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1. 发明授权

US10065995B2 Protein for affinity-separation matrix 有权
公开(公告)号：US10065995B2
公开(公告)日：2018-09-04
申请号：US14007225
申请日：2012-03-26
申请人： Shinichi Yoshida , Dai Murata , Shunichi Taira
发明人： Shinichi Yoshida , Dai Murata , Shunichi Taira
IPC分类号： C07K14/31 , C07K1/22 , C07K16/00 , C07K16/12 , C07K17/12 , B01D15/38 , C07K16/06 , C07K17/00
摘要： An object of the present invention is to provide a technique to create novel engineered protein ligands that, when immobilized through a lysine residue (its side chain ε-amino group) which allows for efficient immobilization to a carrier, show the optimum binding capacity and binding efficiency to a target molecule. The present invention provides an engineered protein having a sequence obtained by replacing all the lysine residues in Protein A, which is the most typical protein ligand, with other amino acids, and adding lysine at a terminal; and an affinity separation matrix in which such an engineered protein is immobilized on a water-insoluble carrier by reductive amination or the like. This affinity separation matrix is characterized by its high binding capacity to a target molecule even when the immobilized amount of the ligand is small.

2. 发明授权

US09108718B2 Composite-material structure and aircraft main wing and aircraft fuselage provided with the same 有权
标题翻译：复合材料结构和飞机主翼和飞机机身提供相同
公开(公告)号：US09108718B2
公开(公告)日：2015-08-18
申请号：US13386737
申请日：2010-10-05
申请人： Shinichi Yoshida , Hideaki Tanaka , Yuya Tanaka
发明人： Shinichi Yoshida , Hideaki Tanaka , Yuya Tanaka
IPC分类号： B32B3/14 , B32B3/24 , B32B3/26 , B32B7/02 , B32B7/08 , B64C1/12 , B64C1/00 , B64C1/06 , B64C3/00 , B64C3/26 , B64C3/18 , B64C1/14 , B32B7/00 , B32B3/08
CPC分类号： B64C3/187 , B32B3/08 , B32B3/14 , B32B3/263 , B32B3/266 , B32B7/005 , B32B7/02 , B32B7/08 , B64C1/061 , B64C1/064 , B64C1/068 , B64C1/069 , B64C1/1446 , B64C1/1492 , B64C3/182 , B64C3/26 , B64C2001/0072 , Y02T50/43 , Y10T428/24322
摘要： A main wing (1) on which a tensile load is exerted in a longitudinal direction includes a holed structural member that is a composite material made of fiber reinforced plastic which extends in the longitudinal direction and in which access holes (5) are formed and that serves as a center portion (3b); and a front portion (3a) and a rear portion (3c) that are composite materials made of fiber reinforced plastic which extend in the longitudinal direction of the main wing and which are connected to side portions of the center portion. The tensile rigidity of the center portion in the longitudinal direction is set to be lower than the tensile rigidity of the front portion and the rear portion in the longitudinal direction.
摘要翻译：在纵向上施加拉伸载荷的主翼（1）包括作为由长度方向延伸并且形成有进入孔（5）的由纤维增强塑料制成的复合材料的孔结构构件，并且形成有进入孔（5）用作中心部分（3b）; 以及作为由所述主翼的长度方向延伸并与所述中心部的侧部连接的由纤维增强塑料制成的复合材料的前部（3a）和后部（3c）。中心部分在纵向上的拉伸刚度被设定为低于前部和后部在纵向上的拉伸刚度。

3. 发明授权

US08902200B2 Touch panel system and electronic device 有权
标题翻译：触摸屏系统和电子设备
公开(公告)号：US08902200B2
公开(公告)日：2014-12-02
申请号：US13589257
申请日：2012-08-20
申请人： Masayuki Miyamoto , Shinichi Yoshida , Akira Nishioka , Manabu Yumoto , Kengo Takahama
发明人： Masayuki Miyamoto , Shinichi Yoshida , Akira Nishioka , Manabu Yumoto , Kengo Takahama
IPC分类号： G06F3/042
CPC分类号： G06F3/044 , G06F3/0416 , G06F3/0418 , G06F2203/04112
摘要： A touch panel system includes a touch panel having sense lines, and drive lines which intersect the sense lines and form capacitance with the sense lines, a touch panel controller for processing signals of the sense lines, and a drive line driving circuit for driving the drive lines in parallel. The touch panel controller includes a subtracting section for finding differences in signals between the sense lines adjacent to each other, a decoding section for calculating a distribution of differences between the capacitances by calculating an inner product of code sequences for driving the drive lines in parallel and difference output sequences which correspond to the code sequences, a touch detecting section for obtaining touch information based on the distribution of differences between the capacitances calculated by the decoding section, and a region setting section for setting an effective region in the touch panel based on the touch information.
摘要翻译：触摸面板系统包括具有感测线的触摸面板和与感测线相交并与感测线形成电容的驱动线，用于处理感测线的信号的触摸面板控制器和用于驱动驱动器的驱动线驱动电路行并行。触摸面板控制器包括用于求出彼此相邻的感测线之间的信号差异的减法部分，用于通过计算并行驱动驱动线的代码序列的内积来计算电容之间的差分布的解码部分，以及对应于代码序列的差分输出序列，用于基于由解码部分计算出的电容之间的差异的分布获得触摸信息的触摸检测部分和用于基于触摸面板设置触摸面板中的有效区域的区域设置部分触摸信息。

