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1. 发明授权

US5137807A Method for determining beta-subunit of human prolyl 4-hydroxylase by immunoassay to detect hepatic disease 失效
标题翻译：通过免疫测定法检测肝脏疾病的人脯氨酰4-羟化酶的β-亚单位的方法
公开(公告)号：US5137807A
公开(公告)日：1992-08-11
申请号：US380751
申请日：1989-07-17
申请人： Shinichi Yoshida , Eiji Ishikawa , Akira Oshima , Yasuo Bai , Yasuteru Muragaki , Kazushi Iwata , Kenichi Obata , Yasuo Nagai
发明人： Shinichi Yoshida , Eiji Ishikawa , Akira Oshima , Yasuo Bai , Yasuteru Muragaki , Kazushi Iwata , Kenichi Obata , Yasuo Nagai
IPC分类号： A61K39/00 , C12Q1/00 , C12Q1/26 , G01N33/573 , G01N33/577
CPC分类号： G01N33/573 , Y10S436/811 , Y10S436/82
摘要： The present invention is directed to a method for detecting hepatic diseases which are associated with fibrosis by determining the level of human prolyl hydroxylase in a serum sample which comprises:(a) contacting a serum sample of a patient suspected of having said hepatic disease associated with fibrosis with a monoclonal antibody specific to the .beta.-subunit of human prolyl hydroxylase to form an antigen antibody complex bound on a solid support;(b) contacting said antigen antibody complex bound on said solid support with an enzyme-labeled monoclonal or enzyme-labeled polyclonal antibody specific to human prolyl hydroxylase to form an antibody antigen enzyme-labeled antibody complex; and(c) measuring the amount of enzyme activity of said bound antibody antigen enzyme-labeled antibody complex to determine the level of human prolyl hydroxylase present in said serum sample.
摘要翻译：本发明涉及通过测定血清样品中人脯氨酰羟化酶水平来检测与纤维化相关的肝病的方法，该方法包括：（a）使疑似患有所述肝病的患者的血清样品与纤维化与对人脯氨酰羟化酶的β亚单位特异的单克隆抗体形成结合在固体支持物上的抗原抗体复合物; （b）将结合在所述固体支持物上的所述抗原抗体复合物与人脯氨酰羟化酶特异性的酶标记的单克隆或酶标记的多克隆抗体接触以形成抗体抗原酶标记的抗体复合物; 和（c）测量所述结合的抗体抗体酶标记的抗体复合物的酶活性的量以确定存在于所述血清样品中的人脯氨酰羟化酶的水平。

2. 发明授权

US5316914A Method for determining human collagen peptides by way of enzyme immunoassay 失效
标题翻译：通过酶免疫测定法测定人胶原肽的方法
公开(公告)号：US5316914A
公开(公告)日：1994-05-31
申请号：US831645
申请日：1992-02-07
申请人： Akira Oshima , Kazushi Iwata , Yasuteru Muragaki , Yasuo Bai , Eisaku Matsumoto , Satoshi Miyamoto
发明人： Akira Oshima , Kazushi Iwata , Yasuteru Muragaki , Yasuo Bai , Eisaku Matsumoto , Satoshi Miyamoto
IPC分类号： G01N33/68 , G01N33/543 , G01N33/576 , G01N33/577
CPC分类号： G01N33/6887
摘要： A method for determining human type III, IV and VI collagen peptides by way of enzyme immunoassay according to the sandwich technique using a monoclonal antibody and a polyclonal antibody each to the human type III, IV or VI collagen peptide, characterized in that the monoclonal antibody to the collagen peptide is used as an antibody to be coated onto a solid phase and/or an antibody to be labeled with an enzyme. Also disclosed is a sandwich technique using two different monoclonal antibodies. This method can be carried out with a smaller amount of samples in a simple manner to obtain a precise result and is thus useful for diagnosis of hepatic diseases.
摘要翻译：一种通过使用单克隆抗体和针对人III，IV或VI型胶原肽的多克隆抗体的夹心技术通过酶免疫测定法测定人III，IV和VI型胶原肽的方法，其特征在于单克隆抗体使用胶原肽作为要涂覆在待用酶标记的固相和/或抗体上的抗体。还公开了使用两种不同单克隆抗体的夹心技术。该方法可以用较少量的样品以简单的方式进行，以获得精确的结果，因此可用于诊断肝脏疾病。

