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1. 发明申请

US20100080843A1 Natural and synthetic sulfur and selenium analogs and polymer conjugated forms thereof for the modulation of angiogenesis 审中-公开
标题翻译：用于血管发生调节的天然和合成的硫和硒类似物及其聚合物缀合形式
公开(公告)号：US20100080843A1
公开(公告)日：2010-04-01
申请号：US11428194
申请日：2006-06-30
申请人： Shaker Mousa , Eric Block
发明人： Shaker Mousa , Eric Block
IPC分类号： A61K31/38 , A61K31/381 , A61K31/10 , A61K31/095 , A61K9/127 , A61P35/00
CPC分类号： A61K31/095 , A61K31/10 , A61K47/60
摘要： The present invention relates to inhibiting angiogenesis with sulfur- or selenium-containing compounds, and polymeric forms thereof, in mammals including animals and humans. Sulfur- or selenium-containing compounds, and polymeric forms thereof, can be used alone or in combination with standard therapies to inhibit angiogenesis-mediated disorders. The present invention also relates to the combined use of sulfur- or selenium-containing compounds, and polymeric forms thereof, with other anti-angiogenesis agents, with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer, and with laser, photodynamic therapy for ocular-related disorders such as diabetic retinopathy or age-related macular degeneration.
摘要翻译：本发明涉及在包括动物和人的哺乳动物中，用含硫或硒的化合物及其聚合物形式抑制血管生成。含硫或硒的化合物及其聚合物形式可以单独使用或与标准治疗组合使用以抑制血管发生介导的病症。本发明还涉及将含硫或硒的化合物及其聚合形式与其它抗血管生成剂与各种抗炎和细胞毒剂以及癌症中的放射治疗剂的组合使用，以及用激光，光动力学治疗眼部相关疾病如糖尿病性视网膜病变或年龄相关性黄斑变性。

2. 发明授权

US4643994A Novel organic trithio oxides and method for the preparation thereof 失效
标题翻译：新型有机三氧化硫及其制备方法
公开(公告)号：US4643994A
公开(公告)日：1987-02-17
申请号：US682435
申请日：1984-12-17
申请人： Eric Block , Saleem Ahmad
发明人： Eric Block , Saleem Ahmad
IPC分类号： A61K31/095 , A61K31/105 , C07C323/65 , C07C381/00 , C07C381/04 , A61K31/60 , C07C149/12
CPC分类号： A61K31/095 , A61K31/105 , C07C323/65 , C07C381/00 , C07C381/04
摘要： This invention relates to novel organic trithio oxides of the formula:R.sup.1 --X --R--X.sup.1 --R.sup.1wherein R is selected from --CH.sub.2 CH.dbd.CH--, ##STR1## and (CH.sub.2).sub.3 ; X is selected from ##STR2## X.sup.1 is selected from --S--S, ##STR3## and, each R.sup.1 is independently selected from carboxyalkyl, alkoxy, alkylthio, amino, alkylamino and acyl substituted and unsubstituted lower alkyl, lower alkenyl, lower alkynyl, phenyl and lower alkylphenyl; provided when R is --CH.sub.2 CH.dbd.CH--, X is ##STR4## and X.sup.1 is --S--S--, then R.sup.1 is not in both instances --CH.sub.2 CH.dbd.CH.sub.2.This invention also relates to a method of preparing the above-identified compounds by heating and further oxidizing various oxides of organic disulfides and to antithrombotic uses of the compounds.
摘要翻译：本发明涉及下式的新型有机三氧化硫：R1-X-R-X1-R1其中R选自-CH2CH = CH-，和（CH2）3; X选自，X 1选自-SS，，每个R 1独立地选自羧基烷基，烷氧基，烷硫基，氨基，烷基氨基和酰基取代和未取代的低级烷基，低级烯基，低级炔基，苯基和低级烷基苯基; 当R是-CH 2 CH = CH-，X是X，且X 1是-S-S-时，则R 2不在两个实例-CH 2 CH = CH 2中。本发明还涉及通过加热和进一步氧化各种有机二硫化物的氧化物和化合物的抗血栓形成方法来制备上述化合物的方法。