4. 发明申请

US20140132541A1 TOUCH PANEL SYSTEM AND ELECTRONIC DEVICE 有权
标题翻译：触控面板系统和电子设备
公开(公告)号：US20140132541A1
公开(公告)日：2014-05-15
申请号：US14127932
申请日：2012-06-04
申请人： Masayuki Miyamoto , Kunihiko Iizuka , Manabu Yumoto , Shinichi Yoshida , Kengo Takahama
发明人： Masayuki Miyamoto , Kunihiko Iizuka , Manabu Yumoto , Shinichi Yoshida , Kengo Takahama
IPC分类号： G06F3/041
CPC分类号： G06F3/041 , G06F3/0418 , G06F3/044
摘要： A touch panel system (71a) includes a capacitance value distribution detection circuit (72). The capacitance value distribution detection circuit (72) switches a connection state between a first connection state and a second connection state, which first connection state makes first signal lines (HL1 to HLM) serve as drive lines (DL1 to DLM) and second signal lines (VL1 to VLM) serve as sense lines (SL1 to SLM), and which second connection state makes the second signal lines (VL1 to VLM) serve as the drive lines (DL1 to DLM) and the first signal lines (HL1 to HLM) serve as the sense lines (SL1 to SLM).
摘要翻译：触摸面板系统（71a）包括电容值分配检测电路（72）。电容值分配检测电路（72）在第一连接状态和第二连接状态之间切换连接状态，第一连接状态使第一信号线（HL1〜HLM）成为驱动线（DL1〜DLM）和第二信号线（VL1〜VLM）作为感测线（SL1〜SLM），第二连接状态使第二信号线（VL1〜VLM）成为驱动线（DL1〜DLM），第一信号线（HL1〜HLM）用作感测线（SL1至SLM）。

5. 发明申请

US20140018524A1 PROTEINACEOUS-SUBSTANCE-BINDING LOW-MOLECULAR-WEIGHT COMPOUND 有权
标题翻译：蛋白质 - 物质结合低分子量化合物
公开(公告)号：US20140018524A1
公开(公告)日：2014-01-16
申请号：US14007000
申请日：2012-03-23
申请人： Dia Murata , Shinichi Yoshida
发明人： Dia Murata , Shinichi Yoshida
IPC分类号： C07K17/00
CPC分类号： C07K17/00 , B01D15/3809 , B01J20/289 , B01J20/3202 , B01J20/3219 , B01J20/3246 , C07K1/22
摘要： The low-molecular-weight compound represented by the general formula (1): ArX-(Linker)-ArYHB (1), wherein ArX is a structure containing an optionally substituted aromatic six-membered ring, ArYHB is a structure containing an optionally substituted aromatic six-membered ring having a proton donor, the atom group “Linker” has not less than 4 and not more than 30 atoms and binds ArX with ArYHB, is used for binding a proteinaceous substance.
摘要翻译：由通式（1）表示的低分子量化合物：ArX-（连接子）-ArYHB（1），其中ArX是含有任意取代的芳香族六元环的结构，ArYHB是含有任意取代的具有质子给体的芳族六元环，原子团“连接子”具有不少于4个且不多于30个的原子并与ArYHB结合ArX，用于结合蛋白质物质。