3. 发明授权

US5130233A Method for determining the .beta.-subunit of human prolyl hydroxylase by radioimmunoassay to detect hepatic disease 失效
标题翻译：通过放射免疫测定法检测肝脏疾病的人脯氨酰羟化酶的β亚单位的方法
公开(公告)号：US5130233A
公开(公告)日：1992-07-14
申请号：US458435
申请日：1989-12-28
申请人： Kazuyoshi Inada , Akira Oshima , Yasuo Bai , Shinichi Yoshida , Kazushi Iwata
发明人： Kazuyoshi Inada , Akira Oshima , Yasuo Bai , Shinichi Yoshida , Kazushi Iwata
IPC分类号： A61K39/00 , C12Q1/00 , C12Q1/26 , G01N33/573 , G01N33/577
CPC分类号： G01N33/573 , Y10S436/811 , Y10S436/82
摘要： A method for determining human prolyl hydroxylase by radioimmunoassay according to the sandwich method wherein a monoclonal antibody to human prolyl hydroxylase and polyclonal antibody to human prolyl hydroxylase are used, characterized in that a monoclonal antibody to human prolyl hydroxylase is used as at least one of the antibodies which are to be coated on a solid support and to be labeled with a radioactive element. This method is simple and operable with small amounts of samples and gives exact results. Thus, this method is useful for the diagnosis of hepatic diseases. A monoclonal antibody specific to the .beta.-subunit of human prolyl hydroxylase is used to test for the human prolyl hydroxylase.
摘要翻译：一种按照夹心法通过放射免疫测定法测定人脯氨酰羟化酶的方法，其中使用人脯氨酰羟化酶的单克隆抗体和人脯氨酰羟化酶的多克隆抗体，其特征在于使用人脯氨酰羟化酶的单克隆抗体作为至少一种将要涂覆在固体支持物上并用放射性元素标记的抗体。该方法简单且可操作，少量样品，并给出精确的结果。因此，该方法对肝脏疾病的诊断有用。使用对人脯氨酰羟化酶的β亚基特异性的单克隆抗体来测试人脯氨酰羟化酶。

4. 发明申请

US20150199619A1 Use-Assisting Tool for Autonomous Mobile Device, Operation Management Center, Operation System, and Autonomous Mobile Device 审中-公开
标题翻译：自主移动设备使用辅助工具，操作管理中心，操作系统和自主移动设备
公开(公告)号：US20150199619A1
公开(公告)日：2015-07-16
申请号：US14419681
申请日：2012-08-07
申请人： Ryoko Ichinose , Takashi Sato , Ai Masuda , Kenjiro Yamamoto , Yukihiko Ono , Akira Oshima
发明人： Ryoko Ichinose , Takashi Sato , Ai Masuda , Kenjiro Yamamoto , Yukihiko Ono , Akira Oshima
IPC分类号： G06Q10/02 , G05D1/00 , G01C21/34 , G05D1/02
CPC分类号： G06Q10/02 , B60S3/00 , G01C21/3469 , G05D1/0022 , G05D1/0217
摘要： Provided are: a use-assisting tool for an autonomous mobile device that enhances convenience for a user of the autonomous mobile device; an operation management center; an operation system; and an autonomous mobile device. The use-assisting tool for an autonomous mobile device provides assistance for using the autonomous mobile device, which travels autonomously along a route to a destination, and is characterized by: being provided with a communication means that communicates with an operation management center, an input means, and a display means; a destination to be visited using the autonomous mobile device being input by means of the input means; and the display means displaying cooperation information established at the destination that is transmitted from the operation management center. The cooperation information established at the destination includes information regarding securing a mobility means at the destination and establishing a reservation at the destination.
摘要翻译：提供：一种用于自主移动设备的使用辅助工具，其增强了对于自主移动设备的用户的便利性; 运营管理中心; 操作系统; 和自主移动设备。用于自主移动设备的使用辅助工具为使用自主地沿着到达目的地的路线行进的自主移动设备提供帮助，其特征在于：设置有与操作管理中心通信的通信装置，输入手段和显示装置; 使用通过输入装置输入的自主移动装置访问的目的地; 并且显示装置显示从操作管理中心发送的在目的地建立的协作信息。在目的地建立的合作信息包括关于在目的地确保移动装置并在目的地建立预留的信息。

