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1. 发明授权

US5523058A Ultrasonic irradiation apparatus and processing apparatus based thereon 失效
标题翻译：超声波照射装置及其处理装置
公开(公告)号：US5523058A
公开(公告)日：1996-06-04
申请号：US240733
申请日：1994-05-12
申请人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
发明人： Shinichiro Umemura , Kenichi Kawabata , Kenko Uchida , Kenji Yasuda , Yasuo Wada , Atsushi Hiraiwa
IPC分类号： A61B17/22 , A61N7/00 , A61N7/02 , B01F11/02 , A61B8/00 , B06B1/00
CPC分类号： A61N7/02 , A61B17/22004 , A61N2007/006 , A61N2007/0078 , A61N2007/0095
摘要： By providing an ultrasonic irradiation apparatus for generating acoustic cavitation efficiently, it is intended to realize an ultrasonic therapeutic apparatus for generating the action of cavitation on a living body suitable for medical treatment of malignant tumors and medical treatment of thrombi and calculi, an ultrasonic diagnostic apparatus for generating cavitation for emphasizing an ultrasonic echo image such as a blood flow and utilizing the reflection capability of the cavitation, an ultrasonic chemical reaction accelerating apparatus, an ultrasonic cleaning apparatus or an ultrasonic sterilizing apparatus. Irradiation focus/code signals for defining irradiated acoustic fields of a fundamental wave and a second harmonic wave as well as focus positions/acoustic pressure distribution forms of the respective waves are applied from an irradiation unit main control circuit to drive phase generating circuits. Generated drive phases are applied to drive signal generating circuits, generated drive signals are applied to element drive circuits and a group of fundamental frequency elements and a group of second harmonic elements are driven. The drive phases are controlled such that the fundamental wave and second harmonic wave are superimposed on each other in a medium near a focal point, thus generating acoustic caviation locally and efficiently.
摘要翻译： PCT No.PCT / JP93 / 01310 Sec。 371日期：1994年5月12日 102（e）日期1994年5月12日PCT提交1993年9月14日PCT公布。公开号WO94 / 06380 日期为1994年3月31日。通过提供用于有效产生声孔的超声波照射装置，旨在实现用于产生适于恶性肿瘤治疗的生物体上的空化作用的超声波治疗装置和血栓的治疗和结石，用于产生用于强调超声波回波图像如血流并利用空化反射能力的超声波诊断装置，超声波化学反应加速装置，超声波清洗装置或超声波消毒装置。用于定义基波和二次谐波的辐射声场以及各波的聚焦位置/声压分布形式的照射焦点/码信号从照射单元主控制电路施加到驱动相位产生电路。产生的驱动相位被施加到驱动信号发生电路，所产生的驱动信号被施加到元件驱动电路，并且一组基频元件和一组二次谐波元件被驱动。控制驱动相位使得基波和二次谐波在焦点附近的介质中彼此叠加，从而局部且有效地产生声空化。

2. 发明授权

US06216538B1 Particle handling apparatus for handling particles in fluid by acoustic radiation pressure 失效
标题翻译：用于通过声辐射压力处理流体中的颗粒的颗粒处理装置
公开(公告)号：US06216538B1
公开(公告)日：2001-04-17
申请号：US08742695
申请日：1996-11-04
申请人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
发明人： Kenji Yasuda , Shin-ichiro Umemura , Kenichi Kawabata , Kazuo Takeda , Kenko Uchida , Yoshinori Harada , Masao Kamahori , Kazuaki Sasaki
IPC分类号： G01H1700
CPC分类号： B01D21/283 , G10K15/00
摘要： An ultrasonic manipulation apparatus has a plurality of ultrasonic wave oscillators arranged in two dimensions to trap, fix or move particles to an optional position in the solution or perform cell fusion by using a gradient force obtained by superposing one over another the gradient force fields generated by ultrasonic waves produced by a plurality of ultrasonic wave oscillators. The ultrasonic wave oscillators, functioning independently of one another, can emit ultrasonic waves with optional intensities and phases, and by using an external force produced by superposed gradient force fields generated by ultrasonic waves, particles are handled easily.
摘要翻译：超声波操作装置具有多个超声波振荡器，其被设置成二维排列，以将颗粒捕获，固定或移动到溶液中的可选位置，或者通过使用通过将颗粒叠加在另一个上而产生的梯度力场而获得的梯度力进行细胞融合由多个超声波振荡器产生的超声波。彼此独立起作用的超声波振荡器可以发射具有可选强度和相位的超声波，并且通过使用由超声波产生的叠加梯度力场产生的外力，可以容易地处理颗粒。