6. 发明申请

US20130243992A1 COMPOSITE MATERIAL STRUCTURE, AND AIRCRAFT WING AND FUSELAGE PROVIDED THEREWITH 审中-公开
标题翻译：复合材料结构和飞机提供的飞机和接头
公开(公告)号：US20130243992A1
公开(公告)日：2013-09-19
申请号：US13881620
申请日：2012-02-03
申请人： Yuya Tanaka , Shinichi Yoshida , Hideaki Tanaka , Hideyuki Suzuki , Toshio Abe , Masahiro Kashiwagi
发明人： Yuya Tanaka , Shinichi Yoshida , Hideaki Tanaka , Hideyuki Suzuki , Toshio Abe , Masahiro Kashiwagi
IPC分类号： B64C1/14
CPC分类号： B64C1/14 , B29C70/887 , B32B3/266 , B32B5/142 , B32B5/26 , B32B27/08 , B32B2260/023 , B32B2260/046 , B32B2262/0269 , B32B2262/101 , B32B2262/106 , B32B2307/54 , B32B2605/18 , B64C3/182 , B64C3/20 , B64C3/34 , B64C2001/0072 , Y02T50/43 , Y10T428/192 , Y10T428/24273
摘要： A composite material structure that can be made lighter in weight is provided, with the stress concentration at peripheral edge regions around holes being taken into consideration. A wing (1) that is a composite material structure is of a composite material that extends in one direction, has access holes (5) formed therein, and is made of fiber reinforced plastic. A lower surface outer plate (3) of the wing (1) is subjected to a tensile load in the longitudinal direction. The longitudinal tensile stiffness of peripheral edge regions (3a) around the access holes (5) is lower than the longitudinal tensile stiffness of other regions (3b) surrounding the peripheral edge regions (3a).
摘要翻译：提供可以使重量更轻的复合材料结构，考虑到孔附近的周边边缘区域处的应力集中。作为复合材料结构的翼（1）是沿一个方向延伸的复合材料，其中形成有入口孔（5），并且由纤维增强塑料制成。机翼（1）的下表面外板（3）沿长度方向承受拉伸载荷。周围边缘区域（3a）围绕进入孔（5）的纵向拉伸刚度低于围绕周边边缘区域（3a）的其它区域（3b）的纵向拉伸刚度。

7. 发明申请

US20120277121A1 KIT FOR DETECTION OF MICROORGANISM 审中-公开
标题翻译：用于检测微生物的工具包
公开(公告)号：US20120277121A1
公开(公告)日：2012-11-01
申请号：US13523738
申请日：2012-06-14
申请人： Shinichi Yoshida , Takashi Soejima
发明人： Shinichi Yoshida , Takashi Soejima
IPC分类号： C12Q1/68 , C40B40/06
CPC分类号： C12Q1/68 , C12Q1/689 , C12Q2523/101
摘要： A kit for use in a method for detecting live cells, injured cells and dead cells of a microorganism in a test sample by a nucleic acid amplification method is disclosed. The kit includes a cross-linker capable of cross-linking DNA by irradiation with light having a wavelength of 350 nm to 700 nm, medium, and a primer (s) for amplifying a DNA target region in the microorganism by a nucleic acid amplification method. The nucleic acid amplification method may be a PCR, LAMP, SDA, LCR or DNA microarray method. A cross-linker may be included in the kit such as ethidium monoazide, ethidium diazide, psoralen, 4,5′,8-trimethyl psoralen, or 8-methoxy psoralen.
摘要翻译：公开了一种用于通过核酸扩增方法检测测试样品中微生物的活细胞，受损细胞和死细胞的方法的试剂盒。试剂盒包括能够通过用波长为350nm至700nm的光照射DNA和通过核酸扩增方法扩增微生物中的DNA靶标区域的引物的交联剂。核酸扩增方法可以是PCR，LAMP，SDA，LCR或DNA微阵列法。试剂盒中可以包括交联剂，例如单乙叠胺，二氮嗪，补骨脂素，4,5'，8-三甲基补骨脂素或8-甲氧基补骨脂素。

8. 发明授权

US08241866B2 Method for detection of microorganism and kit for detection of microorganism 有权
标题翻译：微生物检测方法及微生物检测试剂盒
公开(公告)号：US08241866B2
公开(公告)日：2012-08-14
申请号：US12832740
申请日：2010-07-08
申请人： Shinichi Yoshida , Takashi Soejima
发明人： Shinichi Yoshida , Takashi Soejima
IPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/04 , C12Q1/34 , C12Q1/533 , C12Q2304/10
摘要： A kit is disclosed for preparing a measurement sample for detecting live cells, injured cells, VNC cells and dead microorganism cells in a test sample by the following steps: a) the step of treating the test sample with an enzyme having an activity of decomposing cells other than those of the microorganism, colloidal particles of proteins or lipids existing in the test sample, b) the step of treating the test sample with a topoisomerase poison and/or a DNA gyrase poison. c) the step of treating the test sample treated in the steps a) and b) with a nuclear stain agent, and d) the step of detecting the microorganism in the test sample treated with the nuclear stain agent by flow cytometry.
摘要翻译：公开了用于通过以下步骤制备用于检测测试样品中的活细胞，受损细胞，VNC细胞和死亡微生物细胞的测量样品的试剂盒：a）用具有分解细胞活性的酶处理测试样品的步骤除了微生物之外，存在于测试样品中的蛋白质或脂质的胶体颗粒，b）用拓扑异构酶毒物和/或DNA回旋酶毒物处理测试样品的步骤，c）处理测试样品的步骤在步骤a）和b）中使用核染色剂，以及d）通过流式细胞术检测用核染色剂处理的测试样品中的微生物的步骤。

