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1. 发明授权

US5512159A Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US5512159A
公开(公告)日：1996-04-30
申请号：US293131
申请日：1994-08-19
申请人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
发明人： Toshihiko Yoshioka , Mariko Kawaguri , Shiro Nankai , Haruhiro Tsutsumi , Hideyuki Baba , Yoshinobu Tokuno , Shoji Miyazaki
IPC分类号： G01N27/28 , C12M1/34 , C12M1/40 , C12Q1/00 , C12Q1/54 , G01N27/327 , G01N33/483
CPC分类号： C12Q1/001
摘要： A biosensor of the present invention is provided with an insulating base plate, an electrode system mainly consisting of a working electrode and a counter electrode formed on the insulating base plate, and a reaction layer on the electrode system. The counter electrode is partially a circular arc. A manufacturing method of the biosensor of the present invention is comprised of a step to form a base by arranging leads, an electrode system, and an insulating layer on an insulating base plate, and a step to form a reaction layer mainly composed of an enzyme on the electrode system. Since the counter electrode is partially in the shape of a circular arc, the reaction layer is easily formed and prevented from delaminating, whereby the measuring accuracy, preservative properties and reliability of the biosensor are improved. The present invention enables highly efficient biosensors to be mass produced at low cost.
摘要翻译：本发明的生物传感器设置有绝缘基板，主要由在绝缘基板上形成的工作电极和对电极组成的电极系统和电极系统上的反应层。对电极部分是圆弧。本发明的生物传感器的制造方法包括通过在绝缘基板上排列引线，电极系统和绝缘层形成基底的步骤，以及形成主要由酶组成的反应层的步骤在电极系统上。由于对电极部分为圆弧形状，反应层易于形成并防止分层，从而提高了生物传感器的测量精度，防腐性能和可靠性。本发明能够以低成本批量生产高效生物传感器。

2. 发明授权

US07005048B1 Glucose sensor 有权
标题翻译：葡萄糖传感器
公开(公告)号：US07005048B1
公开(公告)日：2006-02-28
申请号：US09807692
申请日：2000-10-02
申请人： Motokazu Watanabe , Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Nakayama , Shoji Miyazaki , Hideyuki Baba
发明人： Motokazu Watanabe , Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Nakayama , Shoji Miyazaki , Hideyuki Baba
IPC分类号： G01N27/327
CPC分类号： C12Q1/006
摘要： The present invention provides a high-performance glucose sensor having excellent storage stability and an improved response characteristic. This sensor comprises: an electrically insulating base plate; an electrode system including at least a working electrode and a counter electrode formed on the base plate; and a reaction layer containing at least pyrrolo-quinoline quinone dependent glucose dehydrogenase, formed in contact with or in the vicinity of the electrode system, and the reaction layer contains at least one kind of additive selected from the group consisting of gluconic acid and salts thereof.
摘要翻译：本发明提供一种具有优异的储存稳定性和改善的响应特性的高性能葡萄糖传感器。该传感器包括：电绝缘基板; 电极系统，其至少包括形成在所述基板上的工作电极和对电极; 和至少含有与电极体系接触或附近形成的吡咯并喹啉醌依赖型葡萄糖脱氢酶的反应层，反应层含有选自葡萄糖酸及其盐的至少一种添加剂。

3. 发明授权

US06773564B1 Glucose sensor 有权
标题翻译：葡萄糖传感器
公开(公告)号：US06773564B1
公开(公告)日：2004-08-10
申请号：US09406832
申请日：1999-09-28
申请人： Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Iwata , Shoji Miyazaki , Hideyuki Baba , Seiji Takeshima
发明人： Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Iwata , Shoji Miyazaki , Hideyuki Baba , Seiji Takeshima
IPC分类号： G01N27327
CPC分类号： C12Q1/006
摘要： The present invention provides a high performance glucose sensor which can demonstrate high stability against preservation and produces only a low blank value. The glucose sensor comprises an electrically insulating base plate, an electrode system formed on the base plate, and a reaction layer which is formed in contact with or in the vicinity of the electrode system and contains at least a glucose dehydrogenase whose coenzyme is pyrrolo-quinoline quinone, the reaction layer further containing an additive such as phthalic acid.
摘要翻译：本发明提供了一种高性能葡萄糖传感器，其可以显示对保存的高稳定性并且仅产生低的空白值。葡萄糖传感器包括电绝缘基板，形成在基板上的电极系统和与电极系统接触或附近形成的反应层，并且至少含有辅酶是吡咯并喹啉的葡萄糖脱氢酶醌，反应层还含有邻苯二甲酸等添加剂。

