12M1/40 , C12Q1/00 , C12Q1/54 , G01N27/327 , G01N33/483
CPC分类号： C12Q1/001
摘要： A biosensor of the present invention is provided with an insulating base plate, an electrode system mainly consisting of a working electrode and a counter electrode formed on the insulating base plate, and a reaction layer on the electrode system. The counter electrode is partially a circular arc. A manufacturing method of the biosensor of the present invention is comprised of a step to form a base by arranging leads, an electrode system, and an insulating layer on an insulating base plate, and a step to form a reaction layer mainly composed of an enzyme on the electrode system. Since the counter electrode is partially in the shape of a circular arc, the reaction layer is easily formed and prevented from delaminating, whereby the measuring accuracy, preservative properties and reliability of the biosensor are improved. The present invention enables highly efficient biosensors to be mass produced at low cost.
摘要翻译：本发明的生物传感器设置有绝缘基板，主要由在绝缘基板上形成的工作电极和对电极组成的电极系统和电极系统上的反应层。对电极部分是圆弧。本发明的生物传感器的制造方法包括通过在绝缘基板上排列引线，电极系统和绝缘层形成基底的步骤，以及形成主要由酶组成的反应层的步骤在电极系统上。由于对电极部分为圆弧形状，反应层易于形成并防止分层，从而提高了生物传感器的测量精度，防腐性能和可靠性。本发明能够以低成本批量生产高效生物传感器。

7. 发明授权

US5185256A Method for making a biosensor 失效
标题翻译：制作生物传感器的方法
公开(公告)号：US5185256A
公开(公告)日：1993-02-09
申请号：US774129
申请日：1991-10-15
申请人： Shiro Nankai , Mariko Kawaguri , Takashi Iijima
发明人： Shiro Nankai , Mariko Kawaguri , Takashi Iijima
IPC分类号： C12Q1/00 , G01N27/30
CPC分类号： C12Q1/004 , G01N27/3272 , Y10S435/817
摘要： This invention relates to a biosensor which comprises an insulative base, an electrode system formed on the substrate and primarily made of carbon, and a perforated body having an enzyme and an electron acceptor and integrally combined with the electrode system whereby a concentration of a specific component in a biological liquid sample can be electrochemically measured rapidly and accurately by a simple procedure of mere addition of the liquid sample. Several simple biosensors for measuring a specific component in a liquid sample are known including a sensor of the type in which a change of a dye formed by an enzyme reaction is optically detected and a sensor of the type using an enzyme electrode. These sensors, respectively, involve an interference with colored matters in liquid sample and necessity of washing of an electrode system every measuring procedure. In addition, the sensors are complicated in structure and materials therefor are expensive. In the present invention, the electrode system is formed mainly of carbon and is integrally combined with the perforated body, so that washing of the electrode system is unnecessary. Thus, an inexpensive, simply-operated biosensor of the disposable type can be provided.
摘要翻译：本发明涉及一种生物传感器，其包括绝缘基底，形成在基底上并主要由碳制成的电极系统，以及具有酶和电子受体的穿孔体，与电极系统整体结合，由此使特定成分在生物液体样品中，可以通过仅添加液体样品的简单方法快速且准确地进行电化学测量。用于测量液体样品中的特定组分的几种简单的生物传感器是已知的，包括其中光学检测由酶反应形成的染料变化的类型的传感器和使用酶电极的类型的传感器。这些传感器分别涉及对液体样品中的有色物质的干扰和每个测量程序洗涤电极系统的必要性。此外，传感器结构复杂，材料昂贵。在本发明中，电极系主要由碳形成，与多孔体一体地组合，不需要电极系的清洗。因此，可以提供廉价的简单操作的一次性型的生物传感器。