5. 发明授权

US09062980B2 Autonomous mobile system 有权
标题翻译：自主移动系统
公开(公告)号：US09062980B2
公开(公告)日：2015-06-23
申请号：US14359335
申请日：2011-11-22
申请人： Yoshitaka Hara , Akira Oshima , Ryoko Ichinose , Kenjiro Yamamoto
发明人： Yoshitaka Hara , Akira Oshima , Ryoko Ichinose , Kenjiro Yamamoto
IPC分类号： G01C21/28 , G05D1/02 , G01S17/89 , G01C21/30 , G01C21/32
CPC分类号： G01C21/28 , G01C21/30 , G01C21/32 , G01S7/4808 , G01S17/89 , G05D1/024 , G05D1/0248 , G05D1/0251 , G05D1/0274 , G05D2201/0213
摘要： An autonomous mobile system for a mobile body which moves while localizing itself in a space includes a shape detector and travel distance detector for measuring whether objects are present in set regions determined by dividing a three-dimensional space into a plurality of segments, a storage device into which map data is stored that indicates a region of the set regions that has been set as having a stationary object in the region, a determining section that determines, from frequency of the object detection by the shape detector during a predetermined time for each of the set regions, whether the object that has been detected in each set region is a stationary object or a moving object, and a localizer that localizes a vehicle by matching the region that the determining section has determined to have a stationary object in the region, and the map data.
摘要翻译：一种移动体的自主移动系统，其移动同时将其自身定位在空间中，包括形状检测器和行进距离检测器，用于测量物体是否存在于通过将三维空间分割成多个段所确定的设定区域中;存储装置存储指示已经被设置为具有在该区域中具有静止对象的设定区域的区域的地图数据的确定部分，其根据形状检测器在预定时间内的每个物体检测的频率确定设定区域，是否在每个集合区域中检测到的物体是静止物体或移动物体;以及定位器，其通过使确定部分已经确定具有在该区域中具有静止物体的区域匹配来定位车辆; 和地图数据。

6. 发明授权

US09182235B2 Locus correcting method, locus correcting apparatus, and mobile object equipment 有权
标题翻译：轨迹校正方法，轨迹校正装置和移动物体设备
公开(公告)号：US09182235B2
公开(公告)日：2015-11-10
申请号：US14118899
申请日：2011-05-20
申请人： Yoshitaka Hara , Akira Oshima , Kenjiro Yamamoto , Yuji Hosoda
发明人： Yoshitaka Hara , Akira Oshima , Kenjiro Yamamoto , Yuji Hosoda
IPC分类号： G01C21/00 , G01C21/30
CPC分类号： G01C21/005 , G01C21/30
摘要： Calculating a highly accurate locus is a goal. An administrative part (20) for correcting a traveling locus of a mobile object (V) is characterized by including an evaluation function generating unit (21) that sets a plurality of nodes on locus data of the mobile object (V) acquired by a wheel rotation quantity measuring unit (16), correlates position data of the mobile object (V) acquired by the wheel rotation quantity measuring unit (16) to the nodes and correlates position data of the mobile object (V) acquired by other units of measurement means than the wheel rotation quantity measuring unit to the nodes, represents positions at which the nodes may occur by probability, represents positions at which position data correlated to the nodes may occur by probability, and calculates an evaluation function including the nodes and the position data as variables, based on each probability; and a locus optimization calculation unit (22) that calculates a locus on which each node occurs with largest probability, based on the evaluation function.
摘要翻译：计算高精度的轨迹是一个目标。用于校正移动物体（V）的行驶轨迹的管理部分（20）的特征在于包括评估函数生成单元（21），其设置由车轮获取的移动体（V）的轨迹数据上的多个节点旋转量测量单元（16）将由车轮旋转量测量单元（16）获取的移动体（V）的位置数据与节点相关联，并且将由测量装置的其他单元获取的移动体（V）的位置数据相关联，相对于节点的车轮旋转量测量单元，表示以概率出现节点的位置，表示通过概率与节点相关的位置数据的位置，并且计算包括节点和位置数据的评估函数，变量，基于每个概率; 以及轨迹优化计算单元，其基于所述评估函数，以最大概率计算出每个节点出现的轨迹。