4. 发明授权

US06830669B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06830669B2
公开(公告)日：2004-12-14
申请号：US09890761
申请日：2001-10-16
申请人： Shoji Miyazaki , Haruhiro Tsutsumi , Eriko Yamanishi
发明人： Shoji Miyazaki , Haruhiro Tsutsumi , Eriko Yamanishi
IPC分类号： G01N2726
CPC分类号： C12Q1/001 , G01N27/3272
摘要： A biosensor having an electrode layer, which includes a working electrode and a counter electrode, and a reagent layer 10 are formed on an insulating support. Further, a spacer having a long and narrow cut-out portion on the reagent layer is bonded to a cover having an air hole to form a cavity that sucks blood as a liquid sample by capillary phenomenon, and a portion of side walls of the spacer and the cover, which side walls face the cavity, is subjected to a treatment for making the portion itself have hydrophilicity. Accordingly, when blood is sucked into the cavity by capillary phenomenon, the suction is promoted, and the performance of a sensor of the biosensor is improved. Further, the process of manufacturing the sensor is simplified, thereby resulting in increased productivity.
摘要翻译：具有工作电极和对电极的电极层的生物传感器和试剂层10形成在绝缘支撑体上。此外，在试剂层上具有长而窄的切出部分的间隔物结合到具有空气孔的盖上，以形成通过毛细管现象吸取血液作为液体样品的空腔，并且间隔物的侧壁的一部分并且将侧壁面向空腔的盖子进行处理以使该部分本身具有亲水性。因此，当通过毛细管现象将血液吸入空腔时，促进吸力，提高生物传感器的传感器的性能。此外，简化了传感器的制造过程，从而提高了生产率。

5. 发明申请

US20140144791A1 BIOSENSOR, MEASURING INSTRUMENT FOR BIOSENSOR, AND METHOD OF QUANTIFYING SUBSTRATE 有权
标题翻译：生物传感器，生物传感器的测量仪器和定量基板的方法
公开(公告)号：US20140144791A1
公开(公告)日：2014-05-29
申请号：US14166956
申请日：2014-01-29
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Yoshinobu Tokuno
IPC分类号： G01N27/327
CPC分类号： G01N27/327 , A61B5/1486 , A61B2562/0295 , C12Q1/001 , C12Q1/005 , C12Q1/006 , G01N27/26 , G01N27/3272 , G01N27/3274 , G01N33/48771 , G01N33/5438
摘要： A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltages to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.
摘要翻译：提供了测量样品液体中所含的基板的量的方法。该方法可以减少由生物传感器引起的测量误差。生物传感器至少包括绝缘板上的一对电极，插入到测量装置中，该测量装置包括用于可拆卸地支撑生物传感器的支撑部分，要耦合到各个电极的多个连接端子和施加一个电极的驱动电源通过连接端子对各个电极施加电压。只有当生物传感器沿给定方向插入到测量装置中时，生物传感器的电极之一才连接到测量装置的第一和第二连接端子，并且具有使得电极在第一和第二连接之间变得导电的结构由于驱动电源施加的电压引起的端子。

6. 发明申请

US20120043227A1 Method of measuring quantity of substrate 审中-公开
公开(公告)号：US20120043227A1
公开(公告)日：2012-02-23
申请号：US13317662
申请日：2011-10-25
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Yoshinobu Tokuno , Kazuhiro Matsumoto , Yasuhiko Sawada
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Yoshinobu Tokuno , Kazuhiro Matsumoto , Yasuhiko Sawada
IPC分类号： G01N27/327
CPC分类号： G01N27/327 , A61B5/1486 , A61B2562/0295 , C12Q1/001 , C12Q1/005 , C12Q1/006 , G01N27/26 , G01N27/3272 , G01N27/3274 , G01N33/48771 , G01N33/5438
摘要： A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.

7. 发明申请

US20110132776A1 Method of measuring quantity of substrate 有权
公开(公告)号：US20110132776A1
公开(公告)日：2011-06-09
申请号：US12931296
申请日：2011-01-28
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Yoshinobu Tokuno
IPC分类号： G01N27/327 , G01N33/50
CPC分类号： G01N27/327 , A61B5/1486 , A61B2562/0295 , C12Q1/001 , C12Q1/005 , C12Q1/006 , G01N27/26 , G01N27/3272 , G01N27/3274 , G01N33/48771 , G01N33/5438
摘要： A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.