8. 发明授权

US5120420A Biosensor and a process for preparation thereof 失效
标题翻译：生物传感器及其制备方法
公开(公告)号：US5120420A
公开(公告)日：1992-06-09
申请号：US445632
申请日：1989-11-27
申请人： Shiro Nankai , Mariko Kawaguri , Mayumi Ohtani , Takashi Iijima
发明人： Shiro Nankai , Mariko Kawaguri , Mayumi Ohtani , Takashi Iijima
IPC分类号： C12Q1/00 , G01N27/30 , G01N33/487
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/004 , Y10S435/817 , Y10S436/806
摘要： A biosensor of the invention comprises an insulating base board (1) having formed thereon, in sequence, leads (2, 3, 3'), an electrode system mainly made of carbon (4, 5, 5'), an insulating layer (6) and a reaction layer (14) composed of an enzyme and an electron acceptor, and being provided thereon with a space (8) defined by a spacer (7) and a cover 9). When a biological sample solution is brought into contact with the inlet (10) of the biosensor having the above-described structure, the sample solution is introduced into its inside, while the air within the space (8) is rapidly discharged through the outlet (11) and, at the same time, the space (8) is filled with the sample solution up to the neighborhood of the outlet. Thus, measurement can be conducted inexpensively at a high speed with a high accuracy through simple procedures without residual bubbles.
摘要翻译： PCT No.PCT / JP89 / 00337 Sec。 371日期1990年1月31日第 102（e）1990年1月31日PCT PCT 1989年3月31日PCT。出版物WO89 / 09397 日本特开1989年1月5日。本发明的生物传感器包括：绝缘基板（1），其上依次形成引线（2,3,3'），主要由碳（4,5,5 '），由酶和电子受体构成的绝缘层（6）和反应层（14），并且在其上设置有由间隔物（7）和盖9限定的空间（8）。当生物样品溶液与具有上述结构的生物传感器的入口（10）接触时，将样品溶液引入其内部，同时空间（8）内的空气通过出口（ 11），并且同时，空间（8）被填充有样品溶液直到出口附近。因此，通过没有残留气泡的简单程序，可以高精度地以高精度进行测量。

9. 发明授权

US07267750B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07267750B2
公开(公告)日：2007-09-11
申请号：US10466561
申请日：2002-01-10
申请人： Motokazu Watanabe , Tomohiro Yamamoto , Miwa Hasegawa , Shin Ikeda , Shiro Nankai
发明人： Motokazu Watanabe , Tomohiro Yamamoto , Miwa Hasegawa , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27/327
CPC分类号： C12Q1/005 , C12Q1/004
摘要： A biosensor comprising: an electrically insulating base plate; an electrode system comprising a working electrode and a counter electrode formed on the base plate; a cover member which is joined to the base plate to form a sample solution supply pathway for supplying a sample solution to the electrode system between the cover member and the base plate; and a reagent system comprising at least an oxidoreductase and an electron mediator disposed in the sample solution supply pathway, wherein the electron mediator is provided on the base plate and the oxidoreductase is provided on the cover member such that the electron mediator and the oxidoreductase are not in contact with each other.
摘要翻译：一种生物传感器，包括：电绝缘基板; 电极系统，包括形成在所述基板上的工作电极和对电极; 盖构件，其连接到所述基板，以形成用于将样品溶液供应到所述盖构件和所述基板之间的所述电极系统的样品溶液供给路径; 以及试剂系统，其至少包含设置在样品溶液供给路径中的氧化还原酶和电子介体，其中，所述电子介体设置在所述底板上，所述氧化还原酶设置在所述覆盖部件上，使得所述电子介体和所述氧化还原酶不是彼此接触。

10. 发明授权

US07235170B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07235170B2
公开(公告)日：2007-06-26
申请号：US10344671
申请日：2002-05-13
申请人： Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Shiro Nankai
发明人： Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Shiro Nankai
IPC分类号： C12Q1/26
CPC分类号： C12Q1/006 , C12Q1/001 , C12Q1/54
摘要： A biosensor that is highly responsive and capable of rapid and highly sensitive quantification of a specific component contained in a sample is provided. The biosensor of this invention comprises: an electrically insulating base plate; an electrode system comprising a working electrode and a counter electrode disposed on the base plate; and a reagent system comprising an oxidoreductase which catalyzes the oxidation reaction of glucose, gluconolactonase and a buffer. The buffer is selected from the group consisting of phthalic acid and its salts, maleic acid and its salts, succinic acid and its salts, phospholic acid and its salts, acetic acid and its salts, boric acid and its salts, citric acid and its salts, glycine, tris(hydroxymethyl)aminomethane, piperazine-N,N′-bis(2-ethane sulfonic acid) and the like.
摘要翻译：提供了一种生物传感器，其具有高响应性并且能够对包含在样品中的特定成分进行快速和高灵敏度的定量。本发明的生物传感器包括：电绝缘基板; 电极系统，包括设置在所述基板上的工作电极和对置电极; 以及包含催化葡萄糖，葡糖酸内切酶和缓冲液的氧化反应的氧化还原酶的试剂体系。缓冲剂选自邻苯二甲酸及其盐，马来酸及其盐，琥珀酸及其盐，磷酸及其盐，乙酸及其盐，硼酸及其盐，柠檬酸及其盐，甘氨酸，三（羟甲基）氨基甲烷，哌嗪-N，N'-双（2-乙磺酸）等。

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