7. 发明授权

US4872642A Seal mechanism for butterfly valve with press contacting seal effective in both inflow and outflow directions 失效
标题翻译：具有压力接触密封的蝶阀的密封机构在流入和流出方向均有效
公开(公告)号：US4872642A
公开(公告)日：1989-10-10
申请号：US240831
申请日：1988-09-02
申请人： Akira Oshima
发明人： Akira Oshima
IPC分类号： F16K1/226
CPC分类号： F16K1/2261
摘要： A seal mechanism for butterfly valve of concentric opening with press contacting seal, which comprises a ring-formed seal metal arranged surrounding the valve body under insertion in a radially displaceable manner in a circumferential groove formed around the circumference of the valve body, said seal metal having a rounded outer peripheral face; a seal metal disposed surrounding the inner wall of the valve casing and formed integrally therewith, with its seat face inclining relative to the conduit direction of the valve casing; and two tubular buffer rings inserted in said groove of the valve body in between the bottom of the groove and the inner circumference of the seat metal, each of said tubular buffer rings being split along its entire looping length on the upper or lower side of the ring so as to leave a C-shaped cross section to thereby provide a resilient support for said seal metal on said groove bottom at the neutral position on the seat face between the thrust force components in the inflow and the outflow directions of the valve.
摘要翻译：一种具有压力接触密封的同心开口的蝶阀的密封机构，其包括围绕阀体的环形密封金属，该环形密封金属以可径向移动的方式插入围绕阀体的圆周形成的圆周槽中，所述密封金属具有圆形的外周面; 密封金属，其设置在所述阀壳体的内壁周围并与其一体形成，其阀座面相对于所述阀壳体的导管方向倾斜; 以及两个管状缓冲环，其插入在所述槽体的所述凹槽之间的所述凹槽的底部和所述座椅金属的内周之间，每个所述管状缓冲环沿其整个环形长度在所述槽的上侧或下侧分开以便留下C形横截面，从而在阀门的流入和推出方向上的推力分量之间的座面上的中间位置为所述凹槽底部的所述密封金属提供弹性支撑。

8. 发明授权

US3968306A Plastic articles having improved surface characteristics 失效
标题翻译：具有改善的表面特性的塑料制品
公开(公告)号：US3968306A
公开(公告)日：1976-07-06
申请号：US380560
申请日：1973-07-19
申请人： Toshio Yoshihara , Keisuke Yoshihara , Tuneo Ikeda , Yasuyuki Yamasaki , Akira Oshima , Naoyuki Fukabori
发明人： Toshio Yoshihara , Keisuke Yoshihara , Tuneo Ikeda , Yasuyuki Yamasaki , Akira Oshima , Naoyuki Fukabori
IPC分类号： B05D7/24 , C08F2/00 , C08J7/04 , C08J7/12 , B32B27/06 , B32B27/36
CPC分类号： C08J7/047 , C08J2433/00 , Y10S524/911 , Y10T428/265 , Y10T428/31511 , Y10T428/31794 , Y10T428/31797 , Y10T428/31855 , Y10T428/31909 , Y10T428/3192 , Y10T428/31928 , Y10T428/31935 , Y10T428/31938
摘要： A plastic article having improved surface characteristics comprises a plastic body having adhered thereon a cross-linked film of a composition comprising (A) 10 to 90 parts by weight of a cross-linking unsaturated compound having a molecular weight of M and containing in the molecule N polymerizable ethylenically unsaturated radicals (N being an integer of 2 or more), the ratio of said molecular weight, M, to said number, N, of ethylenically unsaturated radicals (M/N) being about 49 to about 600, (B) 90 to 10 parts by weight of an unsaturated monomer containing in the molecule at least one radical copolymerizable with said component (A) and at least one acid radical, and (C) up to 20 parts by weight of other copolymerizable unsaturated compounds, the total of (A), (B) and (C) being 100 parts by weight, at least a part of the acid radicals contained in the film having been converted into alkali salts thereof, said cross-linked film having a thickness of 5 to 500 .mu.. The above plastic article is produced by forming on the surface of a plastic body a cross-linked film of the composition comprising the components (A), (B) and (C) and then treating the cross-linked film with a base to convert the acid radical into its alkali salt.
摘要翻译：具有改善的表面特性的塑料制品包括粘附有组合物的交联膜的塑料体，所述组合物包含（A）10至90重量份的分子量为M且在分子中含有的交联不饱和化合物 N可聚合烯键式不饱和基团（N为2以上的整数），所述分子量M与烯键式不饱和基团（M / N）的数目N的比例为约49〜约600，（B） 90〜10重量份在分子中含有至少一个可与所述组分（A）和至少一个酸基共聚的自由基的不饱和单体，和（C）至多20重量份的其它可共聚的不饱和化合物，（A），（B）和（C）为100重量份，所述膜中所含的酸基的至少一部分已转化为碱金属盐，所述交联膜的厚度为5〜500 亩上述塑料制品通过在塑料体的表面上形成包含组分（A），（B）和（C）的组合物的交联膜，然后用碱处理交联膜来转化将酸根转变为其碱性盐。