3. 发明授权

US09447447B2 Method and apparatus for testing cardiotoxicity and evaluating cardiomyocytes 有权
标题翻译：用于测试心脏毒性和评估心肌细胞的方法和装置
公开(公告)号：US09447447B2
公开(公告)日：2016-09-20
申请号：US13876992
申请日：2011-09-30
申请人： Kenji Yasuda , Tomoyuki Kaneko , Fumimasa Nomura
发明人： Kenji Yasuda , Tomoyuki Kaneko , Fumimasa Nomura
IPC分类号： C12M1/34 , C12Q1/02 , C12M1/42 , C12M1/36 , G01N33/50
CPC分类号： C12Q1/025 , C12M35/02 , C12M41/46 , C12M41/48 , G01N33/48728 , G01N33/5061 , G01N33/5088 , G01N2800/32
摘要： In the present invention, a cardiomyocyte cluster is disposed on a transparent substrate, and the quality of the cardiomyocytes is evaluated from the response of the cells to a forced pulsation stimulus applied to the cardiomyocytes. The cardiomyocyte cluster is disposed on the transparent substrate, and is exposed to the flow of a liquid containing an agent in a manner so that the agent acts on the cells, which configure a network. The extent of cardiac toxicity resulting from the agent is evaluated from measuring the fluctuations obtained from a comparison of adjacent cardiomyocytes of the network.
摘要翻译：在本发明中，将心肌细胞簇设置在透明基质上，根据细胞对施加于心肌细胞的强制脉动刺激的反应来评价心肌细胞的质量。将心肌细胞簇设置在透明基板上，并且以使得试剂作用于构成网络的细胞的方式暴露于含有试剂的液体的流动。通过测量从网络的相邻心肌细胞的比较获得的波动来评估由该试剂产生的心脏毒性的程度。

4. 发明授权

US08361412B2 Cell measuring and sorting chip 有权
标题翻译：电池测量和分选芯片
公开(公告)号：US08361412B2
公开(公告)日：2013-01-29
申请号：US11317004
申请日：2005-12-27
申请人： Kenji Yasuda , Akihiro Hattori , Kazunori Okano
发明人： Kenji Yasuda , Akihiro Hattori , Kazunori Okano
IPC分类号： B01L3/00
CPC分类号： G01N15/147 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , C12M47/04 , G01N35/085 , G01N2015/149 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
摘要： A cell sorting device using an inexpensive chip capable of being exchanged for each sample. The chip includes: a first flow path allowing buffer fluid containing cells to flow down; second and third flow paths which put the first flow path therebetween and allow buffer fluid not containing cells to flow down; a fourth flow path which allows the buffer fluid as a single flow path formed by joining the buffer fluids in the other three flow paths; a cell detecting region for detecting cells flowing with the buffer fluid down the fourth flow path; and a cell sorting region for sorting the cells according to a type of the cells detected. The first to fourth flow paths are cascaded, are supplied with the buffer fluid from reservoirs with the same fluid level, and have substantially the same width or cross-section area.
摘要翻译：一种使用廉价芯片的细胞分选装置，能够对每个样品进行交换。芯片包括：允许包含电池的缓冲流体向下流动的第一流动路径; 第二和第三流动路径，其中第一流动路径在其间并且允许不包含电池的缓冲流体向下流动; 第四流路，其允许缓冲流体作为通过连接其它三个流动路径中的缓冲流体形成的单个流动路径; 细胞检测区域，用于检测沿着第四流动路径流动的缓冲液的细胞; 以及用于根据检测到的细胞的类型对细胞进行分选的细胞分选区域。第一至第四流动路径级联，从具有相同流体水平的储存器提供缓冲流体，并且具有基本上相同的宽度或横截面面积。