3. 发明授权

US06544499B1 Topical compositions comprising protected functional thiols 失效
标题翻译：包含受保护的功能硫醇的局部组合物
公开(公告)号：US06544499B1
公开(公告)日：2003-04-08
申请号：US09478855
申请日：2000-01-07
申请人： Robert Wayne Glenn, Jr. , Alan Roy Katritzky , Eric Block , Matthew David Shair , Matthew David Butts
发明人： Robert Wayne Glenn, Jr. , Alan Roy Katritzky , Eric Block , Matthew David Shair , Matthew David Butts
IPC分类号： A61K706
CPC分类号： A61K8/898 , A61K8/46 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4946 , A61K8/4953 , A61K8/496 , A61K8/69 , A61K8/899 , A61Q3/00 , A61Q5/00 , A61Q5/10 , A61Q5/12 , A61Q11/00 , A61Q19/00
摘要： This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr)m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. A preferred embodiment of the present invention provides a silicone composition and method for making. The composition comprises a polysiloxane or silicone resin, at least one linker, and at least one molecular hook.
摘要翻译：本发明涉及一种用于处理氨基酸基底物的局部组合物，其包含具有所述方法的受保护的硫醇化合物，其中R为官能团，S为硫，Pr为杂环保护基，m为1至100之间的整数。本发明还涉及包含该受保护的硫醇化合物和活化机理的体系。本发明的受保护的硫醇化合物可以用于护发组合物，纺织品护理组合物，化妆品组合物，口腔护理组合物，护肤品，指甲护理，洗衣护理，痤疮护理和动物护理组合物中。本发明的优选实施方案提供一种硅氧烷组合物和制备方法。组合物包含聚硅氧烷或有机硅树脂，至少一个接头和至少一个分子钩。

4. 发明申请

US20100069674A1 GARLIC PROCESSING 有权
标题翻译：加油加工
公开(公告)号：US20100069674A1
公开(公告)日：2010-03-18
申请号：US12514171
申请日：2007-11-09
申请人： Murree Groom , Eric Block
发明人： Murree Groom , Eric Block
IPC分类号： C07C321/12 , C07C315/00
CPC分类号： C07C321/18 , C07C319/24
摘要： A method of producing polysulfides comprising the step of adding elemental sulphur to an allicin-containing plant extract. In preferred embodiments, the plant extract is mechanically treated members of the genus Allium, especially garlic. In further preferred aspects of the invention, the plant extract and sulphur mixture is heated, and the pH is controlled to allow manipulation of the polysulfide chain length. The addition of organic bases, containing nitrogen lone pairs, allows further control of polysulfide chain length.
摘要翻译：一种生产多硫化物的方法，包括向含大蒜素的植物提取物中加入元素硫的步骤。在优选的实施方案中，植物提取物是Allium属的机械处理的成员，特别是大蒜。在本发明的进一步优选方面，加热植物提取物和硫混合物，并且控制pH以允许操纵多硫链长度。加入含有氮离子对的有机碱可以进一步控制多硫链长度。

5. 发明授权

US06495125B2 Topical compositions comprising protected functional thiols 失效
标题翻译：包含受保护的功能硫醇的局部组合物
公开(公告)号：US06495125B2
公开(公告)日：2002-12-17
申请号：US09755817
申请日：2001-01-05
申请人： Robert Wayne Glenn, Jr. , Alan Roy Katritzky , Eric Block , Matthew David Shair , Thomas Ehlis , Joseph Anthony Lupia
发明人： Robert Wayne Glenn, Jr. , Alan Roy Katritzky , Eric Block , Matthew David Shair , Thomas Ehlis , Joseph Anthony Lupia
IPC分类号： A61K706
CPC分类号： A61K8/898 , A61K8/46 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4946 , A61K8/4953 , A61K8/496 , A61K8/69 , A61K8/899 , A61Q3/00 , A61Q5/00 , A61Q5/10 , A61Q5/12 , A61Q11/00 , A61Q19/00
摘要： This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr)m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. Preferred embodiments of the present invention provide a modified UV absorber and a modified antioxidant, methods for making them and compositions conprising them.
摘要翻译：本发明涉及一种用于处理氨基酸基底物的局部组合物，其包含具有所述方法的受保护的硫醇化合物，其中R为官能团，S为硫，Pr为杂环保护基，m为1至100之间的整数。本发明还涉及包含该受保护的硫醇化合物和活化机理的体系。本发明的受保护的硫醇化合物可以用于护发组合物，纺织品护理组合物，化妆品组合物，口腔护理组合物，护肤品，指甲护理，洗衣护理，痤疮护理和动物护理组合物中。本发明的优选实施方案提供了改性的紫外线吸收剂和改性抗氧化剂，制备它们的方法和令人惊奇的组合物。