9. 发明授权

US3968305A Mar-resistant synthetic resin shaped article 失效
标题翻译：耐Mar合成树脂成型制品
公开(公告)号：US3968305A
公开(公告)日：1976-07-06
申请号：US507000
申请日：1974-09-18
申请人： Akira Oshima , Keisuke Yoshihara , Mikio Shiki , Tuneo Ikeda
发明人： Akira Oshima , Keisuke Yoshihara , Mikio Shiki , Tuneo Ikeda
IPC分类号： B29C39/00 , B29C43/22 , C08J5/00 , C08J7/18 , B05D3/06
CPC分类号： C08J7/18 , B29C39/006 , B29C43/22 , C08J5/00 , B29L2007/00 , Y10T428/263 , Y10T428/31507 , Y10T428/31924
摘要： A synthetic resin shaped article having a mar-resistant polymer surface layer integrated with the polymer body is provided. The mar resistant polymer surface layer consisting essentially of, in polymerized form, (a) 20 to 100 wt.% of a compound having a total of at least three acryloxy and/or metharyloxy groups linked with a straight chain aliphatic hydrocarbon residue having not more than 20 carbon atoms (the hydrocarbon residue may contain at least one ether linkage in the main chain) and (b) 0 to 80 wt.% of at least one copolymerizable mono- or diethylenically unsaturated compound.
摘要翻译：提供了一种具有与聚合物主体一体化的耐磨聚合物表面层的合成树脂成形制品。基本上由聚合形式组成的抗阻聚合物表面层（a）20-100重量％的总共具有至少三个丙烯氧基和/或甲氧基的化合物与直链脂族烃残基连接的化合物不超过 20个碳原子（烃残基可以在主链中含有至少一个醚键）和（b）0-80重量％的至少一种可共聚单或二烯属不饱和化合物。

10. 发明授权

US09921069B2 Map data creation device, autonomous movement system and autonomous movement control device 有权
公开(公告)号：US09921069B2
公开(公告)日：2018-03-20
申请号：US14390406
申请日：2012-04-05
申请人： Yukihiko Ono , Kenjiro Yamamoto , Ryoko Ichinose , Akira Oshima
发明人： Yukihiko Ono , Kenjiro Yamamoto , Ryoko Ichinose , Akira Oshima
IPC分类号： G01C21/34 , G01C21/32 , G01C21/36 , G05D1/02
CPC分类号： G01C21/34 , G01C21/32 , G01C21/3602 , G05D1/0248 , G05D1/0274
摘要： The invention is intended to be able to generate map data even if a location not suited for identification of a matching position exists. A map data creation device creates map data, the map data being used for autonomous movement by a vehicle (1a), a vehicle (1b) and/or other vehicles (1), based on a relative position of the vehicle (1b) which exists around the vehicle (1a), relative to the vehicle (1a), the relative position being measured by the vehicle (1a), and object shape data of an object which exists around the vehicle (1b), the object shape being measured by the vehicle (1b). Moreover, the relative position of the vehicle (1b) relative to the vehicle (1a) is calculated based on the object shape data measured by the vehicle (1a).

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