5. 发明授权

US08247222B2 Micro-chamber processing apparatus for cell culture and method 有权
标题翻译：用于细胞培养和方法的微室处理装置
公开(公告)号：US08247222B2
公开(公告)日：2012-08-21
申请号：US13036600
申请日：2011-02-28
申请人： Akihiro Hattori , Kenji Yasuda
发明人： Akihiro Hattori , Kenji Yasuda
IPC分类号： C12M1/00 , C12M1/34
CPC分类号： C12M23/16 , B01J2219/00317 , B01J2219/00441 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00743 , B01L3/5085 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B01L2300/163
摘要： This invention relates to a method and apparatus for processing cell cultures. The apparatus comprises a micro-chamber comprising no more than one absorption layer and at least one gel layer, in this order, laminated on a transparent base plate having no conspicuous absorbency in visible and infrared regions, and at least one light source, the absorption layer having absorbency in visible and infrared regions, and the gel-like material being a substance which has a gel dissolution temperature of 100 degree C. or less, solates when heated and is in a gel state at room temperature and has absorbency for a specific wave length of visible and infrared regions, and the light source having a monochromatic light in the specific wave length, wherein the light source is disposed such that it irradiates on the absorption layer and/or the gel layer, with the exception that when no absorption layer is provided, at least two layers each composed of a gel-like material are laminated on the transparent base plate.
摘要翻译：本发明涉及一种用于处理细胞培养物的方法和装置。该装置包括一个微室，该微室包括不超过一个吸收层和至少一个凝胶层，依次层叠在透明基板上，在可见光和红外区域中没有明显的吸收性，以及至少一个光源，吸收在可见光和红外区域具有吸收性的层，凝胶状材料是凝胶溶解温度为100℃以下的物质，加热时的溶胶化物，在室温下处于凝胶状态，具有特定的吸光度可见光和红外区域的波长，以及具有特定波长的单色光的光源，其中光源被设置成使其照射在吸收层和/或凝胶层上，除了当没有吸收在透明基板上层叠由凝胶状材料构成的至少两层。

6. 发明授权

US07678777B2 Composition for promoting the proliferation of Lactobacillus casei subsp. casei 失效
标题翻译：用于促进干酪乳杆菌亚种增殖的组合物干酪
公开(公告)号：US07678777B2
公开(公告)日：2010-03-16
申请号：US12190121
申请日：2008-08-12
申请人： Kenji Yasuda , Tomohiko Ogawa , Masakatsu Hasegawa
发明人： Kenji Yasuda , Tomohiko Ogawa , Masakatsu Hasegawa
IPC分类号： A61K31/721 , A61K35/74 , C08B37/02
CPC分类号： C12N1/38 , A23K20/163 , A23L29/273 , A23L33/135 , A23V2002/00 , C12N1/20 , A23V2200/3204 , A23V2250/5042 , A23V2200/3202
摘要： A composition for promoting bacterial proliferation and selectively proliferating Lactobacillus casei subsp. casei is disclosed, which includes a dextran. A variety of biological activities originating from L. casei subsp. casei can be sustained in a living body by selectively growing-proliferating and colonizing L. casei subsp. casei in the intestine of a human being, animal, or the like or by selectively growing-proliferating L. casei subsp. casei in the intestine, without supplying L. casei subsp. casei at all times.
摘要翻译：用于促进细菌增殖和选择性增殖的干酪乳杆菌亚种的组合物。公开了干酪素，其包括葡聚糖。来自干酪乳杆菌亚种的各种生物活性干酪素可以通过选择性生长增殖和殖民化的干酪乳杆菌亚种，维持在活体内。在人，动物等的肠中或通过选择性增殖增殖的干酪乳杆菌肠道中的酪蛋白，不提供干酪乳杆菌。干酪素在任何时候。