6. 发明授权

US08658833B2 Garlic processing 有权
标题翻译：大蒜加工
公开(公告)号：US08658833B2
公开(公告)日：2014-02-25
申请号：US12514171
申请日：2007-11-09
申请人： Eric Block , Murree Groom
发明人： Eric Block , Murree Groom
IPC分类号： C07C319/24 , C07C321/20
CPC分类号： C07C321/18 , C07C319/24
摘要： A method of producing polysulfides comprising the step of adding elemental sulphur to an allicin-containing plant extract. In preferred embodiments, the plant extract is mechanically treated members of the genus Allium, especially garlic. In further preferred aspects of the invention, the plant extract and sulphur mixture is heated, and the pH is controlled to allow manipulation of the polysulfide chain length. The addition of organic bases, containing nitrogen lone pairs, allows further control of polysulfide chain length.
摘要翻译：一种生产多硫化物的方法，包括向含大蒜素的植物提取物中加入元素硫的步骤。在优选的实施方案中，植物提取物是Allium属的机械处理的成员，特别是大蒜。在本发明的进一步优选方面，加热植物提取物和硫混合物，并且控制pH以允许操纵多硫链长度。加入含有氮离子对的有机碱可以进一步控制多硫链长度。

7. 发明授权

US08101802B2 Allylic polysulfanes 有权
标题翻译：烯丙基聚硫烷
公开(公告)号：US08101802B2
公开(公告)日：2012-01-24
申请号：US12514370
申请日：2007-11-12
申请人： Murree Groom , Eric Block
发明人： Murree Groom , Eric Block
IPC分类号： C07C321/00 , C07C323/00
CPC分类号： C07C321/18 , C07C319/24
摘要： Diallylic polysulfides (polysulfanes) are provided with sulfur chain lengths of 9 to 22. Also provided are bis(2-methyl-2-propenyl) polysulfides with sulfur chain lengths of 3 to 22. Also provided are 2-substituted bis(2-propenyl) polysulfides with sulfur chain lengths of 3 to 20. Also provided are the 2-cycloalken-1-yl polysulfides, 2-cyclohexen-1-yl polysulfides and 2-cyclopenten-1-yl polysulfides, with sulfur chain lengths of 3 to 20. Also provided are processes for extending the sulfur chain length of diallylic polysulfides and 2-substituted analogues thereof and allyl methyl polysulfides by bringing such compounds into contact with elemental sulfur and heating, or by mixing with molten sulfur.
摘要翻译：二硫代多硫化物（聚硫烷）的硫链长度为9-22。还提供硫链长度为3至22的双（2-甲基-2-丙烯基）多硫化物。还提供了2-取代的双（2-丙烯基）多硫化物，硫链长度为3至20.还提供了2-环烯烃-1-基多硫化物，2-环己烯-1-基多硫化物和2-环戊烯-1-基多硫化物，硫链长度为3至20 还提供了通过使这些化合物与元素硫接触并加热或通过与熔融硫混合来延长二烯基多硫化物及其2-取代的类似物和烯丙基甲基多硫化物的硫链长度的方法。

8. 发明申请

US20100274037A1 ALLYLIC POLYSULFANES 有权
标题翻译：各种聚合物
公开(公告)号：US20100274037A1
公开(公告)日：2010-10-28
申请号：US12514370
申请日：2007-11-12
申请人： Murree Groom , Eric Block
发明人： Murree Groom , Eric Block
IPC分类号： C07C321/18 , C07C321/20 , C07C323/54 , C07F7/08 , C07C323/05 , C07C323/14 , C07C321/22
CPC分类号： C07C321/18 , C07C319/24
摘要： Diallylic polysulfides (polysulfanes) are provided with sulfur chain lengths of 9 to 22. Also provided are bis(2-methyl-2-propenyl) polysulfides with sulfur chain lengths of 3 to 22. Also provided are 2-substituted bis(2-propenyl) polysulfides with sulfur chain lengths of 3 to 20. Also provided are the 2-cycloalken-1-yl polysulfides, 2-cyclohexen-1-yl polysulfides and 2-cyclopenten-1-yl polysulfides, with sulfur chain lengths of 3 to 20. Also provided are processes for extending the sulfur chain length of diallylic polysulfides and 2-substituted analogues thereof and allyl methyl polysulfides by bringing such compounds into contact with elemental sulfur and heating, or by mixing with molten sulfur.
摘要翻译：二硫代多硫化物（聚硫烷）的硫链长度为9-22。还提供硫链长度为3至22的双（2-甲基-2-丙烯基）多硫化物。还提供了2-取代的双（2-丙烯基）多硫化物，硫链长度为3至20.还提供了2-环烯烃-1-基多硫化物，2-环己烯-1-基多硫化物和2-环戊烯-1-基多硫化物，硫链长度为3至20 还提供了通过使这些化合物与元素硫接触并加热或通过与熔融硫混合来延长二烯基多硫化物及其2-取代的类似物和烯丙基甲基多硫化物的硫链长度的方法。