8. 发明申请

US20100252454A1 Method of measuring quantity of substrate 有权
公开(公告)号：US20100252454A1
公开(公告)日：2010-10-07
申请号：US12802608
申请日：2010-06-10
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Yoshinobu Tokuno , Kazuhiro Matsumoto , Yasuhiko Sawada
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Yoshinobu Tokuno , Kazuhiro Matsumoto , Yasuhiko Sawada
IPC分类号： G01N27/403
CPC分类号： G01N27/327 , A61B5/1486 , A61B2562/0295 , C12Q1/001 , C12Q1/005 , C12Q1/006 , G01N27/26 , G01N27/3272 , G01N27/3274 , G01N33/48771 , G01N33/5438
摘要： A method of measuring a quantity of a substrate contained in sample liquid is provided. This method can reduce measurement errors caused by a biosensor. The biosensor includes at least a pair of electrodes on an insulating board and is inserted into a measuring device which includes a supporting section for supporting detachably the biosensor, plural connecting terminals to be coupled to the respective electrodes, and a driving power supply which applies a voltage to the respective electrodes via the connecting terminals. One of the electrodes of the biosensor is connected to the first and second connecting terminals of the measuring device only when the biosensor is inserted into the measuring device in a given direction, and has a structure such that the electrode becomes conductive between the first and second connecting terminals due to a voltage application by the driving power supply.

9. 发明授权

US08480867B2 Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权
标题翻译：生物传感器，薄膜电极形成方法，定量装置和定量方法
公开(公告)号：US08480867B2
公开(公告)日：2013-07-09
申请号：US13135848
申请日：2011-07-15
申请人： Shoji Miyazaki , Masaki Fujiwara , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Masaki Fujiwara , Yoshinobu Tokuno
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： Apparatus are disclosed for measuring substrate content present in a specimen that is applied to a biosensor, where the apparatus include an input for receiving an electrical signal from the biosensor; and a circuit coupled to the input to detect the electrical signal to determine whether an amount of the specimen needed for specimen detection has been supplied to the biosensor; where the apparatus measures the substrate content included in the specimen when the circuit determines that an amount of the specimen needed for specimen detection has been supplied to the biosensor, and the apparatus is prevented from measuring the substrate content included in the specimen when the circuit determines that the specimen has not been sufficiently supplied to the biosensor.
摘要翻译：公开了用于测量施加到生物传感器的样本中存在的底物含量的装置，其中装置包括用于从生物传感器接收电信号的输入端; 以及电路，其耦合到所述输入端以检测所述电信号，以确定是否向所述生物传感器提供了所述样本检测所需的样本量; 其中当电路确定样本检测所需的样本量已被提供给生物传感器时，该装置测量包含在样本中的基底含量，并且当电路确定时检测装置被测量包含在样本中的基底含量样品没有被充分供应给生物传感器。

10. 发明授权

US08475646B2 Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权
标题翻译：生物传感器，薄膜电极形成方法，定量装置和定量方法
公开(公告)号：US08475646B2
公开(公告)日：2013-07-02
申请号：US13135816
申请日：2011-07-15
申请人： Shoji Miyazaki , Masaki Fujiwara , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Masaki Fujiwara , Yoshinobu Tokuno
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： Methods are disclosed for measuring substrate content in a specimen using a biosensor that includes two pairs of electrodes in a specimen supply path, where the methods include the steps of: (a) a first detecting step for detecting an electrical change in the first pair of electrodes; (b) a second detecting step for detecting an electrical change in the second pair of electrodes after the first detecting step; (c) a judging step for judging a shortage of specimen amount that is needed for measurement, when an electrical change is not detected in the second detecting step within a prescribed period of time after the first detecting step; (d) an indicating step for indicating a shortage of the specimen amount; and (e) a stopping step for stopping measurement of substrate content in the specimen once the shortage of specimen amount is indicated in the indicating step.
摘要翻译：公开了用于使用在样本供应路径中包括两对电极的生物传感器来测量样品中的基底含量的方法，其中所述方法包括以下步骤：（a）第一检测步骤，用于检测第一对中的电变化电极（b）第二检测步骤，用于在第一检测步骤之后检测第二对电极中的电变化; （c）当在第一检测步骤之后的规定时间内没有在第二检测步骤中检测到电变化时，判断测量所需的试样量的不足的判断步骤; （d）指示样本量不足的指示步骤; 和（e）一旦在指示步骤中指示了样本量不足，则停止步骤，用于停止测量样本中的基底含量。

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