7. 发明申请

US20080003678A1 Cell separation chip and cell culturing method using the same 审中-公开
标题翻译：细胞分离芯片和细胞培养方法使用相同
公开(公告)号：US20080003678A1
公开(公告)日：2008-01-03
申请号：US11819681
申请日：2007-06-28
申请人： Akihiro Hattori , Hideyuki Terazono , Kenji Yasuda
发明人： Akihiro Hattori , Hideyuki Terazono , Kenji Yasuda
IPC分类号： C12N5/06 , C12M1/00
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , C12M45/00 , C12M47/04 , G01N15/1031 , G01N15/12 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/1081 , G01N2015/149
摘要： An inexpensive cell analysis and separation apparatus using a flow channel formed on one surface of a substrate and a chip replaceable for each sample, and a method for culturing the separated cells without contamination, are provided. A flow channel for allowing a cell-containing buffer solution to flow is provided. Cells are detected in the middle of the flow channel, and separated to a plurality of downstream flow channels based on whether each cell fulfills a predetermined condition. A culturing tank for collecting the condition-fulfilling cells is covered with a semipermeable membrane at a top surface so as to prevent contamination during cell separation. When the cell separation is finished, the flow channel communicated with the culturing tank accommodating the condition-fulfilling cells is closed, and the culturing tank is cut off from the apparatus and put into a culturing device containing a predetermined medium to culture the cells.
摘要翻译：提供了使用形成在基板的一个表面上的流动通道和可替代每个样品的芯片的便宜的电池分析和分离装置，以及用于培养分离的电池而不被污染的方法。提供了允许含细胞的缓冲溶液流动的流动通道。基于每个小区是否满足预定条件，在流信道的中间检测小区，并将其分离成多个下游流信道。用于收集状态满足细胞的培养槽在顶表面被半透膜覆盖，以防止细胞分离过程中的污染。当细胞分离完成时，与容纳条件满足细胞的培养箱连通的流动通道关闭，并将培养箱从装置中切下并放入含有预定培养基的培养装置中以培养细胞。

8. 发明授权

US07217573B1 Method of inspecting a DNA chip 有权
标题翻译：检查DNA芯片的方法
公开(公告)号：US07217573B1
公开(公告)日：2007-05-15
申请号：US09678652
申请日：2000-10-04
申请人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
发明人： Yoshitada Oshida , Toshihiko Nakata , Tomoaki Sakata , Kenji Yasuda , Satoshi Takahashi
IPC分类号： G01N33/00 , G01N33/53 , C12Q1/68 , C12M3/00 , C07H21/04 , H01J3/14
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456 , Y10S436/80 , Y10T436/143333
摘要： A method of inspecting a DNA chip and an apparatus therefor that allow a picture to be reconstructed in the following steps: A plurality of irradiation spots are formed on a DNA probe array mounted on a stage. Then, the stage is displaced in X, Y directions so as to execute a scanning, thereby irradiating substantially all the entire surface of the DNA probe array. Next, a plurality of emitted fluorescent lights, which are generated from the plurality of irradiation spot portions on the DNA probe array, are converged and are then detected simultaneously by multi detectors. Finally, a data processing apparatus processes the detected signals, thereby reconstructing the picture.
摘要翻译：一种用于检查DNA芯片的方法及其装置，其允许以下列步骤重建图像：在安装在平台上的DNA探针阵列上形成多个照射点。然后，在X，Y方向上移位台，以进行扫描，从而基本上照射DNA探针阵列的整个表面。接下来，从DNA探针阵列上的多个照射点部分产生的多个发射荧光灯被会聚，然后由多个检测器同时检测。最后，数据处理装置处理检测到的信号，从而重建图像。