9. 发明授权

US5478959A Method for preparing 1,2-dithiins and precursors of 1,2-dithiins 失效
标题翻译： 1,2-二硫辛烷和1,2-二硫辛前体的制备方法
公开(公告)号：US5478959A
公开(公告)日：1995-12-26
申请号：US318504
申请日：1994-10-05
申请人： Eric Block , Chuangxing Guo
发明人： Eric Block , Chuangxing Guo
IPC分类号： C07C321/18 , C07C327/22 , C07D339/08 , C07F7/08 , C07F7/22 , C07C327/18 , C07C323/05 , C07C323/22
CPC分类号： C07F7/2212 , C07C321/18 , C07C327/22 , C07D339/08 , C07F7/0818
摘要： A method for preparing 1,4-(Z,Z)-disubstituted-1,4-disulfurated-1,3-butadienes is disclosed. The butadienes can be further elaborated to provide 3,6-unsymmetrically-substituted-1,2-dithiins. Also disclosed are butadienes prepared by the method of the invention. These butadienes are useful as intermediates in the synthesis of antibiotic 1,2-dithiins.
摘要翻译：公开了制备1,4-（Z，Z） - 二取代-1,4-二硫化-1,3-丁二烯的方法。可以进一步阐述丁二烯以提供3,6-不对称取代的1,2-二噻吩。还公开了通过本发明的方法制备的丁二烯。这些丁二烯作为合成抗生素1,2-二硫辛酸的中间体是有用的。

10. 发明授权

US4604480A Method for the preparation of sulfones and compounds containing carbon chains having conjugated unsaturation and the compounds resulting from such method 失效
公开(公告)号：US4604480A
公开(公告)日：1986-08-05
申请号：US523276
申请日：1983-08-15
申请人： Eric Block , Mohammad Aslam
发明人： Eric Block , Mohammad Aslam
IPC分类号： C07C2/86 , C07F7/04 , C07C2/76
CPC分类号： C07C2/868
摘要： A method for the preparation of a first sulfone compound of the formula: ##STR1## wherein R.sub.a is ##STR2## where R.sub.b is Br and R.sub.c is H except that R.sub.b and R.sub.c together may be an electron pair when R.sub.6 is a radical of the formula: ##STR3## wherein X.sub.1 is independently chlorine, bromine or iodine and R.sub.1 and R.sub.2 are independently at each occurrence hydrogen or, substituted or unsubstituted, phenyl or alkyl where the substituents are halogen or alkoxy or additional --SO.sub.2 Br groups; provided that, each carbon atom of R.sub.1 or R.sub.2 which contains --SO.sub.2 Br also contains an X.sub.1 group and wherein R.sub.3 through R.sub.9 are independently --OZ,--C.sub.6 M.sub.5,--Z,--SiZ.sub.3 or --X.sub.2, where Z is hydrogen or substituted or unsubstituted phenyl, alkyl, alkenyl or alkynyl; X.sub.2 is chlorine, bromine, iodine or fluorine; M is independently at each occurrence Z or X.sub.2 ; R.sub.3 and R.sub.4 may together be an electron pair; two or more of R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be combined together and with one or more of C.sub.2, C.sub.3 or C.sub.4 to form a ring structure and R.sub.1 and R.sub.2 may be joined together with C.sub.1 to form a ring structure; said method comprising reacting a 1-haloalkyl 1-sulfonyl halide with a second compound of the formula: ##STR4## at a temperature below 25.degree. C. for less than 12 hours where R.sub.3, R.sub.4 and R.sub.5 are as previously described, R.sub.10 is R.sub.6 as previously described or R.sub.11, a radical of the formula: ##STR5##This invention was made with Government support under CHE 811530801 awarded by the National Science Foundation. The Government has certain rights in this invention.

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