9. 发明申请

US20120121854A1 COMPOSITE-MATERIAL STRUCTURE AND AIRCRAFT MAIN WING AND AIRCRAFT FUSELAGE PROVIDED WITH THE SAME 有权
标题翻译：复合材料结构与飞机主机与飞机提供的融合
公开(公告)号：US20120121854A1
公开(公告)日：2012-05-17
申请号：US13386737
申请日：2010-10-05
申请人： Shinichi Yoshida , Hideaki Tanaka , Yuya Tanaka
发明人： Shinichi Yoshida , Hideaki Tanaka , Yuya Tanaka
IPC分类号： B32B3/10
CPC分类号： B64C3/187 , B32B3/08 , B32B3/14 , B32B3/263 , B32B3/266 , B32B7/005 , B32B7/02 , B32B7/08 , B64C1/061 , B64C1/064 , B64C1/068 , B64C1/069 , B64C1/1446 , B64C1/1492 , B64C3/182 , B64C3/26 , B64C2001/0072 , Y02T50/43 , Y10T428/24322
摘要： An object is to provide a main wing whose weight can be reduced, taking into consideration the stress concentration at circumferential edges of access holes. A main wing (1) on which a tensile load is exerted in a longitudinal direction includes a holed structural member that is a composite material made of fiber reinforced plastic which extends in the longitudinal direction and in which access holes (5) are formed and that serves as a center portion (3b); and a front portion (3a) and a rear portion (3c) that are composite materials made of fiber reinforced plastic which extend in the longitudinal direction of the main wing 1 and which are connected to side portions of the center portion (3b). The tensile rigidity of the center portion (3b) in the longitudinal direction is set to be lower than the tensile rigidity of the front portion (3a) and the rear portion (3c) in the longitudinal direction.
摘要翻译：目的是提供一种能够减小重量的主翼，同时考虑到进入孔的圆周边缘处的应力集中。在纵向上施加拉伸载荷的主翼（1）包括作为由长度方向延伸并且形成有进入孔（5）的由纤维增强塑料制成的复合材料的孔结构构件，并且形成有进入孔（5）用作中心部分（3b）; 以及作为由主翼1的长度方向延伸并与中央部3b的侧部连接的纤维增强塑料制的复合材料的前部3a和后部3c。中心部分（3b）在纵向上的拉伸刚度被设定为低于前部（3a）和后部（3c）在纵向上的拉伸刚度。

10. 发明授权

US08143018B2 Method for preparing a measurement sample for detecting live cells of a microorganism in a test sample 有权
标题翻译：制备用于检测试验样品中微生物的活细胞的测量样品的方法
公开(公告)号：US08143018B2
公开(公告)日：2012-03-27
申请号：US12832782
申请日：2010-07-08
申请人： Shinichi Yoshida , Takashi Soejima
发明人： Shinichi Yoshida , Takashi Soejima
IPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/18
CPC分类号： C12Q1/04 , C12Q1/34 , C12Q1/533 , C12Q2304/10
摘要： According to the following steps, live cells, injured cells, VNC cells and dead cells of a microorganism in a test sample are detected by flow cytometry: a) the step of treating the test sample with an enzyme having an activity of decomposing cells other than those of the microorganism, colloidal particles of proteins or lipids existing in the test sample, b) the step of treating the test sample with a topoisomerase poison and/or a DNA gyrase poison. c) the step of treating the test sample treated in the steps a) and b) with a nuclear stain agent, and d) the step of detecting the microorganism in the test sample treated with the nuclear stain agent by flow cytometry.
摘要翻译：根据以下步骤，通过流式细胞术检测试验样品中微生物的活细胞，受损细胞，VNC细胞和死细胞：a）用具有分解细胞以外的细胞活性的酶处理测试样品的步骤微生物的那些，存在于测试样品中的蛋白质或脂质的胶体颗粒，b）用拓扑异构酶毒物和/或DNA回旋酶毒物处理测试样品的步骤，c）处理在测试样品中处理的测试样品的步骤步骤a）和b），以及d）通过流式细胞术检测用核染色剂处理的测试样品中的微生物的步骤。

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