9. 发明申请

US20060194307A1 Cell measuring and sorting chip 有权
标题翻译：电池测量和分选芯片
公开(公告)号：US20060194307A1
公开(公告)日：2006-08-31
申请号：US11317004
申请日：2005-12-27
申请人： Kenji Yasuda , Akihiro Hattori , Kazunori Okano
发明人： Kenji Yasuda , Akihiro Hattori , Kazunori Okano
IPC分类号： C12M1/34 , B07C5/00
CPC分类号： G01N15/147 , B01L3/502761 , B01L2200/0647 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , C12M47/04 , G01N35/085 , G01N2015/149 , G06T7/0012 , G06T2207/10056 , G06T2207/30024
摘要： The present invention provides a cell sorting device using an inexpensive chip capable of being exchanged for each sample for cell sorting. The cell sorting device uses flow paths formed on the substrate and has the following structure. The chip includes: a first flow path allowing a buffer fluid containing cells to flow down; second and third flow paths which put the first flow path therebetween and allow a buffer fluid not containing cells to flow down from both sides of the first flow path; a fourth flow path which allows the buffer fluid as a single flow path formed by the join of the buffer fluid in the first flow path and the buffer fluid in the second and third flow paths; a cell detecting region for detecting cells flowing with a buffer fluid down the fourth flow path; a cell sorting region for sorting the cells according to a type of the cells detected. The first flow path, the second and the third flow paths, the fourth flow path, the cell detecting region and the cell sorting region provided in a cascade. Two flow paths are provided to allow the cells sorted to flow downstream of the cell sorting region. The buffer fluid flowing in the first to the fourth flow paths is supplied from reservoirs having the same fluid level. The first flow path and the fourth flow path are structured to have substantially the same width or cross-section area.
摘要翻译：本发明提供一种使用廉价的芯片的细胞分选装置，其能够用于每个样品进行细胞分选。细胞分选装置使用形成在基板上的流路，具有以下结构。芯片包括：允许包含电池的缓冲流体向下流动的第一流路; 第二和第三流动路径，其将第一流动路径放置在其间并允许不含有电池的缓冲流体从第一流动路径的两侧向下流动; 第四流动路径，其允许缓冲流体作为由第一流动路径中的缓冲流体的连接和第二和第三流动路径中的缓冲流体形成的单个流动路径; 细胞检测区域，用于检测在第四流路下方以缓冲液流动的细胞; 用于根据检测到的细胞的类型对细胞进行分选的细胞分选区域。第一流路，第二流路，第三流路，第四流路，单元检测区域和电池排列区域。提供了两个流动路径以允许排序的细胞流动到细胞分选区域的下游。在第一至第四流动路径中流动的缓冲流体从具有相同流体液位的储存器供应。第一流路和第四流路被构造成具有基本相同的宽度或横截面面积。

10. 发明申请

US20060141619A1 Apparatus and method for machining microchamber for cell culture 有权
标题翻译：用于细胞培养微孔加工的装置和方法
公开(公告)号：US20060141619A1
公开(公告)日：2006-06-29
申请号：US10544799
申请日：2004-02-19
申请人： Akihiro Hattori , Kenji Yasuda
发明人： Akihiro Hattori , Kenji Yasuda
IPC分类号： C12N5/06 , C12M1/00
CPC分类号： C12M23/16 , B01J2219/00317 , B01J2219/00441 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00743 , B01L3/5085 , B01L2200/12 , B01L2300/0819 , B01L2300/12 , B01L2300/163
摘要： There is provided a processing apparatus and a processing method for micro-chamber for cell culture having a desired culturing space. The micro-chamber processing apparatus for cell culture of the present invention comprises a micro-chamber comprising no more than one absorption layer and at least one gel layer, in this order, laminated on a transparent base plate having no conspicuous absorbency in visible and infrared regions, and at least one light source, said absorption layer having absorbency in visible and infrared regions, and said gel-like material being a substance which has a gel dissolution temperature of 100 degree C. or less, solates when heated and is in a gel state at room temperature and has absorbency for a specific wave length of visible and infrared regions, and said light source having a monochromatic light in said specific wave length, wherein said light source is disposed such that it irradiates on said absorption layer and/or said gel layer, with the exception that when no absorption layer is provided, at least two layers each composed of a gel-like material are laminated on said transparent base plate.
摘要翻译：提供了具有期望的培养空间的用于细胞培养的微室的处理装置和处理方法。本发明的细胞培养用微细胞处理装置，具有不超过一个吸收层和至少一层凝胶层的微室，依次层叠在透明基板上，在可见光和红外线中不具有明显的吸收性区域和至少一个光源，所述吸收层在可见光和红外区域具有吸收性，所述凝胶状材料是凝胶溶解温度为100℃以下的物质，加热时的溶胶化物在具有特定波长的可见光和红外区域具有吸收能力，并且所述光源具有所述特定波长的单色光，其中所述光源被设置成使得其照射在所述吸收层和/或所述凝胶层除了没有设置吸收层之外，将由凝胶状材料构成的至少两层层合在所述透明体b上灰板

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